ATE527244T1 - N-(1,1,1,3,3,3-hexafluor-2-hydroxypropan-2- yl)benzyl-n'-arylcarbonylpiperazinderivate als lxr modulatoren - Google Patents

N-(1,1,1,3,3,3-hexafluor-2-hydroxypropan-2- yl)benzyl-n'-arylcarbonylpiperazinderivate als lxr modulatoren

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Publication number
ATE527244T1
ATE527244T1 AT09745770T AT09745770T ATE527244T1 AT E527244 T1 ATE527244 T1 AT E527244T1 AT 09745770 T AT09745770 T AT 09745770T AT 09745770 T AT09745770 T AT 09745770T AT E527244 T1 ATE527244 T1 AT E527244T1
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Austria
Prior art keywords
hexafluorine
hydroxypropane
benzyl
lxr modulators
arylcarbonylpiperazine
Prior art date
Application number
AT09745770T
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English (en)
Inventor
Andrew Cooke
Andrew Edwards
Fiona Andrews
David Bennett
Olaf Nimz
Emma Louise Carswell
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Organon Nv
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Publication date
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Publication of ATE527244T1 publication Critical patent/ATE527244T1/de

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    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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AT09745770T 2008-05-15 2009-05-14 N-(1,1,1,3,3,3-hexafluor-2-hydroxypropan-2- yl)benzyl-n'-arylcarbonylpiperazinderivate als lxr modulatoren ATE527244T1 (de)

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EP08156246 2008-05-15
PCT/EP2009/055790 WO2009138438A1 (en) 2008-05-15 2009-05-14 N- (1, 1, 1, 3, 3, 3-hexafluoro-2-hydroxypropan-2-yl) benzyl-n' -arylcarbonylpiperaz ine derivatives

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AR (1) AR071799A1 (de)
AT (1) ATE527244T1 (de)
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FR2955105B1 (fr) 2010-01-11 2012-04-20 Arkema France Procede de preparation d'aminoethyl imidazolidone ou de son thiocarbonyle
PH12012502112A1 (en) * 2010-04-27 2021-06-23 Mitsubishi Tanabe Pharma Corp Novel amide derivative and use thereof as medicine
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AU2014240049C1 (en) * 2013-03-14 2019-03-07 Amgen Inc. Heterocyclic compounds and their uses
EP3091970B1 (de) 2014-01-10 2020-10-28 Rgenix, Inc. Lxr-agonisten und verwendungen davon
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WO2018068296A1 (en) 2016-10-14 2018-04-19 Merck Sharp & Dohme Corp. PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE
JP7027437B2 (ja) 2016-10-27 2022-03-01 エスカリア バイオサイエンシーズ，ビーブイ ＲＯＲ－γモジュレーター
AU2018373028A1 (en) 2017-11-21 2020-04-30 Inspirna, Inc. Polymorphs and uses thereof
EP3765009A4 (de) 2018-03-12 2021-11-10 Escalier Biosciences, BV Bicyclische ror-gamma-modulatoren
BR112020018718A2 (pt) * 2018-03-12 2021-03-09 Escalier Biosciences B.V. Moduladores de ror-gama espirocíclicos
WO2020092395A1 (en) 2018-10-29 2020-05-07 Forma Therapeutics, Inc. SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE
US20230041621A1 (en) * 2019-12-03 2023-02-09 Kallyope, Inc. Sstr5 antagonists
EP4073025B1 (de) 2019-12-13 2024-03-27 Inspirna, Inc. Metallsalze und verwendungen davon
WO2022268520A1 (de) 2021-06-21 2022-12-29 Bayer Aktiengesellschaft Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen.

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CA2723826A1 (en) 2009-11-19
AU2009248058A1 (en) 2009-11-19
AU2009248058B2 (en) 2014-03-13
US8357679B2 (en) 2013-01-22
JP5756747B2 (ja) 2015-07-29
CN102026986A (zh) 2011-04-20
WO2009138438A1 (en) 2009-11-19
EP2297118B1 (de) 2011-10-05
CA2723826C (en) 2016-08-16
AR071799A1 (es) 2010-07-14
JP2011520837A (ja) 2011-07-21
EP2297118A1 (de) 2011-03-23
CN102026986B (zh) 2014-10-29
CN104262294A (zh) 2015-01-07
US20100029621A1 (en) 2010-02-04
TW201006816A (en) 2010-02-16

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