ATE531389T1 - Lipid- und distickstoffoxidverbindung als hilfsmittel zur erhöhung der impfstoffeffizienz - Google Patents

Lipid- und distickstoffoxidverbindung als hilfsmittel zur erhöhung der impfstoffeffizienz

Info

Publication number: ATE531389T1
Authority: AT; Austria
Prior art keywords: acid; antigen; adjuvant; lipid; tool
Prior art date: 2005-01-28

Application number

AT06710759T

Other languages

English (en)

Inventor

Anne Grobler

Abraham Frederik Kotze

Original Assignee

Univ Northwest

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-28

Filing date

2006-01-26

Publication date

2011-11-15

2006-01-26 Application filed by Univ Northwest filed Critical Univ Northwest

2011-11-15 Application granted granted Critical

2011-11-15 Publication of ATE531389T1 publication Critical patent/ATE531389T1/de

Links

229960005486 vaccine Drugs 0.000 title abstract 3
-1 DINITROGEN OXIDE COMPOUND Chemical class 0.000 title abstract 2
150000002632 lipids Chemical class 0.000 title 1
229960001730 nitrous oxide Drugs 0.000 title 1
239000002671 adjuvant Substances 0.000 abstract 3
239000000427 antigen Substances 0.000 abstract 3
102000036639 antigens Human genes 0.000 abstract 3
108091007433 antigens Proteins 0.000 abstract 3
238000009472 formulation Methods 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 3
GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 abstract 2
DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 abstract 2
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 2
230000028993 immune response Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000003921 oil Substances 0.000 abstract 2
WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 abstract 2
229960003656 ricinoleic acid Drugs 0.000 abstract 2
FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 abstract 2
OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 abstract 1
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 abstract 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 abstract 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 abstract 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
239000005642 Oleic acid Substances 0.000 abstract 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 abstract 1
239000002202 Polyethylene glycol Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 abstract 1
235000020661 alpha-linolenic acid Nutrition 0.000 abstract 1
235000021342 arachidonic acid Nutrition 0.000 abstract 1
229940114079 arachidonic acid Drugs 0.000 abstract 1
239000004359 castor oil Substances 0.000 abstract 1
235000019438 castor oil Nutrition 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
229960005135 eicosapentaenoic acid Drugs 0.000 abstract 1
JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract 1
235000020673 eicosapentaenoic acid Nutrition 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 abstract 1
VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 abstract 1
235000020664 gamma-linolenic acid Nutrition 0.000 abstract 1
229960002733 gamolenic acid Drugs 0.000 abstract 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 abstract 1
229960004488 linolenic acid Drugs 0.000 abstract 1
239000001272 nitrous oxide Substances 0.000 abstract 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 abstract 1
229960002969 oleic acid Drugs 0.000 abstract 1
235000021313 oleic acid Nutrition 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/205—Rhabdoviridae, e.g. rabies virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Mycology (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)

AT06710759T 2005-01-28 2006-01-26 Lipid- und distickstoffoxidverbindung als hilfsmittel zur erhöhung der impfstoffeffizienz ATE531389T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ZA200500856		2005-01-28
PCT/IB2006/050286 WO2006079989A2 (en)	2005-01-28	2006-01-26	Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines

Publications (1)

Publication Number	Publication Date
ATE531389T1 true ATE531389T1 (de)	2011-11-15

Family

ID=36608667

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06710759T ATE531389T1 (de)	2005-01-28	2006-01-26	Lipid- und distickstoffoxidverbindung als hilfsmittel zur erhöhung der impfstoffeffizienz

Country Status (10)

Country	Link
US (2)	US20090010964A1 (de)
EP (1)	EP1843787B1 (de)
JP (1)	JP5159322B2 (de)
CN (1)	CN101123982B (de)
AT (1)	ATE531389T1 (de)
CA (1)	CA2596920C (de)
DK (1)	DK1843787T3 (de)
ES (1)	ES2375267T3 (de)
WO (1)	WO2006079989A2 (de)
ZA (1)	ZA200608016B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2596920C (en)	2005-01-28	2015-05-05	North-West University	Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines
US20100297249A1 (en) *	2007-07-05	2010-11-25	North-West University	Enhancement of the efficacy of therapeutic proteins
US9107906B1 (en)	2014-10-28	2015-08-18	Adma Biologics, Inc.	Compositions and methods for the treatment of immunodeficiency
US10259865B2 (en)	2017-03-15	2019-04-16	Adma Biologics, Inc.	Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
JPWO2018225785A1 (ja) *	2017-06-06	2020-04-16	株式会社Ａｔｏｍｉｓ	ワクチン組成物
WO2019136038A1 (en)	2018-01-02	2019-07-11	Khloris Biosciences, Inc.	Ipsc-based vaccine as a prophylactic and therapeutic treatment for cancer
EP4346886A1 (de)	2021-06-01	2024-04-10	Khloris Biosciences, Inc.	Krebsimpfstoffe auf basis induzierter pluripotenter stammzellen
CN116139266B (zh) *	2023-04-14	2023-07-14	清华大学	长链不饱和脂肪酸在制备用于灭活疫苗的免疫增强剂中的用途
WO2025155909A1 (en) *	2024-01-19	2025-07-24	Hillhurst Biopharmaceuticals, Inc.	Solution of nitrous oxide for the treatment of disease

