ATE530891T1 - Miniaturisierter zellsortierer - Google Patents

Miniaturisierter zellsortierer

Info

Publication number
ATE530891T1
ATE530891T1 AT99933512T AT99933512T ATE530891T1 AT E530891 T1 ATE530891 T1 AT E530891T1 AT 99933512 T AT99933512 T AT 99933512T AT 99933512 T AT99933512 T AT 99933512T AT E530891 T1 ATE530891 T1 AT E530891T1
Authority
AT
Austria
Prior art keywords
cells
branch
detection region
analysis unit
channels
Prior art date
Application number
AT99933512T
Other languages
English (en)
Inventor
Stephen Quake
Anne Fu
Frances Arnold
Charles Spence
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Application granted granted Critical
Publication of ATE530891T1 publication Critical patent/ATE530891T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Optical Measuring Cells (AREA)
AT99933512T 1998-05-22 1999-05-21 Miniaturisierter zellsortierer ATE530891T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8639498P 1998-05-22 1998-05-22
US10889498P 1998-11-17 1998-11-17
PCT/US1999/013050 WO1999061888A2 (en) 1998-05-22 1999-05-21 Microfabricated cell sorter

Publications (1)

Publication Number Publication Date
ATE530891T1 true ATE530891T1 (de) 2011-11-15

Family

ID=26774709

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99933512T ATE530891T1 (de) 1998-05-22 1999-05-21 Miniaturisierter zellsortierer

Country Status (6)

