ATE547413T1 - Andrographolidderivate und deren verwendung bei der herstellung von medikamenten - Google Patents
Andrographolidderivate und deren verwendung bei der herstellung von medikamentenInfo
- Publication number
- ATE547413T1 ATE547413T1 AT08783912T AT08783912T ATE547413T1 AT E547413 T1 ATE547413 T1 AT E547413T1 AT 08783912 T AT08783912 T AT 08783912T AT 08783912 T AT08783912 T AT 08783912T AT E547413 T1 ATE547413 T1 AT E547413T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibit
- pseudomonas aeruginosa
- bacteria
- derivative
- gram
- Prior art date
Links
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical class C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 241000894006 Bacteria Species 0.000 abstract 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 2
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical group OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000191967 Staphylococcus aureus Species 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 229960004308 acetylcysteine Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- -1 inorganic acid radicals Chemical class 0.000 abstract 1
- 235000019136 lipoic acid Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229960002663 thioctic acid Drugs 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710029644A CN100584841C (zh) | 2007-08-08 | 2007-08-08 | 穿心莲内酯衍生物及其在制药中的应用 |
| PCT/CN2008/071919 WO2009018780A1 (en) | 2007-08-08 | 2008-08-07 | Andrographolide derivatives and use thereof in manufacture of medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE547413T1 true ATE547413T1 (de) | 2012-03-15 |
Family
ID=39094001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08783912T ATE547413T1 (de) | 2007-08-08 | 2008-08-07 | Andrographolidderivate und deren verwendung bei der herstellung von medikamenten |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8367720B2 (de) |
| EP (1) | EP2176255B1 (de) |
| JP (1) | JP2010535720A (de) |
| CN (1) | CN100584841C (de) |
| AT (1) | ATE547413T1 (de) |
| WO (1) | WO2009018780A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100584841C (zh) * | 2007-08-08 | 2010-01-27 | 暨南大学 | 穿心莲内酯衍生物及其在制药中的应用 |
| CN103012336A (zh) * | 2007-08-28 | 2013-04-03 | 北京美倍他药物研究有限公司 | 穿心莲内酯及脱水穿心莲内酯的水溶性氨基酸酯衍生物 |
| CN101870768B (zh) * | 2009-04-22 | 2012-02-29 | 中国人民解放军军事医学科学院毒物药物研究所 | 活性内酯类化合物的聚乙二醇化衍生物 |
| CN101590037B (zh) * | 2009-06-29 | 2011-09-07 | 暨南大学 | 一种穿心莲内酯组合物及其用途 |
| KR101625882B1 (ko) | 2009-10-21 | 2016-05-31 | 마뀌 뉴 라이프 에스. 에이. | 안토시아니딘을 포함하는 조성물 및 이용방법 |
| CN101817805B (zh) * | 2010-04-07 | 2012-07-18 | 暨南大学 | 一种穿心莲内酯衍生物及其制备方法和应用 |
| CN102218024B (zh) * | 2010-04-19 | 2013-01-16 | 童玉新 | 一种祛痘的组合物及其在化妆品中的应用 |
| DE102010032484A1 (de) * | 2010-07-28 | 2012-02-02 | Evonik Goldschmidt Gmbh | Zellen und Verfahren zur Herstellung von Rhamnolipiden |
| CN102617527A (zh) * | 2012-03-01 | 2012-08-01 | 湖北荷普药业股份有限公司 | 穿琥宁或炎琥宁的制备方法 |
| CN103145665B (zh) * | 2012-04-12 | 2014-12-31 | 江西青峰药业有限公司 | 17-氢-9-去氢-14,17-环-穿心莲内酯-19-硫酸酯化物、制备方法及其制备药物用途 |
| CN102702147B (zh) * | 2012-06-18 | 2016-06-08 | 辽宁利锋科技开发有限公司 | 穿心莲内酯类似物及其治疗的应用 |
| CN103304523B (zh) * | 2012-11-30 | 2016-05-04 | 暨南大学 | 穿心莲内酯一氧化氮供体类化合物及其制备方法和应用 |
| CN103376328A (zh) * | 2013-07-18 | 2013-10-30 | 上海交通大学医学院附属瑞金医院 | 血清sRAGE水平的检测试剂在筛选改善胰岛素β细胞功能的糖尿病治疗药物中的应用 |
| CN103432118B (zh) * | 2013-08-30 | 2016-05-04 | 暨南大学 | 穿心莲内酯衍生物在制备预防和治疗神经退行性疾病药物中的应用 |
