ATE538125T1 - Neue 2-azaindol-derivate, deren herstellung und pharmazeutische verwendung als kinase-inhibitoren - Google Patents

Neue 2-azaindol-derivate, deren herstellung und pharmazeutische verwendung als kinase-inhibitoren

Info

Publication number: ATE538125T1
Authority: AT; Austria
Prior art keywords: preparation; new; kinase inhibitors; pharmaceutical use; azaindole derivatives
Prior art date: 2004-10-01

Application number

AT05807393T

Other languages

English (en)

Inventor

Conception Nemecek

William Metz

Sylvie Wentzler

Dominique Lesuisse

Youssef El-Ahmad

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-01

Filing date

2005-09-29

Publication date

2012-01-15

2005-09-29 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2012-01-15 Application granted granted Critical

2012-01-15 Publication of ATE538125T1 publication Critical patent/ATE538125T1/de

Links

BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT05807393T 2004-10-01 2005-09-29 Neue 2-azaindol-derivate, deren herstellung und pharmazeutische verwendung als kinase-inhibitoren ATE538125T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0410386A FR2876103B1 (fr)	2004-10-01	2004-10-01	Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
PCT/FR2005/002410 WO2006037875A1 (fr)	2004-10-01	2005-09-29	Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases

Publications (1)

Publication Number	Publication Date
ATE538125T1 true ATE538125T1 (de)	2012-01-15

Family

ID=34952807

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05807393T ATE538125T1 (de)	2004-10-01	2005-09-29	Neue 2-azaindol-derivate, deren herstellung und pharmazeutische verwendung als kinase-inhibitoren

Country Status (20)

Country	Link
US (2)	US7786114B2 (de)
EP (1)	EP1799691B1 (de)
JP (1)	JP2008514683A (de)
KR (1)	KR20070067116A (de)
CN (1)	CN101052642A (de)
AR (1)	AR050963A1 (de)
AT (1)	ATE538125T1 (de)
AU (1)	AU2005291137A1 (de)
BR (1)	BRPI0516841A (de)
CA (1)	CA2580831A1 (de)
EA (1)	EA200700758A1 (de)
FR (1)	FR2876103B1 (de)
IL (1)	IL182054A0 (de)
MA (1)	MA28941B1 (de)
MX (1)	MX2007003872A (de)
NO (1)	NO20072053L (de)
SG (1)	SG155946A1 (de)
TW (1)	TW200626605A (de)
WO (1)	WO2006037875A1 (de)
ZA (1)	ZA200702596B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102639700A (zh)	2009-09-30	2012-08-15	哈佛大学校长及研究员协会	通过调节自噬增强基因产物调节自噬的方法
CN103002922B (zh) *	2010-06-10	2015-11-25	Mida科技有限公司	携带肽的纳米颗粒
JP5760085B2 (ja)	2010-08-04	2015-08-05	武田薬品工業株式会社	縮合複素環化合物
ES2659763T3 (es)	2011-02-14	2018-03-19	The Regents Of The University Of Michigan	Composiciones y procedimientos para el tratamiento de obesidad y trastornos relacionados
MX344474B (es)	2011-03-31	2016-12-16	Carna Biosciences Inc	Nuevos derivados de furanona.
WO2014179734A1 (en)	2013-05-02	2014-11-06	The Regents Of The University Of Michigan	Deuterated amlexanox
HUE038820T2 (hu) *	2013-11-13	2018-11-28	Vertex Pharma	Eljárás influenzavírusok replikációjának inhibitorai elõállítására
US9974795B2 (en)	2014-01-31	2018-05-22	Carna Biosciences, Inc.	Anticancer agent composition
WO2015153959A2 (en) *	2014-04-04	2015-10-08	The Regents Of The University Of Michigan	Small molecule inhibitors of mcl-1 and uses thereof
SG11201702119PA (en)	2014-09-17	2017-04-27	Quanticel Pharmaceuticals Inc	Histone demethylase inhibitors
SG11201702147TA (en)	2014-09-17	2017-04-27	Celgene Quanticel Res Inc	Histone demethylase inhibitors
US10030017B2 (en)	2014-09-17	2018-07-24	Celgene Quanticel Research, Inc.	Histone demethylase inhibitors
WO2017132538A1 (en)	2016-01-29	2017-08-03	The Regents Of The University Of Michigan	Amlexanox analogs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0203895A3 (en)	1999-12-24	2004-09-28	Aventis Pharma Ltd West Mallin	Substituted azaindoles and pharmaceutical compositions containing them and their use
US6476034B2 (en) *	2000-02-22	2002-11-05	Bristol-Myers Squibb Company	Antiviral azaindole derivatives
GB0115109D0 (en) *	2001-06-21	2001-08-15	Aventis Pharma Ltd	Chemical compounds
GB0115393D0 (en) *	2001-06-23	2001-08-15	Aventis Pharma Ltd	Chemical compounds
WO2003024969A1 (en) *	2001-09-14	2003-03-27	Merck & Co., Inc.	Tyrosine kinase inhibitors
US7361671B2 (en) *	2001-11-15	2008-04-22	The Institute For Pharmaceutical Discovery, Inc.	Substituted heteroarylalkanoic acids

