ATE542797T1 - Aminopiperidinderivate als integrin alpha v beta 3 antagonisten - Google Patents
Aminopiperidinderivate als integrin alpha v beta 3 antagonistenInfo
- Publication number
- ATE542797T1 ATE542797T1 AT99913611T AT99913611T ATE542797T1 AT E542797 T1 ATE542797 T1 AT E542797T1 AT 99913611 T AT99913611 T AT 99913611T AT 99913611 T AT99913611 T AT 99913611T AT E542797 T1 ATE542797 T1 AT E542797T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- beta
- integrin alpha
- diseases
- antagonists
- Prior art date
Links
- 108010047852 Integrin alphaVbeta3 Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical class NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 230000008485 antagonism Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010029113 Neovascularisation Diseases 0.000 abstract 1
- 108010035030 Platelet Membrane Glycoprotein IIb Proteins 0.000 abstract 1
- 230000004520 agglutination Effects 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229940127218 antiplatelet drug Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9706698 | 1998-04-09 | ||
| PCT/JP1999/001903 WO1999052872A1 (en) | 1998-04-09 | 1999-04-09 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN αvβ3 ANTAGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE542797T1 true ATE542797T1 (de) | 2012-02-15 |
Family
ID=14182282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99913611T ATE542797T1 (de) | 1998-04-09 | 1999-04-09 | Aminopiperidinderivate als integrin alpha v beta 3 antagonisten |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6420558B1 (de) |
| EP (1) | EP1074543B1 (de) |
| JP (1) | JP4064059B2 (de) |
| KR (1) | KR20010042587A (de) |
| CN (1) | CN1140511C (de) |
| AT (1) | ATE542797T1 (de) |
| AU (1) | AU759449C (de) |
| CA (1) | CA2327673C (de) |
| ES (1) | ES2381591T3 (de) |
| NZ (1) | NZ507222A (de) |
| WO (1) | WO1999052872A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1209152A4 (de) | 1999-08-05 | 2003-03-12 | Meiji Seika Kaisha | Omega-amino-alpha-hydroxy-carbonsäure-derivate mit einem integrin alpha v beta antagonismus |
| CA2392209A1 (en) * | 1999-10-08 | 2001-04-19 | Kazuyuki Fujishima | M-substituted benzoic acid derivatives having integrin .alpha.v.beta.3 antagonistic activity |
| WO2001027082A1 (en) * | 1999-10-08 | 2001-04-19 | Meiji Seika Kaisha, Ltd. | 3-AMINOPIPERIDINE DERIVATIVES AS INTEGRIN αvβ3 ANTAGONISTS |
| AU2525801A (en) * | 1999-12-17 | 2001-06-25 | Sanofi-Synthelabo | Phenoxypropanolamines, method for producing them and pharmaceutical compositionscontaining them |
| FR2802529B1 (fr) * | 1999-12-17 | 2004-07-30 | Sanofi Synthelabo | Phenoxypropanolamines, procede pour les preparer et compositions pharmaceutiques les contenant |
| EP1250935A1 (de) * | 2000-01-25 | 2002-10-23 | Meiji Seika Kaisha Ltd. | Heilmittel mit einem integrin-alpha-beta antagonist zur behandlung von reperfusionsschäden |
| WO2002074743A1 (en) * | 2001-03-19 | 2002-09-26 | Dainippon Pharmaceutical Co., Ltd. | Aryl-substituted alicyclic compound and medical composition comprising the same |
| DE10135043A1 (de) * | 2001-07-11 | 2003-01-30 | Bayer Cropscience Gmbh | Substituierte 3-Heteroaryl(amino- oder oxy)-pyrrolidin-2-one, Verfahren zu deren Herstellung und Verwendung als Herbizide oder als Pflanzenwachstumsregulatoren |
