ATE540019T1 - Extraktion von pravastatin - Google Patents

Extraktion von pravastatin

Info

Publication number: ATE540019T1
Authority: AT; Austria
Prior art keywords: pravastatin; extraction; water; purification; extracting
Prior art date: 2008-04-02

Application number

AT09728835T

Other languages

English (en)

Inventor

Aad Johannes Bouman

De Pater

Piotr Wnukowski

Original Assignee

Dsm Ip Assets Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-02

Filing date

2009-03-31

Publication date

2012-01-15

2009-03-31 Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv

2012-01-15 Application granted granted Critical

2012-01-15 Publication of ATE540019T1 publication Critical patent/ATE540019T1/de

Links

TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title abstract 3
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title abstract 3
229960002965 pravastatin Drugs 0.000 title abstract 3
238000000605 extraction Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/58—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Fats And Perfumes (AREA)
Compounds Of Unknown Constitution (AREA)

AT09728835T 2008-04-02 2009-03-31 Extraktion von pravastatin ATE540019T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08103319		2008-04-02
PCT/EP2009/053791 WO2009121870A1 (en)	2008-04-02	2009-03-31	Pravastatin extraction

Publications (1)

Publication Number	Publication Date
ATE540019T1 true ATE540019T1 (de)	2012-01-15

Family

ID=39766906

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT09728835T ATE540019T1 (de)	2008-04-02	2009-03-31	Extraktion von pravastatin

Country Status (9)

Country	Link
US (1)	US20110130450A1 (de)
EP (1)	EP2274267B1 (de)
CN (1)	CN102046582B (de)
AT (1)	ATE540019T1 (de)
DK (1)	DK2274267T3 (de)
ES (1)	ES2378614T3 (de)
HR (1)	HRP20120184T1 (de)
SI (1)	SI2274267T1 (de)
WO (1)	WO2009121870A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102827123B (zh) *	2012-08-02	2015-04-22	丽珠集团新北江制药股份有限公司	美伐他汀的分离提取工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0877089A1 (de) *	1997-05-07	1998-11-11	Gist-Brocades B.V.	Verfahren zur Herstellung eines Inhibitors der Hmg-Coa Reduktase
US7141602B2 (en) *	1998-09-18	2006-11-28	Lek Pharmaceuticals D.D.	Process for obtaining HMG-CoA reductase inhibitors of high purity
DE60019898T2 (de) *	1999-02-03	2006-08-10	Institute For Drug Research Ltd.	Mikrobielles verfahren zur herstellung von pravastatin
US6444452B1 (en) *	1999-11-30	2002-09-03	Biogal Gyogyszergyar Rt.	Process for recovering statin compounds from a fermentation broth
US6716615B2 (en) *	2002-02-27	2004-04-06	Yung Shin Pharmaceutical Ind. Co., Ltd.	Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
WO2007147827A2 (en) *	2006-06-22	2007-12-27	Dsm Ip Assets B.V.	Production of pravastatin

2009
- 2009-03-31 AT AT09728835T patent/ATE540019T1/de active
- 2009-03-31 WO PCT/EP2009/053791 patent/WO2009121870A1/en not_active Ceased
- 2009-03-31 EP EP09728835A patent/EP2274267B1/de not_active Not-in-force
- 2009-03-31 SI SI200930181T patent/SI2274267T1/sl unknown
- 2009-03-31 ES ES09728835T patent/ES2378614T3/es active Active
- 2009-03-31 HR HR20120184T patent/HRP20120184T1/hr unknown
- 2009-03-31 CN CN2009801204662A patent/CN102046582B/zh not_active Expired - Fee Related
- 2009-03-31 DK DK09728835.1T patent/DK2274267T3/da active
- 2009-03-31 US US12/936,351 patent/US20110130450A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DK2274267T3 (da)	2012-03-19
EP2274267A1 (de)	2011-01-19
ES2378614T3 (es)	2012-04-16
US20110130450A1 (en)	2011-06-02
CN102046582A (zh)	2011-05-04
CN102046582B (zh)	2013-09-18
EP2274267B1 (de)	2012-01-04
SI2274267T1 (sl)	2012-04-30
HK1152931A1 (en)	2012-03-16
HRP20120184T1 (hr)	2012-03-31
WO2009121870A1 (en)	2009-10-08

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