ATE551604T1 - Verfahren zur beurteilung der löslichkeit eines kristallinen stoffes in einem polymer - Google Patents

Verfahren zur beurteilung der löslichkeit eines kristallinen stoffes in einem polymer

Info

Publication number
ATE551604T1
ATE551604T1 AT09742017T AT09742017T ATE551604T1 AT E551604 T1 ATE551604 T1 AT E551604T1 AT 09742017 T AT09742017 T AT 09742017T AT 09742017 T AT09742017 T AT 09742017T AT E551604 T1 ATE551604 T1 AT E551604T1
Authority
AT
Austria
Prior art keywords
drug
solubility
polymer
crystalline
solids
Prior art date
Application number
AT09742017T
Other languages
English (en)
Inventor
Geoff Zhang
Lian Yu
Jing Tao
Ye Sun
Markus Maegerlein
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Application granted granted Critical
Publication of ATE551604T1 publication Critical patent/ATE551604T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
    • G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample
    • G01N25/4866—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample by using a differential method

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
AT09742017T 2008-05-05 2009-04-29 Verfahren zur beurteilung der löslichkeit eines kristallinen stoffes in einem polymer ATE551604T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5041308P 2008-05-05 2008-05-05
PCT/EP2009/055233 WO2009135799A2 (en) 2008-05-05 2009-04-29 Method for evaluating the solubility of a crystalline substance in a polymer

Publications (1)

Publication Number Publication Date
ATE551604T1 true ATE551604T1 (de) 2012-04-15

Family

ID=41010395

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09742017T ATE551604T1 (de) 2008-05-05 2009-04-29 Verfahren zur beurteilung der löslichkeit eines kristallinen stoffes in einem polymer

Country Status (6)

Country Link
US (1) US9004752B2 (de)
EP (1) EP2274609B1 (de)
AT (1) ATE551604T1 (de)
CA (1) CA2723398C (de)
HR (1) HRP20120475T1 (de)
WO (1) WO2009135799A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2526413A1 (de) 2010-01-22 2012-11-28 Abbott GmbH & Co. KG Verfahren zur beurteilung der löslichkeit eines kristallinen stoffes in einem polymer
WO2013056108A2 (en) * 2011-10-14 2013-04-18 Array Biopharma Inc. Solid dispersion
CN104483343B (zh) * 2014-12-29 2017-11-14 成都光明光电股份有限公司 晶化热处理的温度测量方法
EP4220159A1 (de) * 2022-01-27 2023-08-02 Fundació Institut de Recerca Biomèdica (IRB Barcelona) Wirkstoffentdeckungstest zum screening von verbindungen
CN116813542A (zh) * 2022-03-21 2023-09-29 山东新时代药业有限公司 米力农的药物多晶体

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE36736E (en) * 1989-02-06 2000-06-13 Hoffman-La Roche Inc. Substituted pyrroles
US4908801A (en) * 1989-05-30 1990-03-13 Teledyne Exploration Real-time simulation of the far-field signature of a seismic sound source array
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes
TW448160B (en) * 1993-12-28 2001-08-01 Merck & Co Inc Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
DE19903333A1 (de) * 1999-01-28 2000-08-10 Consortium Elektrochem Ind Herstellung von alpha, beta-ungesättigte Carbonsäurereste enthaltenden Organosiliciumverbindungen
US6469179B1 (en) * 2000-10-03 2002-10-22 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
FR2815718B1 (fr) * 2000-10-20 2002-12-06 Inst Francais Du Petrole Methode d'evaluation de la temperature de transition vitreuse d'une piece en polymere en cours d'utilisation
US20020161168A1 (en) * 2000-10-27 2002-10-31 Shalaby Shalaby W. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
JP2005532994A (ja) * 2002-01-24 2005-11-04 ロレアル 半結晶性重合体およびエステルを含む組成物
JP4520719B2 (ja) * 2003-10-09 2010-08-11 東セロ株式会社 熱融着性プロピレン系重合体積層フィルム及びその用途
CA2611081C (en) * 2005-06-03 2016-05-31 Egalet A/S A drug delivery system for delivering active substances dispersed in a dispersion medium
JP2009510213A (ja) * 2005-09-26 2009-03-12 ディーエスエム アイピー アセッツ ビー．ブイ． ポリマー粒子の被覆のための方法
US7713595B2 (en) * 2005-10-18 2010-05-11 Nitto Denko Corporation Optical compensation films produced by a carrier-web-casting process
KR20080086480A (ko) * 2005-12-02 2008-09-25 후지필름 가부시키가이샤 광학 보상 필름, 편광판 및 액정 디스플레이 장치
GB0612929D0 (en) * 2006-06-29 2006-08-09 Univ Cambridge Tech High-performance organic field-effect transistors based on dilute, crystalline-crystalline polymer blends and block copolymers
JP2008052041A (ja) * 2006-08-24 2008-03-06 Fujifilm Corp 光学フィルム、偏光板、液晶表示装置
FR2930947B1 (fr) * 2008-05-07 2011-03-11 Arkema France Composition renfermant un polymere vinylique halogene et un copolymere porteur de groupes associatifs
US8158245B2 (en) * 2009-09-24 2012-04-17 Cytec Technology Corp. Thermoplastic composites and methods of making and using same
US20110256406A1 (en) * 2011-01-13 2011-10-20 Sabic Innovative Plastics Ip B.V. Laser Weldable Thermoplastic Polyester Composition
US20140012534A1 (en) * 2012-07-04 2014-01-09 Christopher D. Prest Non-destructive method to determine crystallinity in amorphous alloy using specific heat capacity

