ATE529752T1 - Antikörperquantifizierung - Google Patents
AntikörperquantifizierungInfo
- Publication number
- ATE529752T1 ATE529752T1 AT07865898T AT07865898T ATE529752T1 AT E529752 T1 ATE529752 T1 AT E529752T1 AT 07865898 T AT07865898 T AT 07865898T AT 07865898 T AT07865898 T AT 07865898T AT E529752 T1 ATE529752 T1 AT E529752T1
- Authority
- AT
- Austria
- Prior art keywords
- antibody
- interest
- biological sample
- antibodies quantification
- ore
- Prior art date
Links
- 238000011002 quantification Methods 0.000 title 1
- 239000012472 biological sample Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000011992 High performance liquid chromatography with tandem mass spectrometry Methods 0.000 abstract 1
- 102000057297 Pepsin A Human genes 0.000 abstract 1
- 108090000284 Pepsin A Proteins 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 abstract 1
- 229940111202 pepsin Drugs 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87137806P | 2006-12-21 | 2006-12-21 | |
| PCT/US2007/088258 WO2008079914A1 (en) | 2006-12-21 | 2007-12-20 | Antibody quantitation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE529752T1 true ATE529752T1 (de) | 2011-11-15 |
Family
ID=39247371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07865898T ATE529752T1 (de) | 2006-12-21 | 2007-12-20 | Antikörperquantifizierung |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100015652A1 (de) |
| EP (1) | EP2097756B1 (de) |
| JP (1) | JP2010515020A (de) |
| AT (1) | ATE529752T1 (de) |
| ES (1) | ES2374403T3 (de) |
| WO (1) | WO2008079914A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009029231A2 (en) | 2007-08-24 | 2009-03-05 | Millipore Corporation | Method of detecting filter extractables in biopharmaceutical products by liquid chromatography-mass spectrometry |
| WO2009029232A1 (en) * | 2007-08-24 | 2009-03-05 | Millipore Corporation | System and method for diversion of a liquid chromatography eluant |
| WO2010086386A1 (en) * | 2009-01-30 | 2010-08-05 | Pronota N.V. | Protein quantification methods and use thereof for candidate biomarker validation |
| WO2010096154A2 (en) * | 2009-02-20 | 2010-08-26 | Onconome, Inc. | Compositions and methods for diagnosis and prognosis of colorectal cancer |
| CA2799746C (en) * | 2010-05-17 | 2020-11-24 | Sai Reddy | Rapid isolation of monoclonal antibodies from animals |
| JP6211931B2 (ja) | 2011-03-09 | 2017-10-11 | セル・シグナリング・テクノロジー・インコーポレイテツド | モノクローナル抗体を作製するための方法および試薬 |
| US8679767B2 (en) | 2011-05-12 | 2014-03-25 | Genentech, Inc. | Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides |
| GB201110371D0 (en) * | 2011-06-17 | 2011-08-03 | Proteome Sciences R & D Gmbh & Co Kg | Materials and methods for determining sensitivity potential of compounds |
| EP2783214A2 (de) | 2011-11-23 | 2014-10-01 | The Board of Regents of The University of Texas System | Proteomischer nachweis von antikörpern |
| EP2861760B1 (de) | 2012-06-15 | 2020-01-01 | The Board of Regents of The University of Texas System | Sequenzierung von mehreren transkripten aus einer einzelnen zelle mit hohem durchsatz |
| US12546782B2 (en) | 2013-03-15 | 2026-02-10 | Mayo Foundation For Medical Education And Research | Identification and monitoring of monoclonal immunoglobulins related to monoclonal gammopathy by molecular mass with mass spectrometry |
| CN105518447B (zh) | 2013-09-09 | 2018-01-16 | 株式会社岛津制作所 | 肽片段的制备方法及该方法中使用的肽片段制备用试剂盒、以及分析方法 |
