ATE553115T1 - Das angiotensin-converting enzyme inhibierende peptide - Google Patents

Das angiotensin-converting enzyme inhibierende peptide

Info

Publication number
ATE553115T1
ATE553115T1 AT06757830T AT06757830T ATE553115T1 AT E553115 T1 ATE553115 T1 AT E553115T1 AT 06757830 T AT06757830 T AT 06757830T AT 06757830 T AT06757830 T AT 06757830T AT E553115 T1 ATE553115 T1 AT E553115T1
Authority
AT
Austria
Prior art keywords
angiotensin
converting enzyme
peptides
enzyme inhibiting
amino acid
Prior art date
Application number
AT06757830T
Other languages
English (en)
Inventor
Jenneke Cadee
Leon Mallee
Original Assignee
Campina Nederland Holding Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Campina Nederland Holding Bv filed Critical Campina Nederland Holding Bv
Application granted granted Critical
Publication of ATE553115T1 publication Critical patent/ATE553115T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
    • A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT06757830T 2005-06-30 2006-06-29 Das angiotensin-converting enzyme inhibierende peptide ATE553115T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05105977 2005-06-30
PCT/NL2006/050155 WO2007004876A2 (en) 2005-06-30 2006-06-29 Peptides inhibiting angiotensin-converting enzyme

Publications (1)

Publication Number Publication Date
ATE553115T1 true ATE553115T1 (de) 2012-04-15

Family

ID=35478912

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06757830T ATE553115T1 (de) 2005-06-30 2006-06-29 Das angiotensin-converting enzyme inhibierende peptide

Country Status (6)

Country Link
US (1) US20100056458A1 (de)
EP (1) EP1907412B1 (de)
JP (1) JP2009500404A (de)
AT (1) ATE553115T1 (de)
TW (1) TW200726777A (de)
WO (1) WO2007004876A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10331202A1 (de) 2003-07-10 2005-03-31 S.K. Enterprise Gmbh Verwendung von Molkenpermeat zur Behandlung des Metabolischen Syndroms
DE102006036285A1 (de) * 2006-08-03 2008-02-07 "S.U.K." Beteiligungs Gmbh Fraktionen aus Molkepermeat und deren Verwendung zur Prävention und Therapie des Typ-2 Diabetes und des Metabolischen Syndroms
EP1967524A1 (de) * 2007-03-06 2008-09-10 Friesland Brands B.V. Verfahren zur Herstellung von ACE-hemmenden Peptiden aus Molke und so hergestellte Peptide
JP2009263255A (ja) * 2008-04-23 2009-11-12 Rohto Pharmaceut Co Ltd 新規ペプチド
DE102008032828A1 (de) * 2008-07-02 2010-01-07 Technische Universität Dresden Tryptophanhaltige Peptide aus alpha-Lactalbumin mit blutdrucksenkender und vasoprotektiver Wirkung für biofunktionelle Lebensmittel
EP2448958A4 (de) * 2009-06-01 2013-11-06 Kenneth James Friel Menschliche milchpeptide
EP2258208A1 (de) * 2009-06-02 2010-12-08 University of Limerick Proteinprodukt mit modifizierter Antigenität
EP2489281A1 (de) * 2011-02-17 2012-08-22 University of Limerick Caseinhydrolysat
ES2394988B2 (es) * 2011-06-15 2013-06-06 Queizúar, S.L. Procedimiento optimizado para la obtención de péptidos inhibidores de la actividad de la eca a partir de suero lácteo, péptidos inhibidores de la eca y alimento que los comprende.
EP2548458B1 (de) * 2011-07-22 2013-07-03 HPF Nutraceutics S.r.L. Lupinen-abgeleitete Verbindungen mit hypotonischer Wirkung und Verfahrensprozess zu ihrer Herstellung
WO2013047128A1 (ja) * 2011-09-28 2013-04-04 森永乳業株式会社 ペプチドおよびアンジオテンシン変換酵素阻害剤
CN102516358B (zh) * 2011-12-08 2013-12-04 鞍山嘉鲜农业发展有限公司 源于鱼鳞胶原蛋白的血管紧张素ⅰ转换酶抑制剂及其应用
CN102786580A (zh) * 2012-07-17 2012-11-21 上海交通大学 抗高血压活性肽ivp
CN102786579B (zh) * 2012-07-17 2014-07-09 上海交通大学 抗高血压活性肽vip
MX374247B (es) * 2013-12-16 2025-03-05 Soc Des Produits Nestle S A Star Peptidos identificados recientemente para el uso en la induccion de la tolerancia oral en mamiferos jovenes.
TW201526907A (zh) * 2014-01-09 2015-07-16 Univ Nat Pingtung Sci & Tech 短鏈活性胜肽及其抑制血管收縮素轉化酶及降血壓之應用
CN104059126A (zh) * 2014-05-29 2014-09-24 无限极（中国）有限公司 一种降血压肽p16及其制备方法和应用
CN104059127A (zh) * 2014-05-29 2014-09-24 无限极（中国）有限公司 一种天然高活性降血压肽及其制备方法和应用
JP6262694B2 (ja) * 2014-08-18 2018-01-17 森永乳業株式会社 プロリルオリゴペプチダーゼ阻害剤
WO2016066758A1 (en) * 2014-10-30 2016-05-06 Laboratorios Ordesa, S.L. Milk protein hydrolysate for use in the treatment of diarrhoea
CN105017122B (zh) * 2015-07-08 2018-01-09 南京葆赫生物技术有限公司 一种抗高血压活性肽、其制备方法及应用
CN106554388B (zh) * 2015-09-25 2020-01-21 中国科学院大连化学物理研究所 具有ace和dpp-iv抑制活性的多肽及其应用
CN108752421B (zh) * 2018-05-24 2022-01-18 华南理工大学 一种合成多肽及其合成方法与应用与编码该合成多肽的基因
CN118556752A (zh) * 2019-05-29 2024-08-30 阿拉食品公司 适口的深度水解乳清蛋白水解物
WO2021219264A1 (en) 2020-04-30 2021-11-04 Grandes Vinos Y Viñedos Sa Wine lees, derivatives thereof and their uses
CN113072621B (zh) * 2021-04-07 2022-02-18 安徽国肽生物科技有限公司 一种牦牛骨降血压肽及其制备方法与应用
CN117683085B (zh) * 2023-12-13 2025-10-28 华南农业大学 一种料酒渣来源ace抑制肽及其制备方法和应用
WO2025133254A2 (en) * 2023-12-20 2025-06-26 Nuritas Limited Angiotensin-converting enzyme (ace) inhibiting peptides.
CN121021623B (zh) * 2025-10-29 2026-08-04 大洲新燕(厦门)生物科技有限公司 一种激活乙醇脱氢酶燕窝肽及其应用
CN122104540A (zh) * 2026-04-30 2026-05-29 湖南营养树生物科技有限公司 短双歧杆菌、发酵羊初乳及其制备方法和增强免疫的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63141995A (ja) * 1986-12-03 1988-06-14 Agency Of Ind Science & Technol 新規活性ペプチド
JPH0616568A (ja) 1991-09-17 1994-01-25 Chiba Seifun Kk アンジオテンシン変換酵素阻害剤
JPH08269087A (ja) * 1992-03-02 1996-10-15 Fumio Yamauchi 新規なテトラペプチド、ペンタペプチドその製法およびそれらを有効成分とする血圧降下剤
US6514941B1 (en) * 1999-12-10 2003-02-04 Campina Melkunie B.V. Method of preparing a casein hydrolysate enriched in anti-hypertensive peptides
NZ506866A (en) * 2000-09-11 2003-05-30 New Zealand Dairy Board Bioactive whey protein hydrolysate free of bitter flavours wherein the enzyme used is a heat labile protease
ES2277468B1 (es) * 2003-05-21 2008-07-01 Grupo Leche Pascual Peptidos bioactivos y derivados, procedimiento de produccion, cepas de enterococcus faecalis productoras de dichos peptidos bioactivos y sus aplicaciones.
DK1831361T3 (da) * 2004-12-23 2012-05-14 Campina Nederland Holding Bv Proteinhydrolysat beriget med peptider, som inhiberer DPP-IV, og deres anvendelse
WO2006108211A1 (en) * 2005-02-25 2006-10-19 The Murdoch Childrens Research Institute Fragments of von willebrand factor a-related protein
EP1726659B1 (de) 2005-05-24 2009-12-30 Chr. Hansen A/S Isolierte Dipeptide mit ACE-Inhibitionseffekt

Also Published As

Publication number Publication date
JP2009500404A (ja) 2009-01-08
WO2007004876A2 (en) 2007-01-11
US20100056458A1 (en) 2010-03-04
WO2007004876A3 (en) 2007-11-08
TW200726777A (en) 2007-07-16
EP1907412B1 (de) 2012-04-11
EP1907412A2 (de) 2008-04-09

Similar Documents

Publication Publication Date Title
TW200726777A (en) Peptides inhibiting angiotensin-converting enzyme
IN2014CN02050A (de)
DE602004032107D1 (de) Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids
NZ600690A (en) Fkbp-l and uses thereof
EP2444412A3 (de) Peptidherstellung und Aufreinigungsverfahren
EA201170878A1 (ru) Полипептиды с ксиланазной активностью
WO2009038195A1 (ja) 変異体ピロリジル－ｔＲＮＡ合成酵素及びこれを用いる非天然アミノ酸組み込みタンパク質の製造方法
EP1801206A4 (de) Verfahren zur herstellung von l-arginin, l-ornithin oder l-citrullin
IL232501A (en) Peptide or polypeptide-resistant protein analogs and their uses
DE502005006284D1 (de) Keratin-bindende polypeptide
ATE308550T1 (de) Verwendungen von sulfatierten fuko- oligosacchariden zum pflanzenschutz
WO2011036443A3 (en) Si protease c- terminal polypeptides and uses thereof for treating inflammation or coagulation disorders
DE60217377D1 (en) Durch thrombin spaltbare chimäre proteine
MX2009000656A (es) Acidos nucleicos que se fijan a sdf-i.
EA200900373A1 (ru) Реконструированные сурфактанты, обладающие улучшенными свойствами
TW200726842A (en) Mutant glucose dehydrogenase
SE9903291D0 (sv) New process
SG10201803541TA (en) Biologically active c-terminal arginine-containing peptides
CY1111630T1 (el) Παραγωγα κυτοκινων
WO2008047370A3 (en) Compositions and methods for inducing angiogenesis
TW200633977A (en) Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives
BR0305638A (pt) Enzima, micróbio, e, método para produzir um dipeptìdeo
EP1765851A4 (de) Auf einem planarresonator basierende optische chemo- und biosensoren
WO2004096832A3 (en) Novel antiangiogenic peptides
SE9800865D0 (sv) New Process