ATE552253T1 - 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren - Google Patents

3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren

Info

Publication number: ATE552253T1
Authority: AT; Austria
Prior art keywords: receptors; substituted; compounds; aryl; ligands
Prior art date: 2002-11-08

Application number

AT03768799T

Other languages

English (en)

Inventor

Alan Hutchison

Jun Yuan

Kyungae Lee

George Maynard

Bertrand Chenard

Nian Liu

Qin Guo

Zihong Guo

Peter Hrnciar

Original Assignee

Novartis Int Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-08

Filing date

2003-11-07

Publication date

2012-04-15

2003-11-07 Application filed by Novartis Int Pharm Ltd filed Critical Novartis Int Pharm Ltd

2012-04-15 Application granted granted Critical

2012-04-15 Publication of ATE552253T1 publication Critical patent/ATE552253T1/de

Links

102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 title abstract 5
108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 title abstract 5
239000003446 ligand Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 4
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
229940125425 inverse agonist Drugs 0.000 abstract 1
230000004807 localization Effects 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000523 sample Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT03768799T 2002-11-08 2003-11-07 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren ATE552253T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42528102P	2002-11-08	2002-11-08
PCT/US2003/035694 WO2004043925A2 (en)	2002-11-08	2003-11-07	3-substituted-6-aryl pyridined as ligands of c5a receptors

Publications (1)

Publication Number	Publication Date
ATE552253T1 true ATE552253T1 (de)	2012-04-15

Family

ID=32312963

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03768799T ATE552253T1 (de)	2002-11-08	2003-11-07	3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren

Country Status (6)

