ATE528644T1 - Verwendung ionischer matrizen zur analyse von gewebeabschnitten durch maldi-massenspektrometrie - Google Patents
Verwendung ionischer matrizen zur analyse von gewebeabschnitten durch maldi-massenspektrometrieInfo
- Publication number
- ATE528644T1 ATE528644T1 AT06795327T AT06795327T ATE528644T1 AT E528644 T1 ATE528644 T1 AT E528644T1 AT 06795327 T AT06795327 T AT 06795327T AT 06795327 T AT06795327 T AT 06795327T AT E528644 T1 ATE528644 T1 AT E528644T1
- Authority
- AT
- Austria
- Prior art keywords
- mass spectrometry
- tissue sections
- maldi mass
- conjugate
- analyzing tissue
- Prior art date
Links
- 238000004949 mass spectrometry Methods 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000003795 desorption Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H01J49/0059—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by a photon beam, photo-dissociation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68784805P | 2005-06-07 | 2005-06-07 | |
| PCT/IB2006/002311 WO2007007192A1 (en) | 2005-06-07 | 2006-06-07 | Use of ionic matrices for maldi mass spectrometry analysis of tissue sections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE528644T1 true ATE528644T1 (de) | 2011-10-15 |
Family
ID=37309311
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06795326T ATE520022T1 (de) | 2005-06-07 | 2006-06-07 | Verwendung von konjugaten mit mittels photodissoziation oder fragmentation spaltbaren bindern für die massenspektrometrieanalyse von gewebeschnitten |
| AT06795327T ATE528644T1 (de) | 2005-06-07 | 2006-06-07 | Verwendung ionischer matrizen zur analyse von gewebeabschnitten durch maldi-massenspektrometrie |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06795326T ATE520022T1 (de) | 2005-06-07 | 2006-06-07 | Verwendung von konjugaten mit mittels photodissoziation oder fragmentation spaltbaren bindern für die massenspektrometrieanalyse von gewebeschnitten |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8148676B2 (de) |
| EP (6) | EP2287602A1 (de) |
| JP (2) | JP2008542784A (de) |
| AT (2) | ATE520022T1 (de) |
| CA (2) | CA2611297A1 (de) |
| ES (1) | ES2371203T3 (de) |
| WO (2) | WO2007000669A2 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7824920B2 (en) * | 2003-02-24 | 2010-11-02 | Simon Fraser University | Method of mass spectrometric analysis from closely packed microspots by their simultaneous laser irradiation |
| DE102007024857B4 (de) * | 2007-05-29 | 2017-11-02 | Bruker Daltonik Gmbh | Bildgebende Massenspektrometrie für kleine Moleküle in flächigen Proben |
| US20090286286A1 (en) * | 2007-11-06 | 2009-11-19 | Ambergen , Inc. | Methods for controlling amplification |
| JP5072682B2 (ja) * | 2008-03-28 | 2012-11-14 | 富士フイルム株式会社 | 質量分析用デバイス、これを用いる質量分析装置および質量分析方法 |
| JP5092861B2 (ja) * | 2008-04-14 | 2012-12-05 | 株式会社島津製作所 | 混合液体マトリックスを用いたmaldi質量分析法 |
| CA2760027A1 (en) * | 2009-06-03 | 2010-12-09 | Wayne State University | Mass spectrometry using laserspray ionization |
| WO2011047087A2 (en) | 2009-10-13 | 2011-04-21 | Nanostring Technologies, Inc. | Protein detection via nanoreporters |
| WO2011073740A1 (en) * | 2009-12-15 | 2011-06-23 | Centre National De La Recherche Scientifique (Cnrs) | Matrices for mass spectrometry imaging |
| WO2011127099A1 (en) | 2010-04-05 | 2011-10-13 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US9523680B2 (en) | 2010-06-30 | 2016-12-20 | Ambergen, Inc. | Global Proteomic screening of random bead arrays using mass spectrometry imaging |
| ES2676183T3 (es) | 2010-07-02 | 2018-07-17 | Ventana Medical Systems, Inc. | Detección de dianas usando marcas de masa y espectrometría de masas |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| FR2976076B1 (fr) | 2011-05-31 | 2015-02-27 | Imabiotech | Procede de detection et de quantification d'une molecule cible dans un tissu |
