ATE536425T1 - Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon - Google Patents

Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon

Info

Publication number
ATE536425T1
ATE536425T1 AT07868439T AT07868439T ATE536425T1 AT E536425 T1 ATE536425 T1 AT E536425T1 AT 07868439 T AT07868439 T AT 07868439T AT 07868439 T AT07868439 T AT 07868439T AT E536425 T1 ATE536425 T1 AT E536425T1
Authority
AT
Austria
Prior art keywords
methods
metabolic age
biomarkers
biomarkers associated
age
Prior art date
Application number
AT07868439T
Other languages
English (en)
Inventor
John Ryals
Mike Milburn
Matthew W Mitchell
Kay A Lawton
Original Assignee
Metabolon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolon Inc filed Critical Metabolon Inc
Application granted granted Critical
Publication of ATE536425T1 publication Critical patent/ATE536425T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7042—Aging, e.g. cellular aging

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
AT07868439T 2006-10-13 2007-10-12 Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon ATE536425T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85146806P 2006-10-13 2006-10-13
PCT/US2007/081268 WO2008063783A2 (en) 2006-10-13 2007-10-12 Biomarkers related to metabolic age and methods using the same

Publications (1)

Publication Number Publication Date
ATE536425T1 true ATE536425T1 (de) 2011-12-15

Family

ID=39430420

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07868439T ATE536425T1 (de) 2006-10-13 2007-10-12 Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon

Country Status (6)

