ATE547401T1 - 3',6-substituierte indirubine und ihre biologische anwendung - Google Patents

3',6-substituierte indirubine und ihre biologische anwendung

Info

Publication number
ATE547401T1
ATE547401T1 AT09802595T AT09802595T ATE547401T1 AT E547401 T1 ATE547401 T1 AT E547401T1 AT 09802595 T AT09802595 T AT 09802595T AT 09802595 T AT09802595 T AT 09802595T AT E547401 T1 ATE547401 T1 AT E547401T1
Authority
AT
Austria
Prior art keywords
biological applications
substituted
halogen
alkyl
indirubins
Prior art date
Application number
AT09802595T
Other languages
English (en)
Inventor
Laurent Meijer
Leandros Skaltsounis
Emmanuel Mikros
Prokopios Magiatis
Carl Johnson
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE547401T1 publication Critical patent/ATE547401T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT09802595T 2008-08-01 2009-07-21 3',6-substituierte indirubine und ihre biologische anwendung ATE547401T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8543208P 2008-08-01 2008-08-01
EP08161646A EP2149553B1 (de) 2008-08-01 2008-08-01 3',6-substituierte Indirubine und ihre biologischen Anwendungen
PCT/IB2009/053153 WO2010013168A1 (en) 2008-08-01 2009-07-21 3',6-substituted indirubins and their biological applications

Publications (1)

Publication Number Publication Date
ATE547401T1 true ATE547401T1 (de) 2012-03-15

Family

ID=40225521

Family Applications (2)

Application Number Title Priority Date Filing Date
AT08161646T ATE529402T1 (de) 2008-08-01 2008-08-01 3',6-substituierte indirubine und ihre biologischen anwendungen
AT09802595T ATE547401T1 (de) 2008-08-01 2009-07-21 3',6-substituierte indirubine und ihre biologische anwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT08161646T ATE529402T1 (de) 2008-08-01 2008-08-01 3',6-substituierte indirubine und ihre biologischen anwendungen

Country Status (6)

Country Link
US (1) US8829203B2 (de)
EP (2) EP2149553B1 (de)
JP (1) JP5577336B2 (de)
AT (2) ATE529402T1 (de)
CA (1) CA2732232C (de)
WO (1) WO2010013168A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5448455B2 (ja) * 2005-12-23 2014-03-19 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク （セ エン エール エス） 新規３’−，７−置換インジルビンおよびそれらの適用
EP2149553B1 (de) 2008-08-01 2011-10-19 Centre National de la Recherche Scientifique 3',6-substituierte Indirubine und ihre biologischen Anwendungen
WO2011003988A1 (en) 2009-07-08 2011-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for inducing extended self-renewal of functionally differentiated somatic cells
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013011841A1 (ja) * 2011-07-15 2013-01-24 学校法人日本大学 悪性腫瘍に対する高選択的細胞毒性を有するインディルビン誘導体
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9512076B2 (en) 2012-02-03 2016-12-06 City Of Hope Indirubin derivatives and uses thereof in treating chronic myelogenous leukemia
US10435367B2 (en) * 2013-03-14 2019-10-08 City Of Hope Indirubin derivatives, and uses thereof
CA2868302A1 (en) 2012-03-23 2013-09-26 Dennis M. Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
CA2902914A1 (en) * 2013-03-14 2014-09-25 City Of Hope 5-bromo-indirubins
US20150259288A1 (en) 2014-03-14 2015-09-17 City Of Hope 5-bromo-indirubins
RU2763346C2 (ru) * 2017-10-31 2021-12-28 Пелемед Ко., Лтд. Фармацевтическая композиция для предупреждения или лечения острого миелоидного лейкоза или метастатического рака молочной железы
US12303490B2 (en) 2019-11-04 2025-05-20 Ck Regeon Inc. Compositions and methods for suppressing and/or treating neurodegenerative diseases and/or a clinical condition thereof
CN113072540B (zh) * 2021-03-29 2023-07-14 贵州医科大学 一种靛玉红衍生的降解剂及其制备与应用
EP4329748A4 (de) * 2021-04-29 2025-10-22 Jawaharlal Nehru Centre For Advanced Scient Research Indirubinverbindungen und verfahren dafür

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200101046A1 (ru) 1999-04-12 2002-04-25 Герхард Айзенбранд Производные индигоидных бис-индолов
EP1686988A1 (de) * 2003-10-28 2006-08-09 The Rockefeller University Verbindungen vom indirubin-typ, zusammensetzungen und anwendungsverfahren
JP5448455B2 (ja) * 2005-12-23 2014-03-19 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク （セ エン エール エス） 新規３’−，７−置換インジルビンおよびそれらの適用
EP2149553B1 (de) 2008-08-01 2011-10-19 Centre National de la Recherche Scientifique 3',6-substituierte Indirubine und ihre biologischen Anwendungen

Also Published As

Publication number Publication date
JP5577336B2 (ja) 2014-08-20
JP2011529873A (ja) 2011-12-15
US20110136808A1 (en) 2011-06-09
EP2328866A1 (de) 2011-06-08
CA2732232A1 (en) 2010-02-04
EP2328866B1 (de) 2012-02-29
US8829203B2 (en) 2014-09-09
ATE529402T1 (de) 2011-11-15
EP2149553B1 (de) 2011-10-19
EP2149553A1 (de) 2010-02-03
CA2732232C (en) 2017-11-07
WO2010013168A1 (en) 2010-02-04

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