| JP2005194192A (ja) * | 2002-01-11 | 2005-07-21 | Meiji Seika Kaisha Ltd | （４−オキソピペリジン−１−イル）安息香酸誘導体およびこれを用いたインテグリンαｖβ３阻害剤の製造法 |
| US7279491B2 (en) | 2002-10-23 | 2007-10-09 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| CN101172997B (zh) * | 2006-11-03 | 2011-01-26 | 上海交通大学医学院附属瑞金医院 | 一种寡肽或其修饰物/衍生物以及它们的应用 |
| RU2442167C1 (ru) * | 2010-07-21 | 2012-02-10 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" | Способ оценки эффективности действия антиагрегантных препаратов, влияющих на метаболизм арахидоновой кислоты путем ингибирования циклооксигеназы-1 как в отдельности, так и совместно с антагонистом рецептора адф p2y12 на тромбоцитарных мембранах, на состояния тромбоцитов крови пациента, принимающего антиагрегантные препараты указанной группы |
| WO2014122228A1 (en) * | 2013-02-07 | 2014-08-14 | Westfaelische Wilhelms-Universitaet Muenster | Labelled compounds that bind to alpha-v-beta-3 integrin |
| ES2864079T3 (es) | 2014-05-30 | 2021-10-13 | Pfizer | Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
| WO2025146725A1 (ja) * | 2024-01-05 | 2025-07-10 | 国立大学法人佐賀大学 | 外用剤 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2150550A1 (en) | 1992-12-01 | 1994-06-09 | Melissa S. Egbertson | Fibrinogen receptor antagonists |
| ATE227567T1 (de) * | 1994-05-27 | 2002-11-15 | Merck & Co Inc | Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption |
| IL118325A0 (en) | 1995-05-25 | 1996-10-31 | Pont Merck And Pharmaceutical | Integrin receptor antagonists and pharmaceutical compositions containing them |
| SI0910563T1 (en) | 1995-06-29 | 2003-10-31 | Smithkline Beecham Corporation | Integrin receptor antagonists |
| MX9801716A (es) | 1995-08-30 | 1998-05-31 | Searle & Co | Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina. |
| CA2240439A1 (en) | 1995-12-22 | 1997-07-03 | The Dupont Merck Pharmaceutical Company | Novel integrin receptor antagonists |
| DE19548709A1 (de) | 1995-12-23 | 1997-07-03 | Merck Patent Gmbh | Tyrosinderivate |
| ZA9610853B (en) | 1995-12-29 | 1998-04-06 | Smithkline Beecham Corp | Processes and intermediates for preparing pharmaceuticals. |
| CN1209744A (zh) | 1995-12-29 | 1999-03-03 | 史密丝克莱恩比彻姆公司 | 玻连蛋白受体拮抗剂 |
| EP0880511A4 (de) | 1996-01-16 | 1999-06-16 | Merck & Co Inc | Integrin-rezeptor-antagonisten |
| AU2421797A (en) | 1996-03-15 | 1997-10-01 | Du Pont Pharmaceuticals Company | Spirocycle integrin inhibitors |
| ATE212990T1 (de) | 1996-03-20 | 2002-02-15 | Hoechst Ag | Inhibitoren der knochenresorption und vitronectinrezeptor-antagonisten |
| JP2000507575A (ja) | 1996-03-29 | 2000-06-20 | ジー．ディー．サール アンド カンパニー | シクロプロピルアルカノイック酸誘導体 |
| DE69713582T2 (de) | 1996-03-29 | 2003-01-09 | G.D. Searle & Co., Chicago | Zimtsäurederivate und deren verwendung als integrin-antagonisten |
| DK0891325T3 (da) | 1996-03-29 | 2002-05-21 | Searle & Co | Para-substituerede phenylpropansyrederivater som integrinantagonister |
| JP2000507952A (ja) | 1996-03-29 | 2000-06-27 | ジー．ディー．サール アンド カンパニー | ｍｅｔａ―置換フェニレンスルホンアミド誘導体 |
