ATE540675T1 - Verbindungen zur behandlung von stoffwechselstörungen - Google Patents
Verbindungen zur behandlung von stoffwechselstörungenInfo
- Publication number
- ATE540675T1 ATE540675T1 AT06784338T AT06784338T ATE540675T1 AT E540675 T1 ATE540675 T1 AT E540675T1 AT 06784338 T AT06784338 T AT 06784338T AT 06784338 T AT06784338 T AT 06784338T AT E540675 T1 ATE540675 T1 AT E540675T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- ring
- alkyl
- hydrogen
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 208000030159 metabolic disease Diseases 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010006895 Cachexia Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000010706 fatty liver disease Diseases 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- -1 perfluoromethoxy Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66745705P | 2005-04-01 | 2005-04-01 | |
| PCT/US2006/012050 WO2006127133A2 (en) | 2005-04-01 | 2006-03-31 | Compounds for the treatment of metabolic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE540675T1 true ATE540675T1 (de) | 2012-01-15 |
Family
ID=37452522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06784338T ATE540675T1 (de) | 2005-04-01 | 2006-03-31 | Verbindungen zur behandlung von stoffwechselstörungen |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8022249B2 (de) |
| EP (1) | EP1868595B1 (de) |
| AT (1) | ATE540675T1 (de) |
| CA (1) | CA2602854C (de) |
| WO (1) | WO2006127133A2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100965201B1 (ko) | 2001-06-12 | 2010-06-24 | 웰스테트 테라퓨틱스 코포레이션 | 대사 질환의 치료용 화합물 |
| US7645772B2 (en) | 2002-11-01 | 2010-01-12 | Wellstat Therapeutics Corporation | Treatment of metabolic disorders |
| EP1601251B1 (de) * | 2003-02-13 | 2014-11-12 | Wellstat Therapeutics Corporation | Verbindungen zur behandlung von stoffwechselstörungen |
| DK1633340T3 (da) | 2003-04-15 | 2011-02-07 | Wellstat Therapeutics Corp | Forbindelser til behandling af stofskifteforstyrrelser |
| WO2007117791A2 (en) * | 2006-03-31 | 2007-10-18 | Wellstat Therapeutics Corporation | Combination treatment of metabolic disorders |
| JP2009537559A (ja) | 2006-05-18 | 2009-10-29 | ウェルスタット セラピューティクス コーポレイション | 代謝障害の処置のための化合物 |
| AU2007285827A1 (en) * | 2006-08-17 | 2008-02-21 | Wellstat Therapeutics Corporation | Combination treatment for metabolic disorders |
| GB0813403D0 (en) * | 2008-07-22 | 2008-08-27 | Lectus Therapeutics Ltd | Potassium ion channel modulators & uses thereof |
| US10040769B2 (en) | 2015-10-27 | 2018-08-07 | Regenacy Pharmaceuticals, Llc | HDAC inhibitors for the treatment of diabetic peripheral neuropathy |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE667498A (de) | 1964-07-28 | 1965-11-16 | ||
| US4053607A (en) * | 1972-04-04 | 1977-10-11 | Beecham Group Limited | Aryloxypyridine for treating hyperglycaemia |
| US4067892A (en) * | 1973-08-23 | 1978-01-10 | Beecham Group Limited | Substituted (4-carboxyphenoxy) phenyl alkane compounds |
| GB1488330A (en) | 1973-12-19 | 1977-10-12 | Smith Kline French Lab | Dihydropyridazinones |
| JPS5225734A (en) | 1975-08-23 | 1977-02-25 | Kyorin Pharmaceut Co Ltd | Process for preparation of 4-(4'-halogenobenzyloxy)-bonzoyl acetate |
| NL7614113A (nl) * | 1976-12-18 | 1978-06-20 | Akzo Nv | Hydroxamzuren. |
| JPS56115747A (en) | 1980-02-19 | 1981-09-11 | Nippon Synthetic Chem Ind Co Ltd:The | 2- 2-hydroxyethylamino -3-substituted benzoylpropionic acid, its preparation and germicide |
| JPS57149254A (en) * | 1981-03-10 | 1982-09-14 | Hodogaya Chem Co Ltd | M-benzyloxybenzamide derivative and herbicide containing the same |
| JPH01216961A (ja) * | 1988-02-25 | 1989-08-30 | Takeda Chem Ind Ltd | １２−リポキシゲネース阻害剤 |
| US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| GB9315595D0 (en) | 1993-07-28 | 1993-09-08 | Res Inst Medicine Chem | New compounds |
| GB9404485D0 (en) | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
| WO1996028423A1 (en) | 1995-03-15 | 1996-09-19 | Sankyo Company, Limited | Dipeptide compounds having ahpba structure |
| KR100965201B1 (ko) * | 2001-06-12 | 2010-06-24 | 웰스테트 테라퓨틱스 코포레이션 | 대사 질환의 치료용 화합물 |
| US6951884B2 (en) * | 2002-06-12 | 2005-10-04 | Hoffmann-La Roche Inc. | Fluorobenzamides and uses thereof |
| US6900354B2 (en) * | 2002-07-15 | 2005-05-31 | Hoffman-La Roche Inc. | 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives |
| US7645772B2 (en) * | 2002-11-01 | 2010-01-12 | Wellstat Therapeutics Corporation | Treatment of metabolic disorders |
| EP1601251B1 (de) * | 2003-02-13 | 2014-11-12 | Wellstat Therapeutics Corporation | Verbindungen zur behandlung von stoffwechselstörungen |
| DK1633340T3 (da) * | 2003-04-15 | 2011-02-07 | Wellstat Therapeutics Corp | Forbindelser til behandling af stofskifteforstyrrelser |
| CN1777576A (zh) * | 2003-04-22 | 2006-05-24 | 维尔斯达医疗公司 | 用于治疗代谢紊乱的化合物 |
| US7442796B2 (en) * | 2003-04-30 | 2008-10-28 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| CA2533890A1 (en) * | 2003-08-20 | 2005-03-03 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| WO2007117791A2 (en) | 2006-03-31 | 2007-10-18 | Wellstat Therapeutics Corporation | Combination treatment of metabolic disorders |
| AU2007285827A1 (en) | 2006-08-17 | 2008-02-21 | Wellstat Therapeutics Corporation | Combination treatment for metabolic disorders |
-
2006
- 2006-03-31 EP EP06784338A patent/EP1868595B1/de not_active Not-in-force
- 2006-03-31 AT AT06784338T patent/ATE540675T1/de active
- 2006-03-31 WO PCT/US2006/012050 patent/WO2006127133A2/en not_active Ceased
- 2006-03-31 CA CA2602854A patent/CA2602854C/en not_active Expired - Fee Related
- 2006-03-31 US US11/909,120 patent/US8022249B2/en active Active - Reinstated
Also Published As
| Publication number | Publication date |
|---|---|
| EP1868595A2 (de) | 2007-12-26 |
| WO2006127133B1 (en) | 2007-03-29 |
| WO2006127133A3 (en) | 2007-02-01 |
| US20090234016A1 (en) | 2009-09-17 |
| WO2006127133A2 (en) | 2006-11-30 |
| CA2602854C (en) | 2013-05-14 |
| EP1868595B1 (de) | 2012-01-11 |
| CA2602854A1 (en) | 2006-11-30 |
| US8022249B2 (en) | 2011-09-20 |
| EP1868595A4 (de) | 2010-06-09 |
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