ATE541851T1 - Bisplatinkomplexe mit antitumorwirkung - Google Patents

Bisplatinkomplexe mit antitumorwirkung

Info

Publication number: ATE541851T1
Authority: AT; Austria
Prior art keywords: alkyl; sulphate; hydrogen; bisplatin; complexes
Prior art date: 2005-12-22

Application number

AT06829802T

Other languages

English (en)

Inventor

Alberto Bernareggi

Mario Grugni

Giulio Mariotti

Ernesto Menta

Gianluca Pardi

Paolo Pavesi

Gabriella Pezzoni

Paola Nicoli

Munari Sergio De

Original Assignee

Cell Therapeutics Inc Sede Secondaria

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-22

Filing date

2006-12-21

Publication date

2012-02-15

2006-12-21 Application filed by Cell Therapeutics Inc Sede Secondaria filed Critical Cell Therapeutics Inc Sede Secondaria

2012-02-15 Application granted granted Critical

2012-02-15 Publication of ATE541851T1 publication Critical patent/ATE541851T1/de

Links

230000000259 anti-tumor effect Effects 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
229910002651 NO3 Inorganic materials 0.000 abstract 2
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 2
QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 abstract 2
VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 abstract 2
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 abstract 2
229910021653 sulphate ion Inorganic materials 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT06829802T 2005-12-22 2006-12-21 Bisplatinkomplexe mit antitumorwirkung ATE541851T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT002449A ITMI20052449A1 (it)	2005-12-22	2005-12-22	Nuovi bis-platino complessi ad attivita' antitumorale
PCT/EP2006/012366 WO2007071415A1 (en)	2005-12-22	2006-12-21	Bis-platinum complexes with antitumor activity

Publications (1)

Publication Number	Publication Date
ATE541851T1 true ATE541851T1 (de)	2012-02-15

Family

ID=37907243

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06829802T ATE541851T1 (de)	2005-12-22	2006-12-21	Bisplatinkomplexe mit antitumorwirkung

Country Status (18)

