ATE55121T1 - Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln. - Google Patents
Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln.Info
- Publication number
- ATE55121T1 ATE55121T1 AT85115640T AT85115640T ATE55121T1 AT E55121 T1 ATE55121 T1 AT E55121T1 AT 85115640 T AT85115640 T AT 85115640T AT 85115640 T AT85115640 T AT 85115640T AT E55121 T1 ATE55121 T1 AT E55121T1
- Authority
- AT
- Austria
- Prior art keywords
- nitrodihydropyridine
- preparation
- optically active
- medicinal products
- heart muscle
- Prior art date
Links
- CYJZDIBYDLTAOK-UHFFFAOYSA-N 1-nitro-2h-pyridine Chemical compound [O-][N+](=O)N1CC=CC=C1 CYJZDIBYDLTAOK-UHFFFAOYSA-N 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 210000004165 myocardium Anatomy 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 230000009090 positive inotropic effect Effects 0.000 abstract 2
- 230000000304 vasodilatating effect Effects 0.000 abstract 2
- YLOHGCDNWWGUOY-UHFFFAOYSA-N 5-nitro-1,2-dihydropyridine Chemical compound [O-][N+](=O)C1=CNCC=C1 YLOHGCDNWWGUOY-UHFFFAOYSA-N 0.000 abstract 1
- 230000000297 inotrophic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003639 vasoconstrictive effect Effects 0.000 abstract 1
- 239000005526 vasoconstrictor agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843447169 DE3447169A1 (de) | 1984-12-22 | 1984-12-22 | Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| EP85115640A EP0186028B1 (de) | 1984-12-22 | 1985-12-09 | Optisch aktive Nitrodihydropyridine, Verfahren zur Herstellung und ihre Verwendung in Arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE55121T1 true ATE55121T1 (de) | 1990-08-15 |
Family
ID=6253728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85115640T ATE55121T1 (de) | 1984-12-22 | 1985-12-09 | Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4764516A (de) |
| EP (1) | EP0186028B1 (de) |
| JP (1) | JPS61155369A (de) |
| AT (1) | ATE55121T1 (de) |
| CA (1) | CA1277984C (de) |
| DE (2) | DE3447169A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3447170A1 (de) * | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| DE3517473A1 (de) * | 1985-05-15 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | Pyrimidinyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| DE3737341A1 (de) * | 1987-11-04 | 1989-05-18 | Bayer Ag | Neue fluormethoxyphenyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| DE3737340A1 (de) * | 1987-11-04 | 1989-05-24 | Bayer Ag | Neue fluormethoxyphenyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| IT1230752B (it) * | 1989-02-17 | 1991-10-29 | Boehringer Biochemia Srl | Processo per la preparazione di 1,4 diidropiridine polisostituite in forma enantiomericamente pura. |
| US5254692A (en) * | 1990-04-06 | 1993-10-19 | Bayer Aktiengesellschaft | 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines |
| DE4011105A1 (de) * | 1990-04-06 | 1991-10-10 | Bayer Ag | Neue 4-chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| DE4202526A1 (de) * | 1992-01-30 | 1993-08-05 | Bayer Ag | Neue 4-cinnolinyl- und 4-naphthyridinyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2752820A1 (de) * | 1977-11-26 | 1979-05-31 | Bayer Ag | Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| SE429652B (sv) * | 1978-06-30 | 1983-09-19 | Haessle Ab | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
| DE2935451A1 (de) * | 1979-09-01 | 1981-03-19 | Bayer Ag, 5090 Leverkusen | Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel |
| US4442100A (en) * | 1979-12-11 | 1984-04-10 | Bayer Aktiengesellschaft | Substituted 2-amino-3,4-dihydropyridine derivatives, their production and their medicinal use |
| DE3018259A1 (de) * | 1980-05-13 | 1981-11-19 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
| DE3207982A1 (de) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln |
| WO1983003249A1 (fr) * | 1982-03-17 | 1983-09-29 | Yoshitomi Pharmaceutical | Derives de 1,4-dihydropyridine-3,5-dicarboxylate |
| FR2528431B1 (fr) * | 1982-06-15 | 1986-01-10 | Sandoz Sa | Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments |
| US4678796A (en) * | 1984-11-30 | 1987-07-07 | Warner-Lambert Company | 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders |
-
1984
- 1984-12-22 DE DE19843447169 patent/DE3447169A1/de not_active Withdrawn
-
1985
- 1985-12-06 US US06/806,071 patent/US4764516A/en not_active Expired - Fee Related
- 1985-12-09 EP EP85115640A patent/EP0186028B1/de not_active Expired - Lifetime
- 1985-12-09 AT AT85115640T patent/ATE55121T1/de not_active IP Right Cessation
- 1985-12-09 DE DE8585115640T patent/DE3578988D1/de not_active Expired - Lifetime
- 1985-12-20 JP JP60285853A patent/JPS61155369A/ja active Pending
- 1985-12-20 CA CA000498247A patent/CA1277984C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61155369A (ja) | 1986-07-15 |
| EP0186028A3 (en) | 1988-05-25 |
| DE3447169A1 (de) | 1986-07-03 |
| EP0186028B1 (de) | 1990-08-01 |
| DE3578988D1 (de) | 1990-09-06 |
| EP0186028A2 (de) | 1986-07-02 |
| US4764516A (en) | 1988-08-16 |
| CA1277984C (en) | 1990-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |