ATE538214T1 - Verfahren und vorrichtung zum nachweis molekularer wechselwirkungen - Google Patents
Verfahren und vorrichtung zum nachweis molekularer wechselwirkungenInfo
- Publication number
- ATE538214T1 ATE538214T1 AT06819282T AT06819282T ATE538214T1 AT E538214 T1 ATE538214 T1 AT E538214T1 AT 06819282 T AT06819282 T AT 06819282T AT 06819282 T AT06819282 T AT 06819282T AT E538214 T1 ATE538214 T1 AT E538214T1
- Authority
- AT
- Austria
- Prior art keywords
- microarray
- molecular interactions
- detecting molecular
- detection
- analytes
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/30—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
- B01F31/31—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Length Measuring Devices With Unspecified Measuring Means (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005052713A DE102005052713A1 (de) | 2005-11-04 | 2005-11-04 | Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen |
| PCT/EP2006/068155 WO2007051863A2 (en) | 2005-11-04 | 2006-11-06 | Method and device for the detection of molecular interactions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538214T1 true ATE538214T1 (de) | 2012-01-15 |
Family
ID=37888265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06819282T ATE538214T1 (de) | 2005-11-04 | 2006-11-06 | Verfahren und vorrichtung zum nachweis molekularer wechselwirkungen |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8828741B2 (de) |
| EP (2) | EP2330215B1 (de) |
| AT (1) | ATE538214T1 (de) |
| DE (1) | DE102005052713A1 (de) |
| WO (1) | WO2007051863A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8916348B2 (en) * | 2004-05-06 | 2014-12-23 | Clondiag Gmbh | Method and device for the detection of molecular interactions |
| DE102005052713A1 (de) | 2005-11-04 | 2007-05-16 | Clondiag Chip Tech Gmbh | Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen |
| DE102006056540A1 (de) * | 2006-11-28 | 2008-05-29 | Zenteris Gmbh | Vorrichtung und Verfahren zur Untersuchung von biologischen und medizinischen Proben |
| KR100907253B1 (ko) * | 2007-10-17 | 2009-07-10 | 한국전자통신연구원 | 랩온어칩 및 그 구동 방법 |
| US8623789B2 (en) * | 2009-09-21 | 2014-01-07 | Akonni Biosystems, Inc. | Integrated cartridge |
| DE102007052281A1 (de) | 2007-11-02 | 2009-05-07 | Zenteris Gmbh | Einschritt-Multiplex-Immuntest |
| DE102008054313B4 (de) | 2008-11-03 | 2012-12-13 | Zenteris Gmbh | Kartusche und Vorrichtung zur Untersuchung biologischer Proben mit temperaturgesteuerten biologischen Reaktionen |
| US8990059B2 (en) * | 2009-10-21 | 2015-03-24 | Koninklijke Philips N.V. | Analyzing tool for amplification reactions |
| CN105974571B (zh) | 2009-10-28 | 2019-05-28 | 阿兰蒂克微科学股份有限公司 | 显微成像 |
| US9075225B2 (en) | 2009-10-28 | 2015-07-07 | Alentic Microscience Inc. | Microscopy imaging |
| US20140152801A1 (en) | 2009-10-28 | 2014-06-05 | Alentic Microscience Inc. | Detecting and Using Light Representative of a Sample |
| CN102762289B (zh) | 2009-12-18 | 2016-08-03 | 艾博特健康公司 | 生物流体分析卡盒 |
| EP2646155A2 (de) | 2010-12-03 | 2013-10-09 | Alere Technologies GmbH | Transformation von materials in einen optisch modulierenden zustand über laserstrahlung |
| JP2013137267A (ja) * | 2011-12-28 | 2013-07-11 | Sony Corp | マイクロチップ及びマイクロチップ型微小粒子測定装置 |
| US10502666B2 (en) | 2013-02-06 | 2019-12-10 | Alentic Microscience Inc. | Sample processing improvements for quantitative microscopy |
| CA2953620C (en) | 2013-06-26 | 2020-08-25 | Alentic Microscience Inc. | Sample processing improvements for microscopy |
| MX371445B (es) * | 2013-10-15 | 2020-01-30 | Bio Molecular Systems Pty Ltd | Reciclador térmico perfeccionado. |
| US9431315B2 (en) | 2013-12-26 | 2016-08-30 | Agency For Science, Technology And Research | Chemical sensor package for highly pressured environment |
| JP6546691B2 (ja) * | 2015-04-07 | 2019-07-17 | セル アイディー ピーティーイー リミテッドCell Id Pte Ltd | Dcヒータ |
| JP2018102228A (ja) * | 2016-12-27 | 2018-07-05 | オリンパス株式会社 | 観察装置 |
| TW202028742A (zh) * | 2018-10-05 | 2020-08-01 | 美商Dots科技公司 | 用於過敏原偵測的系統及方法 |
| US11730193B2 (en) | 2019-12-15 | 2023-08-22 | Shaheen Innovations Holding Limited | Hookah device |
| US11254979B2 (en) * | 2020-06-01 | 2022-02-22 | Shaheen Innovations Holding Limited | Systems and devices for infectious disease screening |
| CN111100782A (zh) * | 2019-12-31 | 2020-05-05 | 广州源起健康科技有限公司 | 一种实时定量基因扩增荧光检测的加热装置及其加热方法 |
| EP4152967A1 (de) | 2020-06-01 | 2023-03-29 | Shaheen Innovations Holding Limited | System zum screening von infektionskrankheiten |
| EP4153354A1 (de) | 2020-06-01 | 2023-03-29 | Shaheen Innovations Holding Limited | Vorrichtung zum screening von infektionskrankheiten |
| AU2021321393B2 (en) * | 2020-08-05 | 2024-05-16 | AusMed Global Limited | Testing device with built-in liquid storage |
| CN113759106B (zh) * | 2021-11-09 | 2022-02-11 | 山东康华生物医疗科技股份有限公司 | 一种独立自动加液检测装置 |
| DE102023212255A1 (de) * | 2023-12-06 | 2025-06-12 | Robert Bosch Gesellschaft mit beschränkter Haftung | Mikrofluidische Vorrichtung, insbesondere Kartusche, mit einem Pad zur Wärmeübertragung auf ein Analysesubstrat |
| DE102022213411A1 (de) * | 2022-12-12 | 2024-06-13 | Robert Bosch Gesellschaft mit beschränkter Haftung | Fluidikplatte für eine mikrofluidische Kartusche und Verfahren zu ihrer Herstellung |
| WO2025077984A1 (en) * | 2023-10-13 | 2025-04-17 | Fida Biosystems Aps | A method of determining a binding parameter between a first particle and a second particle |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5013646A (en) | 1989-11-03 | 1991-05-07 | Transgenic Sciences, Inc. | TMB Formulation for soluble and precipitable HRP-ELISA |
| GB9015793D0 (en) | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
| US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| US6027880A (en) | 1995-08-02 | 2000-02-22 | Affymetrix, Inc. | Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis |
| AU5171696A (en) | 1995-02-27 | 1996-09-18 | Ely Michael Rabani | Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism |
| US5585639A (en) | 1995-07-27 | 1996-12-17 | Hewlett-Packard Company | Optical scanning apparatus |
| JP4468488B2 (ja) | 1996-05-29 | 2010-05-26 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 組み合せたリガーゼ検出およびポリメラーゼ連鎖反応を用いる核酸配列相違の検出 |
| US5760950A (en) | 1996-07-25 | 1998-06-02 | Advanced Scanning, Ltd. | Scanning confocal microscope |
| US5795748A (en) * | 1996-09-26 | 1998-08-18 | Becton Dickinson And Company | DNA microwell device and method |
| DE19706570C1 (de) | 1997-02-19 | 1998-02-26 | Inst Physikalische Hochtech Ev | Verfahren zur Herstellung von strukturierten, selbstorganisierten molekularen Monolagen einzelner molekularer Spezies, insbesondere von Substanzbibliotheken |
| DE19725050C2 (de) | 1997-06-13 | 1999-06-24 | Fraunhofer Ges Forschung | Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu deren Herstellung |
| US5910288A (en) * | 1997-07-10 | 1999-06-08 | Hewlett-Packard Company | Method and apparatus for mixing a thin film of fluid |
| US7070921B2 (en) * | 2000-04-28 | 2006-07-04 | Molecular Devices Corporation | Molecular modification assays |
| WO2000005336A2 (en) | 1998-07-22 | 2000-02-03 | Ljl Biosystems, Inc. | Devices and methods for sample analysis |
| US6197503B1 (en) | 1997-11-26 | 2001-03-06 | Ut-Battelle, Llc | Integrated circuit biochip microsystem containing lens |
| US6271042B1 (en) | 1998-08-26 | 2001-08-07 | Alpha Innotech Corporation | Biochip detection system |
| EP1027379B1 (de) | 1998-08-28 | 2007-02-28 | Poly-An Gesellschaft zur Herstellung von Polymeren für Spezielle Anwendungen und Analytik mbH | Verfahren zur herstellung polymerer festphasenträger |
| AT410718B (de) | 1998-10-28 | 2003-07-25 | Schindler Hansgeorg Dr | Vorrichtung zur visualisierung von molekülen |
| AU2483700A (en) * | 1998-12-23 | 2000-07-31 | American Registry Of Pathology | Apparatus and methods for efficient processing of biological samples on slides |
| MXPA01011915A (es) | 1999-05-19 | 2003-09-04 | Advanced Array Technologies S | Metodo para la identificacion y/o la cuantificacion de un compuesto diana. |
| JP4022069B2 (ja) * | 1999-05-28 | 2007-12-12 | シーフィード | 細胞破壊装置および方法 |