Country Link
EP (1) EP1190229B1 (de)
JP (1) JP2002528699A (de)
AT (1) ATE530891T1 (de)
AU (1) AU763433B2 (de)
CA (1) CA2333201A1 (de)
WO (1) WO1999061888A2 (de)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008931A1 (en) 1996-08-26 1998-03-05 Princeton University Reversibly sealable microstructure sorting devices
EP2264427B1 (de) 1997-01-31 2017-05-03 Xy, Llc Optisches Gerät mit fokussierendem Reflektor zur Konvergenz der Strahlung auf einen Partikelfluss, und zugehöriges Analyseverfahren
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
WO2001019516A1 (en) * 1999-09-13 2001-03-22 Hoffmann La Roche Suspension handling system
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6589729B2 (en) * 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
JP4504501B2 (ja) * 2000-03-15 2010-07-14 株式会社東海理化電機製作所 粒子移動／固定装置
JP2001281233A (ja) * 2000-03-28 2001-10-10 Inst Of Physical & Chemical Res 水性分配用マイクロチップおよびそれを用いた水性分配方法
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
CA2408616C (en) * 2000-05-12 2007-10-02 The Board Of Trustees Of The University Of Illinois Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US7062418B2 (en) 2000-06-27 2006-06-13 Fluidigm Corporation Computer aided design method and system for developing a microfluidic system
US20050153284A1 (en) * 2000-06-30 2005-07-14 Zeno Foldes-Papp Single molecule sequencing method
CA2391317A1 (en) 2000-07-26 2002-01-31 The Regent Of The University Of California Manipulation of live cells and inorganic objects with optical micro beam arrays
WO2002023163A1 (en) 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
GB0023041D0 (en) * 2000-09-20 2000-11-01 Univ Manchester Identification apparatus
US7678547B2 (en) 2000-10-03 2010-03-16 California Institute Of Technology Velocity independent analyte characterization
JP4585170B2 (ja) * 2000-10-03 2010-11-24 ミナーヴァ・バイオテクノロジーズ・コーポレーション 流動の中断に基づく相互作用の電子検出および相互作用の検出
AU2002211389A1 (en) 2000-10-03 2002-04-15 California Institute Of Technology Microfluidic devices and methods of use
EP1336097A4 (de) 2000-10-13 2006-02-01 Fluidigm Corp Probeninjektionssystem auf der basis einer mikrofluidischen einrichtung für analytische einrichtungen
EP1343973B2 (de) 2000-11-16 2020-09-16 California Institute Of Technology Vorrichtung und verfahren zur durchführung von assays und screening mit hohem durchsatz
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
WO2002043486A1 (en) 2000-11-29 2002-06-06 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
JP2004523243A (ja) 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
CN100494360C (zh) * 2001-03-22 2009-06-03 博奥生物有限公司 细胞分离方法及其应用
EP1384022A4 (de) 2001-04-06 2004-08-04 California Inst Of Techn Nukleinsäure-amplifikation verwendende mikrofluidvorrichtungen
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US20030027225A1 (en) * 2001-07-13 2003-02-06 Caliper Technologies Corp. Microfluidic devices and systems for separating components of a mixture
WO2003025563A1 (en) * 2001-09-16 2003-03-27 Chemometec A/S Method and a system for detecting and optionally isolating a rare event particle
WO2003034041A1 (en) * 2001-10-12 2003-04-24 Imperial College Innovations Limited Particle measurement system using time-frequency transform
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
GB0129005D0 (en) * 2001-12-04 2002-01-23 Imp College Innovations Ltd Electroluminescent device
WO2003072255A1 (en) * 2002-02-23 2003-09-04 Nanostream, Inc. Microfluidic multi-splitter
US7223371B2 (en) * 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
AU2003224817B2 (en) * 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
GB0215779D0 (en) * 2002-07-08 2002-08-14 Deltadot Ltd Material separation device
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
JP4595067B2 (ja) 2002-08-01 2010-12-08 エックスワイ，エルエルシー 低圧精子細胞分離システム
CA2534394C (en) 2002-08-15 2013-01-08 Xy, Inc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
JP2006501056A (ja) 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
EP2359689B1 (de) 2002-09-27 2015-08-26 The General Hospital Corporation Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
BRPI0408857B1 (pt) 2003-03-28 2018-09-11 Inguran Llc aparelho, métodos e processos para separar partículas e para prover esperma de animal separado por sexo
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
AU2004229440B2 (en) 2003-04-10 2010-08-12 President And Fellows Of Harvard College Formation and control of fluidic species
ES2541121T3 (es) 2003-05-15 2015-07-16 Xy, Llc Clasificación eficiente de células haploides por sistemas de citometría de flujo
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
WO2005021151A1 (en) 2003-08-27 2005-03-10 President And Fellows Of Harvard College Electronic control of fluidic species
EP1668355A4 (de) 2003-08-28 2011-11-09 Celula Inc Verfahren und vorrichtung zur sortierung von zellen unter verwendung eines optischen schalters in einem mikrofluidischen kanalnetzwerk
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
JP2005161480A (ja) * 2003-12-03 2005-06-23 Canon Inc 物体処理装置、物体の移動方法及びその移動方法を用いて処理された物体
WO2005080605A2 (en) 2004-02-19 2005-09-01 Helicos Biosciences Corporation Methods and kits for analyzing polynucleotide sequences
DK2801363T3 (en) 2004-03-29 2018-05-28 Inguran Llc PROCEDURE FOR STORING SORTED SPERMATOZOES
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US7635562B2 (en) 2004-05-25 2009-12-22 Helicos Biosciences Corporation Methods and devices for nucleic acid sequence determination
US8124032B2 (en) 2004-07-16 2012-02-28 Simon Fraser University Microfluidic device and method of using same
CA2574499C (en) 2004-07-22 2016-11-29 Monsanto Technology Llc Process for enriching a population of sperm cells
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
GB0426609D0 (en) * 2004-12-03 2005-01-05 Ic Innovations Ltd Analysis
JP4601423B2 (ja) 2004-12-28 2010-12-22 独立行政法人科学技術振興機構 細胞計測および分離チップ
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
