ATE528987T1 - Il-18 transgenes tier - Google Patents

Il-18 transgenes tier

Info

Publication number
ATE528987T1
ATE528987T1 AT02745959T AT02745959T ATE528987T1 AT E528987 T1 ATE528987 T1 AT E528987T1 AT 02745959 T AT02745959 T AT 02745959T AT 02745959 T AT02745959 T AT 02745959T AT E528987 T1 ATE528987 T1 AT E528987T1
Authority
AT
Austria
Prior art keywords
animal
offspring
atopic dermatitis
human mammal
fertilized egg
Prior art date
Application number
AT02745959T
Other languages
English (en)
Inventor
Hitoshi Mizutani
Original Assignee
Taiho Pharmaceutical Co Ltd
Nakanishi Kenji
Hitoshi Mizutani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd, Nakanishi Kenji, Hitoshi Mizutani filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE528987T1 publication Critical patent/ATE528987T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
AT02745959T 2001-07-12 2002-07-11 Il-18 transgenes tier ATE528987T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001212218 2001-07-12
PCT/JP2002/007047 WO2003005811A1 (fr) 2001-07-12 2002-07-11 Animal transgenique il-18

Publications (1)

Publication Number Publication Date
ATE528987T1 true ATE528987T1 (de) 2011-11-15

Family

ID=19047412

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02745959T ATE528987T1 (de) 2001-07-12 2002-07-11 Il-18 transgenes tier

Country Status (6)

Country Link
US (1) US7098373B2 (de)
EP (1) EP1405560B1 (de)
JP (1) JP4381138B2 (de)
AT (1) ATE528987T1 (de)
ES (1) ES2372030T3 (de)
WO (1) WO2003005811A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2399148A1 (en) * 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
JP2005304365A (ja) * 2004-04-20 2005-11-04 Japan Science & Technology Agency Ｔｌｒリガンド及びｉｌ−１応答障害性モデル動物
AU2005277404A1 (en) * 2004-08-20 2006-03-02 Smithkline Beecham Corporation Methods of healing wounds by administering human IL-18
EP2992759B1 (de) * 2013-05-01 2019-07-31 Hyogo College Of Medicine Tiermodell für atopische dermatitis und verwendung davon
JP6456015B2 (ja) * 2013-07-19 2019-01-23 国立大学法人三重大学 閉塞性動脈硬化症モデル動物、るい痩研究用モデル動物、及び全身性アミロイドーシスモデル動物としての非ヒト哺乳動物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001095710A1 (en) 2000-06-16 2001-12-20 Nakanishi, Kenji Caspase 1 gene transfer animal

Also Published As

Publication number Publication date
JP4381138B2 (ja) 2009-12-09
EP1405560A1 (de) 2004-04-07
US7098373B2 (en) 2006-08-29
JPWO2003005811A1 (ja) 2004-10-28
US20040187171A1 (en) 2004-09-23
EP1405560A4 (de) 2007-09-05
EP1405560B1 (de) 2011-10-19
ES2372030T3 (es) 2012-01-13
WO2003005811A1 (fr) 2003-01-23

Similar Documents

Publication Publication Date Title
Hu et al. The African turquoise killifish: A research organism to study vertebrate aging and diapause
Ordway et al. Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse
Finch et al. Chance, development, and aging
Naya et al. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
Greer et al. Hoxb8 is required for normal grooming behavior in mice
Ito et al. The Mohawk homeobox gene is a critical regulator of tendon differentiation
Madani et al. Enhanced hippocampal long‐term potentiation and learning by increased neuronal expression of tissue‐type plasminogen activator in transgenic mice
Seidel et al. Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis
Popovic et al. Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes
Fleischmann et al. Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation
Brandt et al. Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells
ATE528987T1 (de) Il-18 transgenes tier
Cook et al. The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors
Buchanan et al. A gut sensor for sugar preference
Peng et al. Cell Type-specific genetic manipulation and impaired circadian rhythms in vip tTA Knock-In mice
Cao et al. Effect of a high estrogen level in early pregnancy on the development and behavior of marmoset offspring
Nakatsuka et al. A novel GABAergic population in the medial vestibular nucleus maintains wakefulness and gates rapid eye movement sleep
Jing et al. Exogenous oxytocin microinjection into the nucleus accumbens shell attenuates social dominance in group-housed male mice
Fujimura et al. Fluorescence visualization of the enteric nervous network in a chemically induced aganglionosis model
US20090081128A1 (en) Model of Alzheimer's Disease
DE69837221T2 (de) Methode zur bewertung von verbindungen in bezug auf ihres effektes auf die haut
Alexander et al. CA2 Neuronal activity controls hippocampal oscillations and social behavior
Knirsch et al. Calcineurin A and calbindin immunoreactivity in the spinal cord of G93A superoxide dismutase transgenic mice
Wu et al. Molecular control of circuit plasticity and the permanence of imprinted odor memory
CN101942463A (zh) 一种建立急性多型性卟啉病转基因小鼠模型的方法

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties