ATE553092T1 - Indazolderivate - Google Patents
IndazolderivateInfo
- Publication number
- ATE553092T1 ATE553092T1 AT04771301T AT04771301T ATE553092T1 AT E553092 T1 ATE553092 T1 AT E553092T1 AT 04771301 T AT04771301 T AT 04771301T AT 04771301 T AT04771301 T AT 04771301T AT E553092 T1 ATE553092 T1 AT E553092T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- unsubstituted
- heterocyclic group
- hydrogen atom
- ararkyl
- Prior art date
Links
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003203508 | 2003-07-30 | ||
| PCT/JP2004/011287 WO2005012257A1 (ja) | 2003-07-30 | 2004-07-30 | インダゾール誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE553092T1 true ATE553092T1 (de) | 2012-04-15 |
Family
ID=34113614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04771301T ATE553092T1 (de) | 2003-07-30 | 2004-07-30 | Indazolderivate |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7470717B2 (de) |
| EP (1) | EP1652842B1 (de) |
| JP (1) | JP4335212B2 (de) |
| KR (1) | KR20060119705A (de) |
| CN (1) | CN100390149C (de) |
| AT (1) | ATE553092T1 (de) |
| AU (1) | AU2004260756B2 (de) |
| BR (1) | BRPI0408876A (de) |
| CA (1) | CA2518950A1 (de) |
| EA (1) | EA010165B1 (de) |
| ES (1) | ES2384568T3 (de) |
| MX (1) | MXPA05011420A (de) |
| NO (1) | NO20055333L (de) |
| WO (1) | WO2005012257A1 (de) |
| ZA (1) | ZA200509952B (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA007270B1 (ru) | 2002-03-13 | 2006-08-25 | Янссен Фармацевтика Н.В. | Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы |
| CA2476067C (en) | 2002-03-13 | 2011-09-20 | Janssen Pharmaceutica N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
| ES2306880T3 (es) | 2002-03-13 | 2008-11-16 | Janssen Pharmaceutica Nv | Derivados de sulfonilamino como inhibidores novedosos de la histona desacetilasa. |
| AU2003218737B2 (en) | 2002-03-13 | 2008-04-10 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
| AU2004260756B2 (en) * | 2003-07-30 | 2010-03-25 | Kyowa Hakko Kirin Co., Ltd. | Indazole derivatives |
| PL1781639T3 (pl) | 2004-07-28 | 2012-07-31 | Janssen Pharmaceutica Nv | Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej |
| EP1847532B1 (de) * | 2005-01-27 | 2013-06-05 | Kyowa Hakko Kirin Co., Ltd. | Igf-1r-inhibitor |
| JP4975616B2 (ja) * | 2005-04-28 | 2012-07-11 | 協和発酵キリン株式会社 | インダゾール−３−イルメチルホスホニウム塩の製造法 |
| AU2006248938B2 (en) | 2005-05-18 | 2011-09-29 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
| EP1943232B1 (de) | 2005-10-27 | 2011-05-18 | Janssen Pharmaceutica NV | Quadratsäurederivate als Inhibitoren von Histondeacetylase |
| CA2635015C (en) | 2006-01-19 | 2014-06-03 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| JP5247470B2 (ja) | 2006-01-19 | 2013-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体 |
| DE602007001190D1 (de) | 2006-01-19 | 2009-07-09 | Janssen Pharmaceutica Nv | Aminophenylderivate als neue inhibitoren von histondeacetylase |
| US20090209537A1 (en) * | 2006-06-30 | 2009-08-20 | Kyowa Hakko Kirin Co., Ltd. | Aurora inhibitors |
| WO2008001885A1 (en) | 2006-06-30 | 2008-01-03 | Kyowa Hakko Kirin Co., Ltd. | Abl KINASE INHIBITOR |
| JPWO2008020606A1 (ja) * | 2006-08-16 | 2010-01-07 | 協和発酵キリン株式会社 | 血管新生阻害剤 |
| GB0619325D0 (en) | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| CA2680161A1 (en) | 2007-03-05 | 2008-09-12 | Kyowa Hakko Kirin Co., Ltd. | Pharmaceutical composition |
| EP2133095A4 (de) | 2007-03-05 | 2012-09-26 | Kyowa Hakko Kirin Co Ltd | Pharmazeutische zusammensetzung |
| WO2008114812A1 (ja) * | 2007-03-19 | 2008-09-25 | Kyowa Hakko Kirin Co., Ltd. | Jak阻害剤 |
| US20090325964A1 (en) * | 2008-05-23 | 2009-12-31 | Wyeth | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression |
| CN103804382A (zh) * | 2012-11-05 | 2014-05-21 | 韩文毅 | 一类治疗湿疹的化合物及其用途 |
| CN103804306A (zh) * | 2012-11-12 | 2014-05-21 | 韩文毅 | 一类治疗糖尿病的化合物及其用途 |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| EA037327B1 (ru) | 2015-09-22 | 2021-03-12 | Грейбуг Вижн, Инк. | Соединения и композиции для лечения глазных расстройств |