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GB425406A (en) *	1933-06-07	1935-03-07	Vincent Gregory Walsh	Improvements in or relating to the manufacture of medical preparations of bacterial toxins
US5585112A (en) *	1989-12-22	1996-12-17	Imarx Pharmaceutical Corp.	Method of preparing gas and gaseous precursor-filled microspheres
JPH04279523A (ja) *	1991-01-11	1992-10-05	Nisshin Flour Milling Co Ltd	免疫賦活油脂加工品
DK17093D0 (da) *	1993-02-15	1993-02-15	Lyfjathroun H F	Farmaceutisk praeparat til topisk administrering af antigener og/eller vacciner til pattedyr via slimhinder
JPH06247849A (ja) *	1993-02-25	1994-09-06	Kao Corp	免疫増強剤
FR2702373B1 (fr) *	1993-03-08	1996-06-07	Rhone Merieux	Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable.
JPH09121766A (ja) *	1995-10-31	1997-05-13	Meiji Milk Prod Co Ltd	ｎ−６系列／ｎ−３系列脂肪酸比率を調整した乳児用食品
NZ322588A (en) *	1995-11-13	1999-01-28	Pitmy Int Nv	An administration medium containing nitrous oxide for use in conjunction with analgesics, anti-inflammatories and anti-pyretics to enhance their action
SE9602280D0 (sv) *	1996-06-10	1996-06-10	Pharmatrix Ab	Immunstimulerande lipidformulering
US6696089B2 (en) *	1998-09-03	2004-02-24	Board Of Regents Of The University Of Nebraska	Nanogel networks including polyion polymer fragments and biological agent compositions thereof
GB9820525D0 (en) *	1998-09-21	1998-11-11	Allergy Therapeutics Ltd	Formulation
SE9900495D0 (sv) *	1999-02-12	1999-02-12	Pharmatrix Ab	Vaccine composition
SE9900496D0 (sv) *	1999-02-12	1999-02-12	Pharmatrix Ab	Vaccine formulation
JP2001029010A (ja) *	1999-07-26	2001-02-06	Snow Brand Milk Prod Co Ltd	栄養組成物
JP2001245686A (ja) *	1999-12-27	2001-09-11	Osaka City	脂肪酸低級アルコールエステルの製造方法
FR2804026B1 (fr) *	2000-01-21	2004-06-11	Merial Sas	Vaccination contre l'herpesvirose canine et vaccins
WO2002005849A2 (en) *	2000-07-19	2002-01-24	Pitmy International N.V.	Transportation of nucleic acid substances
AU2001283586A1 (en) *	2000-07-19	2002-01-30	Pitmy International N.V.	Enhancement of the action of anti-infective agents
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CN1391954A (zh) *	2002-07-09	2003-01-22	新疆大学生命科学与技术学院	增强核酸疫苗免疫的组合物及其生产方法和使用方法
CA2596920C (en)	2005-01-28	2015-05-05	North-West University	Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines

2006
- 2006-01-26 CA CA2596920A patent/CA2596920C/en not_active Expired - Fee Related
- 2006-01-26 DK DK06710759.9T patent/DK1843787T3/da active
- 2006-01-26 JP JP2007552795A patent/JP5159322B2/ja not_active Expired - Fee Related
- 2006-01-26 CN CN200680003424.7A patent/CN101123982B/zh not_active Expired - Fee Related
- 2006-01-26 ES ES06710759T patent/ES2375267T3/es not_active Expired - Lifetime
- 2006-01-26 AT AT06710759T patent/ATE531389T1/de active
- 2006-01-26 EP EP06710759A patent/EP1843787B1/de not_active Expired - Lifetime
- 2006-01-26 WO PCT/IB2006/050286 patent/WO2006079989A2/en not_active Ceased
- 2006-08-03 US US11/794,503 patent/US20090010964A1/en not_active Abandoned
- 2006-09-27 ZA ZA200608016A patent/ZA200608016B/xx unknown
2013
- 2013-11-08 US US14/075,681 patent/US9585955B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20140178431A1 (en)	2014-06-26
US9585955B2 (en)	2017-03-07
CN101123982B (zh)	2015-06-17
ZA200608016B (en)	2008-09-25
CN101123982A (zh)	2008-02-13
US20090010964A1 (en)	2009-01-08
JP2008528570A (ja)	2008-07-31
DK1843787T3 (da)	2012-02-20
CA2596920A1 (en)	2006-08-03
EP1843787A2 (de)	2007-10-17
JP5159322B2 (ja)	2013-03-06
ES2375267T3 (es)	2012-02-28
EP1843787B1 (de)	2011-11-02
WO2006079989A3 (en)	2006-10-12
WO2006079989A2 (en)	2006-08-03
CA2596920C (en)	2015-05-05
HK1118013A1 (en)	2009-01-30

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ATE531389T1 (de)	2011-11-15	Lipid- und distickstoffoxidverbindung als hilfsmittel zur erhöhung der impfstoffeffizienz
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