ATE548369T1 - Pyrrolopyridazinonverbindung als pde4 inhibitor - Google Patents

Pyrrolopyridazinonverbindung als pde4 inhibitor

Info

Publication number: ATE548369T1
Authority: AT; Austria
Prior art keywords: group; substituent; substituted; alkyl; hydroxy
Prior art date: 2006-01-16

Application number

AT07706860T

Other languages

English (en)

Inventor

Masahiko Hagihara

Masayuki Tanaka

Tetsushi Katsube

Makoto Okudo

Noriaki Iwase

Manabu Shigetomi

Tomoko Kanda

Takayuki Nakanishi

Original Assignee

Ube Industries

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-01-16

Filing date

2007-01-16

Publication date

2012-03-15

2007-01-16 Application filed by Ube Industries filed Critical Ube Industries

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE548369T1 publication Critical patent/ATE548369T1/de

Links

-1 PYRROLOPYRIDAZINONE COMPOUND Chemical class 0.000 title abstract 2
229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
125000001424 substituent group Chemical group 0.000 abstract 13
125000005843 halogen group Chemical group 0.000 abstract 7
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 4
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000003277 amino group Chemical class 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical class 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000002926 oxygen Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT07706860T 2006-01-16 2007-01-16 Pyrrolopyridazinonverbindung als pde4 inhibitor ATE548369T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2006006981		2006-01-16
PCT/JP2007/050533 WO2007081030A1 (ja)	2006-01-16	2007-01-16	ピロロピリダジノン化合物

Publications (1)

Publication Number	Publication Date
ATE548369T1 true ATE548369T1 (de)	2012-03-15

Family

ID=38256432

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07706860T ATE548369T1 (de)	2006-01-16	2007-01-16	Pyrrolopyridazinonverbindung als pde4 inhibitor

Country Status (10)

Country	Link
US (1)	US8450319B2 (de)
EP (1)	EP1982986B1 (de)
JP (1)	JP5067165B2 (de)
KR (1)	KR20080094921A (de)
CN (1)	CN101374844B (de)
AT (1)	ATE548369T1 (de)
AU (1)	AU2007205452B2 (de)
CA (1)	CA2637388C (de)
ES (1)	ES2383969T3 (de)
WO (1)	WO2007081030A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010036380A1 (en)	2008-09-26	2010-04-01	Intellikine, Inc.	Heterocyclic kinase inhibitors
US9771326B2 (en)	2012-11-20	2017-09-26	Biogen Ma Inc.	S1P and/or ATX modulating agents
CN104177209B (zh) *	2014-08-05	2015-12-02	太原理工大学	一种芳基末端炔的制备方法
CN110563673A (zh) *	2019-07-23	2019-12-13	武汉药明康德新药开发有限公司	一种(5-(4-(二氟甲氧基)-3-异丙氧基苯基)呋喃-3-基)甲醇的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU225920B1 (en) *	1994-01-19	2008-01-28	Sankyo Co	Pyrrolo[2,3-d]pyridazine derivatives, process for their preparation and pharmaceutical compositions containing them
MXPA02010763A (es)	2000-06-14	2003-03-10	Warner Lambert Co	Heterociclicos biciclos-6,5 fusionados.
ES2211344B1 (es) *	2002-12-26	2005-10-01	Almirall Prodesfarma, S.A.	Nuevos derivados de piridazin-3(2h)-ona.
AR070221A1 (es) *	2008-01-23	2010-03-25	Astrazeneca Ab	Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.

