ATE536425T1 - Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon - Google Patents

Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon

Info

Publication number
ATE536425T1
ATE536425T1 AT07868439T AT07868439T ATE536425T1 AT E536425 T1 ATE536425 T1 AT E536425T1 AT 07868439 T AT07868439 T AT 07868439T AT 07868439 T AT07868439 T AT 07868439T AT E536425 T1 ATE536425 T1 AT E536425T1
Authority
AT
Austria
Prior art keywords
methods
metabolic age
biomarkers
biomarkers associated
age
Prior art date
Application number
AT07868439T
Other languages
English (en)
Inventor
John Ryals
Mike Milburn
Matthew W Mitchell
Kay A Lawton
Original Assignee
Metabolon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolon Inc filed Critical Metabolon Inc
Application granted granted Critical
Publication of ATE536425T1 publication Critical patent/ATE536425T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7042—Aging, e.g. cellular aging

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
AT07868439T 2006-10-13 2007-10-12 Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon ATE536425T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85146806P 2006-10-13 2006-10-13
PCT/US2007/081268 WO2008063783A2 (en) 2006-10-13 2007-10-12 Biomarkers related to metabolic age and methods using the same

Publications (1)

Publication Number Publication Date
ATE536425T1 true ATE536425T1 (de) 2011-12-15

Family

ID=39430420

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07868439T ATE536425T1 (de) 2006-10-13 2007-10-12 Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon

Country Status (6)

Country Link
US (3) US7781160B2 (de)
EP (3) EP2089539B1 (de)
JP (1) JP5363984B2 (de)
AT (1) ATE536425T1 (de)
CA (1) CA2666339A1 (de)
WO (1) WO2008063783A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009153131A1 (en) * 2008-05-28 2009-12-23 Basf Se Means and methods for assessing liver enzyme induction
WO2009153136A2 (en) 2008-05-28 2009-12-23 Basf Se Means and methods for assessing liver toxicity
KR101068996B1 (ko) 2008-09-18 2011-09-30 한국표준과학연구원 안정동위원소의 질량비를 이용한 동물의 월령 측정 방법
PT2391653E (pt) * 2009-01-28 2015-02-13 Ind Tech Res Inst Biomarcadores associados a nefropatia
EP2642294A1 (de) * 2012-03-22 2013-09-25 Nestec S.A. Phenylacetylglutamin als Biomarker für gesundes Altern
EP2642293A1 (de) 2012-03-22 2013-09-25 Nestec S.A. 9-oxo-octadecadiensäure (9-oxo-HODE) als Biomarker für gesundes Altern
EP2642296A1 (de) * 2012-03-22 2013-09-25 Nestec S.A. p-Cresolsulfat als Biomarker für gesundes Altern
EP2642295A1 (de) 2012-03-22 2013-09-25 Nestec S.A. 1-O-alkyl-2-acylglycerophosphocholin (PC-O) 40:1 als Biomarker für gesundes Altern
CL2012001566A1 (es) * 2012-06-11 2013-08-09 Univ De Santiago De Chile Univ Tecnica Federico Santa Maria Metodo analitico para verificar la edad de la carne de animales utilizando perfiles volatiles que comprende introducir una fibra de microextraccion en fase solida en un vial que contiene la carne picada que ha sido calentada, luego desorber en el puerto de inyeccion de un cromatografo de gases, separar los gases y determinar sus concentraciones.
US20160196766A1 (en) * 2013-02-20 2016-07-07 Chistopher Brian Lundin Weight management method
CN105765083B (zh) * 2013-09-27 2021-05-04 加利福尼亚大学董事会 基于表观遗传学标记物来估计组织和细胞类型的年龄的方法
CN106659701B (zh) 2014-06-30 2021-04-27 加尼福尼亚大学董事会 用于治疗年龄相关性症状和疾病的酮基丁酸酯化合物和组合物
US9737761B1 (en) * 2014-10-29 2017-08-22 REVVO, Inc. System and method for fitness testing, tracking and training
US20180275144A1 (en) * 2015-02-03 2018-09-27 Pharnext Diagnostic tools for alzheimer's disease
US10823699B2 (en) 2016-07-29 2020-11-03 Vital Biosciences, Inc. Gel electrophoresis diagnostic kit and methods of using the same
WO2018119437A2 (en) 2016-12-23 2018-06-28 Confer Health, Inc. Electrophoresis diagnostic methods and kits
US10765718B2 (en) 2017-02-02 2020-09-08 Golo Llc Formulations for weight loss and methods of use
CN108956790A (zh) * 2017-05-18 2018-12-07 中国人民解放军第二军医大学第二附属医院 一组氨基酸标志物在急性肾损伤诊断试剂盒中的应用
US12080432B1 (en) 2017-06-01 2024-09-03 The Regents Of The University Of Colorado Plasma metabolome as a predictor of biological aging
CN107273699A (zh) * 2017-07-07 2017-10-20 成都脉安科健生物科技有限公司 营养指导方案获取方法、装置及电子设备
US11484273B2 (en) * 2018-03-06 2022-11-01 International Business Machines Corporation Determining functional age indices based upon sensor data
WO2019208572A1 (en) * 2018-04-24 2019-10-31 Okinawa Institute Of Science And Technology School Corporation The use of saliva and urine metabolites as human-aging biomarkers
CN108663448B (zh) * 2018-05-14 2021-07-13 中国医学科学院医药生物技术研究所 一种复方氨基酸注射液中有关物质的检测方法
WO2020252206A1 (en) * 2019-06-12 2020-12-17 Huntington Medical Research Institutes Methods for evaluation and treatment of alzheimer's disease and applications thereof
CN110658286B (zh) * 2019-11-19 2022-07-08 浙江树人学院（浙江树人大学） 利用rp-hplc法同时快速检测苯乳酸和4-羟基苯乳酸含量的方法
CN113125589B (zh) * 2021-03-17 2022-01-04 广东省农业科学院农业质量标准与监测技术研究所 一种代谢组学分析技术鉴定鸭屎香单丛茶的应用
JPWO2022259950A1 (de) * 2021-06-10 2022-12-15
CN116798518B (zh) * 2023-06-05 2024-03-08 中南大学湘雅医院 构建代谢物衰老分数及代谢衰老速率的方法及其应用
CN120280160B (zh) * 2025-06-10 2025-09-19 上海交通大学医学院附属仁济医院 代谢衰老的识别模型构建系统、存储介质及试剂盒

