ATE533766T1 - Chinolinderivate als ep4-antagonisten - Google Patents

Chinolinderivate als ep4-antagonisten

Info

Publication number: ATE533766T1
Authority: AT; Austria
Prior art keywords: derivatives; group; quinoline derivatives; antagonists; formula
Prior art date: 2005-05-19

Application number

AT06741503T

Other languages

English (en)

Inventor

Michel Belley

Jason Burch

John Colucci

Julie Farand

Mario Girard

Yongxin Han

Original Assignee

Merck Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-19

Filing date

2006-05-15

Publication date

2011-12-15

2006-05-15 Application filed by Merck Canada Inc filed Critical Merck Canada Inc

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE533766T1 publication Critical patent/ATE533766T1/de

Links

229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title abstract 2
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
229910052757 nitrogen Inorganic materials 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
208000002193 Pain Diseases 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
208000000094 Chronic Pain Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000001154 acute effect Effects 0.000 abstract 1
208000005298 acute pain Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
201000008482 osteoarthritis Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Addiction (AREA)
Hematology (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Virology (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Tropical Medicine & Parasitology (AREA)

AT06741503T 2005-05-19 2006-05-15 Chinolinderivate als ep4-antagonisten ATE533766T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68258905P	2005-05-19	2005-05-19
PCT/CA2006/000789 WO2006122403A1 (en)	2005-05-19	2006-05-15	Quinoline derivatives as ep4 antagonists

Publications (1)

Publication Number	Publication Date
ATE533766T1 true ATE533766T1 (de)	2011-12-15

Family

ID=37430885

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06741503T ATE533766T1 (de)	2005-05-19	2006-05-15	Chinolinderivate als ep4-antagonisten

Country Status (7)

Country	Link
US (1)	US8013159B2 (de)
EP (1)	EP1885722B1 (de)
JP (1)	JP5289046B2 (de)
AT (1)	ATE533766T1 (de)
AU (1)	AU2006246930C1 (de)
CA (1)	CA2608214C (de)
WO (1)	WO2006122403A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070072831A1 (en) *	2005-05-16	2007-03-29	Gilead Sciences, Inc.	Integrase inhibitor compounds
UY30121A1 (es)	2006-02-03	2007-08-31	Glaxo Group Ltd	Nuevos compuestos
JP5069752B2 (ja)	2006-12-15	2012-11-07	グラクソグループリミテッド	Ｅｐ４受容体アゴニストとしてのベンズアミド誘導体
CA2679175C (en) *	2007-02-26	2015-01-13	Merck Frosst Canada Ltd.	Indole and indoline cyclopropyl amide derivatives as ep4 receptor antagonists
CN101636385B (zh) *	2007-03-26	2012-09-05	默克弗罗斯特加拿大有限公司	作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物
GB0721611D0 (en)	2007-11-02	2007-12-12	Glaxo Group Ltd	Novel compounds
MX2011003166A (es)	2008-09-25	2011-04-27	Merck Frosst Canada Ltd	Derivados de sulfonilurea beta-carbolina como antagonistas del receptor ep4.
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- 2006-05-15 AT AT06741503T patent/ATE533766T1/de active
- 2006-05-15 US US11/920,275 patent/US8013159B2/en active Active
- 2006-05-15 AU AU2006246930A patent/AU2006246930C1/en not_active Ceased
- 2006-05-15 JP JP2008511515A patent/JP5289046B2/ja not_active Expired - Fee Related
- 2006-05-15 WO PCT/CA2006/000789 patent/WO2006122403A1/en not_active Ceased
- 2006-05-15 CA CA2608214A patent/CA2608214C/en not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
WO2006122403A1 (en)	2006-11-23
AU2006246930C1 (en)	2012-01-19
JP5289046B2 (ja)	2013-09-11
CA2608214A1 (en)	2006-11-23
EP1885722A4 (de)	2010-02-24
AU2006246930A1 (en)	2006-11-23
JP2008540584A (ja)	2008-11-20
US8013159B2 (en)	2011-09-06
CA2608214C (en)	2013-08-20
US20090099226A1 (en)	2009-04-16
AU2006246930B2 (en)	2011-08-18
EP1885722B1 (de)	2011-11-16
EP1885722A1 (de)	2008-02-13

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