| CN103664842A (zh) * | 2013-12-16 | 2014-03-26 | 无锡济民可信山禾药业股份有限公司 | 一种穿心莲内酯的连续色谱分离方法 |
| KR101694958B1 (ko) * | 2014-04-08 | 2017-01-10 | 바이오스펙트럼 주식회사 | 천심련추출물 또는 안드로그라폴라이드 또는 이의 염을 포함하는 피부상태 개선용 조성물 |
| CN104856987B (zh) * | 2015-01-22 | 2017-11-03 | 南京工业大学 | 14‑芳基醚穿心莲內酯衍生物在抗菌领域的应用 |
| CN104629054B (zh) * | 2015-01-28 | 2017-01-25 | 中国科学院化学研究所 | 一种硫缩酮聚合物及其制备方法与应用 |
| CN104744412A (zh) * | 2015-04-07 | 2015-07-01 | 重庆药友制药有限责任公司 | 一种炎琥宁化合物 |
| CN105030764B (zh) * | 2015-06-15 | 2019-04-19 | 广州喜鹊医药有限公司 | 穿心莲内酯衍生物在制备治疗炎症性肠病药物中的应用 |
| CN106606506A (zh) * | 2015-10-21 | 2017-05-03 | 复旦大学 | 对映半日花烷型二萜在制备抗补体药物中的用途 |
| CN106432153B (zh) * | 2016-10-13 | 2019-02-19 | 四川理工学院 | 一类含硫穿心莲内酯衍生物、其药物组合物、合成方法、在制备治疗前列腺癌药物中的应用 |
| JP2018139539A (ja) * | 2017-02-28 | 2018-09-13 | 白鳥製薬株式会社 | 呼気中アルコール濃度低減用飲食品組成物 |
| CN109364063B (zh) * | 2018-11-14 | 2021-05-11 | 株洲千金药业股份有限公司 | 一种具有抗菌作用的化合物及其在制备抗菌药物中的应用 |
| CN111793049A (zh) * | 2019-04-08 | 2020-10-20 | 武汉长联来福制药股份有限公司 | 一种炎琥宁及其中间体的制备方法 |
| CN111096966B (zh) * | 2020-01-06 | 2023-08-15 | 华中科技大学同济医学院附属协和医院 | 穿心莲内酯在治疗主动脉瓣膜钙化病中的用途 |
| CN111920802B (zh) * | 2020-09-11 | 2024-01-23 | 华侨大学 | 穿心莲内酯在制备防治成人t细胞白血病药物的应用 |
| US12599677B2 (en) | 2020-10-05 | 2026-04-14 | Northwestern University | Targeted PH sensitive liposomes |
| CN113133458A (zh) * | 2021-03-12 | 2021-07-20 | 兰州大学 | 一种穿心莲内酯衍生物在防治植物病害中的用途 |
| CN115068491A (zh) * | 2021-03-15 | 2022-09-20 | 中国医学科学院药物研究所 | 穿心莲新苷作为ltb4受体抑制剂的医药用途 |
| CN115068467A (zh) * | 2021-03-15 | 2022-09-20 | 中国医学科学院药物研究所 | 穿心莲内酯作为ltb4受体抑制剂的医药用途 |
| CN114686462B (zh) * | 2022-04-01 | 2024-05-31 | 山东仕达思医疗科技有限公司 | 能瓦解细菌生物被膜和杀灭细菌的蛋白酶LasA及应用 |
| CN116392478B (zh) * | 2023-04-27 | 2025-09-26 | 中国农业大学 | 脱水穿心莲内酯协同增效多黏菌素在制备抗革兰氏阴性菌感染药物中的应用 |
| CN116869995A (zh) * | 2023-09-08 | 2023-10-13 | 中国中医科学院广安门医院 | 一种穿心莲内酯改构化合物j6或其衍生物的用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6388124A (ja) | 1986-09-30 | 1988-04-19 | Toyo Jozo Co Ltd | 抗腫瘍剤 |
| US6410590B1 (en) | 2000-02-03 | 2002-06-25 | Dr. Reddy's Research Foundation | Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them |
| CN1293872C (zh) | 2003-02-21 | 2007-01-10 | 四川省宜宾五粮液集团有限公司 | 一种治疗咽炎的口腔局部给药的药物组合物及其制备方法 |
| CN1478774A (zh) | 2003-02-25 | 2004-03-03 | 北京医工生物技术研究所 | 穿心莲内酯三马来酸酯单钾盐和穿心莲内酯三马来酸酯三钾盐以及它们的药物组合物 |
| US8445533B2 (en) | 2004-11-08 | 2013-05-21 | Cornell Research Foundation, Inc. | Andrographolide derivatives to treat viral infections |
| CN100584841C (zh) | 2007-08-08 | 2010-01-27 | 暨南大学 | 穿心莲内酯衍生物及其在制药中的应用 |
-
2007
- 2007-08-08 CN CN200710029644A patent/CN100584841C/zh not_active Expired - Fee Related
-
2008
- 2008-08-07 JP JP2010519331A patent/JP2010535720A/ja not_active Withdrawn
- 2008-08-07 WO PCT/CN2008/071919 patent/WO2009018780A1/en not_active Ceased
- 2008-08-07 AT AT08783912T patent/ATE547413T1/de active
- 2008-08-07 EP EP08783912A patent/EP2176255B1/de not_active Not-in-force
- 2008-08-07 US US12/672,476 patent/US8367720B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2176255A4 (de) | 2011-01-19 |
| WO2009018780A1 (en) | 2009-02-12 |
| CN101125850A (zh) | 2008-02-20 |
| EP2176255B1 (de) | 2012-02-29 |
| US20110077295A1 (en) | 2011-03-31 |
| EP2176255A1 (de) | 2010-04-21 |
| US8367720B2 (en) | 2013-02-05 |
| JP2010535720A (ja) | 2010-11-25 |
| CN100584841C (zh) | 2010-01-27 |
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