ATE552253T1 - 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren - Google Patents

3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren

Info

Publication number: ATE552253T1
Authority: AT; Austria
Prior art keywords: receptors; substituted; compounds; aryl; ligands
Prior art date: 2002-11-08

Application number

AT03768799T

Other languages

English (en)

Inventor

Alan Hutchison

Jun Yuan

Kyungae Lee

George Maynard

Bertrand Chenard

Nian Liu

Qin Guo

Zihong Guo

Peter Hrnciar

Original Assignee

Novartis Int Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-08

Filing date

2003-11-07

Publication date

2012-04-15

2003-11-07 Application filed by Novartis Int Pharm Ltd filed Critical Novartis Int Pharm Ltd

2012-04-15 Application granted granted Critical

2012-04-15 Publication of ATE552253T1 publication Critical patent/ATE552253T1/de

Links

102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 title abstract 5
108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 title abstract 5
239000003446 ligand Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 4
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
229940125425 inverse agonist Drugs 0.000 abstract 1
230000004807 localization Effects 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000523 sample Substances 0.000 abstract 1

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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A61P11/06—Antiasthmatics
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Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT03768799T 2002-11-08 2003-11-07 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren ATE552253T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42528102P	2002-11-08	2002-11-08
PCT/US2003/035694 WO2004043925A2 (en)	2002-11-08	2003-11-07	3-substituted-6-aryl pyridined as ligands of c5a receptors

Publications (1)

Publication Number	Publication Date
ATE552253T1 true ATE552253T1 (de)	2012-04-15

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AT03768799T ATE552253T1 (de)	2002-11-08	2003-11-07	3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren

Country Status (6)

Country	Link
US (3)	US7342115B2 (de)
EP (1)	EP1565452B1 (de)
AT (1)	ATE552253T1 (de)
AU (1)	AU2003291403A1 (de)
CA (1)	CA2504941C (de)
WO (1)	WO2004043925A2 (de)

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2003
- 2003-11-07 AT AT03768799T patent/ATE552253T1/de active
- 2003-11-07 CA CA2504941A patent/CA2504941C/en not_active Expired - Fee Related
- 2003-11-07 EP EP03768799A patent/EP1565452B1/de not_active Expired - Lifetime
- 2003-11-07 WO PCT/US2003/035694 patent/WO2004043925A2/en not_active Ceased
- 2003-11-07 US US10/704,364 patent/US7342115B2/en not_active Expired - Fee Related
- 2003-11-07 AU AU2003291403A patent/AU2003291403A1/en not_active Abandoned
2008
- 2008-03-03 US US12/041,038 patent/US7863454B2/en not_active Expired - Fee Related
2011
- 2011-01-03 US US12/983,661 patent/US20110281837A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US7863454B2 (en)	2011-01-04
AU2003291403A1 (en)	2004-06-03
EP1565452B1 (de)	2012-04-04
EP1565452A2 (de)	2005-08-24
WO2004043925A2 (en)	2004-05-27
CA2504941C (en)	2012-06-26
US20090176980A1 (en)	2009-07-09
US20110281837A1 (en)	2011-11-17
US7342115B2 (en)	2008-03-11
AU2003291403A8 (en)	2004-06-03
CA2504941A1 (en)	2004-05-27
WO2004043925A3 (en)	2004-08-05
US20040158067A1 (en)	2004-08-12

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