ATE540115T1 - Nukleinsäurekonstruktsysteme mit fähigkeit zur diagnose oder behandlung eines zellzustands - Google Patents
Nukleinsäurekonstruktsysteme mit fähigkeit zur diagnose oder behandlung eines zellzustandsInfo
- Publication number
- ATE540115T1 ATE540115T1 AT08776602T AT08776602T ATE540115T1 AT E540115 T1 ATE540115 T1 AT E540115T1 AT 08776602 T AT08776602 T AT 08776602T AT 08776602 T AT08776602 T AT 08776602T AT E540115 T1 ATE540115 T1 AT E540115T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- transcriptional regulatory
- acid construct
- mammalian transcriptional
- diagnose
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 8
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 230000001105 regulatory effect Effects 0.000 abstract 8
- 230000002103 transcriptional effect Effects 0.000 abstract 8
- 230000001939 inductive effect Effects 0.000 abstract 6
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 abstract 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/007—Vector systems having a special element relevant for transcription cell cycle specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physiology (AREA)
- Toxicology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92973607P | 2007-07-11 | 2007-07-11 | |
| US61930707P | 2007-12-28 | 2007-12-28 | |
| PCT/IL2008/000963 WO2009007980A1 (en) | 2007-07-11 | 2008-07-10 | Nucleic acid construct systems capable of diagnosing or treating a cell state |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE540115T1 true ATE540115T1 (de) | 2012-01-15 |
Family
ID=46705097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08776602T ATE540115T1 (de) | 2007-07-11 | 2008-07-10 | Nukleinsäurekonstruktsysteme mit fähigkeit zur diagnose oder behandlung eines zellzustands |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20100197767A1 (de) |
| EP (2) | EP2176409B1 (de) |
| AT (1) | ATE540115T1 (de) |
| IL (1) | IL203195A0 (de) |
| WO (1) | WO2009007980A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014027351A1 (en) * | 2012-08-16 | 2014-02-20 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | A programmable nor-based device for transcription profile analyses |
| WO2018169901A1 (en) * | 2017-03-13 | 2018-09-20 | Massachusetts Institute Of Technology | Synthetic promoters |
| CN111902539B (zh) * | 2018-02-07 | 2025-05-16 | 吉尼松公司 | 杂合调控元件 |
| JP2022512622A (ja) * | 2018-10-05 | 2022-02-07 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | 改変受容体を含む血小板の作製方法及びその使用法 |
| JP2022538598A (ja) | 2019-06-25 | 2022-09-05 | ミガル ガリラヤ リサーチ インスティテュート リミテッド | プレｍＲＮＡのトランススプライシングに基づく合成転写用論理「ＡＮＤ」ゲートを作製するためのシステムおよびその使用 |
| CN116059405A (zh) * | 2022-09-26 | 2023-05-05 | 华中科技大学同济医学院附属协和医院 | 一种治疗恶性肿瘤且具备特异性与灵敏度的合成基因网络系统 |
| WO2024189614A1 (en) * | 2023-03-12 | 2024-09-19 | Circuit Bio Ltd. | Tissue specific synthetic promoters and circuits and use thereof |
| CN121221507B (zh) * | 2025-12-04 | 2026-02-06 | 康柏利科技（苏州）有限公司 | 一种抗炎舒缓的化妆品组合物 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| WO1995013375A1 (en) * | 1993-11-10 | 1995-05-18 | The Johns Hopkins University | Tumor suppressor waf1 |
| DE19502584C2 (de) * | 1994-01-28 | 1999-08-12 | Medigene Ag Ges Fuer Molekular | Verfahren zur Bestimmung der Aktivität eines regulatorischen Faktors sowie Verwendung dieses Verfahrens |
