ATE540996T1 - Polymerbasierter serumalbumin-ersatzstoff - Google Patents

Polymerbasierter serumalbumin-ersatzstoff

Info

Publication number
ATE540996T1
ATE540996T1 AT06752773T AT06752773T ATE540996T1 AT E540996 T1 ATE540996 T1 AT E540996T1 AT 06752773 T AT06752773 T AT 06752773T AT 06752773 T AT06752773 T AT 06752773T AT E540996 T1 ATE540996 T1 AT E540996T1
Authority
AT
Austria
Prior art keywords
substitute
polymer based
serum albumine
based serum
molecular weight
Prior art date
Application number
AT06752773T
Other languages
English (en)
Inventor
Donald E Brooks
Jayachandran N Kizhakkedathu
Rajesh Kumar Kainthan
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Application granted granted Critical
Publication of ATE540996T1 publication Critical patent/ATE540996T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/42—Ethers, e.g. polyglycol ethers of alcohols or phenols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterized by the type of post-polymerisation functionalisation
    • C08G2650/04—End-capping
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/30—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type branched
    • C08G2650/32—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type branched dendritic or similar
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT06752773T 2005-06-06 2006-06-06 Polymerbasierter serumalbumin-ersatzstoff ATE540996T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68733605P 2005-06-06 2005-06-06
PCT/CA2006/000936 WO2006130978A1 (en) 2005-06-06 2006-06-06 Polymer-based serum albumin substitute

Publications (1)

Publication Number Publication Date
ATE540996T1 true ATE540996T1 (de) 2012-01-15

Family

ID=37498077

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06752773T ATE540996T1 (de) 2005-06-06 2006-06-06 Polymerbasierter serumalbumin-ersatzstoff

Country Status (5)

Country Link
US (2) US9346029B2 (de)
EP (1) EP1891143B1 (de)
AT (1) ATE540996T1 (de)
CA (1) CA2653541C (de)
WO (1) WO2006130978A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2653541C (en) 2005-06-06 2014-12-23 The University Of British Columbia Polymer-based serum albumin substitute
EP2190901A1 (de) * 2007-09-11 2010-06-02 Basf Se Antimikrobielle mittel und zusammensetzungen mit polyglycerol
WO2009055935A1 (en) * 2007-11-02 2009-05-07 The University Of British Columbia Hyperbranched polyglycerol for improving heart function
US8220643B2 (en) * 2008-06-06 2012-07-17 Fresenius Medical Care Holdings, Inc. Urea sorbent
CN101724147B (zh) * 2009-12-03 2011-09-28 苏州大学 一种超支化聚苯醚及其制备方法
EP2542613A4 (de) * 2010-03-01 2013-12-11 Univ British Columbia Derivatisierte hyperverzweigte polyglycerole
AU2015221541B2 (en) * 2010-03-01 2017-03-09 Centre For Drug Research And Development Derivatized hyperbranched polyglycerols
US9919004B2 (en) * 2012-04-24 2018-03-20 The University Of British Columbia Polymer-based dialysate
US20160295856A1 (en) * 2013-11-21 2016-10-13 University Of British Columbia Polymer based transplant preservation solution
CN105622922B (zh) * 2016-04-06 2018-04-20 苏州博纳化学科技有限公司 一种亲水性双羟基化合物的制备方法
AU2018360383A1 (en) 2017-11-02 2020-05-21 Natureceuticals Sdn. Bhd. Extract of orthosiphon stamineus, formulations, and uses thereof
US20180251574A1 (en) * 2018-05-02 2018-09-06 Arc Medical Devices Inc. Fucan-dendrimer based compounds and complexes
WO2025029684A1 (en) * 2023-07-28 2025-02-06 University Of Washington Low volume resuscitants and methods of making and using the same

