ATE52782T1 - ONE-POT PROCESS FOR THE PREPARATION OF 7 BETAAMINO- AND 7 BETA-ACYLAMINO-3-SUBSTITUTES - Google Patents

ONE-POT PROCESS FOR THE PREPARATION OF 7 BETAAMINO- AND 7 BETA-ACYLAMINO-3-SUBSTITUTES

Info

Publication number
ATE52782T1
ATE52782T1 AT84201215T AT84201215T ATE52782T1 AT E52782 T1 ATE52782 T1 AT E52782T1 AT 84201215 T AT84201215 T AT 84201215T AT 84201215 T AT84201215 T AT 84201215T AT E52782 T1 ATE52782 T1 AT E52782T1
Authority
AT
Austria
Prior art keywords
acylamino
betaamino
substitutes
beta
preparation
Prior art date
Application number
AT84201215T
Other languages
German (de)
Inventor
Jan Verweij
Herman Hendrik Grootveld
Henri Gerard Julius Hirs
Veen Gerardus Johannes Van
Jan Kalter
Peter Wolfgang Henniger
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Priority claimed from EP84201215A external-priority patent/EP0137534B1/en
Application granted granted Critical
Publication of ATE52782T1 publication Critical patent/ATE52782T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

7β-amino-and 7β-acylamino-3-substituted methyl-3-cephem-4carboxylic acids derivatives and 7β-amino-3-substituted-3-cephem-4-carboxylic acid derivatives are prepared by improved deoxygenation process of cephalosporin 1-oxide derivatives. Above method is one-pot process and generally can be applied to derivatives of 7β-acylamino-3- cephem-4-carboxylic 1-oxide derivatives.
AT84201215T 1983-10-07 1984-08-24 ONE-POT PROCESS FOR THE PREPARATION OF 7 BETAAMINO- AND 7 BETA-ACYLAMINO-3-SUBSTITUTES ATE52782T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP83201452 1983-10-07
EP84201215A EP0137534B1 (en) 1983-10-07 1984-08-24 One-pot process for preparation of 7beta-amino- and 7beta-acylamino- 3-substituted methyl-3-cephem-4-carboxylic acid derivatives and process for deoxygenation of 7beta-acylamino-3-cephem-4-carboxylic acid 1-oxide derivatives

Publications (1)

Publication Number Publication Date
ATE52782T1 true ATE52782T1 (en) 1990-06-15

Family

ID=26088615

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84201215T ATE52782T1 (en) 1983-10-07 1984-08-24 ONE-POT PROCESS FOR THE PREPARATION OF 7 BETAAMINO- AND 7 BETA-ACYLAMINO-3-SUBSTITUTES

Country Status (2)

Country Link
KR (1) KR870002165B1 (en)
AT (1) ATE52782T1 (en)

Also Published As

Publication number Publication date
KR850002990A (en) 1985-05-28
KR870002165B1 (en) 1987-12-14

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee