ATE531376T1 - Verwendung von thioarabinofuranosyl-verbindungen - Google Patents

Verwendung von thioarabinofuranosyl-verbindungen

Info

Publication number: ATE531376T1
Authority: AT; Austria
Prior art keywords: group; compounds; monoalkylamino; iid; haloalkenyl
Prior art date: 1998-07-23

Application number

AT99935854T

Other languages

English (en)

Inventor

John Secrist

Kamal Tiwari

John Montgomery

Original Assignee

Southern Res Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-23

Filing date

1999-07-23

Publication date

2011-11-15

1999-07-23 Application filed by Southern Res Inst filed Critical Southern Res Inst

2011-11-15 Application granted granted Critical

2011-11-15 Publication of ATE531376T1 publication Critical patent/ATE531376T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
230000004543 DNA replication Effects 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
239000011737 fluorine Chemical group 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
125000000262 haloalkenyl group Chemical group 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1
-1 monoalkylamino Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Hematology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT99935854T 1998-07-23 1999-07-23 Verwendung von thioarabinofuranosyl-verbindungen ATE531376T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9386998P	1998-07-23	1998-07-23
PCT/US1999/016630 WO2000004866A2 (en)	1998-07-23	1999-07-23	Preparation of thioarabinofuranosyl compounds and use thereof

Publications (1)

Publication Number	Publication Date
ATE531376T1 true ATE531376T1 (de)	2011-11-15

Family

ID=22241386

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99935854T ATE531376T1 (de)	1998-07-23	1999-07-23	Verwendung von thioarabinofuranosyl-verbindungen

Country Status (9)

Country	Link
US (5)	US6576621B1 (de)
EP (3)	EP1100512B1 (de)
JP (3)	JP4719356B2 (de)
AT (1)	ATE531376T1 (de)
AU (1)	AU747012B2 (de)
CA (1)	CA2338415C (de)
ES (3)	ES2376862T3 (de)
NZ (1)	NZ509405A (de)
WO (1)	WO2000004866A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2338415C (en) *	1998-07-23	2006-10-10	Southern Research Institute	Preparation of thioarabinofuranosyl compounds and use thereof
WO2004018494A1 (ja) *	2002-08-22	2004-03-04	Geneticlab Co., Ltd.	４’−チオヌクレオチド
US7524831B2 (en) *	2005-03-02	2009-04-28	Schering Corporation	Treatments for Flaviviridae virus infection
KR101582570B1 (ko) *	2007-03-23	2016-01-06	써던 리서취 인스티튜트	관절염 치료 및 예방 방법
AR064165A1 (es)	2007-12-06	2009-03-18	Richmond Sa Com Ind Y Financie	Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento
EP2303226B1 (de) *	2008-06-25	2016-03-23	Endo Pharmaceuticals Solutions Inc.	Verlängerte freisetzung von exenatid und anderen polypeptiden
US20110218170A1 (en) *	2010-03-02	2011-09-08	Southern Research Institute	Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
SG10201603288XA (en)	2012-03-28	2016-05-30	Fujifilm Corp	Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine
JP6351107B2 (ja) *	2014-02-18	2018-07-04	富士フイルム株式会社	チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
EP3109245B1 (de)	2014-02-18	2018-01-03	FUJIFILM Corporation	Verfahren zur herstellung eines thiolanskelettartigen glycokonjugats und thiolanskelettartiges glycokonjugat
JP6245527B2 (ja) *	2014-03-24	2017-12-13	富士フイルム株式会社	チオラン環もしくはチアン環骨格を有する化合物の製造方法
TWI678373B (zh)	2014-10-31	2019-12-01	日商富士軟片股份有限公司	硫代核苷衍生物或其鹽及醫藥組合物
US10815264B2 (en) *	2015-05-27	2020-10-27	Southern Research Institute	Nucleotides for the treatment of cancer
WO2017091836A1 (en) *	2015-11-25	2017-06-01	University Of South Carolina	Enhancement of cytarabine activity by inhibiting cdk8/19
IL265044B2 (en)	2016-08-31	2025-02-01	Fujifilm Corp	An antitumor preparation containing the substances nab-paclitaxel and 1-(2-deoxy-2-fluoro-4-thio-D-beta-arabinofurnosyl)cytosine, a kit containing these substances and their uses
WO2019146130A1 (ja)	2018-01-29	2019-08-01	富士フイルム株式会社	胆道がん用抗腫瘍剤および胆道がんの処置方法
WO2019204637A1 (en) *	2018-04-19	2019-10-24	Southern Research Institute	4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer
EP3993806A4 (de) *	2019-06-05	2023-09-13	Southern Research Institute	Auf thiarabin und thiarabinprodrug basierende behandlungen
EP4138843A4 (de)	2020-04-23	2024-07-10	Southern Research Institute	Zusammensetzung zur behandlung von blutkrebs mit 4'-thio-5-aza-2'-deoxycytidin und verwendungen davon

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6401490A (en) *	1989-09-15	1991-04-18	Southern Research Institute	2'-deoxy-4'-thioribonucleosides as antiviral and anticancer agents
IE74701B1 (en) *	1989-10-04	1997-07-30	Univ Birmingham	Further antiviral pyrimidine nucleosides
JPH04505929A (ja) *	1989-12-08	1992-10-15	シティ・オブ・ホープ	ヒトの抗癌剤の耐性の回避
JPH09249690A (ja)	1995-07-14	1997-09-22	Yamasa Shoyu Co Ltd	４’−チオアラビノプリンヌクレオシド
JPH0925289A (ja)	1995-07-14	1997-01-28	Yamasa Shoyu Co Ltd	４’−チオアラビノピリミジンヌクレオシドの製造方法
JP2943690B2 (ja)	1996-04-17	1999-08-30	日本電気株式会社	セル衝突検出装置
AU749561B2 (en)	1997-05-09	2002-06-27	Ribozyme Pharmaceuticals, Inc.	Nucleic acid molecules having endonuclease and/or catalytic activity
US6548657B1 (en) *	1997-06-09	2003-04-15	Ribozyme Pharmaceuticals, Inc.	Method for screening nucleic acid catalysts
WO1999043690A1 (en)	1998-02-25	1999-09-02	Rational Drug Design Laboratories	L-4'-arabinofuranonucleoside compound and medicine composition comprising the same
CA2338415C (en) *	1998-07-23	2006-10-10	Southern Research Institute	Preparation of thioarabinofuranosyl compounds and use thereof

1999
- 1999-07-23 CA CA002338415A patent/CA2338415C/en not_active Expired - Lifetime
- 1999-07-23 JP JP2000560859A patent/JP4719356B2/ja not_active Expired - Fee Related
- 1999-07-23 ES ES99935854T patent/ES2376862T3/es not_active Expired - Lifetime
- 1999-07-23 WO PCT/US1999/016630 patent/WO2000004866A2/en not_active Ceased
- 1999-07-23 AU AU51239/99A patent/AU747012B2/en not_active Expired
- 1999-07-23 EP EP99935854A patent/EP1100512B1/de not_active Expired - Lifetime
- 1999-07-23 ES ES10170453.4T patent/ES2438144T3/es not_active Expired - Lifetime
- 1999-07-23 ES ES10179999T patent/ES2402799T3/es not_active Expired - Lifetime
- 1999-07-23 EP EP10179999A patent/EP2332551B1/de not_active Expired - Lifetime
- 1999-07-23 EP EP10170453.4A patent/EP2335706B1/de not_active Expired - Lifetime
- 1999-07-23 NZ NZ509405A patent/NZ509405A/en not_active IP Right Cessation
- 1999-07-23 AT AT99935854T patent/ATE531376T1/de active
2000
- 2000-01-28 US US09/493,247 patent/US6576621B1/en not_active Expired - Lifetime
2003
- 2003-04-07 US US10/407,135 patent/US6870052B2/en not_active Expired - Lifetime
2004
- 2004-09-13 US US10/938,542 patent/US7138385B2/en not_active Expired - Lifetime
2006
- 2006-08-24 US US11/509,030 patent/US7691820B2/en not_active Expired - Fee Related
2010
- 2010-02-23 US US12/710,537 patent/US8178510B2/en not_active Expired - Fee Related
- 2010-04-27 JP JP2010102499A patent/JP2010202655A/ja active Pending
- 2010-10-29 JP JP2010243705A patent/JP5357857B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20060287320A1 (en)	2006-12-21
EP2335706A1 (de)	2011-06-22
WO2000004866A2 (en)	2000-02-03
JP2002521318A (ja)	2002-07-16
AU747012B2 (en)	2002-05-09
US20030203872A1 (en)	2003-10-30
US8178510B2 (en)	2012-05-15
CA2338415C (en)	2006-10-10
EP1100512A2 (de)	2001-05-23
US6576621B1 (en)	2003-06-10
EP2332551B1 (de)	2013-01-09
EP1100512A4 (de)	2001-10-10
US7691820B2 (en)	2010-04-06
US20050038025A1 (en)	2005-02-17
US6870052B2 (en)	2005-03-22
JP2010202655A (ja)	2010-09-16
EP1100512B1 (de)	2011-11-02
NZ509405A (en)	2004-10-29
US20100216797A1 (en)	2010-08-26
WO2000004866A9 (en)	2000-08-10
AU5123999A (en)	2000-02-14
EP2332551A1 (de)	2011-06-15
WO2000004866A3 (en)	2000-04-20
ES2402799T3 (es)	2013-05-09
CA2338415A1 (en)	2000-02-03
EP2335706B1 (de)	2013-10-23
JP2011032281A (ja)	2011-02-17
JP4719356B2 (ja)	2011-07-06
ES2438144T3 (es)	2014-01-16
ES2376862T3 (es)	2012-03-20
JP5357857B2 (ja)	2013-12-04
US7138385B2 (en)	2006-11-21

Publication	Publication Date	Title
ATE531376T1 (de)	2011-11-15	Verwendung von thioarabinofuranosyl-verbindungen
ATE165510T1 (de)	1998-05-15	Methode zur hemmung der proliferation weiche muskelzellen und der restenose
ATE149999T1 (de)	1997-03-15	Monofluorierte derivate von n-propargyl-1- aminoindan und deren verwendung als monoamino- oxidaseinhibitoren
ATE120738T1 (de)	1995-04-15	2,4-diamino-pyrimidin-3-oxid-derivate und deren verwendung bei der behandlung und zur verhütung von haarfall.
MY119150A (en)	2005-04-30	Azetidine derivatives, their preparation and medicaments containing them
DE69431316D1 (de)	2002-10-10	Amidderivate und ihre therapeutische Verwendung
PT83961A (de)	1987-01-01	Pyrazolin-derivate ihre herstellung und ihre verwendung als mittel mit insektizider und akarizider wirkung
NO942452D0 (no)	1994-06-29	Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser
DE59108419D1 (de)	1997-01-30	Dicarbonsäureimide, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide
DK337589D0 (da)	1989-07-07	3r,s- og 3r-formerne af 3-substuerede 1-(2-aryl -eller heteroarylethyl)piperidin-forbindelser og deres anvendelse til fremstilling af et laegemiddel til behandling af sygdommme forbundet med aendret motilitet og/eller tonus af glatmuskel samt farmaceutiske praeparater indeholdende disse forbindelser
FR2705962B1 (fr)	1995-07-13	Arylpyrazoles fongicides.
ATE49410T1 (de)	1990-01-15	1-aryl-5-alkoximinoalkylamino-pyrazole.
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ATE245643T1 (de)	2003-08-15	Substituierte isoxazolylthiophenverbindungen
ATE218138T1 (de)	2002-06-15	N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung
NO944722L (no)	1995-06-09	3-(fenylalkylaminoalkyloksy)-5-fenylpyrazol-forbindelser samt fremgangsmåter og mellomprodukter for deres fremstilling, og legemidler som inneholder disse forbindelsene
ES2192342T3 (es)	2003-10-01	2-(2,6-dioxo-3-fluoropiperidin-3-il)-isoindolinas sustituidas y su uso para reducir los niveles de tnfalfa.
DK0462468T3 (da)	1994-10-24	9-amino-2-phenylbicyclo(3.3.1)nonaner og 9-amino-2-phenylbicyclo(3.3.1)non-2-ener og terapeutiske midler indeholdende disse
IT1217900B (it)	1990-03-30	Composti eterociclici azotati ad azione antifungina
SI0937075T1 (en)	2004-06-30	New Imidazo- and Oxazolopyridines as Phosphodiesterase Inhibitors.
NO972942D0 (no)	1997-06-23	4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende disse forbindelsene og deres anvendelse
DK0662081T3 (da)	1997-05-05	Ureidoacetamidderivater, deres fremstilling og lægemidler indeholdende disse derivater
ATE239015T1 (de)	2003-05-15	N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung