ATE543831T1 - Antibakterielle wirkstoffe enthaltende konjugate von glykopeptiden und membranassoziierenden peptiden - Google Patents
Antibakterielle wirkstoffe enthaltende konjugate von glykopeptiden und membranassoziierenden peptidenInfo
- Publication number
- ATE543831T1 ATE543831T1 AT01980689T AT01980689T ATE543831T1 AT E543831 T1 ATE543831 T1 AT E543831T1 AT 01980689 T AT01980689 T AT 01980689T AT 01980689 T AT01980689 T AT 01980689T AT E543831 T1 ATE543831 T1 AT E543831T1
- Authority
- AT
- Austria
- Prior art keywords
- membrane
- glycopeptides
- conjugates
- agents
- active ingredients
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 102000002068 Glycopeptides Human genes 0.000 title 1
- 108010015899 Glycopeptides Proteins 0.000 title 1
- 239000004480 active ingredient Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical group NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 abstract 1
- 108010013639 Peptidoglycan Proteins 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0026924.1A GB0026924D0 (en) | 2000-11-03 | 2000-11-03 | Antibacterial agents |
| PCT/GB2001/004867 WO2002036612A1 (en) | 2000-11-03 | 2001-11-02 | Antibacterial agents comprising conjugates of glycopeptides and peptidic membrane-associating elements |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE543831T1 true ATE543831T1 (de) | 2012-02-15 |
Family
ID=9902519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01980689T ATE543831T1 (de) | 2000-11-03 | 2001-11-02 | Antibakterielle wirkstoffe enthaltende konjugate von glykopeptiden und membranassoziierenden peptiden |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7078380B2 (de) |
| EP (1) | EP1334117B1 (de) |
| JP (1) | JP4209673B2 (de) |
| AT (1) | ATE543831T1 (de) |
| AU (2) | AU1248202A (de) |
| CA (1) | CA2426012C (de) |
| DK (1) | DK1334117T3 (de) |
| ES (1) | ES2381649T3 (de) |
| GB (1) | GB0026924D0 (de) |
| WO (1) | WO2002036612A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0220936D0 (en) | 2002-09-05 | 2002-10-23 | Adprotech Ltd | Modified therapeutic agents |
| CN100506841C (zh) | 2003-05-01 | 2009-07-01 | 科内尔研究基金会 | 将分子递送到细胞的方法和载体复合物 |
| WO2005049819A1 (ja) * | 2003-10-29 | 2005-06-02 | Toagosei Co., Ltd. | 抗菌ペプチド及びその利用 |
| US20060105941A1 (en) * | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
| AU2006225382B2 (en) | 2005-03-21 | 2013-05-09 | Cytacoat Ab | An antimicrobial agent comprising a cysteine compound covalently bound to a substrate, in particular by binding through an S-S bridge via a spacer molecule |
| CA2637221A1 (en) | 2006-02-10 | 2007-08-16 | Dermagen Ab | Novel antimicrobial peptides and use thereof |
| WO2007103548A2 (en) | 2006-03-09 | 2007-09-13 | Inflazyme Pharmaceuticals Ltd. | Novel antibiotic compositions |
| JP5158716B2 (ja) * | 2006-08-24 | 2013-03-06 | 国立大学法人群馬大学 | 乳酸残基を含有するデプシペプチド |
| US20090246248A1 (en) * | 2008-03-27 | 2009-10-01 | Affinergy | Coating compositions having improved performance |
| US8404636B2 (en) | 2008-07-17 | 2013-03-26 | George Mason Intellectual Properties, Inc. | Targeted delivery of antimicrobial agents |
| WO2013039861A2 (en) | 2011-09-12 | 2013-03-21 | modeRNA Therapeutics | Engineered nucleic acids and methods of use thereof |
| CN108949772A (zh) | 2012-04-02 | 2018-12-07 | 现代泰克斯公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| CN104418941B (zh) | 2013-08-19 | 2017-11-07 | 爱斯医药科技(南京)有限公司 | 万古霉素衍生物、制备方法及其应用 |