Also Published As

Publication number Publication date
CA2723398A1 (en) 2009-11-12
EP2274609B1 (de) 2012-03-28
US9004752B2 (en) 2015-04-14
WO2009135799A2 (en) 2009-11-12
WO2009135799A3 (en) 2010-01-28
HRP20120475T1 (hr) 2012-08-31
US20110261857A1 (en) 2011-10-27
EP2274609A2 (de) 2011-01-19
CA2723398C (en) 2017-07-04

Similar Documents

Publication Publication Date Title
Yang et al. Enhanced drug loading in the drug-in-adhesive transdermal patch utilizing a drug–ionic liquid strategy: insight into the role of ionic hydrogen bonding
Casian et al. Electrospun amorphous solid dispersions of meloxicam: Influence of polymer type and downstream processing to orodispersible dosage forms
Ewing et al. Stability of indomethacin with relevance to the release from amorphous solid dispersions studied with ATR-FTIR spectroscopic imaging
Prasad et al. Role of molecular interactions for synergistic precipitation inhibition of poorly soluble drug in supersaturated drug–polymer–polymer ternary solution
Liu et al. Effects of extrusion process parameters on the dissolution behavior of indomethacin in Eudragit® E PO solid dispersions
Çelik Risperidone mucoadhesive buccal tablets: formulation design, optimization and evaluation
ATE551604T1 (de) Verfahren zur beurteilung der löslichkeit eines kristallinen stoffes in einem polymer
Takano et al. Quantitative analysis of the effect of supersaturation on in vivo drug absorption
Pajander et al. Behaviour of HPMC compacts investigated using UV-imaging
Pawar et al. Design and evaluation of topical diclofenac sodium gel using hot melt extrusion technology as a continuous manufacturing process with Kolliphor® P407
Nagy et al. Use of supercritical CO2‐aided and conventional melt extrusion for enhancing the dissolution rate of an active pharmaceutical ingredient
Ha et al. Solvent effect and solubility modeling of rebamipide in twelve solvents at different temperatures
Velasco et al. pH-sensitive polymer hydrogels derived from morpholine to prevent the crystallization of ibuprofen
Gunnam et al. High-solubility salts of the multiple sclerosis drug teriflunomide
Port et al. Differential solution behavior of the new API–API co-crystal of tramadol–celecoxib (CTC) versus its constituents and their combination
US20130028955A1 (en) Sustained release oral matrix and methods of making thereof
Sheikh et al. Formulation design, characterization and in vitro drug release study of orodispersible film comprising BCS class II drugs.
Khonsari et al. Formulation and evaluation of in-vitro characterization of gastic-mucoadhesive microparticles/discs containing metformin hydrochloride
Uekusa et al. Precipitation behavior of pioglitazone on the particle surface of hydrochloride salt in biorelevant media
Bhola et al. Solubility modeling of a bupivacaine hydrochloride in various solvents over a wide temperature range
McCoy et al. Packing polymorphism of dapivirine and its impact on the performance of a dapivirine-releasing silicone elastomer vaginal ring
Isaac et al. Co-milling of telmisartan with poly (vinyl alcohol)–an alkalinizer free green approach to ensure its bioavailability
Raza et al. Self-assembled zein organogels as in situ forming implant drug delivery system and 3D printing ink
Drašković et al. Comprehensive evaluation of formulation factors affecting critical quality attributes of casted orally disintegrating films
He Integration of physical, chemical, mechanical, and biopharmaceutical properties in solid oral dosage form development