| AU2018240462C1 (en) | 2017-03-23 | 2022-12-08 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
| CN111201040A (zh) | 2017-05-10 | 2020-05-26 | 灰色视觉公司 | 用于医学疗法的缓释微粒及其悬浮液 |
| US11629139B2 (en) | 2017-09-08 | 2023-04-18 | President And Fellows Of Harvard College | Small molecule inhibitors of Ebola and Lassa fever viruses and methods of use |
| EA202190170A1 (ru) * | 2018-07-23 | 2021-08-13 | Селджен Квонтисел Рисёрч, Инк. | Способ получения ингибитора бромодомена |
| WO2024052684A1 (en) | 2022-09-09 | 2024-03-14 | MyricX Pharma Limited | Antibody drug conjugate comprising nmt inhibitor and its use |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0232059A (ja) * | 1988-07-18 | 1990-02-01 | Kyowa Hakko Kogyo Co Ltd | インダゾール誘導体 |
| TWI262914B (en) * | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| PE20010306A1 (es) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| US6632815B2 (en) * | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| YU54202A (sh) * | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| US7238853B2 (en) * | 2000-07-14 | 2007-07-03 | Unicrop Ltd | Molecular mechanisms for gene containment in plants |
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
| US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| WO2002083648A1 (fr) * | 2001-04-16 | 2002-10-24 | Eisai Co., Ltd. | Nouveau compose a base de 1h-indazole |
| KR20050004214A (ko) * | 2002-05-31 | 2005-01-12 | 에자이 가부시키가이샤 | 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물 |
| EP1582211A1 (de) * | 2002-12-03 | 2005-10-05 | Kyowa Hakko Kogyo Co., Ltd. | Jnk-inhibitor |
| AU2004260756B2 (en) * | 2003-07-30 | 2010-03-25 | Kyowa Hakko Kirin Co., Ltd. | Indazole derivatives |
-
2004
- 2004-07-30 AU AU2004260756A patent/AU2004260756B2/en not_active Ceased
- 2004-07-30 US US10/548,475 patent/US7470717B2/en not_active Expired - Fee Related
- 2004-07-30 WO PCT/JP2004/011287 patent/WO2005012257A1/ja not_active Ceased
- 2004-07-30 EA EA200600333A patent/EA010165B1/ru not_active IP Right Cessation
- 2004-07-30 MX MXPA05011420A patent/MXPA05011420A/es active IP Right Grant
- 2004-07-30 ES ES04771301T patent/ES2384568T3/es not_active Expired - Lifetime
- 2004-07-30 AT AT04771301T patent/ATE553092T1/de active
- 2004-07-30 CN CNB2004800104880A patent/CN100390149C/zh not_active Expired - Fee Related
- 2004-07-30 KR KR1020057018013A patent/KR20060119705A/ko not_active Abandoned
- 2004-07-30 JP JP2005512586A patent/JP4335212B2/ja not_active Expired - Fee Related
- 2004-07-30 BR BRPI0408876-0A patent/BRPI0408876A/pt not_active IP Right Cessation
- 2004-07-30 CA CA002518950A patent/CA2518950A1/en not_active Abandoned
- 2004-07-30 EP EP04771301A patent/EP1652842B1/de not_active Expired - Lifetime
-
2005
- 2005-11-11 NO NO20055333A patent/NO20055333L/no unknown
- 2005-12-07 ZA ZA200509952A patent/ZA200509952B/en unknown
-
2008
- 2008-11-21 US US12/275,614 patent/US7919517B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200509952B (en) | 2006-09-27 |
| AU2004260756A1 (en) | 2005-02-10 |
| JPWO2005012257A1 (ja) | 2006-09-14 |
| WO2005012257A1 (ja) | 2005-02-10 |
| CN1777590A (zh) | 2006-05-24 |
| ES2384568T3 (es) | 2012-07-09 |
| EP1652842A4 (de) | 2008-10-01 |
| NO20055333L (no) | 2005-11-11 |
| US7919517B2 (en) | 2011-04-05 |
| CN100390149C (zh) | 2008-05-28 |
| US20090082348A1 (en) | 2009-03-26 |
| EP1652842A1 (de) | 2006-05-03 |
| BRPI0408876A (pt) | 2006-04-11 |
| AU2004260756B2 (en) | 2010-03-25 |
| EA200600333A1 (ru) | 2006-06-30 |
| CA2518950A1 (en) | 2005-02-10 |
| EA010165B1 (ru) | 2008-06-30 |
| MXPA05011420A (es) | 2005-12-12 |
| US20070117856A1 (en) | 2007-05-24 |
| JP4335212B2 (ja) | 2009-09-30 |
| KR20060119705A (ko) | 2006-11-24 |
| US7470717B2 (en) | 2008-12-30 |
| EP1652842B1 (de) | 2012-04-11 |
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