ATE535617T1 - Verfahren zur prognostischen bestimmung von chemotherapie, basierend auf einem verlust an heterozygosität (loh) des thymidilatsynthase locus - Google Patents
Verfahren zur prognostischen bestimmung von chemotherapie, basierend auf einem verlust an heterozygosität (loh) des thymidilatsynthase locusInfo
- Publication number
- ATE535617T1 ATE535617T1 AT04713289T AT04713289T ATE535617T1 AT E535617 T1 ATE535617 T1 AT E535617T1 AT 04713289 T AT04713289 T AT 04713289T AT 04713289 T AT04713289 T AT 04713289T AT E535617 T1 ATE535617 T1 AT E535617T1
- Authority
- AT
- Austria
- Prior art keywords
- heterozygosity
- loh
- loss
- chemotherapy based
- thymidilate synthase
- Prior art date
Links
- 238000002512 chemotherapy Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/373,752 US20040170983A1 (en) | 2003-02-27 | 2003-02-27 | Methods of determining a chemotherapuetic regimin based on loss of heterozygosity at the thymidylate synthase locus |
| PCT/US2004/004867 WO2004075833A2 (en) | 2003-02-27 | 2004-02-20 | Methods of determining a chemotherapeutic regimen based on loss of heterozygosity at the thymidylate synthase locus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE535617T1 true ATE535617T1 (de) | 2011-12-15 |
Family
ID=32907701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04713289T ATE535617T1 (de) | 2003-02-27 | 2004-02-20 | Verfahren zur prognostischen bestimmung von chemotherapie, basierend auf einem verlust an heterozygosität (loh) des thymidilatsynthase locus |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20040170983A1 (de) |
| EP (1) | EP1597393B1 (de) |
| JP (1) | JP2006520197A (de) |
| KR (1) | KR101109062B1 (de) |
| CN (1) | CN1777685A (de) |
| AR (1) | AR043398A1 (de) |
| AT (1) | ATE535617T1 (de) |
| AU (1) | AU2004216231B2 (de) |
| CA (1) | CA2517384C (de) |
| ES (1) | ES2377062T3 (de) |
| IL (1) | IL170217A (de) |
| MX (1) | MXPA05009162A (de) |
| NZ (1) | NZ542500A (de) |
| TW (1) | TWI346701B (de) |
| WO (1) | WO2004075833A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2704303T3 (es) | 2010-08-24 | 2019-03-15 | Dana Farber Cancer Inst Inc | Procedimientos para la predicción de una respuesta contra el cáncer |
| ES2768344T3 (es) | 2011-06-17 | 2020-06-22 | Myriad Genetics Inc | Métodos y materiales para evaluar el desequilibrio alélico |
| JP6325453B2 (ja) | 2011-12-21 | 2018-05-16 | ミリアド・ジェネティックス・インコーポレイテッド | ヘテロ接合性の消失(lossofheterozygosity)を評価するための方法および材料 |
| ES2687024T3 (es) | 2012-02-23 | 2018-10-23 | Children's Medical Center Corporation | Procedimientos para predecir la respuesta contra el cáncer |
| CA2867434C (en) | 2012-06-07 | 2021-10-12 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| CA2931181C (en) | 2013-12-09 | 2023-01-24 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| DK3686288T3 (da) | 2014-08-15 | 2023-05-22 | Myriad Genetics Inc | Fremgangsmåder og materialer til analyse af homolog rekombinationsdeficiens |
| CN108459157B (zh) * | 2018-01-11 | 2020-11-27 | 中国药科大学 | 一种预测伊立替康化疗毒性生物标志物的组合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998151A (en) * | 1995-12-01 | 1999-12-07 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for predicting the efficacy of a chemotherapeutic regimen for gastrointestinal cancers using antibodies specific for thymidylate synthase |
-
2003
- 2003-02-27 US US10/373,752 patent/US20040170983A1/en not_active Abandoned
-
2004
- 2004-02-13 TW TW093103498A patent/TWI346701B/zh not_active IP Right Cessation
- 2004-02-20 WO PCT/US2004/004867 patent/WO2004075833A2/en not_active Ceased
- 2004-02-20 NZ NZ542500A patent/NZ542500A/en not_active IP Right Cessation
- 2004-02-20 AT AT04713289T patent/ATE535617T1/de active
- 2004-02-20 MX MXPA05009162A patent/MXPA05009162A/es active IP Right Grant
- 2004-02-20 ES ES04713289T patent/ES2377062T3/es not_active Expired - Lifetime
- 2004-02-20 KR KR1020057015973A patent/KR101109062B1/ko not_active Expired - Fee Related
- 2004-02-20 AU AU2004216231A patent/AU2004216231B2/en not_active Ceased
- 2004-02-20 CA CA2517384A patent/CA2517384C/en not_active Expired - Fee Related
- 2004-02-20 JP JP2006503700A patent/JP2006520197A/ja active Pending
- 2004-02-20 CN CNA2004800106956A patent/CN1777685A/zh active Pending
- 2004-02-20 EP EP04713289A patent/EP1597393B1/de not_active Expired - Lifetime
- 2004-02-26 AR ARP040100598A patent/AR043398A1/es active IP Right Grant
-
2005
- 2005-08-10 IL IL170217A patent/IL170217A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2517384C (en) | 2013-01-22 |
| EP1597393A2 (de) | 2005-11-23 |
| US20040170983A1 (en) | 2004-09-02 |
| WO2004075833A3 (en) | 2004-11-11 |
| KR20050105498A (ko) | 2005-11-04 |
| ES2377062T3 (es) | 2012-03-22 |
| AR043398A1 (es) | 2005-07-27 |
| AU2004216231B2 (en) | 2009-07-23 |
| AU2004216231A1 (en) | 2004-09-10 |
| WO2004075833A2 (en) | 2004-09-10 |
| CA2517384A1 (en) | 2004-09-10 |
| TW200510546A (en) | 2005-03-16 |
| KR101109062B1 (ko) | 2012-01-31 |
| MXPA05009162A (es) | 2005-10-26 |
| JP2006520197A (ja) | 2006-09-07 |
| TWI346701B (en) | 2011-08-11 |
| CN1777685A (zh) | 2006-05-24 |
| EP1597393B1 (de) | 2011-11-30 |
| NZ542500A (en) | 2008-04-30 |
| IL170217A (en) | 2010-12-30 |
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