Country	Link
US (3)	US7342115B2 (de)
EP (1)	EP1565452B1 (de)
AT (1)	ATE552253T1 (de)
AU (1)	AU2003291403A1 (de)
CA (1)	CA2504941C (de)
WO (1)	WO2004043925A2 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2366655C2 (ru) *	2003-03-14	2009-09-10	Оно Фармасьютикал Ко., Лтд.	Азотсодержащие гетероциклические производные и лекарственные средства, содержащие их в качестве активного ингредиента
EP1670794A2 (de)	2003-09-30	2006-06-21	Amgen Inc.	Vanilloidrezeptorliganden und deren verwendung bei behandlungen
EP1775295A1 (de) *	2003-09-30	2007-04-18	Amgen Inc.	Vanilloidrezeptorliganden und deren Verwendung in Behandlungen
ES2611018T3 (es) *	2004-04-08	2017-05-04	Dow Agrosciences Llc	Sulfoximinas N-sustituidas insecticidas
JP4906715B2 (ja) *	2004-05-08	2012-03-28	ニューロジェン・コーポレーション	４，５−ジ置換−２−アリールピリミジン類
US8143404B2 (en)	2004-09-13	2012-03-27	Ono Pharmaceutical Co., Ltd	Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient
ES2382068T3 (es)	2004-12-28	2012-06-05	Kinex Pharmaceuticals, Llc	Composiciones y métodos para tratar trastornos de proliferación celular
US7968574B2 (en)	2004-12-28	2011-06-28	Kinex Pharmaceuticals, Llc	Biaryl compositions and methods for modulating a kinase cascade
GT200600042A (es) *	2005-02-10	2006-09-27	Aventis Pharma Inc	Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
EP2343304B1 (de)	2005-02-16	2015-06-10	Anacor Pharmaceuticals, Inc.	Biozide Boronophthalidverbindungen
US20060258691A1 (en) *	2005-05-13	2006-11-16	Joseph Barbosa	Methods and compositions for improving cognition
ES2434467T3 (es) *	2005-05-13	2013-12-16	Lexicon Pharmaceuticals, Inc.	Compuestos multicíclicos y métodos para su uso
EP1739078A1 (de)	2005-05-30	2007-01-03	Jerini AG	C5a-Rezeptor-Antagonisten
CA2654440C (en) *	2005-06-06	2013-09-03	Girish J. Kotwal	Methods for treatment or prophylaxis of atherosclerosis and reperfusion injury
WO2007034406A1 (en) *	2005-09-22	2007-03-29	Actelion Pharmaceuticals Ltd	Pyrrolidine-3-carboxylic acid amide derivatives and their use as inhibitors of renin
KR20080086917A (ko) *	2005-12-29	2008-09-26	노파르티스 아게	콜레스테릴 에스테르 전달 단백질 (ｃｅｔｐ) 억제제로서의피리디닐 아민 유도체
MX335993B (es) *	2005-12-30	2016-01-07	Anacor Pharmaceuticals Inc	Moleculas pequeñas que contienen boro.
KR20080110984A (ko)	2005-12-30	2008-12-22	아나코르 파마슈티칼스 인코포레이티드	보론함유 소분자
TW201309635A (zh) *	2006-02-10	2013-03-01	Dow Agrosciences Llc	殺蟲性之ｎ-取代（６-鹵烷基吡啶-３-基）烷基磺醯亞胺（二）
CA2644368A1 (en) *	2006-03-10	2007-09-20	Ono Pharmaceutical Co., Ltd.	Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
CA2649288C (en)	2006-04-19	2015-11-24	Novartis Ag	6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling
US8232403B2 (en)	2006-05-10	2012-07-31	Novartis Ag	Bicyclic derivatives as CETP inhibitors
TWI381811B (zh) *	2006-06-23	2013-01-11	Dow Agrosciences Llc	用以防治可抵抗一般殺蟲劑之昆蟲的方法
JP5564251B2 (ja)	2006-06-29	2014-07-30	キネックスファーマシューティカルズ，エルエルシー	キナーゼカスケードを調節するためのビアリール組成物および方法
TWI387585B (zh) *	2006-09-01	2013-03-01	Dow Agrosciences Llc	殺蟲性之ｎ-取代（雜芳基）烷基烴基硫亞胺
EP2338884A1 (de) *	2006-09-01	2011-06-29	Dow AgroSciences LLC	N-Substituierte(2-Substituierte-1,3-Thiazol)Alkyl-Sulfoximine als Insektizide
TW200827345A (en) *	2006-11-07	2008-07-01	Lexicon Pharmaceuticals Inc	(R)-phenyl(heterocycle)methanol-based compounds, compositions comprising them and methods of their use
TW200823193A (en) *	2006-11-07	2008-06-01	Lexicon Pharmaceuticals Inc	(S)-phenyl(heterocycle)methanol-based compounds, compositions comprising them and methods of their use
TWI395737B (zh) *	2006-11-08	2013-05-11	Dow Agrosciences Llc	作為殺蟲劑之雜芳基（取代的）烷基ｎ-取代的磺醯亞胺
DE102006059710A1 (de) *	2006-12-18	2008-06-19	Freie Universität Berlin	Substituierte 4-Hydroxypyridine
EP1939180A1 (de) *	2006-12-20	2008-07-02	sanofi-aventis	Heteroarylacrylamide und ihre Verwendung als Arzneimittel für die Stimulation der Expression der endothelialen NO-Synthase
US7935697B2 (en)	2006-12-28	2011-05-03	Kinex Pharmaceuticals, Llc	Compositions for modulating a kinase cascade and methods of use thereof
US7939529B2 (en)	2007-05-17	2011-05-10	Kinex Pharmaceuticals, Llc	Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
US7709648B2 (en) *	2007-02-09	2010-05-04	Dow Agrosciences Llc	Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines
AR066366A1 (es) *	2007-05-01	2009-08-12	Dow Agrosciences Llc	Mezclas sinergicas plaguicidas
US8124605B2 (en)	2007-07-06	2012-02-28	Kinex Pharmaceuticals, Llc	Compositions and methods for modulating a kinase cascade
ATE523083T1 (de) *	2007-07-20	2011-09-15	Dow Agrosciences Llc	Erhöhte pflanzenvitalität
DE102007042754A1 (de)	2007-09-07	2009-03-12	Bayer Healthcare Ag	Substituierte 6-Phenylnikotinsäuren und ihre Verwendung
RU2010116821A (ru)	2007-10-01	2011-11-10	Ф.Хоффманн-Ля Аг (Ch)	N-гетероциклические биарильные карбоксамиды в качестве антагонистов рецептора ccr
EP2268615B1 (de) *	2008-03-03	2016-08-17	Dow AgroSciences LLC	Pestizide
AU2009259496A1 (en) *	2008-06-18	2009-12-23	F. Hoffmann-La Roche Ag	Novel heteroaryl carboxamide derivatives
RS54998B1 (sr)	2008-12-22	2016-11-30	Chemocentryx Inc	Antagonisti c5ar
AU2010264720A1 (en)	2009-06-24	2011-12-08	Boehringer Ingelheim International Gmbh	New compounds, pharmaceutical composition and methods relating thereto
AR077214A1 (es)	2009-06-24	2011-08-10	Neurocrine Biosciences Inc	Heterociclos nitrogenados y composiciones farmaceuticas que los contienen
MX2012006776A (es)	2009-12-14	2012-10-05	Merck Patent Gmbh	Inhibidores de la esfingosina quinasa.
WO2011129936A2 (en)	2010-04-16	2011-10-20	Kinex Pharmaceuticals, Llc	Compositions and methods for the prevention and treatment of cancer
US8802058B2 (en) *	2010-04-19	2014-08-12	Gelmed, Llc	Pharmaceutical compositions and methods for administering the same
RS56332B1 (sr)	2010-06-24	2017-12-29	Chemocentryx Inc	Antagonisti c5ar
US9394290B2 (en) *	2010-10-21	2016-07-19	Universitaet Des Saarlandes Campus Saarbruecken	Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
CN102850321A (zh) *	2011-06-28	2013-01-02	中国科学院上海药物研究所	芳香氧基嘧啶甲酰胺或芳香氧基吡啶甲酰胺类化合物及其制备方法、药物组合物和用途
JP6006794B2 (ja) *	2011-07-29	2016-10-12	カリオファームセラピューティクス，インコーポレイテッド	核内輸送調節因子およびその使用
EP4234545A3 (de)	2011-07-29	2023-09-06	Karyopharm Therapeutics Inc.	Hydrazidhaltige kerntransportmodulatoren und verwendungen davon
US10531655B2 (en)	2011-12-02	2020-01-14	The Regents Of The University Of California	Reperfusion protection solution and uses thereof
WO2013170068A2 (en)	2012-05-09	2013-11-14	Karyopharm Therapeutics, Inc.	Nuclear transport modulators and uses thereof
EP2861590B1 (de) *	2012-06-15	2017-10-25	Curegenix Inc.	Verbindung als wnt-signalübertragungshemmer, zusammensetzung und verwendung davon
CA2883144C (en)	2012-08-30	2023-01-17	Kinex Pharmaceuticals, Llc	N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl) acetamide as protein\|tyrosine kinase modulators
CN105142641A (zh)	2013-03-12	2015-12-09	广州源生医药科技有限公司	用于治疗癌症的化合物
EP2968278B8 (de)	2013-03-15	2019-05-22	Karyopharm Therapeutics Inc.	Verfahren zur förderung der wundheilung mit crm1-inhibitoren
MX2015014688A (es)	2013-04-22	2016-02-19	Abbvie Inc	Tiazoles y usos de los mismos.
ME03421B (de)	2013-06-21	2020-01-20	Karyopharm Therapeutics Inc	1,2,4-triazole als nukleartransportmodulatoren und verwendungen davon
CN106660956A (zh)	2014-01-27	2017-05-10	弗特鲁斯控股有限责任公司	制备2‑氯‑5‑甲基吡啶的方法
KR102608259B1 (ko)	2014-08-15	2023-11-29	카리오팜 쎄라퓨틱스, 인코포레이티드	셀리넥소의 다형태
DK3200791T3 (da)	2014-09-29	2020-05-25	Chemocentryx Inc	Fremgangsmåder og mellemprodukter i fremstilling af C5AR- antagonister
CN107530302A (zh) *	2015-03-04	2018-01-02	丹娜法伯癌症研究院	Melk的水杨酸酯抑制剂和使用方法
US20180243370A1 (en) *	2015-09-14	2018-08-30	Children's Hospital Medical Center	Methods and compositions for treatment of gaucher disease via modulation of c5a receptor
US12084472B2 (en)	2015-12-18	2024-09-10	Ardelyx, Inc.	Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
TWI773657B (zh)	2015-12-18	2022-08-11	美商亞德利克斯公司	作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物
EP3397634A1 (de)	2015-12-31	2018-11-07	Karyopharm Therapeutics, Inc.	Nukleartransportmodulatoren und verwendungen davon
US10526295B2 (en)	2015-12-31	2020-01-07	Karyopharm Therapeutics Inc.	Nuclear transport modulators and uses thereof
JP7339733B2 (ja)	2016-01-14	2023-09-06	ケモセントリックス，インコーポレイティド	Ｃ３腎症を処置する方法
EP3439658B1 (de)	2016-04-04	2021-11-24	ChemoCentryx, Inc.	Lösliche c5ar-antagonisten
US11602530B2 (en)	2016-11-28	2023-03-14	Biogen Ma Inc.	CRM1 inhibitors for treating epilepsy
JP2017095498A (ja) *	2017-01-18	2017-06-01	キュアジェニックスインコーポレイテッド	Ｗｎｔシグナリング阻害剤、組成物およびその用途としての化合物
US10562896B2 (en)	2017-05-31	2020-02-18	Chemocentryx, Inc.	6-5 fused rings as C5a inhibitors
WO2018222601A1 (en)	2017-05-31	2018-12-06	Chemocentryx, Inc.	5-5 FUSED RINGS AS C5a INHIBITORS
CA3077395A1 (en)	2017-10-30	2019-05-09	Chemocentryx, Inc.	Deuterated compounds as immunomodulators
WO2019126424A1 (en)	2017-12-22	2019-06-27	Chemocentryx, Inc.	DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
MX2020006460A (es)	2017-12-22	2020-11-06	Chemocentryx Inc	Compuestos de anillo 5,5 fusionado sustituido con diarilo como inhibidores de c5ar.
MX2020009517A (es) *	2018-03-13	2021-01-20	Jubilant Prodel LLC	Compuestos biciclicos como inhibidores de la interaccion/activacio n de pdl/pd-l1.
BR112020019822A2 (pt)	2018-04-02	2021-03-16	Chemocentryx, Inc.	Profármacos de antagonistas bicíclicos fundidos de c5ar