Country Link
US (3) US7781160B2 (de)
EP (3) EP2813580A1 (de)
JP (1) JP5363984B2 (de)
AT (1) ATE536425T1 (de)
CA (1) CA2666339A1 (de)
WO (1) WO2008063783A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2286236B1 (de) 2008-05-28 2016-04-20 Basf Se Verfahren zur beurteilung einer lebertoxizität
BRPI0912175A2 (pt) 2008-05-28 2015-10-06 Basf Se métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado
KR101068996B1 (ko) 2008-09-18 2011-09-30 한국표준과학연구원 안정동위원소의 질량비를 이용한 동물의 월령 측정 방법
DK2391653T3 (en) * 2009-01-28 2015-02-09 Ind Tech Res Inst Biomarkers associated nephropathy
EP2642296A1 (de) * 2012-03-22 2013-09-25 Nestec S.A. p-Cresolsulfat als Biomarker für gesundes Altern
EP2642294A1 (de) * 2012-03-22 2013-09-25 Nestec S.A. Phenylacetylglutamin als Biomarker für gesundes Altern
EP2642295A1 (de) 2012-03-22 2013-09-25 Nestec S.A. 1-O-alkyl-2-acylglycerophosphocholin (PC-O) 40:1 als Biomarker für gesundes Altern
EP2642293A1 (de) 2012-03-22 2013-09-25 Nestec S.A. 9-oxo-octadecadiensäure (9-oxo-HODE) als Biomarker für gesundes Altern
CL2012001566A1 (es) * 2012-06-11 2013-08-09 Univ De Santiago De Chile Univ Tecnica Federico Santa Maria Metodo analitico para verificar la edad de la carne de animales utilizando perfiles volatiles que comprende introducir una fibra de microextraccion en fase solida en un vial que contiene la carne picada que ha sido calentada, luego desorber en el puerto de inyeccion de un cromatografo de gases, separar los gases y determinar sus concentraciones.
US20160196766A1 (en) * 2013-02-20 2016-07-07 Chistopher Brian Lundin Weight management method
EP3049535B1 (de) * 2013-09-27 2021-12-01 The Regents of the University of California Verfahren zur schätzung des alters von geweben und zelltypen auf basis epigenetischer marker
KR102596106B1 (ko) 2014-06-30 2023-10-30 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 연령-관련 증상 및 질환의 치료를 위한 케토부티레이트 화합물 및 조성물
US9737761B1 (en) * 2014-10-29 2017-08-22 REVVO, Inc. System and method for fitness testing, tracking and training
WO2016124574A1 (en) * 2015-02-03 2016-08-11 Pharnext Diagnostic tools for alzheimer's disease
WO2018023088A1 (en) 2016-07-29 2018-02-01 Confer Health, Inc. Gel electrophoresis diagnostic kit and methods of using the same
CA3048210A1 (en) 2016-12-23 2018-06-28 Vital Biosciences, Inc. Electrophoresis diagnostic methods and kits
WO2018144911A1 (en) 2017-02-02 2018-08-09 Golo Llc Formulations for weight loss and methods of use
CN108956790A (zh) * 2017-05-18 2018-12-07 中国人民解放军第二军医大学第二附属医院 一组氨基酸标志物在急性肾损伤诊断试剂盒中的应用
US12080432B1 (en) 2017-06-01 2024-09-03 The Regents Of The University Of Colorado Plasma metabolome as a predictor of biological aging
CN107273699A (zh) * 2017-07-07 2017-10-20 成都脉安科健生物科技有限公司 营养指导方案获取方法、装置及电子设备
US11484273B2 (en) * 2018-03-06 2022-11-01 International Business Machines Corporation Determining functional age indices based upon sensor data
WO2019208572A1 (en) * 2018-04-24 2019-10-31 Okinawa Institute Of Science And Technology School Corporation The use of saliva and urine metabolites as human-aging biomarkers
CN108663448B (zh) * 2018-05-14 2021-07-13 中国医学科学院医药生物技术研究所 一种复方氨基酸注射液中有关物质的检测方法
WO2020252206A1 (en) * 2019-06-12 2020-12-17 Huntington Medical Research Institutes Methods for evaluation and treatment of alzheimer's disease and applications thereof
CN110658286B (zh) * 2019-11-19 2022-07-08 浙江树人学院（浙江树人大学） 利用rp-hplc法同时快速检测苯乳酸和4-羟基苯乳酸含量的方法
CN113125589B (zh) * 2021-03-17 2022-01-04 广东省农业科学院农业质量标准与监测技术研究所 一种代谢组学分析技术鉴定鸭屎香单丛茶的应用
JPWO2022259950A1 (de) * 2021-06-10 2022-12-15
CN116798518B (zh) * 2023-06-05 2024-03-08 中南大学湘雅医院 构建代谢物衰老分数及代谢衰老速率的方法及其应用
CN120280160B (zh) * 2025-06-10 2025-09-19 上海交通大学医学院附属仁济医院 代谢衰老的识别模型构建系统、存储介质及试剂盒
CN121577896B (zh) * 2025-11-25 2026-07-28 沈阳药科大学 C1inh作为衰老生物标志物、干预靶点在评估衰老程度及抗衰老干预中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096787A (en) * 1990-08-03 1992-03-17 Globe-Union Inc. Hydrostatic pump with static resistance for a mobile vehicle battery
JP3350189B2 (ja) * 1993-04-30 2002-11-25 本田技研工業株式会社 電気自動車用バッテリボックス装置
JPH11301077A (ja) 1998-04-23 1999-11-02 Olympus Optical Co Ltd ドットコード評価装置及びドットコード評価方法
JPH11301078A (ja) 1998-04-27 1999-11-02 Ricoh Co Ltd 複合装置
JPH11301079A (ja) 1998-04-27 1999-11-02 Canon Inc 印刷方法、印刷システムおよび記録媒体
US6569624B1 (en) * 1999-08-12 2003-05-27 Wisconsin Alumni Research Foundation Identification of genetic markers of biological age and metabolism
US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
WO2001078652A2 (en) * 2000-04-14 2001-10-25 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
JP3792547B2 (ja) * 2001-07-19 2006-07-05 株式会社タニタ 生体測定装置
CA2457370A1 (en) * 2001-08-15 2003-02-27 Elixir Pharmaceuticals, Inc. Age-associated markers
EP1540560B1 (de) * 2002-06-14 2011-03-16 Pfizer Limited Metabolische phänotypisierung
WO2004085996A2 (en) 2003-03-20 2004-10-07 Albert Einstein College Of Medicine Of Yeshiva University Biomarkers for longevity and disease and uses thereof
EP1656155A2 (de) * 2003-06-02 2006-05-17 Ohio University Verwendung von genen, die im alter unterschiedlich exprimiert werden, in medizin und diagnose
JP4255321B2 (ja) 2003-06-25 2009-04-15 本田技研工業株式会社 アシスト搬送方法及びその装置
JP4384896B2 (ja) * 2003-11-14 2009-12-16 フィールファイン株式会社 年齢アセスメントシステム及びプログラム
JP2006134676A (ja) 2004-11-05 2006-05-25 Fuji Electric Fa Components & Systems Co Ltd 加熱温度制御装置
JP2006134677A (ja) 2004-11-05 2006-05-25 Fuji Electric Holdings Co Ltd 固体高分子型燃料電池用セパレータ及びその製造方法
JP2006134678A (ja) 2004-11-05 2006-05-25 Toyota Central Res & Dev Lab Inc 固体高分子型燃料電池及び燃料電池システム

Also Published As

Publication number Publication date
US20160116461A1 (en) 2016-04-28
US7781160B2 (en) 2010-08-24
EP2428587A3 (de) 2012-07-18
EP2089539A2 (de) 2009-08-19
EP2428587A2 (de) 2012-03-14
JP5363984B2 (ja) 2013-12-11
US20080124752A1 (en) 2008-05-29
US20100279337A1 (en) 2010-11-04
EP2089539A4 (de) 2010-03-17
WO2008063783A3 (en) 2008-12-24
JP2010507075A (ja) 2010-03-04
CA2666339A1 (en) 2008-05-29
EP2813580A1 (de) 2014-12-17
WO2008063783A2 (en) 2008-05-29
EP2089539B1 (de) 2011-12-07

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