ATE538651T1 - Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit - Google Patents
Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheitInfo
- Publication number
- ATE538651T1 ATE538651T1 AT07853004T AT07853004T ATE538651T1 AT E538651 T1 ATE538651 T1 AT E538651T1 AT 07853004 T AT07853004 T AT 07853004T AT 07853004 T AT07853004 T AT 07853004T AT E538651 T1 ATE538651 T1 AT E538651T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- treatment
- alzheimer
- inhibitors
- disease
- Prior art date
Links
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title abstract 4
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title abstract 4
- JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical compound C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 title abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85518006P | 2006-10-30 | 2006-10-30 | |
| PCT/US2007/022819 WO2008054698A2 (en) | 2006-10-30 | 2007-10-29 | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538651T1 true ATE538651T1 (de) | 2012-01-15 |
Family
ID=39344862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07853004T ATE538651T1 (de) | 2006-10-30 | 2007-10-29 | Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8293759B2 (de) |
| EP (1) | EP2091328B1 (de) |
| JP (1) | JP2010508272A (de) |
| AT (1) | ATE538651T1 (de) |
| AU (1) | AU2007314338A1 (de) |
| CA (1) | CA2668065A1 (de) |
| WO (1) | WO2008054698A2 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE538651T1 (de) | 2006-10-30 | 2012-01-15 | Merck Sharp & Dohme | Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit |
| AU2007342368A1 (en) | 2007-01-04 | 2008-07-17 | Merck & Co., Inc. | Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
| CA2736130C (en) | 2008-09-11 | 2014-01-14 | Amgen Inc. | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use |
| CA2743584A1 (en) * | 2008-11-23 | 2010-05-27 | Pfizer Inc. | Lactams as beta secretase inhibitors |
| MX2012002993A (es) | 2009-09-11 | 2012-04-19 | Probiodrug Ag | Derivados heterociclicos como inhibidores de ciclasa glutaminilo. |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| WO2011115938A1 (en) | 2010-03-15 | 2011-09-22 | Amgen Inc. | Spiro-tetracyclic ring compounds as beta - secretase modulators |
| AU2011227501B9 (en) | 2010-03-15 | 2013-08-22 | Amgen Inc. | Amino -dihydrooxazine and amino - dihydrothiazine spiro compounds as Beta - secretase modulators and their medical use |
| WO2012019056A1 (en) | 2010-08-05 | 2012-02-09 | Amgen Inc. | Amino-iso-indole, amino-aza-iso-indole, amino-dihydroisoquinoline and amino-benzoxazine compounds as beta-secretase modulators and methods of use |
| WO2012071279A1 (en) | 2010-11-23 | 2012-05-31 | Amgen Inc. | Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use |
| US9346827B2 (en) | 2011-02-07 | 2016-05-24 | Amgen Inc. | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use |
| EP2675810A1 (de) | 2011-02-15 | 2013-12-25 | Amgen Inc. | Spiro-amino-imidazo-kondensierte heterocyclische verbindungen als beta-sekretase-modulatoren und verwendungsverfahren dafür |
| US9296759B2 (en) | 2011-09-21 | 2016-03-29 | Amgen Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| WO2014078314A1 (en) | 2012-11-15 | 2014-05-22 | Amgen Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| CN112979537B (zh) * | 2021-02-23 | 2022-04-29 | 浙江工业大学 | 一种卡因类药物中间体(s)-2-哌啶甲酸的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| AU4562799A (en) | 1998-06-15 | 2000-01-05 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| KR100974901B1 (ko) | 2001-12-28 | 2010-08-10 | 아카디아 파마슈티칼스 인코포레이티드 | 모노아민 수용체 조정자로서의 스피로아자사이클릭 화합물 |
| US7439251B2 (en) * | 2002-05-03 | 2008-10-21 | Israel Institute For Biological Research | Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor |
| EP1554260A1 (de) | 2002-10-22 | 2005-07-20 | Glaxo Group Limited | Aryloxyalkylamine derivate als h3 rezeptor liganden |
| CA2508581A1 (en) | 2002-12-04 | 2004-06-17 | Merck & Co., Inc. | Spirocyclic ureas, compositions containing such compounds and methods of use |
| CA2583342A1 (en) | 2004-10-13 | 2006-04-27 | Merck And Co., Inc. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer's disease |
| US8211904B2 (en) | 2005-07-18 | 2012-07-03 | Merck, Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| KR20080081359A (ko) | 2006-01-30 | 2008-09-09 | 아이알엠 엘엘씨 | Ｐｐａｒ 조절제로서의 스피로 이미다졸 유도체 |
| AU2007293416A1 (en) * | 2006-09-07 | 2008-03-13 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
| EP2073635B1 (de) | 2006-10-06 | 2012-03-21 | Merck Sharp & Dohme Corp. | Makrozyklische spiropiperidin-beta-sekretase-hemmer zur behandlung von morbus alzheimer |
| ATE538651T1 (de) | 2006-10-30 | 2012-01-15 | Merck Sharp & Dohme | Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit |
-
2007
- 2007-10-29 AT AT07853004T patent/ATE538651T1/de active
- 2007-10-29 EP EP07853004A patent/EP2091328B1/de not_active Not-in-force
- 2007-10-29 US US12/447,802 patent/US8293759B2/en active Active
- 2007-10-29 JP JP2009534689A patent/JP2010508272A/ja not_active Withdrawn
- 2007-10-29 WO PCT/US2007/022819 patent/WO2008054698A2/en not_active Ceased
- 2007-10-29 CA CA002668065A patent/CA2668065A1/en not_active Abandoned
- 2007-10-29 AU AU2007314338A patent/AU2007314338A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010508272A (ja) | 2010-03-18 |
| EP2091328A2 (de) | 2009-08-26 |
| EP2091328B1 (de) | 2011-12-28 |
| AU2007314338A1 (en) | 2008-05-08 |
| US8293759B2 (en) | 2012-10-23 |
| WO2008054698A2 (en) | 2008-05-08 |
| CA2668065A1 (en) | 2008-05-08 |
| EP2091328A4 (de) | 2010-11-03 |
| US20100069419A1 (en) | 2010-03-18 |
| WO2008054698A3 (en) | 2008-06-19 |
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