| GB201402267D0 (en) * | 2014-02-10 | 2014-03-26 | Cambridge Entpr Ltd | Antibacterial agents |
| WO2015164666A1 (en) * | 2014-04-23 | 2015-10-29 | Avrygen Corporation | Nanoparticles for targeted gene therapy and methods of use thereof |
| GB201415776D0 (en) * | 2014-09-05 | 2014-10-22 | Singh Ishwar And Taylor Edward | New antibacterial products |
| EP3303338A1 (de) * | 2015-05-28 | 2018-04-11 | President and Fellows of Harvard College | Inhibitoren von bakteriellen glycosyltransferasen |
| US11168131B2 (en) | 2015-11-10 | 2021-11-09 | Visterra, Inc. | Antibody molecule-drug conjugates and uses thereof |
| CN110062760A (zh) | 2016-10-10 | 2019-07-26 | 约翰霍普金斯大学 | 抗d,d-转肽酶和l,d-转肽酶的抗细菌剂 |
| ES2994374T3 (en) | 2017-01-18 | 2025-01-23 | Visterra Inc | Antibody molecule-drug conjugates and uses thereof |
| CN110240656A (zh) * | 2019-04-24 | 2019-09-17 | 中山大学附属第三医院 | 一种融合蛋白及其制备方法与应用 |
| EP4126064A1 (de) | 2020-04-03 | 2023-02-08 | Visterra, Inc. | Antikörpermolekül-wirkstoff-konjugate und verwendungen davon |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3067099A (en) | 1955-09-16 | 1962-12-04 | Lilly Co Eli | Vancomycin and method for its preparation |
| US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| US5840684A (en) | 1994-01-28 | 1998-11-24 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
| US5834430A (en) | 1995-05-31 | 1998-11-10 | Biosynth S.R.L. | Potentiation of antibiotics |
| US5919756A (en) | 1996-06-28 | 1999-07-06 | Eli Lilly And Company | Amides |
| GB9614871D0 (en) | 1996-07-15 | 1996-09-04 | Smithkline Beecham Plc | Compounds |
| CA2291074C (en) | 1997-05-21 | 2008-04-01 | The Board Of Trustees Of The Leland Stanford Junior University | Composition and method for enhancing transport across biological membranes |
| EP1212094A2 (de) | 1999-04-23 | 2002-06-12 | St. Jude Medical, Inc. | Abgabe von antimikrobieller toxine |
| EP1296718A1 (de) | 2000-04-06 | 2003-04-02 | Pantheco A/S | Pharmazeutische zusammensetzungen enthaltend modifizierte pns-moleküle |
-
2000
- 2000-11-03 GB GBGB0026924.1A patent/GB0026924D0/en not_active Ceased
-
2001
- 2001-11-02 AU AU1248202A patent/AU1248202A/xx active Pending
- 2001-11-02 AT AT01980689T patent/ATE543831T1/de active
- 2001-11-02 DK DK01980689.2T patent/DK1334117T3/da active
- 2001-11-02 JP JP2002539370A patent/JP4209673B2/ja not_active Expired - Fee Related
- 2001-11-02 CA CA2426012A patent/CA2426012C/en not_active Expired - Lifetime
- 2001-11-02 WO PCT/GB2001/004867 patent/WO2002036612A1/en not_active Ceased
- 2001-11-02 US US10/415,935 patent/US7078380B2/en not_active Expired - Lifetime
- 2001-11-02 EP EP01980689A patent/EP1334117B1/de not_active Expired - Lifetime
- 2001-11-02 AU AU2002212482A patent/AU2002212482B2/en not_active Expired
- 2001-11-02 ES ES01980689T patent/ES2381649T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7078380B2 (en) | 2006-07-18 |
| AU2002212482B2 (en) | 2006-09-21 |
| JP4209673B2 (ja) | 2009-01-14 |
| WO2002036612A1 (en) | 2002-05-10 |
| JP2004513132A (ja) | 2004-04-30 |
| ES2381649T3 (es) | 2012-05-30 |
| EP1334117B1 (de) | 2012-02-01 |
| CA2426012A1 (en) | 2002-05-10 |
| GB0026924D0 (en) | 2000-12-20 |
| EP1334117A1 (de) | 2003-08-13 |
| AU1248202A (en) | 2002-05-15 |
| US20040106544A1 (en) | 2004-06-03 |
| CA2426012C (en) | 2013-06-11 |
| DK1334117T3 (da) | 2012-05-29 |
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