ATE545422T1 - Beta-glycolipide als immunomodulatoren - Google Patents

Beta-glycolipide als immunomodulatoren

Info

Publication number: ATE545422T1
Authority: AT; Austria
Prior art keywords: ceramide; immunomodulators; relates; lactosyl; glycolipids
Prior art date: 2005-11-24

Application number

AT06809778T

Other languages

English (en)

Inventor

Yaron Ilan

Original Assignee

Enzo Biochem Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-24

Filing date

2006-10-23

Publication date

2012-03-15

2006-10-23 Application filed by Enzo Biochem Inc filed Critical Enzo Biochem Inc

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE545422T1 publication Critical patent/ATE545422T1/de

Links

239000002955 immunomodulating agent Substances 0.000 title abstract 2
229940121354 immunomodulator Drugs 0.000 title abstract 2
239000000203 mixture Substances 0.000 abstract 3
QYWVASPEUXEHSY-NNRNTGNWSA-N beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-(docosanoyl)sphingosine Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 QYWVASPEUXEHSY-NNRNTGNWSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
102000004127 Cytokines Human genes 0.000 abstract 1
108090000695 Cytokines Proteins 0.000 abstract 1
OTGQIQQTPXJQRG-UHFFFAOYSA-N N-(octadecanoyl)ethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCCO OTGQIQQTPXJQRG-UHFFFAOYSA-N 0.000 abstract 1
YDNKGFDKKRUKPY-UHFFFAOYSA-N N-palmitoyldihydro-sphingosine Natural products CCCCCCCCCCCCCCCC(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-UHFFFAOYSA-N 0.000 abstract 1
210000000447 Th1 cell Anatomy 0.000 abstract 1
210000004241 Th2 cell Anatomy 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
POQRWMRXUOPCLD-HIIAJUEOSA-N beta-D-galactosyl-N-(tetracosanoyl)sphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O POQRWMRXUOPCLD-HIIAJUEOSA-N 0.000 abstract 1
YIGARKIIFOHVPF-CNUVFPMCSA-N beta-D-glucosyl-N-(docosanoyl)sphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YIGARKIIFOHVPF-CNUVFPMCSA-N 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)

AT06809778T 2005-11-24 2006-10-23 Beta-glycolipide als immunomodulatoren ATE545422T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL172175A IL172175A0 (en)	2005-11-24	2005-11-24	Beta glycolipids as immuno-modulators
PCT/IL2006/001217 WO2007060652A1 (en)	2005-11-24	2006-10-23	Beta glycolipids as immuno-modulators

Publications (1)

Publication Number	Publication Date
ATE545422T1 true ATE545422T1 (de)	2012-03-15

Family

ID=37813589

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06809778T ATE545422T1 (de)	2005-11-24	2006-10-23	Beta-glycolipide als immunomodulatoren

Country Status (8)

Country	Link
US (1)	US7897580B2 (de)
EP (1)	EP1957083B1 (de)
JP (1)	JP2009517378A (de)
CN (1)	CN101384268A (de)
AT (1)	ATE545422T1 (de)
CA (1)	CA2630935C (de)
IL (3)	IL172175A0 (de)
WO (1)	WO2007060652A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL142802A (en) *	2000-04-27	2015-01-29	Enzo Therapeutics Inc	Use of one or more HBV antigens for the preparation of oral pharmaceutical preparations for the treatment of a person with active HBV infection or hepatocellular carcinoma
WO2005032462A2 (en)	2003-02-27	2005-04-14	Enzo Therapeutics, Inc.	Glucocerebroside treatment of disease
US9717754B2 (en) *	2003-02-27	2017-08-01	Enzo Therapeutics, Inc.	Glucocerebroside treatment of disease
JP2007533632A (ja) *	2003-09-30	2007-11-22	エンゾーセラピューティクス，インコーポレイテッド	疾患のグルコセレブロシド処理
US7883703B2 (en) *	2003-11-14	2011-02-08	The Brigham And Women's Hospital, Inc.	Methods of modulating immunity
IL178821A0 (en) *	2006-05-25	2007-07-04	Ilan Yaron	Direct and indirect modulation of composition and structure of cell membrane by ??-glycolipids
IL187959A0 (en) *	2007-12-06	2008-12-29	Haim Lotan	Beta glycolipids for the treatment of calcification related degenerative disorders
WO2009090656A2 (en)	2008-01-18	2009-07-23	Hadasit Medical Research Services & Development Ltd.	Combination therapy of beta-glycolipids and antibodies for the treatment of immune-related disorders
NZ571856A (en) *	2008-10-09	2011-02-25	Fonterra Corporate Res And Dev Ltd	Use of a phospholipid and ganglioside composition for the treatment or prevention of gout
BR112012004689A2 (pt)	2009-09-01	2019-09-24	Lz Therapeutics Inc	métodos para extração e purificação de gangliosídeos.
WO2011146804A2 (en) *	2010-05-20	2011-11-24	Lazarus Therapeutics, Inc.	Gm3 ganglioside replacement therapy
JP5967754B2 (ja) *	2011-05-02	2016-08-10	興人ライフサイエンス株式会社	酵母エキス抽出残渣の利用法
WO2013049220A1 (en) *	2011-09-30	2013-04-04	University Of Southern California	Novel vaccination strategies or therapeutic treatment for influenza virus
US9556467B2 (en)	2012-01-20	2017-01-31	Garnet Bio Therapeutics, Inc.	Methods of ganglioside production
US20170035791A1 (en) *	2014-04-14	2017-02-09	Natural Shield Israel 2016 Ltd	Combination of beta-glucosylceramide and polyethoxylated castor oil and other adjuvants for controling blood sugar levels, immunoprotection and hepatoprotection
CN104383528B (zh) *	2014-10-24	2016-08-24	江苏省农业科学院	猪流行性腹泻灭活疫苗及其制备方法
US20190254992A1 (en) *	2016-06-29	2019-08-22	Hadasit Medical Research Services & Development Limited	Combinations of beta-glycolipides and 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol, compositions and uses thereof in the treatment of disorders associated with protein misfolding and protein aggregations
CN115010775A (zh) *	2021-03-03	2022-09-06	东莞市东阳光冬虫夏草研发有限公司	一类脑苷脂化合物作为免疫抑制剂的用途
CN115028671A (zh) *	2021-03-03	2022-09-09	东莞市东阳光冬虫夏草研发有限公司	一种冬虫夏草提取物、制备方法及其用途
EP4565199A1 (de) *	2022-08-05	2025-06-11	Carbocode S.A.	Verminderung der anzeichen der hautalterung

