ATE537181T1 - Benzimidazolderivate und deren medizinische verwendungen - Google Patents

Benzimidazolderivate und deren medizinische verwendungen

Info

Publication number: ATE537181T1
Authority: AT; Austria
Prior art keywords: optionally substituted; halogen atom; useful; alkyl group; substituted alkyl
Prior art date: 2003-12-26

Application number

AT04807647T

Other languages

English (en)

Inventor

Norihiko Kikuchi

Yoshinori Nonaka

Kazuya Tatani

Masahiro Hiratochi

Yu Kuramochi

Masayuki Isaji

Kazuo Shimizu

Takashi Miyagi

Original Assignee

Kissei Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-26

Filing date

2004-12-16

Publication date

2011-12-15

2004-12-16 Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE537181T1 publication Critical patent/ATE537181T1/de

Links

229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
150000001556 benzimidazoles Chemical class 0.000 title 1
125000005843 halogen group Chemical group 0.000 abstract 3
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
201000005569 Gout Diseases 0.000 abstract 1
201000001431 Hyperuricemia Diseases 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
102000019055 Nucleoside Transport Proteins Human genes 0.000 abstract 1
206010046337 Urate nephropathy Diseases 0.000 abstract 1
LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 1
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract 1
230000005856 abnormality Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
108091006527 nucleoside transporters Proteins 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
229940116269 uric acid Drugs 0.000 abstract 1
208000008281 urolithiasis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT04807647T 2003-12-26 2004-12-16 Benzimidazolderivate und deren medizinische verwendungen ATE537181T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2003432581		2003-12-26
PCT/JP2004/019290 WO2005063788A1 (ja)	2003-12-26	2004-12-16	ベンズイミダゾール誘導体及びその医薬用途

Publications (1)

Publication Number	Publication Date
ATE537181T1 true ATE537181T1 (de)	2011-12-15

Family

ID=34736480

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04807647T ATE537181T1 (de)	2003-12-26	2004-12-16	Benzimidazolderivate und deren medizinische verwendungen

Country Status (8)

Country	Link
US (1)	US7547680B2 (de)
EP (1)	EP1698635B1 (de)
JP (1)	JP4914611B2 (de)
AT (1)	ATE537181T1 (de)
CA (1)	CA2550441C (de)
ES (1)	ES2377937T3 (de)
TW (1)	TW200530224A (de)
WO (1)	WO2005063788A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040265323A1 (en) *	2003-05-16	2004-12-30	Mccormick Beth A.	Compositions comprising pathogen elicited epithelial chemoattractant (eicosanoid hepoxilin A3), inhibitors thereof and methods of use thereof
WO2006012438A2 (en)	2004-07-21	2006-02-02	University Of Florida Research Foundation, Inc.	Compositions and methods for treatment and prevention of insulin resistance
JPWO2006115137A1 (ja) *	2005-04-22	2008-12-18	キッセイ薬品工業株式会社	２−アミノベンズイミダゾール誘導体及びその医薬用途
CA2617161A1 (en) *	2005-07-21	2007-02-15	University Of Florida Research Foundation, Inc.	Compositions and methods for treatment and prevention of hyperuricemia related health consequences
JO3126B1 (ar) *	2007-11-14	2017-09-20	Janssen Pharmaceutica Nv	مثبطات ناقل نيوكليوسيد متوازن اي ان تي 1
BRPI0913129A2 (pt) *	2008-05-22	2016-01-05	Bristol Myers Squibb Co	método para tratamento de hiperuricemia empregando um inibidor de sglt2 e composição contendo o mesmo
US20110171192A1 (en) *	2008-09-05	2011-07-14	Hiroshi Tomiyama	Substituted amine derivative and medicinal composition comprising same as the active ingredient
WO2010071865A1 (en)	2008-12-19	2010-06-24	Nuon Therapeutics, Inc.	Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
US20100160351A1 (en) *	2008-12-19	2010-06-24	Nuon Therapeutics, Inc.	Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
WO2011032175A1 (en)	2009-09-14	2011-03-17	Nuon Therapeutics, Inc.	Combination formulations of tranilast and allopurinol and methods related thereto
CA2794798C (en)	2010-03-30	2017-05-30	Ardea Biosciences, Inc.	Treatment of gout
CA2802407C (en)	2010-06-15	2018-01-23	Ardea Biosciences, Inc.	Treatment of gout and hyperuricemia
EP2627331A4 (de) *	2010-10-15	2014-03-12	Ardea Biosciences Inc	Verfahren zur behandlung von hyperurikämie und damit zusammenhängenden erkrankungen
CN105372372B (zh) *	2012-12-14	2018-05-01	贵州信邦制药股份有限公司	一种非布索坦片剂的检测方法
US11116737B1 (en)	2020-04-10	2021-09-14	University Of Georgia Research Foundation, Inc.	Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9413724D0 (en) *	1994-07-07	1994-08-24	Wellcome Found	Therapeutic nucleosides
GB9600143D0 (en)	1996-01-05	1996-03-06	Wellcome Found	Therapeutic compounds

2004
- 2004-12-16 AT AT04807647T patent/ATE537181T1/de active
- 2004-12-16 CA CA2550441A patent/CA2550441C/en not_active Expired - Fee Related
- 2004-12-16 WO PCT/JP2004/019290 patent/WO2005063788A1/ja not_active Ceased
- 2004-12-16 ES ES04807647T patent/ES2377937T3/es not_active Expired - Lifetime
- 2004-12-16 JP JP2005516622A patent/JP4914611B2/ja not_active Expired - Fee Related
- 2004-12-16 EP EP04807647A patent/EP1698635B1/de not_active Expired - Lifetime
- 2004-12-23 TW TW093140242A patent/TW200530224A/zh unknown
2006
- 2006-06-23 US US11/473,957 patent/US7547680B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1698635A1 (de)	2006-09-06
EP1698635B1 (de)	2011-12-14
TW200530224A (en)	2005-09-16
EP1698635A4 (de)	2009-06-17
US20080038242A1 (en)	2008-02-14
ES2377937T3 (es)	2012-04-03
CA2550441C (en)	2012-08-28
WO2005063788A1 (ja)	2005-07-14
US7547680B2 (en)	2009-06-16
JP4914611B2 (ja)	2012-04-11
JPWO2005063788A1 (ja)	2007-07-19
CA2550441A1 (en)	2005-07-14

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