ATE548389T1 - Therapeutische und diagnostische verfahren und zusammensetzungen zum targeting von 4ig-b7-h3 und dem entsprechenden nk-zellen-rezeptor - Google Patents
Therapeutische und diagnostische verfahren und zusammensetzungen zum targeting von 4ig-b7-h3 und dem entsprechenden nk-zellen-rezeptorInfo
- Publication number
- ATE548389T1 ATE548389T1 AT05775603T AT05775603T ATE548389T1 AT E548389 T1 ATE548389 T1 AT E548389T1 AT 05775603 T AT05775603 T AT 05775603T AT 05775603 T AT05775603 T AT 05775603T AT E548389 T1 ATE548389 T1 AT E548389T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- targeting
- therapeutic
- compositions
- cell receptor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59872704P | 2004-08-03 | 2004-08-03 | |
| PCT/IB2005/002688 WO2006016276A2 (en) | 2004-08-03 | 2005-08-02 | Therapeutic and diagnostic methods and compositions targeting 4ig-b7-h3 and its counterpart nk cell receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE548389T1 true ATE548389T1 (de) | 2012-03-15 |
Family
ID=35241619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05775603T ATE548389T1 (de) | 2004-08-03 | 2005-08-02 | Therapeutische und diagnostische verfahren und zusammensetzungen zum targeting von 4ig-b7-h3 und dem entsprechenden nk-zellen-rezeptor |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7732131B2 (de) |
| EP (2) | EP1773884B1 (de) |
| JP (2) | JP5130044B2 (de) |
| AT (1) | ATE548389T1 (de) |
| AU (1) | AU2005270918B2 (de) |
| CA (1) | CA2575607C (de) |
| DK (2) | DK2412728T3 (de) |
| ES (2) | ES2534288T3 (de) |
| WO (1) | WO2006016276A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001283507A1 (en) | 2000-07-27 | 2002-02-13 | Mayo Foundation For Medical Education And Research | B7-h3 and b7-h4, novel immunoregulatory molecules |
| EP1914242A1 (de) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Neue Antikörper gegen CD38 zur Behandlung von Krebs |
| AU2007325872B2 (en) * | 2006-11-08 | 2012-12-13 | Macrogenics West, Inc. | TES7 and antibodies that bind thereto |
| US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
| WO2008100934A1 (en) * | 2007-02-14 | 2008-08-21 | Mayo Foundation For Medical Education And Research | B7-h3 in cancer |
| JP5785490B2 (ja) | 2008-04-02 | 2015-09-30 | マクロジェニクス,インコーポレーテッド | Bcr複合体特異的抗体およびその使用方法 |
| WO2009129333A1 (en) * | 2008-04-15 | 2009-10-22 | Oxigene, Inc. | Methods for enhancing the efficacy of vascular disrupting agents |
| FR2937470B1 (fr) | 2008-10-16 | 2010-12-10 | Fibercryst | Systeme amplificateur optique pour laser impulsionnel a base d'un milieu a gain guidant et laser impulisionnel le comprenant |
| EP2399130A4 (de) * | 2009-02-20 | 2012-06-06 | Wayne John Cancer Inst | Assay mit b7-h3-antikörper-gekoppelten kügelchen zur isolation und erkennung zirkulierender tumorzellen in körperflüssigkeiten von melanom- und brustkrebspatienten |
| CA2772204A1 (en) | 2009-08-31 | 2011-03-03 | Amplimmune, Inc. | Methods and compositions for the inhibition of transplant rejection |
| HUE052213T2 (hu) | 2009-11-06 | 2021-04-28 | Univ Leland Stanford Junior | Grafitkilökõdés nem invazív diagnosztizálása szervátültetett betegekben |
| PH12018501083A1 (en) | 2010-03-04 | 2019-02-18 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| WO2012004410A1 (en) * | 2010-07-09 | 2012-01-12 | Oslo Universitetssykehus Hf | B7-h3 antagonists and taxanes |
| KR102030987B1 (ko) * | 2011-04-25 | 2019-11-11 | 다이이찌 산쿄 가부시키가이샤 | 항 b7-h3항체 |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| KR20160135190A (ko) * | 2014-02-14 | 2016-11-25 | 앤드류 에스. 카이 | 혈관형성 암의 치료를 위한 개선된 방법 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| AU2016282723B2 (en) | 2015-06-22 | 2021-09-23 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (ADCs) and antibody prodrug conjugates (APDCs) with enzymatically cleavable groups |
| CN107850596B (zh) | 2015-07-24 | 2020-12-04 | 先天制药公司 | 用于检测组织浸润nk细胞的方法 |