| DE69706407T2 (de) | 1996-03-29 | 2002-05-29 | G.D. Searle & Co., Chicago | META-SUBSTITUIERTE PHENYLENDERIVATE UND IHRE VERWENDUNG ALS ALPHAvBETA3 INTERGRIN-ANTAGONISTEN ODER INHIBITOREN |
| ES2185009T3 (es) | 1996-04-10 | 2003-04-16 | Merck & Co Inc | Antagonistas de alfa y beta 3'. |
| SE507094C3 (sv) | 1996-07-09 | 1998-04-27 | Tetra Laval Holdings & Finance | Foerpackningsbehaalare avsedd foer kyllagring av flytande livsmedel i is eller vatten |
| DE19629816A1 (de) | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| DE19629817A1 (de) | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| JP2002511052A (ja) | 1996-08-29 | 2002-04-09 | メルク エンド カンパニー インコーポレーテッド | インテグリンアンタゴニスト |
| CA2268940A1 (en) | 1996-10-30 | 1998-05-07 | Merck & Co., Inc. | Integrin antagonists |
| DE19653646A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
| CO4920232A1 (es) | 1997-01-08 | 2000-05-29 | Smithkline Beecham Corp | Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin |
| DE19705450A1 (de) | 1997-02-13 | 1998-08-20 | Merck Patent Gmbh | Bicyclische aromatische Aminosäuren |
| WO1998043962A1 (en) | 1997-03-28 | 1998-10-08 | Du Pont Pharmaceuticals Company | Heterocyclic integrin inhibitor prodrugs |
| AU7105498A (en) | 1997-04-14 | 1998-11-11 | Merck & Co., Inc. | Combination therapy for the prevention and treatment of osteoporosis |
| DE19726890B4 (de) | 1997-06-25 | 2007-11-15 | Kampf Gmbh & Co Maschinenfabrik | Sprühdüse und Sprühsystem zum Aufsprühen von Flüssigkeit auf eine Materialbahn |
| GB2327672A (en) | 1997-07-23 | 1999-02-03 | Merck & Co Inc | 4-(1,2,3,4-Tetrahydro-1,8-naphthyridin-7-yl)butanoyl-glycyl-3(S)-quinolin-3-yl-beta-alanine |
| US6239138B1 (en) | 1997-07-25 | 2001-05-29 | Smithkline Beecham Corporation | Vitronectin receptor antagonist |
-
1999
- 1999-04-09 WO PCT/JP1999/001903 patent/WO1999052872A1/ja not_active Ceased
- 1999-04-09 KR KR1020007011257A patent/KR20010042587A/ko not_active Ceased
- 1999-04-09 CN CNB998066575A patent/CN1140511C/zh not_active Expired - Fee Related
- 1999-04-09 US US09/673,017 patent/US6420558B1/en not_active Expired - Lifetime
- 1999-04-09 CA CA002327673A patent/CA2327673C/en not_active Expired - Fee Related
- 1999-04-09 ES ES99913611T patent/ES2381591T3/es not_active Expired - Lifetime
- 1999-04-09 JP JP2000543435A patent/JP4064059B2/ja not_active Expired - Lifetime
- 1999-04-09 AT AT99913611T patent/ATE542797T1/de active
- 1999-04-09 EP EP99913611A patent/EP1074543B1/de not_active Expired - Lifetime
- 1999-04-09 NZ NZ507222A patent/NZ507222A/en not_active IP Right Cessation
- 1999-04-09 AU AU31678/99A patent/AU759449C/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999052872A1 (en) | 1999-10-21 |
| EP1074543A1 (de) | 2001-02-07 |
| NZ507222A (en) | 2003-05-30 |
| AU759449B2 (en) | 2003-04-17 |
| AU759449C (en) | 2003-10-30 |
| CA2327673C (en) | 2009-08-25 |
| CA2327673A1 (en) | 1999-10-21 |
| ES2381591T3 (es) | 2012-05-29 |
| JP4064059B2 (ja) | 2008-03-19 |
| CN1303377A (zh) | 2001-07-11 |
| KR20010042587A (ko) | 2001-05-25 |
| CN1140511C (zh) | 2004-03-03 |
| AU3167899A (en) | 1999-11-01 |
| US6420558B1 (en) | 2002-07-16 |
| EP1074543A4 (de) | 2006-04-26 |
| EP1074543B1 (de) | 2012-01-25 |
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