ATE553089T1 - Hydrophile, chemilumineszente acridiniummarkierungsreagenzien - Google Patents

Hydrophile, chemilumineszente acridiniummarkierungsreagenzien

Info

Publication number
ATE553089T1
ATE553089T1 AT03793122T AT03793122T ATE553089T1 AT E553089 T1 ATE553089 T1 AT E553089T1 AT 03793122 T AT03793122 T AT 03793122T AT 03793122 T AT03793122 T AT 03793122T AT E553089 T1 ATE553089 T1 AT E553089T1
Authority
AT
Austria
Prior art keywords
hydrophilic
acridinium
embraces
present
tetraethylene oxide
Prior art date
Application number
AT03793122T
Other languages
English (en)
Inventor
Ramon Evangelista
Martha Garrity
Original Assignee
Quest Diagnostics Invest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/225,084 external-priority patent/US6924154B2/en
Application filed by Quest Diagnostics Invest Inc filed Critical Quest Diagnostics Invest Inc
Priority claimed from US10/643,556 external-priority patent/US20040089535A1/en
Application granted granted Critical
Publication of ATE553089T1 publication Critical patent/ATE553089T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT03793122T 2002-08-20 2003-08-18 Hydrophile, chemilumineszente acridiniummarkierungsreagenzien ATE553089T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/225,084 US6924154B2 (en) 2002-08-20 2002-08-20 Hydrophilic chemilumescent acridinium labeling reagents
US10/643,556 US20040089535A1 (en) 2002-08-16 2003-08-18 Process and apparatus for pulsed dc magnetron reactive sputtering of thin film coatings on large substrates using smaller sputter cathodes
PCT/US2003/025922 WO2004018418A2 (en) 2002-08-20 2003-08-18 Hydrophilic chemiluminescent acridinium labeling reagents

Publications (1)

Publication Number Publication Date
ATE553089T1 true ATE553089T1 (de) 2012-04-15

Family

ID=31949777

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03793122T ATE553089T1 (de) 2002-08-20 2003-08-18 Hydrophile, chemilumineszente acridiniummarkierungsreagenzien

Country Status (5)

Country Link
EP (1) EP1539702B1 (de)
JP (1) JP4699756B2 (de)
AT (1) ATE553089T1 (de)
AU (1) AU2003263917A1 (de)
WO (1) WO2004018418A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4860352B2 (ja) * 2006-05-23 2012-01-25 信一郎 礒部 診断薬及びそれを用いた測定方法
JP4851367B2 (ja) * 2007-03-05 2012-01-11 富士フイルム株式会社 ローカルプラズモン増強蛍光センサ
JP5130540B2 (ja) * 2007-12-12 2013-01-30 学校法人福岡大学 蛍光誘導体化試薬ならびに蛍光誘導体化方法
JP5852578B2 (ja) * 2009-11-16 2016-02-03 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 両性イオン含有アクリジニウム化合物
CN104411688B (zh) * 2012-07-10 2019-01-08 西门子医疗保健诊断公司 由9,10-二氢吖啶的n-烷基化合成吖啶鎓化合物
WO2021026403A1 (en) * 2019-08-07 2021-02-11 Abbott Laboratories Methods for detecting assay interferents and increasing dynamic range
CN114245830A (zh) * 2019-08-07 2022-03-25 深圳华大基因科技有限公司 含吖啶酯的化合物及将其用于基于化学发光的单色测序的方法
JP7765173B2 (ja) * 2020-10-01 2025-11-06 積水化学工業株式会社 重合体、検査薬、アナライト濃度測定法、及び、アナライト濃度測定装置
CN113009141A (zh) * 2021-02-05 2021-06-22 深圳市国赛生物技术有限公司 化学发光免疫检测试剂盒、用途和检测方法
JP2024527110A (ja) 2021-07-29 2024-07-19 ユーロイミューン・メディツィニシェ・ラボルディアグノシュティカ・アクチエンゲゼルシャフト 化学ルミネセンスシグナルを増大させる方法および試薬
US20260008819A1 (en) * 2022-12-21 2026-01-08 Siemens Healthcare Diagnostics Inc. Cyclosporine-acridinium esters and methods of production and use thereof
CN119775347B (zh) * 2024-12-31 2025-10-10 英科新创（苏州）生物科技有限公司 水溶性吖啶磺酰胺羧酸标记物、制备方法、其应用及试剂盒

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283334A (en) * 1987-12-31 1994-02-01 London Diagnostics, Inc. Side-chain functional chemiluminescent labels and their conjugates, and assays therefrom
US5656426A (en) * 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
JPH03172522A (ja) * 1989-11-29 1991-07-25 Komatsu Ltd 内燃機関のオイルクーラ
DE4004296A1 (de) * 1990-02-13 1991-08-14 Hoechst Ag Verbesserte markierte haptene, verfahren zu deren herstellung sowie verwendung dieser markierten haptene in immunoassays
US5395938A (en) * 1992-08-21 1995-03-07 Nichols Institute Diagnostics Biotinylated chemiluminescent labels and their conjugates, assays and assay kits
ATE340866T1 (de) * 1994-10-28 2006-10-15 Gen Probe Inc Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen
US6165800A (en) * 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
DE69927240T2 (de) * 1998-11-25 2006-06-22 Bayer Corp. Messung von hydriden mit hilfe chemilumineszierender acridiniumverbindungen
US6187566B1 (en) * 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
ATE291096T1 (de) * 1999-07-30 2005-04-15 Bayer Ag Chemilumineszenz-substrate von hydrolytischen enzymen wie phosphatasen
US6664043B2 (en) * 2001-07-03 2003-12-16 Bayer Corporation Acridinium ester labels having hydrophilic modifiers

Also Published As

Publication number Publication date
WO2004018418A2 (en) 2004-03-04
AU2003263917A1 (en) 2004-03-11
EP1539702A2 (de) 2005-06-15
EP1539702B1 (de) 2012-04-11
JP2005536748A (ja) 2005-12-02
AU2003263917A8 (en) 2004-03-11
EP1539702A4 (de) 2005-09-07
JP4699756B2 (ja) 2011-06-15
WO2004018418A3 (en) 2004-11-11

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