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1180268A (en) *	1967-09-26	1970-02-04	Ici Ltd	Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives
GB1188416A (en) *	1968-04-01	1970-04-15	Ici Ltd	Heterocyclic Amines
FR2164482A1 (en) *	1971-12-21	1973-08-03	Aries Robert	Phenyl pyridyl acylamino pyrazolones - antiinflammatories antipyretics and analgesics
JPH0710846B2 (ja) *	1985-01-18	1995-02-08	ダイセル化学工業株式会社	４−置換オキシ−３−ピリジンカルボキサミド化合物
US4857527A (en) *	1985-12-12	1989-08-15	Fujisawa Pharmaceutical Co., Ltd.	Morpholine containing pyridine compounds, compositions and use
US4990507A (en) *	1985-12-12	1991-02-05	Fujisawa Pharmaceutical Co., Ltd.	N-containing heterocyclic compounds, and composition comprising the same
GB8530602D0 (en) *	1985-12-12	1986-01-22	Fujisawa Pharmaceutical Co	Heterocyclic compounds
US5008168A (en)	1988-04-18	1991-04-16	Canon Kabushiki Kaisha	Photosensitive member for electrophotography
US5283242A (en) *	1991-10-24	1994-02-01	American Home Products Corporation	Substituted benzimidazoles and quinazolines as antihypertensives
US5807824A (en)	1993-12-06	1998-09-15	Ciba-Geigy Corporation	C5A receptor antagonists having substantially no agonist activity
DE4427199A1 (de)	1994-08-01	1996-02-08	Hoechst Ag	3,4-Difluorpyridine und ihre Verwendung in flüssigkristallinen Mischungen
AU1504599A (en) *	1997-12-17	1999-07-05	Shionogi & Co., Ltd.	Novel pyridine compounds
US6147085A (en)	1999-04-01	2000-11-14	Neurogen Corporation	Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives
JP2000226372A (ja)	1999-02-01	2000-08-15	Nippon Soda Co Ltd	アミド化合物、その製造方法及び農園芸用殺虫剤
US6627633B2 (en) *	1999-03-17	2003-09-30	Albany Molecular Research, Inc.	6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
US6355644B1 (en)	1999-06-14	2002-03-12	Neurogen Corporation	Benzylpiperazinyl-indolinylethanones
US6482611B1 (en)	1999-09-23	2002-11-19	Neurogen Corporation	Human capsaicin receptor and uses thereof
US6310212B1 (en)	2000-03-28	2001-10-30	Neurogen Corporation	4-substituted quinoline derivatives
CA2418652C (en)	2000-08-10	2010-03-23	Mitsubishi Pharma Corporation	Novel 3-substituted urea derivatives and medicinal use thereof
JP5260818B2 (ja) *	2000-09-29	2013-08-14	ノバルティス・インターナショナル・ファーマシューティカル・リミテッド	高親和性低分子Ｃ５ａ受容体調節物質
HUP0400316A2 (hu) *	2001-05-22	2005-02-28	Neurogen Corporation	CRF1 modulátor hatású 5-szubsztituált-2-arilpiridin származékok és ezeket tartalmazó gyógyszerkészítmények

