ATE535252T1 - Peptid-konjugat-zusammensetzungen und -verfahren zur prävention und behandlung von alzheimer- krankheit - Google Patents

Peptid-konjugat-zusammensetzungen und -verfahren zur prävention und behandlung von alzheimer- krankheit

Info

Publication number
ATE535252T1
ATE535252T1 AT06751930T AT06751930T ATE535252T1 AT E535252 T1 ATE535252 T1 AT E535252T1 AT 06751930 T AT06751930 T AT 06751930T AT 06751930 T AT06751930 T AT 06751930T AT E535252 T1 ATE535252 T1 AT E535252T1
Authority
AT
Austria
Prior art keywords
methods
disease
preventing
immunogenic fragment
peptide conjugate
Prior art date
Application number
AT06751930T
Other languages
English (en)
Inventor
Victor GARSKY
Joseph JOYCE
Paul Keller
Gene Kinney
Xiaoping Liang
John SHIVER
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE535252T1 publication Critical patent/ATE535252T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06751930T 2005-05-05 2006-05-01 Peptid-konjugat-zusammensetzungen und -verfahren zur prävention und behandlung von alzheimer- krankheit ATE535252T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67788605P 2005-05-05 2005-05-05
PCT/US2006/016481 WO2006121656A2 (en) 2005-05-05 2006-05-01 Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
ATE535252T1 true ATE535252T1 (de) 2011-12-15

Family

ID=37019042

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06751930T ATE535252T1 (de) 2005-05-05 2006-05-01 Peptid-konjugat-zusammensetzungen und -verfahren zur prävention und behandlung von alzheimer- krankheit

Country Status (16)

Country Link
US (2) US7850973B2 (de)
EP (2) EP1879613B1 (de)
JP (1) JP2008540417A (de)
KR (1) KR20080005260A (de)
CN (1) CN101171031B (de)
AT (1) ATE535252T1 (de)
AU (1) AU2006246382A1 (de)
BR (1) BRPI0610093A2 (de)
CA (1) CA2607868A1 (de)
IL (1) IL186793A0 (de)
MX (1) MX2007013825A (de)
NO (1) NO20076239L (de)
NZ (1) NZ562434A (de)
RU (1) RU2406529C2 (de)
WO (1) WO2006121656A2 (de)
ZA (1) ZA200708635B (de)

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KR20180058863A (ko) 2005-11-30 2018-06-01 애브비 인코포레이티드 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도
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ES2498040T3 (es) 2007-07-27 2014-09-24 Janssen Alzheimer Immunotherapy Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados
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EP2586795B1 (de) 2007-10-05 2018-05-16 Genentech, Inc. Verwendung eines Anti-Amyloid-Beta-Antikörpers bei Augenkrankheiten
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JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
EP2226081A4 (de) 2007-10-25 2011-10-12 Univ Kagoshima Peptid-vakzine mit einem mimic-molekül von amyloid-peptid
JP5722770B2 (ja) 2008-07-01 2015-05-27 デ スタート デル ネダーランデン、フェルト．ドール デ ミニスター ファン フォルクスヘーゾンドハイド、フェルジイン アン スポルト アミロイド折りたたみ中間体に対するワクチン
JP2011527681A (ja) * 2008-07-08 2011-11-04 メルク・シャープ・エンド・ドーム・コーポレイション アルツハイマー病治療用ワクチン
EP2149380A1 (de) * 2008-07-29 2010-02-03 Medivet Pharma, S.L. Tierärztliche Immuntherapiezusammensetzung für altersbedingte kognitive Dysfunktion
AU2009301631A1 (en) * 2008-10-06 2010-04-15 Commonwealth Scientific And Industrial Research Organisation Amyloid-beta peptide crystal structure
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EP2258398A1 (de) * 2009-05-26 2010-12-08 Araclón Biotech, S. L. Albumin/Amyloidpeptid-Konjugate und deren Verwendungen
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MX336196B (es) 2010-04-15 2016-01-11 Abbvie Inc Proteinas de union a amiloide beta.
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EP3533803B1 (de) 2010-08-14 2021-10-27 AbbVie Inc. Anti-amyloid-beta antikörper
US20120321694A1 (en) * 2010-10-27 2012-12-20 Daniel Larocque Compositions and uses
WO2012072611A1 (de) * 2010-11-29 2012-06-07 Philipps-Universität Marburg SYNTHETISCHE LIGANDEN FÜR HUMANE ANTI-Aβ-ANTIKÖRPER
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WO2013059322A2 (en) * 2011-10-17 2013-04-25 Lawrence Steinman Amyloid beta peptide as a therapy for inflammation
JP2017513849A (ja) * 2014-04-15 2017-06-01 グリフィス・ユニバーシティＧｒｉｆｆｉｔｈ Ｕｎｉｖｅｒｓｉｔｙ Ａ群レンサ球菌ワクチン
JP6913018B2 (ja) 2014-07-08 2021-08-04 ニューヨーク・ユニバーシティ タウイメージングリガンド、ならびにタウ異常症の診断および治療におけるそれらの使用
EP3334453A4 (de) 2015-08-13 2019-02-06 New York University Antikörperbasierte, für das verkürzte asp421-epitop von tau spezifische moleküle und deren verwendungen in der diagnose und behandlung von tauopathie
ES2571055B1 (es) * 2016-02-15 2016-12-28 Araclon Biotech, S.L. Conjugado amiloide y usos y procedimientos del mismo
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JP7368856B2 (ja) 2017-07-25 2023-10-25 トゥルーバインディング，インコーポレイテッド Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療
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Also Published As

Publication number Publication date
RU2007145052A (ru) 2009-06-10
KR20080005260A (ko) 2008-01-10
WO2006121656A2 (en) 2006-11-16
JP2008540417A (ja) 2008-11-20
CA2607868A1 (en) 2006-11-16
EP1879613A2 (de) 2008-01-23
NO20076239L (no) 2008-01-30
US20110052611A1 (en) 2011-03-03
EP1879613B1 (de) 2011-11-30
CN101171031B (zh) 2011-09-28
US7850973B2 (en) 2010-12-14
RU2406529C2 (ru) 2010-12-20
ZA200708635B (en) 2008-10-29
NZ562434A (en) 2010-04-30
WO2006121656A3 (en) 2007-01-04
EP2269633A1 (de) 2011-01-05
CN101171031A (zh) 2008-04-30
US20090098155A1 (en) 2009-04-16
BRPI0610093A2 (pt) 2008-12-09
IL186793A0 (en) 2008-02-09
MX2007013825A (es) 2008-01-18
AU2006246382A1 (en) 2006-11-16

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