ATE532854T1 - Kultivierte zellen aus den langerhansschen inseln - Google Patents
Kultivierte zellen aus den langerhansschen inselnInfo
- Publication number
- ATE532854T1 ATE532854T1 AT02786886T AT02786886T ATE532854T1 AT E532854 T1 ATE532854 T1 AT E532854T1 AT 02786886 T AT02786886 T AT 02786886T AT 02786886 T AT02786886 T AT 02786886T AT E532854 T1 ATE532854 T1 AT E532854T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- langerhans
- islands
- cultivated cells
- planted
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000002124 endocrine Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 210000004153 islets of langerhan Anatomy 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/40—Nucleotides, nucleosides or bases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33720501P | 2001-12-04 | 2001-12-04 | |
| PCT/US2002/038848 WO2003048336A2 (en) | 2001-12-04 | 2002-12-04 | Cultured cells from pancreatic islets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE532854T1 true ATE532854T1 (de) | 2011-11-15 |
Family
ID=23319544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02786886T ATE532854T1 (de) | 2001-12-04 | 2002-12-04 | Kultivierte zellen aus den langerhansschen inseln |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070081980A1 (de) |
| EP (1) | EP1461440B1 (de) |
| JP (1) | JP2005511046A (de) |
| AT (1) | ATE532854T1 (de) |
| AU (1) | AU2002351238B2 (de) |
| CA (1) | CA2469209C (de) |
| ES (1) | ES2377099T3 (de) |
| MX (1) | MXPA04005439A (de) |
| WO (1) | WO2003048336A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030082155A1 (en) * | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| WO2001039784A1 (en) | 1999-12-06 | 2001-06-07 | The General Hospital Corporation | Pancreatic stem cells and their use in transplantation |
| CN1820069A (zh) * | 2003-06-03 | 2006-08-16 | 器官恢复体系股份有限公司 | 祖细胞的选择和增殖 |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| CA2530732C (en) | 2003-06-27 | 2015-03-31 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| WO2006071802A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells |
| JP5289970B2 (ja) | 2005-12-16 | 2013-09-11 | エシコン・インコーポレイテッド | 組織適合性不適合な移植における逆免疫反応を抑制するための組成物および方法 |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| DK2650360T3 (da) * | 2006-03-02 | 2019-10-07 | Viacyte Inc | Endokrine prekursorceller, pancreatiske hormon udtrykkende celler og fremgangsmåder til fremstilling |
| PL2356227T3 (pl) * | 2008-11-14 | 2018-07-31 | Viacyte, Inc. | Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych |
| BRPI0923068B1 (pt) | 2008-12-19 | 2021-05-25 | Advanced Technologies And Regenerative Medicine, Llc | Uso de células derivadas de tecido de cordão umbilical para tratar um paciente tendo uma doença, distúrbio ou injúria pulmonar |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| ES2629003T3 (es) | 2009-03-26 | 2017-08-07 | DePuy Synthes Products, Inc. | Células de tejido de cordón umbilical humano como tratamiento para la enfermedad de alzheimer |
| US9328331B2 (en) | 2009-05-21 | 2016-05-03 | Joslin Diabetes Center, Inc. | Compositions and methods for promoting beta cell maturity |
| AU2012358810B2 (en) | 2011-12-23 | 2018-03-15 | DePuy Synthes Products, Inc. | Detection of human umbilical cord tissue-derived cells |
| KR101327630B1 (ko) * | 2012-03-05 | 2013-11-13 | 울산대학교 산학협력단 | 아텔로콜라겐을 이용한 췌도세포 이식용 담체의 제조방법 그리고 이를 이용하여 제조된 인공췌장 |
| GB201715930D0 (en) * | 2017-09-30 | 2017-11-15 | Upside Biotechnologies Ltd | Cell Culture Medium |
| WO2021051256A1 (en) * | 2019-09-17 | 2021-03-25 | Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences | Pancreatic pro-endocrine progenitor cells and use thereof |
| CA3207286A1 (en) * | 2021-02-03 | 2022-08-11 | Symbiocelltech, Llc | Cell clusters comprising stem and islet cells, methods of making, and treatment of diabetes mellitus therewith |
| NL2036164B1 (en) * | 2023-11-01 | 2025-05-13 | Academisch Ziekenhuis Leiden | Enrichment or isolation of cell clusters |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3317550C2 (de) | 1983-05-13 | 1985-08-22 | Stephan Priv.Doz.Dr.rer.nat.Dr.med.habil. 8000 München Nees | Verfahren zum Züchten einer lückenlosen Zellschicht und Vorrichtung zur Durchführung dieses Verfahrens |
| US5026649A (en) | 1986-03-20 | 1991-06-25 | Costar Corporation | Apparatus for growing tissue cultures in vitro |
| JPH051280Y2 (de) | 1987-10-12 | 1993-01-13 | ||
| CA2018228C (en) | 1989-06-05 | 1996-02-27 | Nancy L. Parenteau | Cell culture systems and media |
| US6071697A (en) * | 1992-08-03 | 2000-06-06 | Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. | Method for testing the differentiation status in pancreatic cells of a mammal |
| US5366893A (en) | 1993-01-13 | 1994-11-22 | Becton, Dickinson And Company | Culture vessel |
| EP0759932A4 (de) | 1994-05-11 | 1997-11-19 | Organo Genesis Inc | Kollagen aus zellkulturen |
| US5766937A (en) | 1996-02-15 | 1998-06-16 | Becton Dickinson And Company | Culture vessel and assembly |
| WO2001039784A1 (en) * | 1999-12-06 | 2001-06-07 | The General Hospital Corporation | Pancreatic stem cells and their use in transplantation |
| US6436704B1 (en) * | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| EP1453954A4 (de) * | 2001-11-09 | 2004-12-15 | Artecel Sciences Inc | Endokrine pankreasdifferenzierung von aus fettgewebe stammenden stromazellen und ihre verwendung |
| CA2470539C (en) * | 2001-12-07 | 2011-10-04 | Geron Corporation | Islet cells from human embryonic stem cells |
-
2002
- 2002-12-04 WO PCT/US2002/038848 patent/WO2003048336A2/en not_active Ceased
- 2002-12-04 CA CA2469209A patent/CA2469209C/en not_active Expired - Fee Related
- 2002-12-04 EP EP02786886A patent/EP1461440B1/de not_active Expired - Lifetime
- 2002-12-04 JP JP2003549515A patent/JP2005511046A/ja active Pending
- 2002-12-04 AU AU2002351238A patent/AU2002351238B2/en not_active Ceased
- 2002-12-04 AT AT02786886T patent/ATE532854T1/de active
- 2002-12-04 ES ES02786886T patent/ES2377099T3/es not_active Expired - Lifetime
-
2004
- 2004-06-04 MX MXPA04005439A patent/MXPA04005439A/es active IP Right Grant
-
2006
- 2006-12-08 US US11/608,542 patent/US20070081980A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003048336A3 (en) | 2004-04-01 |
| EP1461440B1 (de) | 2011-11-09 |
| US20070081980A1 (en) | 2007-04-12 |
| CA2469209A1 (en) | 2003-06-12 |
| ES2377099T3 (es) | 2012-03-22 |
| AU2002351238B2 (en) | 2009-01-08 |
| CA2469209C (en) | 2012-04-24 |
| EP1461440A2 (de) | 2004-09-29 |
| JP2005511046A (ja) | 2005-04-28 |
| WO2003048336A2 (en) | 2003-06-12 |
| EP1461440A4 (de) | 2005-11-30 |
| AU2002351238A1 (en) | 2003-06-17 |
| MXPA04005439A (es) | 2004-10-11 |
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