ATE536359T1 - Neuartiges verfahren zur herstellung von oligonukleotiden mit einem 5'-phosphat-monoester- oder einem 5'-thiophosphat-monoester-ende - Google Patents

Neuartiges verfahren zur herstellung von oligonukleotiden mit einem 5'-phosphat-monoester- oder einem 5'-thiophosphat-monoester-ende

Info

Publication number: ATE536359T1
Authority: AT; Austria
Prior art keywords: monoester; novel process; thiophosphate; phosphate; producing oligonucleotides
Prior art date: 2008-04-16

Application number

AT09745933T

Other languages

English (en)

Inventor

Eric Defrancq

Remi M Lartia

Original Assignee

Univ Joseph Fourier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-16

Filing date

2009-04-15

Publication date

2011-12-15

2009-04-15 Application filed by Univ Joseph Fourier filed Critical Univ Joseph Fourier

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE536359T1 publication Critical patent/ATE536359T1/de

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 2
229910019142 PO4 Inorganic materials 0.000 title abstract 2
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 2
239000010452 phosphate Substances 0.000 title abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)

AT09745933T 2008-04-16 2009-04-15 Neuartiges verfahren zur herstellung von oligonukleotiden mit einem 5'-phosphat-monoester- oder einem 5'-thiophosphat-monoester-ende ATE536359T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0802097A FR2930250B1 (fr)	2008-04-16	2008-04-16	Nouveau procede de preparation d'oligonucleotides comportant une extremite 5'-phosphate monoester ou 5'-thiophosphate monoester.
PCT/FR2009/050689 WO2009138614A2 (fr)	2008-04-16	2009-04-15	Nouveau procede de preparation d'oligonucleotides comportant une extremite 5'-phosphate monoester ou 5'-thiophosphate monoester

Publications (1)

Publication Number	Publication Date
ATE536359T1 true ATE536359T1 (de)	2011-12-15

Family

ID=40254759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT09745933T ATE536359T1 (de)	2008-04-16	2009-04-15	Neuartiges verfahren zur herstellung von oligonukleotiden mit einem 5'-phosphat-monoester- oder einem 5'-thiophosphat-monoester-ende

Country Status (6)

Country	Link
US (1)	US20110112285A1 (de)
EP (1)	EP2271653B1 (de)
JP (1)	JP2011517695A (de)
AT (1)	ATE536359T1 (de)
FR (1)	FR2930250B1 (de)
WO (1)	WO2009138614A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2017043490A1 (ja) *	2015-09-07	2017-03-16	協和発酵バイオ株式会社	自然免疫誘導効果が増強した二重鎖リボ核酸

2008
- 2008-04-16 FR FR0802097A patent/FR2930250B1/fr not_active Expired - Fee Related
2009
- 2009-04-15 EP EP09745933A patent/EP2271653B1/de not_active Not-in-force
- 2009-04-15 AT AT09745933T patent/ATE536359T1/de active
- 2009-04-15 WO PCT/FR2009/050689 patent/WO2009138614A2/fr not_active Ceased
- 2009-04-15 JP JP2011504510A patent/JP2011517695A/ja active Pending
- 2009-04-15 US US12/988,220 patent/US20110112285A1/en not_active Abandoned

Also Published As

Publication number	Publication date
FR2930250B1 (fr)	2010-06-18
WO2009138614A3 (fr)	2010-05-06
FR2930250A1 (fr)	2009-10-23
EP2271653B1 (de)	2011-12-07
JP2011517695A (ja)	2011-06-16
EP2271653A2 (de)	2011-01-12
WO2009138614A2 (fr)	2009-11-19
US20110112285A1 (en)	2011-05-12

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