ATE527255T1 - Aryl-isoxazol-4-yl-imidazol-derivate - Google Patents

Aryl-isoxazol-4-yl-imidazol-derivate

Info

Publication number
ATE527255T1
ATE527255T1 AT06841367T AT06841367T ATE527255T1 AT E527255 T1 ATE527255 T1 AT E527255T1 AT 06841367 T AT06841367 T AT 06841367T AT 06841367 T AT06841367 T AT 06841367T AT E527255 T1 ATE527255 T1 AT E527255T1
Authority
AT
Austria
Prior art keywords
isoxazole
aryl
imidazole derivatives
imidazole
derivatives
Prior art date
Application number
AT06841367T
Other languages
English (en)
Inventor
Bernd Buettelmann
Bo Han
Henner Knust
Andrew Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE527255T1 publication Critical patent/ATE527255T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT06841367T 2005-12-27 2006-12-14 Aryl-isoxazol-4-yl-imidazol-derivate ATE527255T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05113011 2005-12-27
PCT/EP2006/069722 WO2007074078A2 (en) 2005-12-27 2006-12-14 Aryl-isoxazol-4-yl-imidazole derivatives

Publications (1)

Publication Number Publication Date
ATE527255T1 true ATE527255T1 (de) 2011-10-15

Family

ID=38218337

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06841367T ATE527255T1 (de) 2005-12-27 2006-12-14 Aryl-isoxazol-4-yl-imidazol-derivate

Country Status (20)

Country Link
US (1) US7414061B2 (de)
EP (1) EP1968973B1 (de)
JP (1) JP2009521516A (de)
KR (1) KR101121372B1 (de)
CN (1) CN101351461B (de)
AR (1) AR058760A1 (de)
AT (1) ATE527255T1 (de)
AU (1) AU2006331437B2 (de)
BR (1) BRPI0620773A2 (de)
CA (1) CA2633367A1 (de)
DK (1) DK1968973T3 (de)
ES (1) ES2371935T3 (de)
IL (1) IL192235A0 (de)
NO (1) NO20082747L (de)
PL (1) PL1968973T3 (de)
PT (1) PT1968973E (de)
RU (1) RU2425045C2 (de)
TW (1) TWI324998B (de)
WO (1) WO2007074078A2 (de)
ZA (1) ZA200805353B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2090570T3 (pl) 2006-09-05 2012-03-30 Kyowa Hakko Kirin Co Ltd Pochodna imidazolu
BRPI0814718A2 (pt) * 2007-06-22 2015-02-24 Hoffmann La Roche Derivados de isoxazol-imidazol
EP2227467B1 (de) 2007-12-04 2014-12-31 F. Hoffmann-La Roche AG Isoxazolo-pyridin-derivate
TW201033201A (en) * 2009-02-19 2010-09-16 Hoffmann La Roche Isoxazole-isoxazole and isoxazole-isothiazole derivatives
US8466181B2 (en) * 2010-12-10 2013-06-18 Hoffmann-La Roche Inc. 1,2,3-triazole-imidazole compounds
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2876778A1 (en) 2012-06-26 2014-01-03 Saniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
KR20150033679A (ko) 2012-06-26 2015-04-01 사니오나 에이피에스 페닐 트리아졸 유도체 및 이의 gabaa 수용체 복합체 조절용 용도
WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
KR101676212B1 (ko) * 2012-10-01 2016-11-14 에프. 호프만-라 로슈 아게 Cns 활성제로서 벤즈이미다졸
BR102019014802A2 (pt) 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4112451A1 (de) * 1991-04-12 1992-10-15 Schering Ag Isoxazolylimidazolderivate, verfahren zu deren herstellung und deren verwendung in arzneimitteln
NZ506507A (en) * 1998-02-09 2003-08-29 Dimensional Pharm Inc Heteroaryl amidine, methylamidine or guanidine derivatives useful as urokinase inhibitors
IT1314191B1 (it) 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
GB0108475D0 (en) 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
IL159697A0 (en) 2001-07-05 2004-06-20 Synaptic Pharma Corp Substituted anilinic piperidines as mch selective antagonists
GB0128160D0 (en) * 2001-11-23 2002-01-16 Merck Sharp & Dohme Novel compounds
US20040132755A1 (en) * 2002-09-06 2004-07-08 Mark Ledeboer Isoxazoles and uses thereof
JP2008502687A (ja) 2004-06-14 2008-01-31 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
BRPI0620146A2 (pt) * 2005-12-23 2011-11-01 Hoffmann La Roche derivados de aril-isoxazolo-4-il-oxadiazol, processo para a preparação dos referidos derivados, medicamento que os contém e usos de um desses derivados
JP4864982B2 (ja) * 2005-12-27 2012-02-01 エフ．ホフマン−ラ ロシュ アーゲー アリール−イソオキサゾール−４−イル−イミダゾ［１，５−ａ］ピリジン誘導体

Also Published As

Publication number Publication date
PL1968973T3 (pl) 2012-03-30
KR20080080229A (ko) 2008-09-02
TWI324998B (en) 2010-05-21
US7414061B2 (en) 2008-08-19
AR058760A1 (es) 2008-02-20
DK1968973T3 (da) 2011-10-31
ES2371935T3 (es) 2012-01-11
TW200736251A (en) 2007-10-01
CA2633367A1 (en) 2007-07-05
RU2008125039A (ru) 2010-02-10
PT1968973E (pt) 2011-12-09
CN101351461B (zh) 2011-09-07
US20070161654A1 (en) 2007-07-12
WO2007074078A2 (en) 2007-07-05
IL192235A0 (en) 2009-02-11
JP2009521516A (ja) 2009-06-04
ZA200805353B (en) 2009-10-28
EP1968973B1 (de) 2011-10-05
AU2006331437A1 (en) 2007-07-05
AU2006331437B2 (en) 2012-07-05
KR101121372B1 (ko) 2012-04-12
WO2007074078A3 (en) 2008-01-17
NO20082747L (no) 2008-09-22
CN101351461A (zh) 2009-01-21
EP1968973A2 (de) 2008-09-17
RU2425045C2 (ru) 2011-07-27
BRPI0620773A2 (pt) 2011-11-22

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