Country	Link
US (1)	US8426625B2 (de)
EP (1)	EP1968991B9 (de)
JP (1)	JP5436862B2 (de)
KR (1)	KR101415094B1 (de)
CN (1)	CN101341161A (de)
AT (1)	ATE541851T1 (de)
AU (1)	AU2006328970B2 (de)
BR (1)	BRPI0620065A2 (de)
CA (1)	CA2634355C (de)
EA (1)	EA015619B1 (de)
ES (1)	ES2383432T3 (de)
IL (1)	IL192295A0 (de)
IT (1)	ITMI20052449A1 (de)
MX (1)	MX2008007932A (de)
NO (1)	NO20082722L (de)
NZ (1)	NZ569258A (de)
WO (1)	WO2007071415A1 (de)
ZA (1)	ZA200805341B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20052449A1 (it)	2005-12-22	2007-06-23	Cell Therapeutics Europe Srl	Nuovi bis-platino complessi ad attivita' antitumorale
ITMI20081660A1 (it) *	2008-09-18	2010-03-19	Cell Therapeutics Inc Sede Secon Daria	Complesso di platino ad attivita' antitumorale
GB201313423D0 (en)	2013-07-26	2013-09-11	Innospec Ltd	Compositions and methods
EP3119859A1 (de) *	2014-03-18	2017-01-25	Council Of Scientific & Industrial Research	Halogenfreie ionische flüssigkeiten als schmiermittel- oder schmiermitteladditive und verfahren zur herstellung davon
GB201413355D0 (en) *	2014-07-28	2014-09-10	Innospec Ltd	Compositons and methods
CN110075120B (zh) *	2018-10-11	2022-03-11	广东众尔健生物科技有限公司	一种组合物及其在抗肿瘤药物中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6296A (ja)	1985-03-06	1987-01-06	Sumitomo Pharmaceut Co Ltd	脂溶性白金（２）錯体
IT1200467B (it)	1985-05-06	1989-01-18	Boehringer Biochemia Srl	Formulazione farmaceutica
US5117022A (en)	1985-10-18	1992-05-26	The Board Of Regents, The University Of Texas System	Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
JPS63501568A (ja) *	1985-10-18	1988-06-16	ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム	リポソ−ムに有効に組み込まれた疎水性シス−プラチナ複合体
US4797393A (en)	1986-07-25	1989-01-10	University Of Vermont And State Agricultural College	Bis-platinum complexes as chemotherapeutic agents
US5107007A (en)	1989-09-01	1992-04-21	The University Of Vermont And State Agricultural College	Bis-platinum complexes as chemotherapeutic agents
DE3768419D1 (de)	1986-10-07	1991-04-11	Boehringer Biochemia Srl	Pharmazeutische zusammensetzungen mit antineoplastischer wirkung.
ZA976421B (en) *	1996-07-22	1998-01-22	Boehringer Mannheim Italia	New bis-platinum complexes with polyamine ligands as antitumor agents.
ZA976422B (en) *	1996-07-22	1998-01-22	Boehringer Mannheim Italia	New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.
ITMI991508A1 (it) *	1999-07-09	2001-01-09	Novuspharma Spa	Nitrati di bis-platino complessi con ligandi poliamminici
IT1313594B1 (it) *	1999-08-03	2002-09-09	Novuspharma Spa	Bisplatino complessi attivi per via orale.
US7579373B2 (en) *	2001-08-22	2009-08-25	Virginia Commonwealth University	Targeted bisplatinum polyamines as pro-drugs: selective release of platinum
EP1734937A1 (de) *	2004-03-26	2006-12-27	Cell Therapeutics Europe S.R.L.	Nanoteilchen-formulierungen von platinverbindungen
ITMI20052449A1 (it)	2005-12-22	2007-06-23	Cell Therapeutics Europe Srl	Nuovi bis-platino complessi ad attivita' antitumorale

2005
- 2005-12-22 IT IT002449A patent/ITMI20052449A1/it unknown
2006
- 2006-12-21 EA EA200801355A patent/EA015619B1/ru not_active IP Right Cessation
- 2006-12-21 JP JP2008546261A patent/JP5436862B2/ja not_active Expired - Fee Related
- 2006-12-21 NZ NZ569258A patent/NZ569258A/en not_active IP Right Cessation
- 2006-12-21 AT AT06829802T patent/ATE541851T1/de active
- 2006-12-21 US US12/086,547 patent/US8426625B2/en not_active Expired - Fee Related
- 2006-12-21 AU AU2006328970A patent/AU2006328970B2/en not_active Ceased
- 2006-12-21 CA CA2634355A patent/CA2634355C/en not_active Expired - Fee Related
- 2006-12-21 BR BRPI0620065-6A patent/BRPI0620065A2/pt not_active IP Right Cessation
- 2006-12-21 ZA ZA200805341A patent/ZA200805341B/xx unknown
- 2006-12-21 CN CNA2006800478888A patent/CN101341161A/zh active Pending
- 2006-12-21 ES ES06829802T patent/ES2383432T3/es active Active
- 2006-12-21 EP EP06829802A patent/EP1968991B9/de not_active Not-in-force
- 2006-12-21 MX MX2008007932A patent/MX2008007932A/es active IP Right Grant
- 2006-12-21 WO PCT/EP2006/012366 patent/WO2007071415A1/en not_active Ceased
- 2006-12-21 KR KR1020087014856A patent/KR101415094B1/ko not_active Expired - Fee Related
2008
- 2008-06-19 IL IL192295A patent/IL192295A0/en not_active IP Right Cessation
- 2008-06-19 NO NO20082722A patent/NO20082722L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2006328970B2 (en)	2012-11-29
AU2006328970A1 (en)	2007-06-28
NZ569258A (en)	2011-08-26
ITMI20052449A1 (it)	2007-06-23
US20100292322A1 (en)	2010-11-18
CN101341161A (zh)	2009-01-07
KR101415094B1 (ko)	2014-08-06
EP1968991B9 (de)	2012-08-08
EP1968991B1 (de)	2012-01-18
CA2634355C (en)	2015-03-31
EA200801355A1 (ru)	2008-12-30
JP2009520731A (ja)	2009-05-28
WO2007071415A1 (en)	2007-06-28
CA2634355A1 (en)	2007-06-28
US8426625B2 (en)	2013-04-23
EA015619B1 (ru)	2011-10-31
NO20082722L (no)	2008-09-17
ZA200805341B (en)	2009-10-28
IL192295A0 (en)	2008-12-29
KR20080096643A (ko)	2008-10-31
JP5436862B2 (ja)	2014-03-05
EP1968991A1 (de)	2008-09-17
MX2008007932A (es)	2008-09-11
ES2383432T9 (es)	2012-11-06
ES2383432T3 (es)	2012-06-21
BRPI0620065A2 (pt)	2011-11-01

