ATE538118T1 - Pyrimidinylisoxazolderivat - Google Patents

Pyrimidinylisoxazolderivat

Info

Publication number: ATE538118T1
Authority: AT; Austria
Prior art keywords: stands; pyrimidinylisoxazole; derivative; substituted; hydrogen
Prior art date: 2004-12-28

Application number

AT05824638T

Other languages

English (en)

Inventor

Koichi Hasumi

Shuji Ohta

Takahisa Saito

Shuichiro Sato

Jun-Ya Kato

Jun Sato

Hiroyuki Suzuki

Hajime Asano

Mami Okada

Yasuhiro Matsumoto

Kazuhiko Shirota

Original Assignee

Aska Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-28

Filing date

2005-12-27

Publication date

2012-01-15

2005-12-27 Application filed by Aska Pharm Co Ltd filed Critical Aska Pharm Co Ltd

2012-01-15 Application granted granted Critical

2012-01-15 Publication of ATE538118T1 publication Critical patent/ATE538118T1/de

Links

NGJCUJZBSJGQPY-UHFFFAOYSA-N 3-pyrimidin-2-yl-1,2-oxazole Chemical class O1C=CC(C=2N=CC=CN=2)=N1 NGJCUJZBSJGQPY-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
150000002545 isoxazoles Chemical class 0.000 abstract 1
102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Oncology (AREA)
Endocrinology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Molecular Biology (AREA)

AT05824638T 2004-12-28 2005-12-27 Pyrimidinylisoxazolderivat ATE538118T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2004381733		2004-12-28
PCT/JP2005/024244 WO2006070927A1 (ja)	2004-12-28	2005-12-27	ピリミジニルイソオキサゾール誘導体

Publications (1)

Publication Number	Publication Date
ATE538118T1 true ATE538118T1 (de)	2012-01-15

Family

ID=36615031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05824638T ATE538118T1 (de)	2004-12-28	2005-12-27	Pyrimidinylisoxazolderivat

Country Status (10)

Country	Link
US (1)	US7939536B2 (de)
EP (1)	EP1832584B1 (de)
JP (1)	JP5100126B2 (de)
KR (1)	KR101181692B1 (de)
CN (1)	CN101080404B (de)
AT (1)	ATE538118T1 (de)
AU (1)	AU2005320544B2 (de)
CA (1)	CA2591912C (de)
ES (1)	ES2375633T3 (de)
WO (1)	WO2006070927A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2396251T3 (es) *	2006-06-28	2013-02-20	Aska Pharmaceutical Co., Ltd.	Derivado de piridilisoxazol
US20090192164A1 (en) *	2006-06-28	2009-07-30	Aska Pharmaceutical Co., Ltd.	Treating agent of inflammatory bowel disease
JP4588791B2 (ja) *	2007-02-16	2010-12-01	あすか製薬株式会社	微粒子油性懸濁液を含む医薬組成物
BRPI0814718A2 (pt) *	2007-06-22	2015-02-24	Hoffmann La Roche	Derivados de isoxazol-imidazol
EP3659626A4 (de)	2017-07-26	2021-05-05	The Doshisha	Arzneimittel zur behandlung oder prävention von durch tgf-signale verursachten störungen und verwendung davon
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019071144A1 (en)	2017-10-05	2019-04-11	Fulcrum Therapeutics, Inc.	USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9300141A (es)	1992-01-13	1994-07-29	Smithkline Beecham Corp	Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
ATE223390T1 (de)	1995-02-13	2002-09-15	Searle & Co	Substituierte isoxazole zur behandlung von entzündung
JP2002508754A (ja)	1997-05-22	2002-03-19	ジーディサールアンドカンパニ	ｐ３８キナーゼ阻害剤としての置換基を有するピラゾール類
JP4191825B2 (ja) *	1998-09-10	2008-12-03	あすか製薬株式会社	５−アミノイソキサゾール誘導体
ES2244231T3 (es)	1998-12-25	2005-12-01	Teikoku Hormone Mfg. Co., Ltd.	Derivados de aminopirazol.
WO2002083668A1 (en)	2001-04-10	2002-10-24	Vertex Pharmaceuticals Incorporated	Isoxaxole derivatives as inhibitors of src and other protein kinases
US6689778B2 (en) *	2001-07-03	2004-02-10	Vertex Pharmaceuticals Incorporated	Inhibitors of Src and Lck protein kinases
US20030207873A1 (en) *	2002-04-10	2003-11-06	Edmund Harrington	Inhibitors of Src and other protein kinases
DE10237883A1 (de)	2002-08-19	2004-03-04	Merckle Gmbh Chem.-Pharm. Fabrik	Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie
US20040132755A1 (en)	2002-09-06	2004-07-08	Mark Ledeboer	Isoxazoles and uses thereof

2005
- 2005-12-27 AT AT05824638T patent/ATE538118T1/de active
- 2005-12-27 WO PCT/JP2005/024244 patent/WO2006070927A1/ja not_active Ceased
- 2005-12-27 EP EP05824638A patent/EP1832584B1/de not_active Expired - Lifetime
- 2005-12-27 KR KR1020077014699A patent/KR101181692B1/ko not_active Expired - Fee Related
- 2005-12-27 JP JP2006550874A patent/JP5100126B2/ja not_active Expired - Fee Related
- 2005-12-27 ES ES05824638T patent/ES2375633T3/es not_active Expired - Lifetime
- 2005-12-27 CN CN2005800435089A patent/CN101080404B/zh not_active Expired - Fee Related
- 2005-12-27 US US11/794,180 patent/US7939536B2/en active Active
- 2005-12-27 AU AU2005320544A patent/AU2005320544B2/en not_active Ceased
- 2005-12-27 CA CA2591912A patent/CA2591912C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1832584A1 (de)	2007-09-12
AU2005320544A1 (en)	2006-07-06
KR20070089829A (ko)	2007-09-03
EP1832584A4 (de)	2010-09-08
CA2591912C (en)	2013-06-25
CA2591912A1 (en)	2006-07-06
US20080114003A1 (en)	2008-05-15
US7939536B2 (en)	2011-05-10
WO2006070927A1 (ja)	2006-07-06
AU2005320544B2 (en)	2011-03-24
ES2375633T3 (es)	2012-03-02
JP5100126B2 (ja)	2012-12-19
EP1832584B1 (de)	2011-12-21
CN101080404A (zh)	2007-11-28
CN101080404B (zh)	2011-06-08
KR101181692B1 (ko)	2012-09-19
JPWO2006070927A1 (ja)	2008-06-12

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