ATE532517T1 - Thioridazin und seine derivate zur umkehr von antimikrobieller arzneimittelresistenz - Google Patents
Thioridazin und seine derivate zur umkehr von antimikrobieller arzneimittelresistenzInfo
- Publication number
- ATE532517T1 ATE532517T1 AT04798860T AT04798860T ATE532517T1 AT E532517 T1 ATE532517 T1 AT E532517T1 AT 04798860 T AT04798860 T AT 04798860T AT 04798860 T AT04798860 T AT 04798860T AT E532517 T1 ATE532517 T1 AT E532517T1
- Authority
- AT
- Austria
- Prior art keywords
- thioridazine
- antibacterials
- derivatives
- reverting
- drug resistance
- Prior art date
Links
- KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002784 thioridazine Drugs 0.000 title abstract 4
- 239000004599 antimicrobial Substances 0.000 title abstract 2
- 206010059866 Drug resistance Diseases 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 5
- 229940088710 antibiotic agent Drugs 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301690 | 2003-11-13 | ||
| PCT/IB2004/003730 WO2005046694A1 (en) | 2003-11-13 | 2004-11-15 | Thioridazine and derivatives thereof for reversing anti-microbial drug-resistance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE532517T1 true ATE532517T1 (de) | 2011-11-15 |
Family
ID=34585771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04798860T ATE532517T1 (de) | 2003-11-13 | 2004-11-15 | Thioridazin und seine derivate zur umkehr von antimikrobieller arzneimittelresistenz |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8623864B2 (de) |
| EP (1) | EP1689405B1 (de) |
| AT (1) | ATE532517T1 (de) |
| DK (1) | DK1689405T3 (de) |
| ES (1) | ES2377016T3 (de) |
| WO (1) | WO2005046694A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005046694A1 (en) | 2003-11-13 | 2005-05-26 | Københavns Universitet | Thioridazine and derivatives thereof for reversing anti-microbial drug-resistance |
| MXPA06012566A (es) * | 2004-04-30 | 2007-05-09 | Bkg Pharma Aps | Tratamiento de enfermedades infecciosas. |
| EP2246349A1 (de) * | 2009-04-20 | 2010-11-03 | BKG Pharma ApS | Behandlung von Infektionskrankheiten |
| US9198916B1 (en) | 2014-05-27 | 2015-12-01 | B&G Partners, Llc | Compounds and methods for treating tumors |
| WO2016036676A1 (en) * | 2014-09-02 | 2016-03-10 | Jane Hsiao | Pharmaceutical composition for treatment of cancer using phenothiazine |
| WO2017212239A1 (en) * | 2016-06-07 | 2017-12-14 | Novabiotics Limited | Treatment of drug-resistant microbial infections |
| WO2018070874A1 (en) * | 2016-10-12 | 2018-04-19 | Rijksuniversiteit Groningen | Means and methods for reducing or avoiding antibiotic resistance and spread of virulence in human pathogens |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL105360C (de) | 1957-07-31 | |||
| FR2813792B1 (fr) | 2000-09-12 | 2003-03-14 | Inst Necker | Moyens pour la regulation des defenses immunitaires |
| US6569853B1 (en) * | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
| EP1360180A1 (de) | 2001-01-19 | 2003-11-12 | Cytokinetics, Inc. | Phenothiazinkinesininhibitoren |
| WO2002089810A1 (en) * | 2001-05-07 | 2002-11-14 | United States Army Medical Research And Materiel Command | Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof |
| US20030229082A1 (en) * | 2002-01-16 | 2003-12-11 | The Regents Of The University Of California | Inhibition of RNA function |
| WO2005046694A1 (en) | 2003-11-13 | 2005-05-26 | Københavns Universitet | Thioridazine and derivatives thereof for reversing anti-microbial drug-resistance |
-
2004
- 2004-11-15 WO PCT/IB2004/003730 patent/WO2005046694A1/en not_active Ceased
- 2004-11-15 EP EP04798860A patent/EP1689405B1/de not_active Expired - Lifetime
- 2004-11-15 AT AT04798860T patent/ATE532517T1/de active
- 2004-11-15 DK DK04798860.5T patent/DK1689405T3/da active
- 2004-11-15 US US10/579,112 patent/US8623864B2/en not_active Expired - Fee Related
- 2004-11-15 ES ES04798860T patent/ES2377016T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1689405B1 (de) | 2011-11-09 |
| ES2377016T3 (es) | 2012-03-21 |
| DK1689405T3 (da) | 2012-02-20 |
| US20070287702A1 (en) | 2007-12-13 |
| US8623864B2 (en) | 2014-01-07 |
| WO2005046694A1 (en) | 2005-05-26 |
| EP1689405A1 (de) | 2006-08-16 |
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