Publication	Publication Date	Title
NO20082722L (no)	2008-09-17	Bis-platina komplekser med antitumoraktivitet
MX2009006397A (es)	2009-08-13	Derivados de imidazotiazol.
MX2007005933A (es)	2007-06-20	Compuestos de acetamida como fungicidas.
MXPA05010652A (es)	2005-12-12	Pirazoles sustituidos.
CY1111706T1 (el)	2015-10-07	Παραγωγα αρυλο- και ετεροαρυλο-πιπεριδινοκαρβοξυλικων αλατων, η παρασκευη τους και η εφαρμογη τους ως αναστολεις του ενζυμου faah
DE60333746D1 (de)	2010-09-23	Thienylverbindungen
EP1826196A3 (de)	2007-11-14	Vinylether-Verbindungen
ES2335410T8 (es)	2011-07-01	Derivados de aminopropanol.
CY1109740T1 (el)	2014-09-10	Νεα μεθοδος συνθεσης παραγωγων της 1,3,4,5 -τετραϋδρο-2η- 3-βενζαζεπιν-2-ονης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων προσθηκης της σε ενα φαρμακευτικως αποδεκτο οξυ
TW201129558A (en)	2011-09-01	Piperazine compound having a pgds inhibitory effect
UA86013C2 (ru)	2009-03-25	Производные арилалкилкарбаматов, их получение и применение в лечении
GB1350420A (en)	1974-04-18	Alkanedioxy titanium chelates
ATE422163T1 (de)	2009-02-15	Absorbierbare alpha-cyanacrylat-zusammensetzungen
IL177887A0 (en)	2006-12-31	Synthetic multiple quaternary ammonium salts
SE0302129D0 (sv)	2003-07-25	Farmaceutiska kompositioner med antibiotisk aktivitet
CO5550494A2 (es)	2005-08-31	Derivados de diamina, proceso para producir los derivados de diamina, y fungicidas que contienen los derivados de diamina como ingrediente activo
MXPA05010651A (es)	2005-12-12	Compuestos de pirazol.
DE60306671D1 (de)	2006-08-17	Azoverbindungen
GB0307268D0 (en)	2003-05-07	Organic compounds
TW200637870A (en)	2006-11-01	Novel pyrimidine nucleoside compound and salt thereof
FR2812637B1 (fr)	2002-10-25	Nouveaux composes derives de dihydroporphyrine et leurs applications
DE502004009016D1 (de)	2009-04-02	Verwendung von chinaldin-und naphthalinderivaten als kristallisationsmodifikatoren
IT1223067B (it)	1990-09-12	Composto fotocromatico ed articoli fotocromatici che lo contengono
ATE374778T1 (de)	2007-10-15	Organosiliziumverbindungen und deren verwendung
BRPI0518998A2 (pt)	2008-12-23	âmega-feniloctanamidas