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096787A (en) * 1990-08-03 1992-03-17 Globe-Union Inc. Hydrostatic pump with static resistance for a mobile vehicle battery
JP3350189B2 (ja) * 1993-04-30 2002-11-25 本田技研工業株式会社 電気自動車用バッテリボックス装置
JPH11301077A (ja) 1998-04-23 1999-11-02 Olympus Optical Co Ltd ドットコード評価装置及びドットコード評価方法
JPH11301079A (ja) 1998-04-27 1999-11-02 Canon Inc 印刷方法、印刷システムおよび記録媒体
JPH11301078A (ja) 1998-04-27 1999-11-02 Ricoh Co Ltd 複合装置
AU782102B2 (en) * 1999-08-12 2005-07-07 Wisconsin Alumni Research Foundation Identification of genetic markers of biological age and metabolism
US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US20020009740A1 (en) * 2000-04-14 2002-01-24 Rima Kaddurah-Daouk Methods for drug discovery, disease treatment, and diagnosis using metabolomics
JP3792547B2 (ja) * 2001-07-19 2006-07-05 株式会社タニタ 生体測定装置
US20030082597A1 (en) * 2001-08-15 2003-05-01 Cannon L. Edward Age-associated markers
ATE502343T1 (de) * 2002-06-14 2011-04-15 Pfizer Metabolische phänotypisierung
WO2004085996A2 (en) 2003-03-20 2004-10-07 Albert Einstein College Of Medicine Of Yeshiva University Biomarkers for longevity and disease and uses thereof
US20070111933A1 (en) * 2003-06-02 2007-05-17 Kopchick John J Diagnosis and treatment methods related to aging, especially of liver
JP4255321B2 (ja) 2003-06-25 2009-04-15 本田技研工業株式会社 アシスト搬送方法及びその装置
JP4384896B2 (ja) * 2003-11-14 2009-12-16 フィールファイン株式会社 年齢アセスメントシステム及びプログラム
JP2006134678A (ja) 2004-11-05 2006-05-25 Toyota Central Res & Dev Lab Inc 固体高分子型燃料電池及び燃料電池システム
JP2006134676A (ja) 2004-11-05 2006-05-25 Fuji Electric Fa Components & Systems Co Ltd 加熱温度制御装置
JP2006134677A (ja) 2004-11-05 2006-05-25 Fuji Electric Holdings Co Ltd 固体高分子型燃料電池用セパレータ及びその製造方法

Also Published As

Publication number Publication date
EP2089539A2 (de) 2009-08-19
EP2089539B1 (de) 2011-12-07
US20100279337A1 (en) 2010-11-04
US7781160B2 (en) 2010-08-24
EP2089539A4 (de) 2010-03-17
EP2428587A3 (de) 2012-07-18
JP2010507075A (ja) 2010-03-04
EP2428587A2 (de) 2012-03-14
WO2008063783A2 (en) 2008-05-29
EP2813580A1 (de) 2014-12-17
US20160116461A1 (en) 2016-04-28
JP5363984B2 (ja) 2013-12-11
CA2666339A1 (en) 2008-05-29
WO2008063783A3 (en) 2008-12-24
US20080124752A1 (en) 2008-05-29

Similar Documents

Publication Publication Date Title
ATE536425T1 (de) Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon
ATE514755T1 (de) Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung
ATE535805T1 (de) Verfahren zur erkennung von autoantikörpern zur diagnostizierung und charakterisierung von erkrankungen
MX2010000414A (es) Biomarcadores para prediabetes, enfermedades cardiovasculares y otros trastornos relacionados con sindrome metabolico, y metodos de uso de los mismos.
DE602005012969D1 (de) Verfahren zur vergrösserung der positionsverfügbarkeit
BR112014025520A2 (pt) método para estimar características de uma formação
SI3156422T1 (sl) Človeška protitelesa z visoko afiniteto do PCSK9
EP1934941A4 (de) Bidirektionales tracking unter verwendung von trajektorien-segmentanalyse
DK2024747T3 (da) Anvendelse af protein SATB2 som prognotisk markør for colerectal cancer
DE602007008157D1 (de) Schreibgerät mit direkter Flüssigkeitszufuhr
DK2002016T3 (da) Fremgangsmåde til bestemmelse af kopital
EP2212700B8 (de) Verfahren zur beurteilung von kolorektalem krebs anhand einer stuhlprobe durch verwendung einer marker-kombination aus calprotectin und einem hämoglobin/haptoglobin-komplex
MX378733B (es) Métodos in vitro y composiciones para identificar y usarse en el tratamiento de lupus.
DE602007012068D1 (de) Optischer parametrischer oszillator mit mehreren ports
WO2007082144A3 (en) B7-h1 and survivin in cancer
ATE454632T1 (de) Verfahren zur beurteilung der lebensfähigkeit von embryos
ATE374367T1 (de) Verwendung von cyanin-farbstoffen zur diagnose von krankheiten, welche mit angiogenese assoziert sind
DE602006013151D1 (de) Verfahren zur herstellung von polymermaleimiden
ATE488772T1 (de) Biomarker zur beurteilung der leberfunktion
ATE468535T1 (de) Verwendung von nnmt als marker für lungenkrebs
WO2010043393A8 (en) Use of biglycan in the assessment of heart failure
EA201290948A1 (ru) МАРКЕРЫ HbF И A1M В КАЧЕСТВЕ МАРКЕРОВ РАННЕЙ СТАДИИ ПРЕЭКЛАМПСИИ
DE602006011211D1 (de) Auskleidungskomponente zur verwendung in der bergbau- oder abbauindustrie
DE602006003830D1 (de) Fahrzeug mit erhöhter wahrgenommener Genauigkeit
ATE511636T1 (de) Verfahren zum nachweis biologischer organismen mittels raman-streuung