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5112876A (en) 1988-10-28 1992-05-12 Takeda Chemical Industries, Ltd. Polyether polyol and rigid polyurethane foam
US5407528A (en) 1992-07-28 1995-04-18 The Center For Innovative Technology Oxygen plasma resistant polymeric film and fiber forming macromolecules containing the phosphine oxide moiety
US5407428A (en) * 1993-06-04 1995-04-18 Biotime, Inc. Solutions for use as plasma expanders and substitutes
US5635571A (en) * 1995-06-30 1997-06-03 Cornell Research Foundation, Inc. Polymerizable macromonomers and polymers prepared therefrom
US5688977A (en) 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
AU6876498A (en) 1997-04-03 1998-10-22 Point Biomedical Corporation Intravesical drug delivery system
US20020164374A1 (en) 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
US6822068B2 (en) 1998-12-22 2004-11-23 Bayer Aktiengesellschaft Method for producing highly-branched glycidol-based polyols
EP1144479A3 (de) 1999-06-09 2001-12-05 Ucb, S.A. Modifizierte hyperverzweigte polyesterpolyole, ihre darstellung und verwendung
AUPQ259399A0 (en) 1999-09-01 1999-09-23 Lustre Investments Pte Ltd Therapeutic agents
US6949335B2 (en) 1999-11-30 2005-09-27 21St Century Medicine, Inc. Polyglycerol and lactose compositions for the protection of living systems from states of reduced metabolism
EP1306864B1 (de) * 2000-06-07 2005-05-25 Nisshinbo Industries, Inc. Elektrolytzusammensetzung für einen elektrischen doppelschichtkondensator, festpolymerelektrolyt, zusammensetzung für eine polare elektrode, polare elektrode und elektrischer doppelschichtkondensator
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7265186B2 (en) 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
JP2004532847A (ja) 2001-04-20 2004-10-28 ザ ユニヴァーシティ オヴ ブリティッシュ コロンビア 疎水性薬物のためのミセル薬物送達システム
DE10121807A1 (de) 2001-05-04 2002-11-07 Bayer Ag Verfahren zur Herstellung von Polyetherpolyolen
WO2003015698A2 (en) 2001-08-13 2003-02-27 University Of Pittsburgh Application of lipid vehicles and use for drug delivery
US7393841B2 (en) * 2001-08-22 2008-07-01 Supramol Parenteral Colloids Gmbh Hyperbranched amylopectin for use in methods for surgical or therapeutic treatment of mammals or in diagnostic methods, especially for use as a plasma volume expander
EP2060259B1 (de) 2001-11-01 2010-01-20 Spectrum Pharmaceuticals, Inc. Medizinische Zusammensetzungen zur intravesikalen Behandlung von Blasenkrebs
DE10203058A1 (de) * 2002-01-26 2003-07-31 Bayer Ag Dentritisch modifizierte Polyurethane
KR100573289B1 (ko) 2002-07-20 2006-04-24 대화제약 주식회사 방광내 투여를 통한 방광암치료용 파클리탁셀 조성물 및그의 제조 방법
DE10237442B4 (de) * 2002-08-16 2004-08-19 Fresenius Kabi Deutschland Gmbh Hochverzweigte, niedrig substituierte Stärkeprodukte
ES2321841T3 (es) 2003-08-26 2009-06-12 Smithkline Beecham Corporation Copolimeros heterofuncionales de glicerol y polietilenglicol, sus conjugados y composiciones.
CN1852740B (zh) 2003-09-17 2011-05-11 耐科塔医药公司 多支链聚合物的药物前体
WO2005079856A1 (en) 2004-02-23 2005-09-01 The University Of British Columbia Drug delivery compositions comprising hydrophobic polymers and amphipathic molecules
US7396861B2 (en) * 2004-07-15 2008-07-08 Agfa Graphics Nv Radiation curable compositions
US7875698B2 (en) * 2004-07-15 2011-01-25 Agfa Graphics Nv Polymeric initiators
CA2653541C (en) 2005-06-06 2014-12-23 The University Of British Columbia Polymer-based serum albumin substitute
EP2330101A1 (de) 2006-10-20 2011-06-08 Scinopharm Singapore Pte, Ltd. Herstellungsverfahren für kristalline docetaxel
MX2009005780A (es) 2006-11-30 2009-06-10 Nektar Therapeutics Al Corp Metodo para preparar un conjugado de polimeros.
WO2008074154A1 (en) 2006-12-18 2008-06-26 The University Of British Columbia Polymers comprising zwitterionic endgroups
KR100878455B1 (ko) 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
WO2009055935A1 (en) 2007-11-02 2009-05-07 The University Of British Columbia Hyperbranched polyglycerol for improving heart function
WO2009123934A2 (en) 2008-03-29 2009-10-08 Emory University Branched multifunctional nanoparticle conjugates and their use
EP2123304A1 (de) 2008-05-23 2009-11-25 Freie Universität Berlin Verbindungen geeignet als Nanoträger für aktive Substanzen und ihre Verwendungen
EP2542613A4 (de) 2010-03-01 2013-12-11 Univ British Columbia Derivatisierte hyperverzweigte polyglycerole
US20130217789A1 (en) 2010-09-03 2013-08-22 North Carolina Central University Biodegradable liquogel and ph sensitive nanocarriers
US8519189B2 (en) 2011-06-01 2013-08-27 University Of British Columbia Polymers for reversing heparin-based anticoagulation
US9919004B2 (en) 2012-04-24 2018-03-20 The University Of British Columbia Polymer-based dialysate

Also Published As

Publication number Publication date
EP1891143A1 (de) 2008-02-27
CA2653541A1 (en) 2006-12-14
EP1891143B1 (de) 2012-01-11
US9346029B2 (en) 2016-05-24
US9789056B2 (en) 2017-10-17
US20170042804A1 (en) 2017-02-16
CA2653541C (en) 2014-12-23
WO2006130978A1 (en) 2006-12-14
EP1891143A4 (de) 2009-07-15
US20080292579A1 (en) 2008-11-27

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