| US11378580B2 (en) | 2014-02-18 | 2022-07-05 | Shimadzu Corporation | Protein detection method using mass spectrometry |
| CA2944767C (en) | 2014-04-04 | 2022-07-12 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
| EP3270154B1 (de) | 2015-03-09 | 2020-03-04 | Shimadzu Corporation | Verfahren zur detektion eines monoklonalen antikörpers unter verwendung von massenspektrometrie |
| WO2016143227A1 (ja) * | 2015-03-10 | 2016-09-15 | 株式会社島津製作所 | モノクローナル抗体の検出のためのサンプル調製用キット |
| US10513733B2 (en) | 2015-03-23 | 2019-12-24 | Board Of Regents, The University Of Texas System | High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies |
| EP3353200A4 (de) | 2015-09-24 | 2019-06-26 | Mayo Foundation for Medical Education and Research | Identifizierung von freien leichten ketten aus immunglobulin durch massenspektrometrie |
| GB201603291D0 (en) | 2016-02-25 | 2016-04-13 | Binding Site Group The Ltd | Antibodies |
| EP3465221B1 (de) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Bioanalytisches verfahren zur charakterisierung von ortsspezifischen antikörper-wirkstoff-konjugaten |
| US11020686B2 (en) | 2016-08-16 | 2021-06-01 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
| AU2017325022B2 (en) | 2016-09-07 | 2022-10-13 | Mayo Foundation For Medical Education And Research | Identification and monitoring of cleaved immunoglobulins by molecular mass |
| US12153052B2 (en) | 2017-09-13 | 2024-11-26 | Mayo Foundation For Medical Education And Research | Identification and monitoring of immunoglobulin J chains |
| US11946937B2 (en) | 2017-09-13 | 2024-04-02 | Mayo Foundation For Medical Education And Research | Identification and monitoring of apoptosis inhibitor of macrophage |
| WO2019084538A1 (en) | 2017-10-27 | 2019-05-02 | Board Of Regents, The University Of Texas System | TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF |
| GB2607197B (en) * | 2018-06-06 | 2023-04-26 | Bruker Daltonics Gmbh & Co Kg | Targeted protein characterization by mass spectrometry |
| CA3179460A1 (en) * | 2020-06-09 | 2021-12-16 | Regeneron Pharmaceuticals, Inc. | A high-throughput and mass-spectrometry-based method for quantitating antibodies |
| US20240385199A1 (en) * | 2021-06-23 | 2024-11-21 | Shimadzu Corporation | Antibody analysis method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3491748B2 (ja) * | 1999-07-22 | 2004-01-26 | 株式会社いかがく | 血液中の低比重リポ蛋白（ｌｄｌ）もしくは変性低比重リポ蛋白の検出方法 |
| JP4604345B2 (ja) * | 2000-12-21 | 2011-01-05 | 住友化学株式会社 | タンパク質のｎ末端のアミノ酸配列決定方法 |
| EP1457499A1 (de) * | 2003-03-12 | 2004-09-15 | Tufts University School Of Medicine | Inhibitoren des extrazellulären Hitzeschockproteins Hsp90 |
| WO2005101017A1 (en) * | 2004-04-07 | 2005-10-27 | Genentech, Inc. | Mass spectrometry of antibody conjugates |
-
2007
- 2007-12-20 JP JP2009543205A patent/JP2010515020A/ja active Pending
- 2007-12-20 EP EP07865898A patent/EP2097756B1/de not_active Not-in-force
- 2007-12-20 ES ES07865898T patent/ES2374403T3/es active Active
- 2007-12-20 WO PCT/US2007/088258 patent/WO2008079914A1/en not_active Ceased
- 2007-12-20 AT AT07865898T patent/ATE529752T1/de not_active IP Right Cessation
- 2007-12-20 US US12/520,031 patent/US20100015652A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008079914A1 (en) | 2008-07-03 |
| EP2097756B1 (de) | 2011-10-19 |
| EP2097756A1 (de) | 2009-09-09 |
| JP2010515020A (ja) | 2010-05-06 |
| US20100015652A1 (en) | 2010-01-21 |
| ES2374403T3 (es) | 2012-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |