ATE539071T1 - Verfahren zur herstellung von s-(-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-ca bonsäure - Google Patents
Verfahren zur herstellung von s-(-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-ca bonsäureInfo
- Publication number
- ATE539071T1 ATE539071T1 AT07830535T AT07830535T ATE539071T1 AT E539071 T1 ATE539071 T1 AT E539071T1 AT 07830535 T AT07830535 T AT 07830535T AT 07830535 T AT07830535 T AT 07830535T AT E539071 T1 ATE539071 T1 AT E539071T1
- Authority
- AT
- Austria
- Prior art keywords
- tetramethylchromane
- hydroxy
- carboxylic acid
- general formula
- producing
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006291628 | 2006-10-26 | ||
| PCT/JP2007/070801 WO2008050829A1 (en) | 2006-10-26 | 2007-10-25 | Method of producing s-(-)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid and product obtained by the method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE539071T1 true ATE539071T1 (de) | 2012-01-15 |
Family
ID=39324614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07830535T ATE539071T1 (de) | 2006-10-26 | 2007-10-25 | Verfahren zur herstellung von s-(-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-ca bonsäure |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8080676B2 (de) |
| EP (1) | EP2088144B1 (de) |
| JP (1) | JPWO2008050829A1 (de) |
| AT (1) | ATE539071T1 (de) |
| WO (1) | WO2008050829A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA038941B1 (ru) | 2007-11-06 | 2021-11-12 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ |
| JP5598330B2 (ja) * | 2008-10-29 | 2014-10-01 | 三菱瓦斯化学株式会社 | 光学活性有機カルボン酸の製造方法 |
| DK3233786T3 (da) | 2014-12-16 | 2022-05-09 | Ptc Therapeutics Inc | Polymorfe og amorfe former af (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6- dioxocyclohexa-1,4-dienyl)butanamid |
| EP3233819A1 (de) * | 2014-12-16 | 2017-10-25 | Bioelectron Technology Corporation | Verfahren für chirale auflösung von trolox |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4026907A (en) | 1973-11-19 | 1977-05-31 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
| JPS6092283A (ja) | 1983-10-27 | 1985-05-23 | Nippon Oil Co Ltd | クロマン化合物の選択的合成法 |
| US5348973A (en) | 1990-10-09 | 1994-09-20 | Rhone-Poulenc Chimie | Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis |
| JP3400039B2 (ja) | 1993-09-28 | 2003-04-28 | 株式会社クラレ | クロマン化合物の製造方法 |
| JP3913329B2 (ja) | 1997-09-11 | 2007-05-09 | 株式会社クラレ | （±）−クロマンカルボン酸の光学分割法 |
| WO2002012221A1 (en) | 2000-08-03 | 2002-02-14 | Kuraray Co., Ltd. | Method for optical resolution of (±)-6-hydroxy-2,5,7,8-tetramethylcoumarone-2-carboxylic acid |
| JP2003146981A (ja) | 2001-11-14 | 2003-05-21 | Mitsubishi Gas Chem Co Inc | ６−ヒドロキシ−２，５，７，８−テトラメチルクロマン−２−カルボン酸エステルの製造方法 |
| EP1634958B1 (de) | 2003-06-04 | 2009-02-18 | Mitsubishi Gas Chemical Company, Inc. | Verfahren zur herstellung von optisch aktivem chroman-carbonsäureester |
| JP4904816B2 (ja) | 2004-01-30 | 2012-03-28 | 三菱瓦斯化学株式会社 | クロマン化合物の製造方法 |
| JP4826133B2 (ja) | 2005-04-28 | 2011-11-30 | 三菱瓦斯化学株式会社 | Ｓ−（−）−６−ヒドロキシ−２，５，７，８−テトラメチルクロマン−２−カルボン酸及びその製造方法 |
| JP4826132B2 (ja) | 2005-04-28 | 2011-11-30 | 三菱瓦斯化学株式会社 | ６−ヒドロキシ−２，５，７，８−テトラメチルクロマン−２−カルボン酸及びその製造方法 |
-
2007
- 2007-10-25 US US12/312,125 patent/US8080676B2/en not_active Expired - Fee Related
- 2007-10-25 EP EP07830535A patent/EP2088144B1/de not_active Not-in-force
- 2007-10-25 AT AT07830535T patent/ATE539071T1/de active
- 2007-10-25 WO PCT/JP2007/070801 patent/WO2008050829A1/ja not_active Ceased
- 2007-10-25 JP JP2008541018A patent/JPWO2008050829A1/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2088144A1 (de) | 2009-08-12 |
| US8080676B2 (en) | 2011-12-20 |
| EP2088144A4 (de) | 2010-01-27 |
| JPWO2008050829A1 (ja) | 2010-02-25 |
| EP2088144B1 (de) | 2011-12-28 |
| WO2008050829A1 (en) | 2008-05-02 |
| US20100063305A1 (en) | 2010-03-11 |
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