| CA2841249C (en) * | 2011-07-29 | 2023-09-26 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
| HK1205686A1 (en) * | 2012-02-29 | 2015-12-24 | Ambrx, Inc. | Novel prodrug containing molecule compostions and their uses |
| EP4592400A3 (de) | 2012-10-17 | 2025-10-29 | 10x Genomics Sweden AB | Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe |
| EP2767832A1 (de) * | 2013-02-18 | 2014-08-20 | Imabiotech | Photo- oder chemolabile Konjugate zur Detektion von Molekülen |
| ES2693037T3 (es) | 2013-02-25 | 2018-12-07 | Imabiotech | Método para evaluar la acción selectiva de una molécula de interés por un tejido |
| US9618520B2 (en) | 2013-04-25 | 2017-04-11 | Vladislav B. Bergo | Microarray compositions and methods of their use |
| CA2916662C (en) | 2013-06-25 | 2022-03-08 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
| WO2015038784A1 (en) * | 2013-09-13 | 2015-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry |
| AU2015222268B2 (en) * | 2014-02-26 | 2017-06-29 | Ventana Medical Systems, Inc. | Photo-selective method for biological sample analysis field |
| DE102015003440A1 (de) * | 2015-03-16 | 2016-09-22 | Friedrich-Schiller-Universität Jena | Verfahren zur MALDI-MSI Analytik von Objekten, insbesondere biologischen Gewebeproben, und Target zur Analytik sowie dessen Herstellung |
| EP3901282B1 (de) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben |
| SG10202107053QA (en) * | 2015-07-17 | 2021-08-30 | Nanostring Technologies Inc | Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue |
| WO2017015097A1 (en) * | 2015-07-17 | 2017-01-26 | Nanostring Technologies, Inc. | Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue |
| JP6954899B2 (ja) | 2015-12-04 | 2021-10-27 | 10エックス ゲノミクス,インコーポレイテッド | 核酸の解析のための方法及び組成物 |
| WO2017151748A1 (en) * | 2016-03-01 | 2017-09-08 | Trustees Of Boston University | Light-stimulated release of cargo from oligonucleotides |
| GR20160100143A (el) * | 2016-04-11 | 2017-11-30 | Αχιλλεας Αλεξανδρος Βαϊρης | Ελεγχος κατεργασιων συγκολλησης με τριβη |
| EP3336546B1 (de) * | 2016-12-13 | 2020-07-01 | Miltenyi Biotec B.V. & Co. KG | Umkehrbare zellmarkierung mit konjugaten mit zwei lösbaren bindungsstellen |
| WO2018143357A1 (ja) * | 2017-02-01 | 2018-08-09 | 国立大学法人浜松医科大学 | 標的物質と親和性の高い物質をスクリーニングする方法 |
| AU2018327347A1 (en) | 2017-09-07 | 2020-03-19 | Adeptrix Corp. | Multiplexed bead arrays for proteomics |
| US20190249248A1 (en) | 2018-02-12 | 2019-08-15 | Nanostring Technologies, Inc. | Biomolecular probes and methods of detecting gene and protein expression |
| CN109917058A (zh) * | 2019-03-14 | 2019-06-21 | 南京农业大学 | 细胞内四种游离脱氧核苷酸的高效液相测定方法 |
| JP7384358B2 (ja) * | 2020-04-27 | 2023-11-21 | 株式会社島津製作所 | 有機化合物の構造解析方法 |
| GB2628478A (en) | 2020-10-29 | 2024-09-25 | Ambergen Inc | Novel photocleavable mass-tags for multiplexed mass spectrometric imaging of tissues using biomolecular probes |
| CN113861074B (zh) * | 2021-09-23 | 2025-01-24 | 中国检验检疫科学研究院 | 一种离子液体maldi基质的制备方法及应用 |
| CN115541692A (zh) * | 2022-10-20 | 2022-12-30 | 中国科学院兰州化学物理研究所 | 一种同时分析小扁豆萌发过程中多种脂类成分空间分布变化的质谱成像方法 |
| WO2024108178A1 (en) * | 2022-11-18 | 2024-05-23 | Genentech, Inc. | Signal amplification and multiplexing using mass tags for ia-lc-ms/ms based assays |
| WO2024238393A1 (en) * | 2023-05-10 | 2024-11-21 | Northwestern University | Proteoform imaging and characterization mass spectrometry |
| WO2025242912A1 (en) | 2024-05-23 | 2025-11-27 | Institut National de la Santé et de la Recherche Médicale | Conjugates for mass spectrometry imaging |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4625014A (en) * | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| DE69700902T2 (de) * | 1996-01-23 | 2000-07-20 | Rapigene, Inc. | Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit |
| US5808300A (en) * | 1996-05-10 | 1998-09-15 | Board Of Regents, The University Of Texas System | Method and apparatus for imaging biological samples with MALDI MS |
