ATE555082T1 - Salz von aliskiren mit orotsäure - Google Patents
Salz von aliskiren mit orotsäureInfo
- Publication number
- ATE555082T1 ATE555082T1 AT07819654T AT07819654T ATE555082T1 AT E555082 T1 ATE555082 T1 AT E555082T1 AT 07819654 T AT07819654 T AT 07819654T AT 07819654 T AT07819654 T AT 07819654T AT E555082 T1 ATE555082 T1 AT E555082T1
- Authority
- AT
- Austria
- Prior art keywords
- aliskiren
- salt
- orotic acid
- orotic
- acid
- Prior art date
Links
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 title 2
- UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 title 1
- 229960004601 aliskiren Drugs 0.000 title 1
- 229960005010 orotic acid Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06123758 | 2006-11-09 | ||
| PCT/EP2007/009644 WO2008055669A1 (en) | 2006-11-09 | 2007-11-07 | Salt of aliskiren with orotic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE555082T1 true ATE555082T1 (de) | 2012-05-15 |
Family
ID=38002048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07819654T ATE555082T1 (de) | 2006-11-09 | 2007-11-07 | Salz von aliskiren mit orotsäure |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20100130616A1 (de) |
| EP (1) | EP2089356B1 (de) |
| JP (1) | JP2010509254A (de) |
| KR (1) | KR20090081010A (de) |
| CN (1) | CN101528672A (de) |
| AR (1) | AR063597A1 (de) |
| AT (1) | ATE555082T1 (de) |
| AU (1) | AU2007316878B2 (de) |
| BR (1) | BRPI0718701A2 (de) |
| CA (1) | CA2665073A1 (de) |
| CL (1) | CL2007003216A1 (de) |
| MX (1) | MX2009004628A (de) |
| PE (1) | PE20081167A1 (de) |
| RU (1) | RU2456267C2 (de) |
| TW (1) | TW200838836A (de) |
| WO (1) | WO2008055669A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101808630A (zh) * | 2007-09-28 | 2010-08-18 | 诺瓦提斯公司 | 阿利吉仑的盖仑制剂 |
| KR20100135936A (ko) * | 2008-05-23 | 2010-12-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 알리스키렌 모노푸마레이트 및 이의 제조 방법 |
| US8148576B2 (en) | 2009-02-05 | 2012-04-03 | Teva Pharmaceutical Industries Ltd. | Solid state forms of aliskiren compounds |
| WO2010089105A2 (en) | 2009-02-05 | 2010-08-12 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Moisture-activated granulation process |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| KR100690471B1 (ko) * | 2000-07-05 | 2007-03-09 | 스페델 파르마 아게 | 치환된 옥타노일 아미드의 제조방법 |
| BR0310084A (pt) * | 2002-05-17 | 2005-02-15 | Novartis Ag | Composição farmacêutica compreendendo um inibidor de renina, um bloqueador de canal de cálcio e um diurético |
| NZ545133A (en) * | 2003-09-04 | 2009-12-24 | Cephalon Inc | Modafinil compositions |
| PE20142101A1 (es) * | 2004-03-17 | 2014-12-27 | Novartis Ag | Composiciones farmaceuticas de aliskiren |
-
2007
- 2007-11-07 MX MX2009004628A patent/MX2009004628A/es active IP Right Grant
- 2007-11-07 AT AT07819654T patent/ATE555082T1/de active
- 2007-11-07 CA CA002665073A patent/CA2665073A1/en not_active Abandoned
- 2007-11-07 EP EP07819654A patent/EP2089356B1/de not_active Not-in-force
- 2007-11-07 US US12/312,384 patent/US20100130616A1/en not_active Abandoned
- 2007-11-07 KR KR1020097011750A patent/KR20090081010A/ko not_active Withdrawn
- 2007-11-07 PE PE2007001529A patent/PE20081167A1/es not_active Application Discontinuation
- 2007-11-07 JP JP2009535624A patent/JP2010509254A/ja not_active Ceased
- 2007-11-07 AU AU2007316878A patent/AU2007316878B2/en not_active Ceased
- 2007-11-07 CN CNA2007800398021A patent/CN101528672A/zh active Pending
- 2007-11-07 RU RU2009121646/04A patent/RU2456267C2/ru not_active IP Right Cessation
- 2007-11-07 BR BRPI0718701-7A patent/BRPI0718701A2/pt not_active IP Right Cessation
- 2007-11-07 AR ARP070104954A patent/AR063597A1/es unknown
- 2007-11-07 WO PCT/EP2007/009644 patent/WO2008055669A1/en not_active Ceased
- 2007-11-08 CL CL200703216A patent/CL2007003216A1/es unknown
- 2007-11-08 TW TW096142251A patent/TW200838836A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007316878B2 (en) | 2011-07-14 |
| AU2007316878A1 (en) | 2008-05-15 |
| EP2089356B1 (de) | 2012-04-25 |
| AR063597A1 (es) | 2009-02-04 |
| JP2010509254A (ja) | 2010-03-25 |
| WO2008055669A1 (en) | 2008-05-15 |
| MX2009004628A (es) | 2009-05-15 |
| RU2009121646A (ru) | 2010-12-20 |
| TW200838836A (en) | 2008-10-01 |
| US20100130616A1 (en) | 2010-05-27 |
| CA2665073A1 (en) | 2008-05-15 |
| PE20081167A1 (es) | 2008-10-03 |
| BRPI0718701A2 (pt) | 2013-12-31 |
| EP2089356A1 (de) | 2009-08-19 |
| CN101528672A (zh) | 2009-09-09 |
| CL2007003216A1 (es) | 2008-06-13 |
| KR20090081010A (ko) | 2009-07-27 |
| RU2456267C2 (ru) | 2012-07-20 |
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