ATE552837T1 - Verwendung von hochdosierten oxazaphosphorin- arzneimitteln zur behandlung von immunstörungen - Google Patents
Verwendung von hochdosierten oxazaphosphorin- arzneimitteln zur behandlung von immunstörungenInfo
- Publication number
- ATE552837T1 ATE552837T1 AT06840105T AT06840105T ATE552837T1 AT E552837 T1 ATE552837 T1 AT E552837T1 AT 06840105 T AT06840105 T AT 06840105T AT 06840105 T AT06840105 T AT 06840105T AT E552837 T1 ATE552837 T1 AT E552837T1
- Authority
- AT
- Austria
- Prior art keywords
- high dose
- immune disorders
- treat immune
- dose oxazaphosphorine
- drugs
- Prior art date
Links
- ZZVDXRCAGGQFAK-UHFFFAOYSA-N 2h-oxazaphosphinine Chemical compound N1OC=CC=P1 ZZVDXRCAGGQFAK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 208000026278 immune system disease Diseases 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 231100000355 lymphocytotoxic Toxicity 0.000 abstract 1
- 230000001391 lymphocytotoxic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001400 myeloablative effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74217205P | 2005-12-02 | 2005-12-02 | |
| PCT/US2006/061549 WO2007065167A1 (en) | 2005-12-02 | 2006-12-04 | Use of high-dose oxazaphosphorine drugs for treating immune disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE552837T1 true ATE552837T1 (de) | 2012-04-15 |
Family
ID=37898760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06840105T ATE552837T1 (de) | 2005-12-02 | 2006-12-04 | Verwendung von hochdosierten oxazaphosphorin- arzneimitteln zur behandlung von immunstörungen |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20070202077A1 (de) |
| EP (2) | EP1957082B1 (de) |
| AT (1) | ATE552837T1 (de) |
| AU (1) | AU2006320162B2 (de) |
| CA (1) | CA2631760A1 (de) |
| WO (1) | WO2007065167A1 (de) |
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| US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| AU2006320162B2 (en) * | 2005-12-02 | 2013-07-25 | The Johns Hopkins University | Use of high-dose oxazaphosphorine drugs for treating immune disorders |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| WO2008034071A2 (en) | 2006-09-15 | 2008-03-20 | The Johns Hopkins University | Method of identifying patients suitable for high-dose cyclophosphamide treatment |
| WO2008034076A2 (en) | 2006-09-15 | 2008-03-20 | The Johns Hopkins University | Cyclophosphamide in combination with immune therapeutics |
| WO2008034074A2 (en) | 2006-09-15 | 2008-03-20 | The Johns Hopkins University | Cyclosphosphamide in combination with anti-idiotypic vaccines |
| WO2008156494A1 (en) * | 2006-11-03 | 2008-12-24 | The Johns Hopkins University | Use of high-dose oxazaphosphorine drugs in combination with monoclonal antibodies for treating immune disorders |
| JP2010540634A (ja) * | 2007-10-01 | 2010-12-24 | ザ・ジョンズ・ホプキンス・ユニバーシティー | シクロホスファミドを用いて自己免疫神経疾患を処置する方法 |
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| WO2009067690A2 (en) * | 2007-11-21 | 2009-05-28 | Accentia Biopharmaceuticals, Inc. | Methods for safe and effective treatment using oxazaphosphorine drugs |
| US9026372B2 (en) * | 2007-11-21 | 2015-05-05 | Accentia Biopharmaceuticals, Inc. | Methods for providing a system of care for a high-dose oxazaphosphorine drug regimen |
| WO2009073146A2 (en) * | 2007-11-29 | 2009-06-11 | Celgene Corporation | Use of immunomodulatory compounds for the treatment of transverse myelitis, multiple sclerosis, and other disorders |
| WO2009094456A2 (en) * | 2008-01-22 | 2009-07-30 | Johns Hopkins University | Use of high-dose, post-transplantation oxazaphosphorine drugs for reduction of transplant rejection |
| JP2011529078A (ja) * | 2008-07-25 | 2011-12-01 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 自己免疫疾患を治療および予防するための方法および組成物 |
| RS54233B1 (sr) | 2008-08-25 | 2015-12-31 | Amplimmune Inc. | Kompozicije pd-1 antagonista i postupci za njihovu primenu |
| EP2328920A2 (de) * | 2008-08-25 | 2011-06-08 | Amplimmune, Inc. | Zielgerichtete, kostimulierende polypeptide und anwendungsverfahren zur behandlung von krebs |
| WO2011011706A2 (en) * | 2009-07-24 | 2011-01-27 | The Johns Hopkins University | Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents |
| US8840889B2 (en) | 2009-08-13 | 2014-09-23 | The Johns Hopkins University | Methods of modulating immune function |
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| US8465413B2 (en) | 2010-11-25 | 2013-06-18 | Coloplast A/S | Method of treating Peyronie's disease |
| US9987354B2 (en) | 2011-04-29 | 2018-06-05 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers for antigen-specific deletion of T effector cells |
| CN110251675A (zh) | 2013-05-03 | 2019-09-20 | 西莱克塔生物科技公司 | 降低或预防响应于非变应原性抗原的过敏反应的致耐受性合成纳米载体 |
| PL405506A1 (pl) * | 2013-09-30 | 2015-04-13 | Warszawski Uniwersytet Medyczny | Zastosowanie pochodnej kwasu 7-aminocefalosporanowego jako inhibitora aktywności biologicznej IL-15 i IL-2 |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| EP3848047A1 (de) * | 2014-07-24 | 2021-07-14 | Reponex Pharmaceuticals APS | Zusammensetzungen mit faktor zur stimulierung von granulozyt-makrophagen-kolonien zur behandlung von entzündlicher darmerkrankung |
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| JP2019528311A (ja) | 2016-08-03 | 2019-10-10 | ネクストキュア インコーポレイテッド | Lairシグナル伝達を調節するための組成物及び方法 |
| ES2982558T3 (es) | 2016-09-21 | 2024-10-16 | Nextcure Inc | Anticuerpos para Siglec-15 y métodos de uso de los mismos |
| EP4360714A3 (de) | 2016-09-21 | 2024-07-24 | Nextcure, Inc. | Antikörper für siglec-15 und verfahren zur verwendung davon |
| ES3036482T3 (en) | 2017-03-11 | 2025-09-19 | Cartesian Therapeutics Inc | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| EP4653429A1 (de) | 2017-09-07 | 2025-11-26 | Augusta University Research Institute, Inc. | Spezifischer akt3-aktivator und verwendungen davon |
| US11021540B2 (en) | 2017-09-07 | 2021-06-01 | Augusta University Research Institute, Inc. | Antibodies to programmed cell death protein 1 |
| BR112020014929A2 (pt) | 2018-01-23 | 2020-12-08 | Nextcure, Inc. | Composição farmacêutica, métodos para aumentar, para reduzir, para intensificar ou induzir uma resposta imune em um indivíduo, molécula, anticorpo monoclonal ou fragmento de ligação ao antígeno do mesmo, ácido nucleico, anticorpo monoclonal anti-b7h4 ou fragmento de ligação ao antígeno do mesmo, anticorpo anti-b7h4 ou fragmento de ligação ao antígeno do mesmo, cadeias leve e pesada de anticorpo anti-b7h4, e, cadeias leve e pesada de anticorpo |
| US20210002373A1 (en) | 2018-03-01 | 2021-01-07 | Nextcure, Inc. | KLRG1 Binding Compositions and Methods of Use Thereof |
| US20200077906A1 (en) | 2018-09-07 | 2020-03-12 | Augusta University Research Institute, Inc. | Method and System for Monitoring Brain Function and Intracranial Pressure |
| KR20210143718A (ko) | 2019-01-17 | 2021-11-29 | 조지아 테크 리서치 코포레이션 | 산화된 콜레스테롤을 함유하는 약물 전달 시스템 |
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| US11897950B2 (en) | 2019-12-06 | 2024-02-13 | Augusta University Research Institute, Inc. | Osteopontin monoclonal antibodies |
| US20230201188A1 (en) | 2020-04-17 | 2023-06-29 | Augusta University Research Institute, Inc. | Compositions and methods for treating leukemia |
| AU2022328272A1 (en) * | 2021-08-11 | 2024-02-22 | Sun Pharmaceutical Industries, Inc. | Treatment of hair loss disorders with deuterated jak inhibitors |
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| AU2006320162B2 (en) * | 2005-12-02 | 2013-07-25 | The Johns Hopkins University | Use of high-dose oxazaphosphorine drugs for treating immune disorders |
| WO2009067690A2 (en) * | 2007-11-21 | 2009-05-28 | Accentia Biopharmaceuticals, Inc. | Methods for safe and effective treatment using oxazaphosphorine drugs |
| US9026372B2 (en) * | 2007-11-21 | 2015-05-05 | Accentia Biopharmaceuticals, Inc. | Methods for providing a system of care for a high-dose oxazaphosphorine drug regimen |
-
2006
- 2006-12-04 AU AU2006320162A patent/AU2006320162B2/en not_active Ceased
- 2006-12-04 AT AT06840105T patent/ATE552837T1/de active
- 2006-12-04 US US11/566,296 patent/US20070202077A1/en not_active Abandoned
- 2006-12-04 EP EP06840105A patent/EP1957082B1/de not_active Not-in-force
- 2006-12-04 WO PCT/US2006/061549 patent/WO2007065167A1/en not_active Ceased
- 2006-12-04 EP EP11001548A patent/EP2345412A1/de not_active Withdrawn
- 2006-12-04 CA CA002631760A patent/CA2631760A1/en not_active Abandoned
-
2010
- 2010-05-11 US US12/777,729 patent/US20110092462A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1957082B1 (de) | 2012-04-11 |
| EP2345412A1 (de) | 2011-07-20 |
| CA2631760A1 (en) | 2007-06-07 |
| WO2007065167A1 (en) | 2007-06-07 |
| AU2006320162B2 (en) | 2013-07-25 |
| AU2006320162A1 (en) | 2007-06-07 |
| US20110092462A1 (en) | 2011-04-21 |
| EP1957082A1 (de) | 2008-08-20 |
| US20070202077A1 (en) | 2007-08-30 |
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