| US6458559B1 (en) * | 1998-04-22 | 2002-10-01 | Cornell Research Foundation, Inc. | Multivalent RNA aptamers and their expression in multicellular organisms |
| US6706491B1 (en) * | 1999-04-09 | 2004-03-16 | The Board Of Trustees Of The University Of Illinois | Reagents and methods for identifying and modulating expression of genes regulated by p21 |
| AU4141500A (en) * | 1999-05-03 | 2000-11-17 | Technion Research & Development Foundation Ltd. | Novel thiamine transporter, a polynucleotide encoding same and their uses |
| AU1074401A (en) * | 1999-10-07 | 2001-05-10 | Genetic Technologies, L.P. | Adjustable sensitivity, genetic molecular interaction systems, including protein-protein interaction systems for detection and analysis |
| US6251676B1 (en) * | 2000-03-24 | 2001-06-26 | The General Hospital Corporation | Mammalian cell two-hybrid system |
| EP1278762A4 (de) * | 2000-05-01 | 2003-06-18 | Rappaport Family Inst For Res | System zum herstellen von nukleinsäuren und verfahren zur anwendung, um protein-protein-interaktionen zu identifizieren |
| WO2001096373A2 (en) * | 2000-06-14 | 2001-12-20 | Clontech Laboratories, Inc. | Fluorescent timer proteins and methods for their use |
| US6787321B1 (en) * | 2000-10-13 | 2004-09-07 | The Regents Of The University Of California | Mammalian two-hybrid system for screening for modulators of the accumulation of metabolic products |
| US7060459B2 (en) * | 2000-12-08 | 2006-06-13 | Juan Saus | TNF-inducible promoters and methods for using |
| US7109029B2 (en) * | 2001-02-23 | 2006-09-19 | Cell Genesys, Inc. | Vector constructs |
| AU2002303282A1 (en) * | 2001-04-06 | 2002-10-21 | University Of Rochester | Suppression of androgen receptor transactivation through new pathways to AR and AR coactivators and repressors |
| JP4528623B2 (ja) * | 2002-09-16 | 2010-08-18 | プロメガ コーポレイション | 迅速分解性レポーター融合タンパク質 |
| WO2004078984A1 (en) * | 2003-03-05 | 2004-09-16 | Janssen Pharmaceutica N.V. | Animal model for the fast identification of pharmaceutical active compounds in vivo |
| PE20061416A1 (es) * | 2005-05-19 | 2007-01-26 | Schering Ag | Sistema de expresion genetica que comprende un interferon-beta |
| BRPI0612287A8 (pt) * | 2005-06-27 | 2019-01-22 | Exelixis Inc | composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear |
| US20100203024A1 (en) * | 2006-05-30 | 2010-08-12 | Terman David S | Sickled Erythrocytes, Nucleated Precursors & Erythroleukemia Cells for Targeted Delivery of Oncolytic Viruses, Anti-tumor Proteins, Plasmids, Toxins, Hemolysins & Chemotherapy |
-
2008
- 2008-07-10 EP EP08776602A patent/EP2176409B1/de not_active Not-in-force
- 2008-07-10 EP EP20110196209 patent/EP2500428A3/de not_active Withdrawn
- 2008-07-10 US US12/452,573 patent/US20100197767A1/en not_active Abandoned
- 2008-07-10 WO PCT/IL2008/000963 patent/WO2009007980A1/en not_active Ceased
- 2008-07-10 AT AT08776602T patent/ATE540115T1/de active
-
2010
- 2010-01-07 IL IL203195A patent/IL203195A0/en unknown
-
2013
- 2013-06-11 US US13/914,686 patent/US20130260386A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2500428A2 (de) | 2012-09-19 |
| IL203195A0 (en) | 2011-08-01 |
| US20100197767A1 (en) | 2010-08-05 |
| EP2500428A3 (de) | 2012-12-26 |
| US20130260386A1 (en) | 2013-10-03 |
| EP2176409B1 (de) | 2012-01-04 |
| EP2176409A1 (de) | 2010-04-21 |
| WO2009007980A1 (en) | 2009-01-15 |
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