ATE529109T1 - Hemmung der p38 kinase aktivität durch substituierte heterocyclische harnstoffe - Google Patents
Hemmung der p38 kinase aktivität durch substituierte heterocyclische harnstoffeInfo
- Publication number
- ATE529109T1 ATE529109T1 AT98964709T AT98964709T ATE529109T1 AT E529109 T1 ATE529109 T1 AT E529109T1 AT 98964709 T AT98964709 T AT 98964709T AT 98964709 T AT98964709 T AT 98964709T AT E529109 T1 ATE529109 T1 AT E529109T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibition
- kinase activity
- substituted heterocyclic
- heterocyclic ureas
- ureas
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- -1 aryl ureas Chemical class 0.000 abstract 1
- 230000003157 cancerolytic effect Effects 0.000 abstract 1
- 235000013877 carbamide Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99575097A | 1997-12-22 | 1997-12-22 | |
| PCT/US1998/026080 WO1999032111A1 (en) | 1997-12-22 | 1998-12-22 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE529109T1 true ATE529109T1 (de) | 2011-11-15 |
Family
ID=25542167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98964709T ATE529109T1 (de) | 1997-12-22 | 1998-12-22 | Hemmung der p38 kinase aktivität durch substituierte heterocyclische harnstoffe |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1041982B1 (de) |
| JP (1) | JP4403482B2 (de) |
| AT (1) | ATE529109T1 (de) |
| AU (1) | AU739642B2 (de) |
| CA (1) | CA2315720A1 (de) |
| DE (1) | DE1041982T1 (de) |
| ES (1) | ES2154253T3 (de) |
| IL (3) | IL136738A0 (de) |
| MX (1) | MXPA00006233A (de) |
| WO (1) | WO1999032111A1 (de) |
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| US3646059A (en) * | 1969-05-05 | 1972-02-29 | Du Pont | Plant growth regulatory ureidopyrazoles |
| DE69221794T2 (de) * | 1991-01-21 | 1998-03-19 | Shionogi Seiyaku Kk | 3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga |
| US5162360A (en) * | 1991-06-24 | 1992-11-10 | Warner-Lambert Company | 2-heteroatom containing urea and thiourea ACAT inhibitors |
| DE4227989A1 (de) | 1992-08-21 | 1994-06-09 | Schering Ag | Mittel zur transdermalen Applikation enthaltend 3-Keto-desogestrel |
| CN1048731C (zh) * | 1993-09-17 | 2000-01-26 | 史密丝克莱恩比彻姆公司 | 编码细胞因子抑制性抗炎药物结合蛋白质的多核苷酸 |
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| EP1019394A1 (de) * | 1997-05-22 | 2000-07-19 | G.D. Searle & Co. | PYRAZOLDERIVATE ALS p38-KINASE-INHIBITOREN |
| IL132736A0 (en) * | 1997-05-22 | 2001-03-19 | Searle & Co | 3(5)-Heteroaryl substituted pyrazoles as p38 kinase inhibitors |
| DE69826695T2 (de) * | 1997-05-23 | 2006-02-02 | Bayer Pharmaceuticals Corp., West Haven | Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen |
| AU7966198A (en) * | 1997-06-13 | 1998-12-30 | Smithkline Beecham Corporation | Novel pyrazole and pyrazoline substituted compounds |
| EP1028953A1 (de) * | 1997-11-03 | 2000-08-23 | Boehringer Ingelheim Pharmaceuticals Inc. | Aromatische heterocyclische verbindungen als antiinflammatorische mittel |
| PT1056725E (pt) * | 1997-12-22 | 2006-09-29 | Bayer Pharmaceuticals Corp | Inibicao da raf-quinase usando ureias heterociclicas substituidas com arilo e heteroarilo |
| IL136768A0 (en) * | 1997-12-22 | 2001-06-14 | Bayer Ag | INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS |
| DE69831013T2 (de) * | 1997-12-22 | 2006-04-20 | Bayer Pharmaceuticals Corp., West Haven | Inhibierung der raf-kinase durch substituierte heterocyclische harnstoffverbindungen |
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1998
- 1998-12-22 AT AT98964709T patent/ATE529109T1/de not_active IP Right Cessation
- 1998-12-22 DE DE1041982T patent/DE1041982T1/de active Pending
- 1998-12-22 JP JP2000525102A patent/JP4403482B2/ja not_active Expired - Fee Related
- 1998-12-22 WO PCT/US1998/026080 patent/WO1999032111A1/en not_active Ceased
- 1998-12-22 IL IL13673898A patent/IL136738A0/xx active IP Right Grant
- 1998-12-22 MX MXPA00006233A patent/MXPA00006233A/es not_active Application Discontinuation
- 1998-12-22 AU AU19971/99A patent/AU739642B2/en not_active Ceased
- 1998-12-22 ES ES98964709T patent/ES2154253T3/es not_active Expired - Lifetime
- 1998-12-22 EP EP98964709A patent/EP1041982B1/de not_active Expired - Lifetime
- 1998-12-22 CA CA002315720A patent/CA2315720A1/en not_active Abandoned
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2000
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|---|---|
| IL136738A0 (en) | 2001-06-14 |
| ES2154253T1 (es) | 2001-04-01 |
| MXPA00006233A (es) | 2002-09-18 |
| DE1041982T1 (de) | 2001-06-07 |
| JP2001526223A (ja) | 2001-12-18 |
| ES2154253T3 (es) | 2012-01-27 |
| IL170201A (en) | 2006-12-31 |
| WO1999032111A1 (en) | 1999-07-01 |
| AU1997199A (en) | 1999-07-12 |
| EP1041982A1 (de) | 2000-10-11 |
| JP4403482B2 (ja) | 2010-01-27 |
| AU739642B2 (en) | 2001-10-18 |
| IL136738A (en) | 2007-06-17 |
| EP1041982B1 (de) | 2011-10-19 |
| EP1041982A4 (de) | 2006-06-14 |
| CA2315720A1 (en) | 1999-07-01 |
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