| CN108136010A (zh) | 2015-10-08 | 2018-06-08 | 宏观基因有限公司 | 用于治疗癌症的联合疗法 |
| JP7251981B2 (ja) | 2016-03-24 | 2023-04-04 | バイエル ファーマ アクチエンゲゼルシャフト | 酵素開裂基を有する細胞毒性活性剤のプロドラッグ |
| CA3020864A1 (en) | 2016-04-15 | 2017-10-19 | Macrogenics, Inc. | Novel b7-h3-binding molecules, antibody drug conjugates thereof and methods of use thereof |
| WO2017216028A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| CN109863175A (zh) | 2016-10-21 | 2019-06-07 | 依奈特制药公司 | 用抗-kir3dl2药剂进行的治疗 |
| KR102556826B1 (ko) | 2016-12-21 | 2023-07-18 | 바이엘 파마 악티엔게젤샤프트 | 효소적으로 절단가능한 기를 갖는 항체 약물 접합체 (adc) |
| CA3047491A1 (en) | 2016-12-21 | 2018-06-28 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| WO2018114804A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
| WO2020102779A1 (en) * | 2018-11-16 | 2020-05-22 | Albert Einstein College Of Medicine | MONOCLONAL ANTIBODIES AGAINST IgV DOMAIN OF B7-H3 AND USES THEREOF |
| CN113151285B (zh) * | 2019-12-30 | 2023-01-24 | 白素梅 | 人4IgB7-H3的突变编码基因及其调节免疫的应用 |
| KR20230019949A (ko) * | 2020-06-03 | 2023-02-09 | 리젠츠 오브 더 유니버시티 오브 미네소타 | B7h3-표적화 단백질 및 이의 사용 방법 |
Family Cites Families (44)
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| FR401702A (fr) | 1908-08-04 | 1909-09-13 | Charles Marenghi Et Cie Soc | Dispositif permettant d'imiter mécaniquement la mandoline |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| FR2604092B1 (fr) | 1986-09-19 | 1990-04-13 | Immunotech Sa | Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo |
| ATE159982T1 (de) | 1988-09-15 | 1997-11-15 | Univ Columbia | Antikörper mit modifiziertem kohlenhydratgehalt und verfahren zur herstellung und verwendung |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
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| DK0615451T3 (da) | 1992-05-26 | 2006-04-24 | Immunex Corp | Hidtil ukendt cytokin der binder til CD30 |
| US5539094A (en) | 1993-11-12 | 1996-07-23 | La Jolla Cancer Research Foundation | DNA encoding Bcl-2-associated proteins |
| US5583034A (en) | 1994-02-22 | 1996-12-10 | La Jolla Institute For Allergy And Immunology | Enhancement of adoptosis using antisense oligonucleotides |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| WO1996002555A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6936439B2 (en) | 1995-11-22 | 2005-08-30 | Amgen Inc. | OB fusion protein compositions and methods |
| ATE365562T1 (de) | 1996-05-03 | 2007-07-15 | Immunomedics Inc | Zielgerichtete kombinations-immuntherapie für krebs |
| US6750044B1 (en) | 1996-10-17 | 2004-06-15 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids |
| WO1999046281A2 (en) | 1998-03-10 | 1999-09-16 | Genentech, Inc. | Novel polypeptides and nucleic acids encoding the same |
| CA2275183A1 (en) | 1996-12-20 | 1998-07-02 | Amgen Inc. | Ob fusion protein compositions and methods |
| DE69840723D1 (de) | 1997-02-11 | 2009-05-20 | Immunomedics Inc | Stimulation einer immunantwort durch antikörper, welche mit dem alpha-galaktosylepitop markiert sind |
| JPH11279009A (ja) | 1998-03-26 | 1999-10-12 | Sumitomo Chem Co Ltd | 除草剤組成物 |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| WO2000014207A2 (en) | 1998-09-08 | 2000-03-16 | E.I. Du Pont De Nemours And Company | Plant farnesyltransferases |
| IL145941A (en) | 1999-04-28 | 2007-08-19 | Univ Texas | Compositions and methods for cancer treatment by selectively inhibiting vegf |
| AU4640600A (en) | 1999-05-11 | 2000-11-21 | Eli Lilly And Company | Amyloid precursor protein protease and related nucleic acid compounds |
| KR20020018197A (ko) | 1999-05-19 | 2002-03-07 | 추후보정 | Fc 융합 단백질로서의 인터페론-알파 단백질의 발현 및분비 |
| EP1067182A3 (de) | 1999-07-08 | 2001-11-21 | Helix Research Institute | Sekretorische- oder Membranproteine |
| US6429303B1 (en) | 1999-09-03 | 2002-08-06 | Curagen Corporation | Nucleic acids encoding members of the human B lymphocyte activation antigen B7 family and methods of using the same |