2007
- 2007-01-16 KR KR1020087020087A patent/KR20080094921A/ko not_active Abandoned
- 2007-01-16 JP JP2007553988A patent/JP5067165B2/ja not_active Expired - Fee Related
- 2007-01-16 ES ES07706860T patent/ES2383969T3/es active Active
- 2007-01-16 AT AT07706860T patent/ATE548369T1/de active
- 2007-01-16 WO PCT/JP2007/050533 patent/WO2007081030A1/ja not_active Ceased
- 2007-01-16 US US12/087,864 patent/US8450319B2/en not_active Expired - Fee Related
- 2007-01-16 AU AU2007205452A patent/AU2007205452B2/en not_active Ceased
- 2007-01-16 CN CN2007800024201A patent/CN101374844B/zh not_active Expired - Fee Related
- 2007-01-16 EP EP07706860A patent/EP1982986B1/de not_active Not-in-force
- 2007-01-16 CA CA2637388A patent/CA2637388C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2007205452A1 (en)	2007-07-19
JPWO2007081030A1 (ja)	2009-06-11
CN101374844B (zh)	2012-10-24
CN101374844A (zh)	2009-02-25
EP1982986B1 (de)	2012-03-07
US8450319B2 (en)	2013-05-28
JP5067165B2 (ja)	2012-11-07
CA2637388C (en)	2013-12-17
US20090036453A1 (en)	2009-02-05
AU2007205452A2 (en)	2008-10-30
EP1982986A1 (de)	2008-10-22
ES2383969T3 (es)	2012-06-27
KR20080094921A (ko)	2008-10-27
CA2637388A1 (en)	2007-07-19
AU2007205452B2 (en)	2012-04-12
EP1982986A4 (de)	2010-11-03
WO2007081030A1 (ja)	2007-07-19

Publication	Publication Date	Title
EP1591120A4 (de)	2009-06-10	Rezeptor-agonisten
EP1889842A4 (de)	2009-07-29	Heterozyklische verbindung
MX2011008305A (es)	2012-08-15	Compuestos de piridazinona.
WO2008146914A1 (ja)	2008-12-04	複素環化合物
WO2005116028A3 (en)	2006-03-30	Bicyclic heterocycles as kinase inhibitors
TW200710086A (en)	2007-03-16	Diaryl-substituted hetero 5-membered ring derivatives
CR9710A (es)	2008-04-16	Proceso para la preparacion de ciertos derivados de fenilpropargileter
WO2008145839A8 (fr)	2009-11-19	Dérivés de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur préparation et leur application en thérapeutique
WO2008140066A3 (en)	2008-12-31	Pyridone derivatives as p38a mapk inhibitors
EP1790636A4 (de)	2009-07-01	Piperidinderivate und deren anwendung
EA201200891A1 (ru)	2013-01-30	Производные 3,4,4a,10d-тетрагидро-1h-тиопирано[4,3-c]изохинолина
WO2006034093A3 (en)	2006-07-13	3- (2-acylamino-1-hydroxyethyl)- morpholine derivatives and their use as bace inhibitors
WO2009063990A1 (ja)	2009-05-22	ベンズアゼピノン化合物
GB0423405D0 (en)	2004-11-24	Organic compounds
WO2008033299A3 (en)	2008-11-20	Use of n-containing spirocompounds for the enhancement of cognitive function
WO2006030977A3 (en)	2006-07-13	Imidazole derivatives as large conductance calcium-activated k channel openers
WO2005035537A3 (en)	2005-06-09	Substituted tricyclic heterocycles and their uses
EP1982986A4 (de)	2010-11-03	Pyrrolopyridazinonverbindung
WO2005115984A3 (en)	2006-03-02	Large conductance calcium-activitated k channel opener
ATE516291T1 (de)	2011-07-15	Thenopyrimidin-verbindungen mit fungizider aktivität
WO2007062308A3 (en)	2007-10-04	Homo- and heterocyclic compounds suitable as cetp inhibitors
GB0412314D0 (en)	2004-07-07	Compounds
EP1726584A4 (de)	2009-05-13	2-aminochinazolinderivat
ATE486071T1 (de)	2010-11-15	Azabicycloä3.1.0ühexan-derivate als modulatoren des dopamin-d3-rezeptors
WO2006026034A3 (en)	2006-06-29	Processes for the preparation of isothiazole derivatives