ATE529417T1 - 3',4',5-trimethoxyflavonderivate als die schleimsekretion stimulierendes mittel, entsprechendes verfahren und pharmazeutische zusammensetzung, die diese enthält - Google Patents

3',4',5-trimethoxyflavonderivate als die schleimsekretion stimulierendes mittel, entsprechendes verfahren und pharmazeutische zusammensetzung, die diese enthält

Info

Publication number: ATE529417T1
Authority: AT; Austria
Prior art keywords: pharmaceutical composition; mucus secretion; trimethoxyflavone; derivatives; composition containing
Prior art date: 2007-06-07

Application number

AT08766040T

Other languages

English (en)

Inventor

Seul-Min Choi

Kyung-Koo Kang

Dong-Sung Kim

Jeong-Hoon Kim

Byoung-Ok Ahn

Moo-Hi Yoo

Mi-Jeong Seo

Ju-Mi Kim

Yong-Duck Kim

Sun-Woo Jang

Yong-Sung Shon

Original Assignee

Dong A Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-07

Filing date

2008-06-02

Publication date

2011-11-15

2008-06-02 Application filed by Dong A Pharm Co Ltd filed Critical Dong A Pharm Co Ltd

2011-11-15 Application granted granted Critical

2011-11-15 Publication of ATE529417T1 publication Critical patent/ATE529417T1/de

Links

IIOQEHSFZUYICM-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-methoxychromen-4-one Chemical class C1=C(OC)C(OC)=CC=C1C1=CC(=O)C2=C(OC)C=CC=C2O1 IIOQEHSFZUYICM-UHFFFAOYSA-N 0.000 title abstract 3
210000003097 mucus Anatomy 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
230000028327 secretion Effects 0.000 title abstract 2
208000003556 Dry Eye Syndromes Diseases 0.000 abstract 2
206010013774 Dry eye Diseases 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
208000028006 Corneal injury Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
210000000795 conjunctiva Anatomy 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT08766040T 2007-06-07 2008-06-02 3',4',5-trimethoxyflavonderivate als die schleimsekretion stimulierendes mittel, entsprechendes verfahren und pharmazeutische zusammensetzung, die diese enthält ATE529417T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR1020070055427A KR100930467B1 (ko)	2007-06-07	2007-06-07	점액분비를 촉진시키는 3',4',5-트리메톡시 플라본 유도체화합물, 그의 제조방법 및 약학적 용도
PCT/KR2008/003078 WO2008150085A2 (en)	2007-06-07	2008-06-02	3',4',5-trimethoxy flavone derivatives as stimulant of mucus secretion, method of the same, and pharmaceutical composition comprising the same

Publications (1)

Publication Number	Publication Date
ATE529417T1 true ATE529417T1 (de)	2011-11-15

Family

ID=40094296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08766040T ATE529417T1 (de)	2007-06-07	2008-06-02	3',4',5-trimethoxyflavonderivate als die schleimsekretion stimulierendes mittel, entsprechendes verfahren und pharmazeutische zusammensetzung, die diese enthält

Country Status (14)

Country	Link
US (1)	US8203011B2 (de)
EP (1)	EP2170857B1 (de)
JP (1)	JP5295230B2 (de)
KR (1)	KR100930467B1 (de)
CN (1)	CN101679341B (de)
AT (1)	ATE529417T1 (de)
AU (1)	AU2008260829B2 (de)
BR (1)	BRPI0812494A2 (de)
CA (1)	CA2689136C (de)
DK (1)	DK2170857T3 (de)
ES (1)	ES2375184T3 (de)
MX (1)	MX2009013062A (de)
PT (1)	PT2170857E (de)
WO (1)	WO2008150085A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009018350A1 (en) *	2007-07-31	2009-02-05	Limerick Biopharma, Inc.	Pyrone analog compositions and methods
EP2424541A2 (de) *	2009-04-27	2012-03-07	Limerick BioPharma, Inc.	Phosphorylierte und phosphonierte pyron-analoga zur therapeutischen behandlung
CN102796066B (zh) *	2012-08-31	2014-09-03	云南民族大学	一种黄酮类化合物及其制备方法与应用
CN103059005B (zh) *	2012-11-22	2015-04-22	中南民族大学	白杨素酰胺衍生物及其医药用途
WO2017033060A1 (en) *	2015-08-24	2017-03-02	University Of Macau	Composition for treating dry eye diseases and sjögren's syndrome
CN107373745B (zh) *	2017-07-28	2020-04-03	云南中烟工业有限责任公司	一种防止烟草料液腐败变质的添加剂及其应用
KR102040810B1 (ko) *	2018-01-31	2019-11-05	인제대학교 산학협력단	알파-휴물렌을 유효성분으로 함유하는 안구 건조증 예방 또는 치료용 조성물
KR102685191B1 (ko) *	2021-07-26	2024-07-15	동아제약 주식회사	레코플라본 또는 이의 염을 포함하는 피부개선용 화장료 조성물
US20250082603A1 (en) *	2021-08-05	2025-03-13	Gl Pharmtech Corp.	Ophthalmic composition containing recoflavone for the treatment of dry eye disease and method for preparing the same
CN117794515A (zh) *	2021-08-05	2024-03-29	格里医药科技公司	用于治疗干眼综合征的包含瑞可黄酮的滴眼剂组合物及其制备方法
KR102356603B1 (ko) *	2021-08-05	2022-02-08	지엘팜텍주식회사	안구건조증 치료를 위한 레코플라본 함유 점안 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA873745B (en) *	1986-06-04	1988-10-26	Daiichi Seiyaku Co	Benzopyran derivatives
DE3628590A1 (de) *	1986-08-22	1988-02-25	Musikon Gmbh	Raumeinheit fuer die aufnahme und/oder wiedergabe von akustischen signalen
US5006550A (en) *	1989-12-29	1991-04-09	Allergan, Inc.	Chroman esters of phenols and benzoic acids having retinoid-like activity
KR100447918B1 (ko) *	1996-07-25	2005-09-28	동아제약주식회사	대장을포함한위장관보호작용을갖는플라본및플라바논화합물
FR2753969B1 (fr)	1996-09-27	1998-10-30	Adir	Nouveaux derives de flavones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP3957795B2 (ja) *	1996-10-04	2007-08-15	興和株式会社	フラボン誘導体及びこれを含有する医薬
JPH11279062A (ja) *	1998-01-30	1999-10-12	Fujisawa Pharmaceut Co Ltd	眼科用剤
KR100327621B1 (ko)	1999-09-22	2002-03-15	유충식	7-카르복시메틸옥시-3',4',5-트리메톡시플라본의 제조방법
JP2001233775A (ja) *	2000-02-28	2001-08-28	Cci Corp	涙液分泌促進剤
KR20050024121A (ko) *	2003-09-04	2005-03-10	동아제약주식회사	7-카르복시메틸옥시-3',4',5-트리메톡시 플라본.일수화물, 이의 제조방법 및 용도
US8017649B2 (en)	2005-03-11	2011-09-13	Howard Florey Institute Of Experimental Physiology And Medicine	Flavonoid compounds and uses thereof
DK2444079T3 (en) *	2005-05-17	2017-01-30	Sarcode Bioscience Inc	Compositions and Methods for the Treatment of Eye Diseases

2007
- 2007-06-07 KR KR1020070055427A patent/KR100930467B1/ko active Active
2008
- 2008-06-02 CN CN2008800190634A patent/CN101679341B/zh not_active Expired - Fee Related
- 2008-06-02 WO PCT/KR2008/003078 patent/WO2008150085A2/en not_active Ceased
- 2008-06-02 MX MX2009013062A patent/MX2009013062A/es active IP Right Grant
- 2008-06-02 ES ES08766040T patent/ES2375184T3/es active Active
- 2008-06-02 BR BRPI0812494-9A patent/BRPI0812494A2/pt not_active IP Right Cessation
- 2008-06-02 DK DK08766040.3T patent/DK2170857T3/da active
- 2008-06-02 US US12/451,902 patent/US8203011B2/en not_active Expired - Fee Related
- 2008-06-02 AU AU2008260829A patent/AU2008260829B2/en not_active Ceased
- 2008-06-02 JP JP2010511105A patent/JP5295230B2/ja not_active Expired - Fee Related
- 2008-06-02 PT PT08766040T patent/PT2170857E/pt unknown
- 2008-06-02 AT AT08766040T patent/ATE529417T1/de active
- 2008-06-02 CA CA2689136A patent/CA2689136C/en not_active Expired - Fee Related
- 2008-06-02 EP EP08766040A patent/EP2170857B1/de active Active

Also Published As

Publication number	Publication date
EP2170857A2 (de)	2010-04-07
PT2170857E (pt)	2011-12-12
WO2008150085A2 (en)	2008-12-11
MX2009013062A (es)	2010-01-18
KR20080107542A (ko)	2008-12-11
AU2008260829B2 (en)	2012-11-08
EP2170857B1 (de)	2011-10-19
JP5295230B2 (ja)	2013-09-18
ES2375184T3 (es)	2012-02-27
CA2689136C (en)	2012-11-13
BRPI0812494A2 (pt)	2015-06-16
US8203011B2 (en)	2012-06-19
EP2170857A4 (de)	2010-06-23
WO2008150085A3 (en)	2009-02-26
CN101679341A (zh)	2010-03-24
US20100130448A1 (en)	2010-05-27
CN101679341B (zh)	2012-06-06
DK2170857T3 (da)	2011-12-05
KR100930467B1 (ko)	2009-12-08
CA2689136A1 (en)	2008-12-11
AU2008260829A1 (en)	2008-12-11
JP2010529112A (ja)	2010-08-26

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2012-05-15

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