2004
- 2004-10-01 FR FR0410386A patent/FR2876103B1/fr not_active Expired - Fee Related
2005
- 2005-09-28 AR ARP050104094A patent/AR050963A1/es not_active Application Discontinuation
- 2005-09-29 MX MX2007003872A patent/MX2007003872A/es active IP Right Grant
- 2005-09-29 AU AU2005291137A patent/AU2005291137A1/en not_active Abandoned
- 2005-09-29 CA CA002580831A patent/CA2580831A1/fr not_active Abandoned
- 2005-09-29 EP EP05807393A patent/EP1799691B1/de not_active Expired - Lifetime
- 2005-09-29 SG SG200906276-1A patent/SG155946A1/en unknown
- 2005-09-29 KR KR1020077007423A patent/KR20070067116A/ko not_active Withdrawn
- 2005-09-29 BR BRPI0516841-4A patent/BRPI0516841A/pt not_active IP Right Cessation
- 2005-09-29 CN CNA2005800378315A patent/CN101052642A/zh active Pending
- 2005-09-29 EA EA200700758A patent/EA200700758A1/ru unknown
- 2005-09-29 AT AT05807393T patent/ATE538125T1/de active
- 2005-09-29 WO PCT/FR2005/002410 patent/WO2006037875A1/fr not_active Ceased
- 2005-09-29 JP JP2007534048A patent/JP2008514683A/ja active Pending
- 2005-09-29 ZA ZA200702596A patent/ZA200702596B/xx unknown
- 2005-09-30 TW TW094134114A patent/TW200626605A/zh unknown
2007
- 2007-03-20 IL IL182054A patent/IL182054A0/en unknown
- 2007-03-28 US US11/692,321 patent/US7786114B2/en not_active Expired - Fee Related
- 2007-04-20 MA MA29840A patent/MA28941B1/fr unknown
- 2007-04-20 NO NO20072053A patent/NO20072053L/no not_active Application Discontinuation
2010
- 2010-06-23 US US12/821,371 patent/US20100256141A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MX2007003872A (es)	2007-06-07
SG155946A1 (en)	2009-10-29
NO20072053L (no)	2007-04-20
TW200626605A (en)	2006-08-01
MA28941B1 (fr)	2007-10-01
JP2008514683A (ja)	2008-05-08
US7786114B2 (en)	2010-08-31
EP1799691B1 (de)	2011-12-21
US20080045561A1 (en)	2008-02-21
AR050963A1 (es)	2006-12-06
FR2876103A1 (fr)	2006-04-07
ZA200702596B (en)	2009-09-30
BRPI0516841A (pt)	2008-09-23
KR20070067116A (ko)	2007-06-27
CN101052642A (zh)	2007-10-10
AU2005291137A1 (en)	2006-04-13
WO2006037875A1 (fr)	2006-04-13
IL182054A0 (en)	2007-07-24
EA200700758A1 (ru)	2007-10-26
EP1799691A1 (de)	2007-06-27
FR2876103B1 (fr)	2008-02-22
CA2580831A1 (fr)	2006-04-13
US20100256141A1 (en)	2010-10-07

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