| ES2219374T3 (es) | 1999-07-02 | 2004-12-01 | Clondiag Chip Technologies Gmbh | Dispositivo de matriz de microchip para la multiplicacion y la caracterizacion de acidos nucleicos. |
| EP1235932A2 (de) * | 1999-10-08 | 2002-09-04 | Protogene Laboratories, Inc. | Verfahren und vorrichtung zur durchführung von hohen zahlen von reaktionen unter benutzung von arrays |
| US6589778B1 (en) * | 1999-12-15 | 2003-07-08 | Amersham Biosciences Ab | Method and apparatus for performing biological reactions on a substrate surface |
| US6569674B1 (en) * | 1999-12-15 | 2003-05-27 | Amersham Biosciences Ab | Method and apparatus for performing biological reactions on a substrate surface |
| CN1416365A (zh) * | 2000-02-22 | 2003-05-07 | 基因谱公司 | 微阵列制造技术及设备 |
| AU7637601A (en) | 2000-07-01 | 2002-01-14 | Clondiag Chip Tech Gmbh | Method for qualitative and/or quantitative detecting of molecular interactions on probe arrays |
| US7223363B2 (en) * | 2001-03-09 | 2007-05-29 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
| AU2002339853A1 (en) * | 2001-05-24 | 2002-12-03 | Genospectra, Inc. | Pairs of nucleic acid probes with interactive signaling moieties and nucleic acid probes with enhanced hybridization efficiency and specificity |
| DE10132785A1 (de) | 2001-07-06 | 2003-01-16 | Clondiag Chip Tech Gmbh | Verfahren zum Nachweis von in einer Polymerase-Kettenreaktion amplifizierten Nukleinsäuremolekülen |
| DE10142643A1 (de) | 2001-08-31 | 2003-04-24 | Clondiag Chip Tech Gmbh | Detektion von Wechselwirkungen auf Sonden-Arrays |
| WO2003022421A2 (en) * | 2001-09-07 | 2003-03-20 | Corning Incorporated | Microcolumn-platform based array for high-throughput analysis |
| US6939032B2 (en) * | 2001-10-25 | 2005-09-06 | Erie Scientific Company | Cover slip mixing apparatus |
| EP1576184B1 (de) * | 2001-12-24 | 2007-05-23 | Arrowhead Research Corporation | Verfahren zur in-vitro selektion von bindern |
| DE10253966B4 (de) | 2002-11-19 | 2005-03-24 | Clondiag Chip Technologies Gmbh | Microarray-basiertes Verfahren zur Amplifikation und Detektion von Nukleinsäuren in einem kontinuierlichen Prozess |
| US20060094108A1 (en) * | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays |
| US20040137607A1 (en) * | 2003-01-09 | 2004-07-15 | Yokogawa Electric Corporation | Biochip cartridge |
| DE10315074A1 (de) | 2003-04-02 | 2004-10-14 | Clondiag Chip Technologies Gmbh | Vorrichtung zur Vervielfältigung und zum Nachweis von Nukleinsäuren |
| US8916348B2 (en) * | 2004-05-06 | 2014-12-23 | Clondiag Gmbh | Method and device for the detection of molecular interactions |
| DE102005052752A1 (de) | 2005-11-04 | 2007-05-10 | Clondiag Chip Technologies Gmbh | Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen |
| DE102004022263A1 (de) * | 2004-05-06 | 2005-12-15 | Clondiag Chip Technologies Gmbh | Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen |
| DE102005052713A1 (de) | 2005-11-04 | 2007-05-16 | Clondiag Chip Tech Gmbh | Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen |
-
2005
- 2005-11-04 DE DE102005052713A patent/DE102005052713A1/de not_active Ceased
-
2006
- 2006-11-06 EP EP10176034.6A patent/EP2330215B1/de not_active Not-in-force
- 2006-11-06 AT AT06819282T patent/ATE538214T1/de active
- 2006-11-06 EP EP06819282A patent/EP1943360B1/de not_active Not-in-force
- 2006-11-06 WO PCT/EP2006/068155 patent/WO2007051863A2/en not_active Ceased
- 2006-11-06 US US12/092,643 patent/US8828741B2/en not_active Expired - Fee Related
-
2014
- 2014-09-01 US US14/474,274 patent/US9580745B2/en not_active Expired - Fee Related
-
2017
- 2017-02-27 US US15/443,759 patent/US20180135116A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090082219A1 (en) | 2009-03-26 |
| WO2007051863A3 (en) | 2007-06-28 |
| WO2007051863A2 (en) | 2007-05-10 |
| EP2330215B1 (de) | 2014-04-30 |
| US20180135116A1 (en) | 2018-05-17 |
| EP1943360B1 (de) | 2011-12-21 |
| US9580745B2 (en) | 2017-02-28 |
| US8828741B2 (en) | 2014-09-09 |
| EP1943360A2 (de) | 2008-07-16 |
| DE102005052713A1 (de) | 2007-05-16 |
| EP2330215A1 (de) | 2011-06-08 |
| US20150284785A1 (en) | 2015-10-08 |
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