2003
- 2003-11-07 AU AU2003291403A patent/AU2003291403A1/en not_active Abandoned
- 2003-11-07 CA CA2504941A patent/CA2504941C/en not_active Expired - Fee Related
- 2003-11-07 AT AT03768799T patent/ATE552253T1/de active
- 2003-11-07 US US10/704,364 patent/US7342115B2/en not_active Expired - Fee Related
- 2003-11-07 EP EP03768799A patent/EP1565452B1/de not_active Expired - Lifetime
- 2003-11-07 WO PCT/US2003/035694 patent/WO2004043925A2/en not_active Ceased
2008
- 2008-03-03 US US12/041,038 patent/US7863454B2/en not_active Expired - Fee Related
2011
- 2011-01-03 US US12/983,661 patent/US20110281837A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090176980A1 (en)	2009-07-09
US7863454B2 (en)	2011-01-04
AU2003291403A8 (en)	2004-06-03
WO2004043925A3 (en)	2004-08-05
US20040158067A1 (en)	2004-08-12
WO2004043925A2 (en)	2004-05-27
US20110281837A1 (en)	2011-11-17
AU2003291403A1 (en)	2004-06-03
CA2504941A1 (en)	2004-05-27
EP1565452B1 (de)	2012-04-04
EP1565452A2 (de)	2005-08-24
CA2504941C (en)	2012-06-26
US7342115B2 (en)	2008-03-11