| EP0963443B1 (de) * | 1996-12-10 | 2006-03-08 | Sequenom, Inc. | Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung |
| GB9815166D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
| US20030215421A1 (en) * | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
| WO2000068434A2 (en) | 1999-05-07 | 2000-11-16 | Yale University | Multiple tag analysis |
| CA2419159A1 (en) * | 2000-08-11 | 2002-02-21 | Agilix Corporation | Ultra-sensitive detection systems |
| EP1366356B1 (de) * | 2001-02-14 | 2010-07-21 | Picoliter, Inc. | Einführung akustischer proben zur analyse und/oder verarbeitung |
| US7183116B2 (en) * | 2001-05-14 | 2007-02-27 | The Institute For Systems Biology | Methods for isolation and labeling of sample molecules |
| US6756586B2 (en) * | 2001-10-15 | 2004-06-29 | Vanderbilt University | Methods and apparatus for analyzing biological samples by mass spectrometry |
| DE10238069A1 (de) * | 2002-08-19 | 2004-03-04 | N.V. Nutricia | MALDI-Matrix |
| GB0228429D0 (en) * | 2002-12-05 | 2003-01-08 | Novartis Ag | Organic compounds |
| WO2005067648A2 (en) | 2004-01-08 | 2005-07-28 | Vanderbilt University | Multiplex spatial profiling of gene expression |
| US7588906B2 (en) * | 2004-02-24 | 2009-09-15 | Wisconsin Alumni Research Foundation | Hydrogels for biomolecule analysis and corresponding method to analyze biomolecules |
| EP1756307A1 (de) | 2004-05-20 | 2007-02-28 | Trillion Genomics Limited | Verwendung massenmarkierter sonden zum nachweis von zielnukleinsäuren mittels massenspektrometrie |
-
2006
- 2006-06-07 WO PCT/IB2006/002309 patent/WO2007000669A2/en not_active Ceased
- 2006-06-07 AT AT06795326T patent/ATE520022T1/de not_active IP Right Cessation
- 2006-06-07 EP EP10180422A patent/EP2287602A1/de not_active Withdrawn
- 2006-06-07 EP EP10167398.6A patent/EP2325631B1/de not_active Not-in-force
- 2006-06-07 WO PCT/IB2006/002311 patent/WO2007007192A1/en not_active Ceased
- 2006-06-07 ES ES06795326T patent/ES2371203T3/es active Active
- 2006-06-07 US US11/916,558 patent/US8148676B2/en not_active Expired - Fee Related
- 2006-06-07 JP JP2008515318A patent/JP2008542784A/ja active Pending
- 2006-06-07 EP EP06795326A patent/EP1889047B1/de not_active Not-in-force
- 2006-06-07 EP EP10167401.8A patent/EP2322921B1/de not_active Not-in-force
- 2006-06-07 CA CA002611297A patent/CA2611297A1/en not_active Abandoned
- 2006-06-07 EP EP10167400.0A patent/EP2322920B1/de not_active Not-in-force
- 2006-06-07 CA CA2611266A patent/CA2611266C/en not_active Expired - Fee Related
- 2006-06-07 EP EP06795327A patent/EP1891426B1/de not_active Not-in-force
- 2006-06-07 JP JP2008515317A patent/JP5220593B2/ja not_active Expired - Fee Related
- 2006-06-07 US US11/921,678 patent/US8221972B2/en not_active Expired - Fee Related
- 2006-06-07 AT AT06795327T patent/ATE528644T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007007192A1 (en) | 2007-01-18 |
| JP5220593B2 (ja) | 2013-06-26 |
| JP2008542784A (ja) | 2008-11-27 |
| CA2611297A1 (en) | 2007-01-18 |
| US8221972B2 (en) | 2012-07-17 |
| WO2007007192A8 (en) | 2008-04-17 |
| CA2611266C (en) | 2015-11-24 |
| ES2371203T3 (es) | 2011-12-28 |
| EP1891426B1 (de) | 2011-10-12 |
| JP2008542783A (ja) | 2008-11-27 |
| ATE520022T1 (de) | 2011-08-15 |
| EP2322920A1 (de) | 2011-05-18 |
| EP2325631B1 (de) | 2015-01-28 |
| EP1889047A2 (de) | 2008-02-20 |
| EP1889047B1 (de) | 2011-08-10 |
| US8148676B2 (en) | 2012-04-03 |
| EP1891426A1 (de) | 2008-02-27 |
| WO2007000669A3 (en) | 2007-12-06 |
| EP2325631A1 (de) | 2011-05-25 |
| EP2322920B1 (de) | 2014-12-10 |
| US20080203289A1 (en) | 2008-08-28 |
| WO2007000669A2 (en) | 2007-01-04 |
| EP2322921A1 (de) | 2011-05-18 |
| EP2287602A1 (de) | 2011-02-23 |
| EP2322921B1 (de) | 2014-08-06 |
| US20110151451A1 (en) | 2011-06-23 |
| CA2611266A1 (en) | 2007-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |