ATE529514T1 - Sirna zur hemmung der il-6-expression und diese enthaltende zusammensetzung - Google Patents

Sirna zur hemmung der il-6-expression und diese enthaltende zusammensetzung

Info

Publication number
ATE529514T1
ATE529514T1 AT06757677T AT06757677T ATE529514T1 AT E529514 T1 ATE529514 T1 AT E529514T1 AT 06757677 T AT06757677 T AT 06757677T AT 06757677 T AT06757677 T AT 06757677T AT E529514 T1 ATE529514 T1 AT E529514T1
Authority
AT
Austria
Prior art keywords
composition containing
sirna
expression
inhibiting
containing same
Prior art date
Application number
AT06757677T
Other languages
English (en)
Inventor
Hae-Ok Byun
Bun-Soon Choi
Seong-Hyang Sohn
Original Assignee
Ajou Univ Ind Acad Coop Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajou Univ Ind Acad Coop Found filed Critical Ajou Univ Ind Acad Coop Found
Application granted granted Critical
Publication of ATE529514T1 publication Critical patent/ATE529514T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT06757677T 2005-05-20 2006-05-09 Sirna zur hemmung der il-6-expression und diese enthaltende zusammensetzung ATE529514T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020050042427A KR20060119412A (ko) 2005-05-20 2005-05-20 ＩＬ-6 발현 억제를 위한 ｓｉＲＮＡ 및 이를 함유하는조성물
PCT/KR2006/001737 WO2006123867A1 (en) 2005-05-20 2006-05-09 siRNA FOR INHIBITING IL-6 EXPRESSION AND COMPOSITION CONTAINING THEM

Publications (1)

Publication Number Publication Date
ATE529514T1 true ATE529514T1 (de) 2011-11-15

Family

ID=37431419

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06757677T ATE529514T1 (de) 2005-05-20 2006-05-09 Sirna zur hemmung der il-6-expression und diese enthaltende zusammensetzung

Country Status (5)

Country Link
US (1) US20080234218A1 (de)
EP (1) EP1899468B1 (de)
KR (1) KR20060119412A (de)
AT (1) ATE529514T1 (de)
WO (1) WO2006123867A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3208337A1 (de) 2008-09-02 2017-08-23 Alnylam Pharmaceuticals, Inc. Zusammensetzungen zur kombinationshemmung der expression eines mutanten egfr und il-6
WO2011082382A2 (en) * 2009-12-31 2011-07-07 The Trustees Of Columbia University In The City Of New York Methods for detecting and regulating alopecia areata and gene cohorts thereof
JP2023507501A (ja) * 2019-12-23 2023-02-22 ヴェルサメブ アーゲー 遺伝子の発現を同時に調節するための組成物及び方法
CN120241771B (zh) * 2025-04-03 2025-11-04 安徽医科大学 一种他克莫司联合siRNA的双载药微针及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA000852B1 (ru) * 1996-04-09 2000-06-26 Апплайд Резеч Системз Арс Холдинг Н.В. Мутантный il-6 человека и его внутренний фрагмент, кодирующие их последовательности днк, способы их получения, содержащие их фармацевтические композиции, содержащие их векторы, линии клеток-хозяев и способ лечения il-6 опосредованных заболеваний
WO2001068836A2 (en) * 2000-03-16 2001-09-20 Genetica, Inc. Methods and compositions for rna interference
AU2003207708A1 (en) * 2002-02-20 2003-09-09 Sirna Therapeutics, Inc. Rna interference mediated inhibition of map kinase genes
JP2006507841A (ja) * 2002-11-14 2006-03-09 ダーマコン， インコーポレイテッド 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ

Also Published As

Publication number Publication date
EP1899468A4 (de) 2010-08-25
EP1899468A1 (de) 2008-03-19
KR20060119412A (ko) 2006-11-24
WO2006123867A1 (en) 2006-11-23
US20080234218A1 (en) 2008-09-25
EP1899468B1 (de) 2011-10-19

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