| AU783899B2 (en) | 1999-11-15 | 2005-12-22 | Innate Pharma S.A.S. | Novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells, and antibodies that identify the same |
| FR2804027B1 (fr) | 2000-01-20 | 2002-08-30 | Monoclonal Antibodies Therapeu | Utilisation d'anticorps monoclonaux anti-ferritines dans le traitement de certains cancers |
| WO2001094413A2 (en) | 2000-06-06 | 2001-12-13 | Bristol-Myers Squibb Company | B7-related nucleic acids and polypeptides and their uses for immunomodulation |
| US6635750B1 (en) | 2000-07-20 | 2003-10-21 | Millennium Pharmaceuticals, Inc. | B7-H2 nucleic acids, members of the B7 family |
| AU2001283507A1 (en) | 2000-07-27 | 2002-02-13 | Mayo Foundation For Medical Education And Research | B7-h3 and b7-h4, novel immunoregulatory molecules |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| US7740845B2 (en) * | 2000-10-18 | 2010-06-22 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| CA2423843A1 (en) | 2000-10-18 | 2002-04-25 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8h9 |
| US7399595B2 (en) | 2000-12-18 | 2008-07-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Means for the diagnosis and therapy of CTCL |
| KR100988949B1 (ko) | 2001-10-25 | 2010-10-20 | 제넨테크, 인크. | 당단백질 조성물 |
| EP1516054B1 (de) | 2002-02-10 | 2009-12-02 | Topotarget Switzerland SA | Fusionkonstrukte, enthaltend aktive abschnitte von tnf-liganden |
| EP1369128A1 (de) | 2002-06-07 | 2003-12-10 | Procorde GmbH | Glycoprotein VI Inhibitoren und deren therapeutische Verwendung |
| ATE488530T1 (de) | 2002-06-19 | 2010-12-15 | Raven Biotechnologies Inc | Internalisierende antikörper spezifisch für das raag10 zelloberflächenziel |
| EP2292264A3 (de) | 2003-07-24 | 2012-12-19 | Innate Pharma | Methoden und Zusammensetzungen zur Erhöhung der Wirksamkeit von therapeutischen Antikörper unter Verwendung von Verbindungen, die NK-Zellen potenzieren |
-
2005
- 2005-08-02 ES ES11186925.1T patent/ES2534288T3/es not_active Expired - Lifetime
- 2005-08-02 AT AT05775603T patent/ATE548389T1/de active
- 2005-08-02 WO PCT/IB2005/002688 patent/WO2006016276A2/en not_active Ceased
- 2005-08-02 CA CA2575607A patent/CA2575607C/en not_active Expired - Lifetime
- 2005-08-02 DK DK11186925T patent/DK2412728T3/en active
- 2005-08-02 ES ES05775603T patent/ES2381557T3/es not_active Expired - Lifetime
- 2005-08-02 JP JP2007524425A patent/JP5130044B2/ja not_active Expired - Fee Related
- 2005-08-02 DK DK05775603.3T patent/DK1773884T3/da active
- 2005-08-02 AU AU2005270918A patent/AU2005270918B2/en not_active Ceased
- 2005-08-02 US US11/659,175 patent/US7732131B2/en active Active
- 2005-08-02 EP EP05775603A patent/EP1773884B1/de not_active Expired - Lifetime
- 2005-08-02 EP EP11186925.1A patent/EP2412728B1/de not_active Expired - Lifetime
-
2010
- 2010-05-07 US US12/775,531 patent/US8465931B2/en not_active Expired - Fee Related
-
2012
- 2012-06-20 JP JP2012138816A patent/JP5560301B2/ja not_active Expired - Fee Related
-
2013
- 2013-06-07 US US13/912,333 patent/US20130315892A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006016276A3 (en) | 2006-05-04 |
| WO2006016276A2 (en) | 2006-02-16 |
| JP5130044B2 (ja) | 2013-01-30 |
| AU2005270918B2 (en) | 2011-03-03 |
| EP2412728B1 (de) | 2015-01-07 |
| ES2381557T3 (es) | 2012-05-29 |
| DK1773884T3 (da) | 2012-05-21 |
| ES2534288T3 (es) | 2015-04-21 |
| DK2412728T3 (en) | 2015-04-07 |
| JP2012197311A (ja) | 2012-10-18 |
| CA2575607A1 (en) | 2006-02-16 |
| EP1773884B1 (de) | 2012-03-07 |
| US7732131B2 (en) | 2010-06-08 |
| AU2005270918A1 (en) | 2006-02-16 |
| EP1773884A2 (de) | 2007-04-18 |
| JP5560301B2 (ja) | 2014-07-23 |
| US20080081346A1 (en) | 2008-04-03 |
| US8465931B2 (en) | 2013-06-18 |
| EP2412728A3 (de) | 2012-05-02 |
| JP2008509130A (ja) | 2008-03-27 |
| US20130315892A1 (en) | 2013-11-28 |
| CA2575607C (en) | 2017-07-11 |
| US20100285531A1 (en) | 2010-11-11 |
| EP2412728A2 (de) | 2012-02-01 |
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