Family Cites Families (10)

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ATE115859T1 (de) *	1987-06-26	1995-01-15	Solco Basel Ag	Neue pharmazeutische präparate sowie neue lactosylverbindungen und ihre herstellung.
US5686426A (en) *	1994-11-17	1997-11-11	Bristol-Myers Squibb Company	Dicarboxymethylated glycolipid derivatives as cell adhesion inhibitors
FR2728707A1 (fr) *	1994-12-22	1996-06-28	Alcatel Postal Automation Syst	Dispositif de lecture d'un code a barres pour une installation de tri postal
US6492337B1 (en) *	1997-12-30	2002-12-10	A+ Science Ab	Galactosylceramide, glucosylceramide, lactosylceramide, and specific catchers therefor for use in the prophylaxis or therapy of prediabetes, diabetes and/or associated complication
AUPP675898A0 (en)	1998-10-27	1998-11-19	Walter And Eliza Hall Institute Of Medical Research, The	A method of activating t cells and agents useful for same
IL140537A0 (en) *	2000-12-25	2002-02-10	Hadasit Med Res Service	Educated nk t cells and their uses in the treatment of immune-related disorders
EP1434859A2 (de) *	2001-07-25	2004-07-07	New York University	Verwendung von glycosylceramiden als adjuvantien für vakzine gegen infektionen und krebs
US20040171522A1 (en)	2003-02-27	2004-09-02	Yaron Ilan	Regulation of immune responses by manipulation of intermediary metabolite levels
WO2005032462A2 (en)	2003-02-27	2005-04-14	Enzo Therapeutics, Inc.	Glucocerebroside treatment of disease
EP1653977A2 (de)	2003-07-17	2006-05-10	THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES	Behandlung von erkrankungen im zusammenhang mit natürlichen killer-t-zellen

2005
- 2005-11-24 IL IL172175A patent/IL172175A0/en unknown
- 2005-11-25 US US11/287,502 patent/US7897580B2/en active Active
2006
- 2006-10-23 WO PCT/IL2006/001217 patent/WO2007060652A1/en not_active Ceased
- 2006-10-23 CN CNA2006800517473A patent/CN101384268A/zh active Pending
- 2006-10-23 AT AT06809778T patent/ATE545422T1/de active
- 2006-10-23 EP EP06809778A patent/EP1957083B1/de active Active
- 2006-10-23 JP JP2008541906A patent/JP2009517378A/ja active Pending
- 2006-10-23 CA CA2630935A patent/CA2630935C/en active Active
2008
- 2008-05-22 IL IL191627A patent/IL191627A/en active IP Right Grant
2017
- 2017-02-27 IL IL250832A patent/IL250832B/en active IP Right Grant

Also Published As

Publication number	Publication date
US20070117778A1 (en)	2007-05-24
JP2009517378A (ja)	2009-04-30
IL191627A (en)	2017-03-30
CA2630935A1 (en)	2007-05-31
IL250832B (en)	2019-03-31
IL172175A0 (en)	2011-08-01
IL191627A0 (en)	2008-12-29
CN101384268A (zh)	2009-03-11
EP1957083A1 (de)	2008-08-20
US7897580B2 (en)	2011-03-01
CA2630935C (en)	2014-08-12
WO2007060652A1 (en)	2007-05-31
IL250832A0 (en)	2017-04-30
EP1957083B1 (de)	2012-02-15

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