Publication	Publication Date	Title
ATE552253T1 (de)	2012-04-15	3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren
WO2006042102A3 (en)	2007-02-22	Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
TW200608976A (en)	2006-03-16	4,5-disubstituted-2-aryl pyrimidines
AP1503A (en)	2005-12-24	Benzimidazole and pyridylimidazole derivatives as ligands for GABA receptors
ATE461178T1 (de)	2010-04-15	Pyridazinyl-piperazine und deren verwendung als histamin-h3-rezeptorliganden
DE602008005771D1 (de)	2011-05-05	Disubstituierte alkyl-8-azabicycloä3.2.1üoktan-verbindungen als mu-opioid-rezeptorantagonisten
ATE362932T1 (de)	2007-06-15	Azaindolverbindungen als kinaseinhibitoren
EA200701036A1 (ru)	2007-12-28	Лактамные соединения и их применение в качестве фармацевтических препаратов
EA200970207A1 (ru)	2009-08-28	Соединения пиридо[2,3-d]пиримидинона и их применение в качестве pi3 ингибиторов
MA33178B1 (fr)	2012-04-02	Pipéridines substituées comme antagonistes de ccr3
EA200601897A1 (ru)	2007-02-27	Производные тетрагидронафтиридина, пригодные в качестве лигандов рецептора н3 гистамина
ATE433962T1 (de)	2009-07-15	Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors
EA200700251A1 (ru)	2007-08-31	Амидосоединения и их применение в качестве фармацевтических средств
DE60335891D1 (de)	2011-03-10	Sulphonylaminoessigsaeure derivate und deren verwendung als orexin rezeptor antagoniste
UA92670C2 (ru)	2010-11-25	Пиразолиновые соединения и их фармацевтическое применение, композиция на их основе
CY1108321T1 (el)	2014-02-12	Καινοφανη παραγωγα δικαρβοξυλικου οξεος
GEP20115201B (en)	2011-04-11	Cinnamoyl-piperazine derivatives and their use as par- i antagonists
TW200624432A (en)	2006-07-16	Imidazo [1,2-a] pyridine compounds, compositions, uses and methods related thereto
MX2010002171A (es)	2010-04-30	Compuestos 8-azabiciclo[3.2.1] octil-2 hidroxibenzamida como antagonistas de los receptores opioides mu.
SE0403171D0 (sv)	2004-12-23	New compounds
ATE247652T1 (de)	2003-09-15	4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
PL1877364T3 (pl)	2009-09-30	Pochodne fenyloacetylenu o powinowactwie do receptora mGluR5
ATE554768T1 (de)	2012-05-15	1-aryl-4-substituierte isochinoline
WO2005007087A3 (en)	2006-03-30	Substituted (heterocycloalkyl)methyl azole derivatives as c5a receptor modulators
TW200745024A (en)	2007-12-16	Carboxamide derivatives as muscarinic receptor antagonists