ATE551993T1 - Verfahren und reaktor zur herstellung von pulvern für inhalative medikamente - Google Patents

Verfahren und reaktor zur herstellung von pulvern für inhalative medikamente

Info

Publication number
ATE551993T1
ATE551993T1 AT03748117T AT03748117T ATE551993T1 AT E551993 T1 ATE551993 T1 AT E551993T1 AT 03748117 T AT03748117 T AT 03748117T AT 03748117 T AT03748117 T AT 03748117T AT E551993 T1 ATE551993 T1 AT E551993T1
Authority
AT
Austria
Prior art keywords
fluid
reactor
inhalative
medications
producing powders
Prior art date
Application number
AT03748117T
Other languages
English (en)
Inventor
Nathalie Jongen
Jacques Lemaitre
Paul Bowen
Marcel Donnet
Joerg Schiewe
Bernd Zierenberg
Lucica Soare
Original Assignee
Boehringer Ingelheim Pharma
Ecole Polytech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Ecole Polytech filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of ATE551993T1 publication Critical patent/ATE551993T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1688Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/005Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054Use of anti-solvent
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/0081Use of vibrations, e.g. ultrasound
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • B01F33/302Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0413Numerical information
    • B01F2215/0418Geometrical information
    • B01F2215/0431Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00788Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00873Heat exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00925Irradiation
    • B01J2219/00932Sonic or ultrasonic vibrations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03748117T 2002-10-17 2003-10-06 Verfahren und reaktor zur herstellung von pulvern für inhalative medikamente ATE551993T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02023273 2002-10-17
PCT/EP2003/011010 WO2004034943A2 (en) 2002-10-17 2003-10-06 Process and reactor for the manufacture of powders of inhalable medicaments

Publications (1)

Publication Number Publication Date
ATE551993T1 true ATE551993T1 (de) 2012-04-15

Family

ID=32103884

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03748117T ATE551993T1 (de) 2002-10-17 2003-10-06 Verfahren und reaktor zur herstellung von pulvern für inhalative medikamente

Country Status (6)

Country Link
EP (1) EP1585585B1 (de)
JP (1) JP5172075B2 (de)
AT (1) ATE551993T1 (de)
AU (1) AU2003267433A1 (de)
CA (1) CA2502502C (de)
WO (1) WO2004034943A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0302029D0 (sv) * 2003-07-07 2003-07-07 Astrazeneca Ab Novel process
US20060120213A1 (en) * 2004-11-17 2006-06-08 Tonkovich Anna L Emulsion process using microchannel process technology
EP2263789A1 (de) * 2006-05-11 2010-12-22 Corning Incorporated Hoch-Durchsatz Mikroreaktoren mit Temperaturkontrolle und Verfahren
US9855538B2 (en) 2013-03-08 2018-01-02 The Board Of Trustees Of The University Of Illinois Ultrasonic method and apparatus for producing particles having a controlled size distribution
FI20146163A (fi) * 2014-12-30 2016-07-01 Lappeenrannan Teknillinen Yliopisto Menetelmä ja laite jatkuvatoimiseen kiteytykseen ja niiden käyttö
CN112358521B (zh) * 2019-10-15 2022-02-01 河南利华制药有限公司 一种利用切向流管式反应器合成倍他米松的生产工艺
CN110922363A (zh) * 2019-12-28 2020-03-27 新华制药(寿光)有限公司 一种紫脲酸连续化生产工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1262240B (de) * 1964-11-14 1968-03-07 Helmut Pelzer Dipl Chem Dr Verfahren zur Herstellung feinster Teilchen kristallisierbarer Verbindungen
DE69707288T2 (de) * 1996-07-15 2002-07-18 Calcitech Ltd., Hamilton Herstellung von pulvern
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
GB9919693D0 (en) * 1999-08-19 1999-10-20 Rhone Poulenc Rorer Ltd Process
GB0016002D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
EP1409101B1 (de) * 2001-05-05 2006-04-12 Accentus plc Bildung kleiner krsitalle

Also Published As

Publication number Publication date
WO2004034943A3 (en) 2004-05-27
CA2502502C (en) 2013-06-25
CA2502502A1 (en) 2004-04-29
EP1585585A2 (de) 2005-10-19
WO2004034943A2 (en) 2004-04-29
AU2003267433A1 (en) 2004-05-04
AU2003267433A8 (en) 2004-05-04
EP1585585B1 (de) 2012-04-04
JP5172075B2 (ja) 2013-03-27
JP2006504746A (ja) 2006-02-09

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