EP1874920A4 (de) * 2005-04-05 2009-11-04 Cellpoint Diagnostics Vorrichtungen und verfahren zur anreicherung und veränderung zirkulierender tumorzellen und anderer partikel
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
WO2007077627A1 (ja) * 2006-01-06 2007-07-12 Kawamura Institute Of Chemical Research 物質分離デバイスおよび物質分離方法
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US7569789B2 (en) * 2006-03-16 2009-08-04 Visiongate, Inc. Cantilevered coaxial flow injector apparatus and method for sorting particles
EP2530167A1 (de) 2006-05-11 2012-12-05 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2029779A4 (de) 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
EP2077912B1 (de) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
CN101135650A (zh) * 2006-08-29 2008-03-05 彭兴跃 一种细胞观测实验方法及其装置
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
ES2817249T3 (es) 2007-04-16 2021-04-06 Corium Inc Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
CA3069082C (en) 2008-09-20 2022-03-22 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US8438903B2 (en) * 2010-01-27 2013-05-14 International Business Machines Corporation Molecule detection device formed in a semiconductor structure
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP4484577A3 (de) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digitale analytanalyse
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
KR101177033B1 (ko) 2010-03-31 2012-08-27 고려대학교 산학협력단 실리콘 나노선을 이용한 세포 분리칩
EP2566501B1 (de) 2010-05-04 2019-03-13 Corium International, Inc. Verfahren und vorrichtung zur transdermalen verabreichung von parathormon mithilfe eines mikroprojektions-arrays
CA2803632A1 (en) * 2010-06-30 2012-01-05 Anpac Bio-Medical Science Co., Ltd. Detection of a response to a signal applied to a biological subject
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
KR101250751B1 (ko) * 2010-10-22 2013-04-03 연세대학교 산학협력단 다중 형광 정도 이용 세포 분리 장치 및 전극구조와 다중 형광 정도 이용 세포 분리 방법
JP5732816B2 (ja) 2010-10-29 2015-06-10 ソニー株式会社 細胞分取装置及び細胞分取チップ
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
DE102011050254A1 (de) * 2011-05-10 2012-11-15 Technische Universität Dortmund Verfahren zur Separation polarisierbarer Biopartikel
EP3216872B1 (de) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzymquantifizierung
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US9689863B2 (en) 2012-03-08 2017-06-27 Shanghai Xinshenpai Technology Co., Ltd. Micro-devices for improved disease detection
CN102703373A (zh) * 2012-06-26 2012-10-03 重庆城市管理职业学院 一种计算机图像识别细胞分离方法及系统
US9194786B2 (en) * 2012-08-01 2015-11-24 Owl biomedical, Inc. Particle manipulation system with cytometric capability
CN110579435B (zh) 2012-10-15 2023-09-26 纳诺赛莱克特生物医药股份有限公司 颗粒分选的系统、设备和方法
JP2013081943A (ja) * 2012-11-02 2013-05-09 Kurabo Ind Ltd 流体中の微粒子選別装置
EP2934660B1 (de) 2012-12-21 2019-07-17 Corium, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe und verfahren zur herstellung davon
EP4094799A1 (de) 2013-03-12 2022-11-30 Corium, Inc. Mikroprojektionsapplikatoren
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
EP2968119B1 (de) 2013-03-15 2019-09-18 Corium International, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe, verfahren zur verwendung und verfahren zur herstellung
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
US20180163713A1 (en) * 2015-06-23 2018-06-14 Nanocellect Biomedical, Inc. Systems, apparatuses, and methods for cell sorting and flow cytometry
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017027519A1 (en) * 2015-08-11 2017-02-16 Apocell, Inc. Systems and methods for isolating target particles and their use in diagnostic, prognostic, and therapeutic, methods
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2018175411A1 (en) 2017-03-20 2018-09-27 Nanocellect Biomedical, Inc. Systems, apparatuses, and methods for cell sorting and flow cytometry
CN107894511B (zh) * 2017-10-27 2023-09-15 河北莱博瑞特电子科技有限公司 一种元素形态分析仪
CN112384790A (zh) * 2018-03-20 2021-02-19 路玛赛特有限责任公司 利用激光力细胞学的改进生物物理和生物化学细胞监测和定量
CN108956558B (zh) * 2018-05-24 2023-09-15 深圳市帝迈生物技术有限公司 一种微流控芯片和免疫荧光分析仪
US12258551B2 (en) * 2018-11-16 2025-03-25 Cairn Biosciences, Inc. Methods for dynamic evolution and monitoring of characteristics in living cells using a microfluidic-enabled multi-well cell culture devices and systems
CN109880744B (zh) * 2019-03-22 2022-07-29 华南师范大学 光流控细胞分选芯片及其分选细胞的方法
CN110130194B (zh) * 2019-06-25 2023-12-01 广州肖宁道路工程技术研究事务所有限公司 一种沥青路面综合评价方法及装置
WO2021072306A1 (en) 2019-10-10 2021-04-15 1859, Inc. Methods and systems for microfluidic screening
US20210237064A1 (en) 2020-01-31 2021-08-05 Astrin Biosciences, Inc. Biological Fluid Filtration System
CN112871229B (zh) * 2021-01-21 2022-06-28 中国科学技术大学 一种用于水体介电泳细菌分选的芯片
EP4597094A4 (de) * 2022-09-30 2026-01-14 Fujifilm Corp Elektrophoresevorrichtung, steuerungsverfahren für elektrophoresevorrichtung und steuerungsprogramm für elektrophoresevorrichtung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560754A (en) * 1965-11-17 1971-02-02 Ibm Photoelectric particle separator using time delay
US3984307A (en) * 1973-03-05 1976-10-05 Bio/Physics Systems, Inc. Combined particle sorter and segregation indicator
US4936465A (en) * 1987-12-07 1990-06-26 Zoeld Tibor Method and apparatus for fast, reliable, and environmentally safe dispensing of fluids, gases and individual particles of a suspension through pressure control at well defined parts of a closed flow-through system
GB9008044D0 (en) * 1990-04-09 1990-06-06 Hatfield Polytechnic Higher Ed Microfabricated device for biological cell sorting
SE470347B (sv) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
DE19520298A1 (de) * 1995-06-02 1996-12-05 Bayer Ag Sortiervorrichtung für biologische Zellen oder Viren
US5726404A (en) * 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
CN1173776C (zh) * 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
DK0925494T3 (da) * 1996-09-04 2002-07-01 Scandinavian Micro Biodevices Mikrostrømningssystem til partikelseparation og analyse

Also Published As

Publication number Publication date
EP1190229A2 (de) 2002-03-27
CA2333201A1 (en) 1999-12-02
WO1999061888A8 (en) 2000-04-20
WO1999061888A2 (en) 1999-12-02
AU4955799A (en) 1999-12-13
AU763433B2 (en) 2003-07-24
WO1999061888A3 (en) 2001-12-13
EP1190229B1 (de) 2011-10-26
JP2002528699A (ja) 2002-09-03
WO1999061888A9 (en) 2000-06-02

Similar Documents

Publication Publication Date Title
ATE530891T1 (de) Miniaturisierter zellsortierer
US4609286A (en) Dispersion prism for separation of wavelengths of spectrally rich light in a flow cytometry apparatus
ATE357663T1 (de) Teilchenförmiges markierungsmittel verwendendes analytassay
DK0941465T3 (da) Fremgangsmåde til at skelne og detektere partikler i en sonde ved identifikation af tidsopløste signalafsnit,optiske råsignaler fra en sonde på basis af detektion af enkeltfotoner
EP0745856A3 (de) Testkarte für Analysen
BR9814007A (pt) Dispositivo de ensaio cromatográfico e processo para detectar a presença de um analito em uma amostra de sangue
WO2005010489A3 (en) Automated multi-detector analyzer
MY107807A (en) One step test for absolute counts.
EP0780680A3 (de) Analysator zur Analyse von Urinbestandteilen
DE69533159D1 (de) Miniaturisierte probenvorbereitungsvorrichtungen sowie systeme zur feststellung und behandlung von analyten
BR9305886A (pt) Processo para determinar número total de células por volume de espécime de célula
DK0931254T3 (da) Fremgangsmåde til analyse af prøver ved bestemmelse af en funktion af specifik lysstyrke
DE69617742D1 (de) Mit einer vielzahl von kapillaren ausgerüstetes biochemisches analysegerät mit absperrvorrichtung
DE69906986D1 (de) Analytisches testgerät und verfahren
DE69936916D1 (de) Liganden-bindetest und kit mit einer abtrennzone für störende probenkomponenten
DE50016074D1 (de) Vorrichtung zur röntgenfluoreszenzanalyse
DK0809807T3 (da) Immunoassay til tælling af celler
DE50113353D1 (de) Vorrichtung und verfahren zur analyse der qualitativen und/oder quantitativen zusammensetzung von fluiden
DE60207207D1 (de) Harnbestimmung der ovarienreserve
BR9915406A (pt) Dispositivo e método para a análise de uma amostra biológica
DK1017993T3 (da) Spektroskopisk analyse af pröver med uklarhed og höj absorbans
NO20003709L (no) Fremgangsmate for detektering av en analytt, og omsluttingsmiddel og kit for anvendelse deri
ATE404866T1 (de) System und verfahren zur in-vitro-analyse von therapeutischen wirkstoffen
DE69719737D1 (de) Immunoassay von vollblutproben
DE60219642D1 (de) Bestimung und quantifizierung von erythrocytenpopulationen in proben

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties