ATE555096T1 - Heterocyclische verbindungen als viruzide - Google Patents
Heterocyclische verbindungen als viruzideInfo
- Publication number
- ATE555096T1 ATE555096T1 AT09780611T AT09780611T ATE555096T1 AT E555096 T1 ATE555096 T1 AT E555096T1 AT 09780611 T AT09780611 T AT 09780611T AT 09780611 T AT09780611 T AT 09780611T AT E555096 T1 ATE555096 T1 AT E555096T1
- Authority
- AT
- Austria
- Prior art keywords
- virucides
- heterocyclic compounds
- heterocyclic
- compounds
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000012873 virucide Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8284708P | 2008-07-23 | 2008-07-23 | |
| US20792509P | 2009-02-17 | 2009-02-17 | |
| US17983709P | 2009-05-20 | 2009-05-20 | |
| PCT/EP2009/059039 WO2010010017A1 (en) | 2008-07-23 | 2009-07-15 | Heterocyclic antiviral compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE555096T1 true ATE555096T1 (de) | 2012-05-15 |
Family
ID=41057595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09780611T ATE555096T1 (de) | 2008-07-23 | 2009-07-15 | Heterocyclische verbindungen als viruzide |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8273773B2 (de) |
| EP (1) | EP2307372B1 (de) |
| JP (1) | JP2011528686A (de) |
| KR (1) | KR20110033291A (de) |
| CN (1) | CN102099335A (de) |
| AR (1) | AR072824A1 (de) |
| AT (1) | ATE555096T1 (de) |
| AU (1) | AU2009273327A1 (de) |
| BR (1) | BRPI0916233A2 (de) |
| CA (1) | CA2730517A1 (de) |
| CL (1) | CL2011000136A1 (de) |
| ES (1) | ES2383273T3 (de) |
| IL (1) | IL209696A0 (de) |
| MX (1) | MX2011000656A (de) |
| PE (1) | PE20110409A1 (de) |
| TW (1) | TW201008922A (de) |
| WO (1) | WO2010010017A1 (de) |
| ZA (1) | ZA201009183B (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104628654A (zh) | 2007-09-17 | 2015-05-20 | 艾伯维巴哈马有限公司 | 抗感染嘧啶及其用途 |
| CN105693626A (zh) | 2007-09-17 | 2016-06-22 | 艾伯维巴哈马有限公司 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| CN102746239B (zh) | 2007-09-17 | 2016-02-10 | 艾伯维巴哈马有限公司 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| EP2334662A1 (de) * | 2008-09-26 | 2011-06-22 | F. Hoffmann-La Roche AG | Pyrin- oder pyrazinderivate zur behandlung von hcv |
| BRPI0919973A2 (pt) | 2008-10-30 | 2015-12-08 | Hoffmann La Roche | derivados de arilpiridona antivirais heterocíclicos |
| EP2403844A1 (de) * | 2009-03-06 | 2012-01-11 | F. Hoffmann-La Roche AG | Heterocyclische antivirale verbindungen |
| RU2524573C2 (ru) * | 2009-03-24 | 2014-07-27 | Эбботт Лэборетриз | Способ получения (e)-n-(3-трет-бутил-5-(2,4-диоксо-3,4-дигидропиримидин-1(2н)-ил)-2-метокси-стирил)фенил)метансульфонамида и промежуточные соединения для его получения |
| CN105924386A (zh) | 2009-03-25 | 2016-09-07 | Abbvie 公司 | 抗病毒化合物和其用途 |
| EP2421831A1 (de) * | 2009-04-25 | 2012-02-29 | F. Hoffmann-La Roche AG | Heterocyclische antivirale verbindungen |
| BRPI1010900A2 (pt) * | 2009-05-20 | 2016-03-15 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| PT2471786E (pt) * | 2009-08-07 | 2016-03-04 | Hoffmann La Roche | Derivado de aminopirazol |
| BR112012005616A2 (pt) * | 2009-09-21 | 2016-06-21 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| BR112012012085A2 (pt) | 2009-11-21 | 2016-05-17 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| EP3461556A1 (de) | 2010-07-16 | 2019-04-03 | AbbVie Ireland Unlimited Company | Phosphinliganden für katalytische reaktionen |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| EP3056486B1 (de) | 2010-07-16 | 2018-07-11 | AbbVie Ireland Unlimited Company | Verfahren zur herstellung von zwischenverbindungen antiviraler verbindungen |
| JP5620417B2 (ja) * | 2011-02-07 | 2014-11-05 | 中外製薬株式会社 | アミノピラゾール誘導体を含む医薬 |
| NO2686520T3 (de) | 2011-06-06 | 2018-03-17 | ||
| TW201329025A (zh) | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
| BR112015001308A2 (pt) * | 2012-07-31 | 2017-07-04 | Dow Global Technologies Llc | método para preparar sal de tetracis(pentafluorofenil)borato de amônio, composição catalisadora útil na polimerização de uma ou mais olefinas e processo de polimerização |
| WO2014095555A1 (en) | 2012-12-19 | 2014-06-26 | Basf Se | New substituted triazoles and imidazoles and their use as fungicides |
| CN114404414A (zh) | 2013-06-13 | 2022-04-29 | 阿克比治疗有限公司 | 用于治疗贫血症的组合物和方法 |
| MX362994B (es) | 2013-07-31 | 2019-03-01 | Chugai Pharmaceutical Co Ltd | Preparacion farmaceutica que comprende un derivado de aminopirazol. |
| JP6463580B2 (ja) * | 2013-12-13 | 2019-02-06 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ナトリウムチャネルの調節剤として有用なピリドンアミドのプロドラッグ |
| ES2756175T3 (es) | 2013-12-27 | 2020-04-27 | Chugai Pharmaceutical Co Ltd | Genes mutantes guardián de fgfr y fármacos que se dirigen a los mismos |
| EP3247355A4 (de) | 2015-01-23 | 2018-06-13 | Akebia Therapeutics, Inc. | Feste formen von 2-(5-(3-fluorphenyl)-3-hydroxypicolinamido)essigsäure, zusammensetzungen und verwendungen davon |
| EA036920B1 (ru) | 2015-04-01 | 2021-01-15 | Экебиа Терапьютикс, Инк. | Композиции и способы для лечения анемии |
| US10479780B2 (en) | 2015-06-17 | 2019-11-19 | Chugai Seiyaku Kabushiki Kaisha | Aminopyrazole derivatives |
| TW202406895A (zh) | 2018-05-09 | 2024-02-16 | 美商阿克比治療有限公司 | 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法 |
| CN110724091B (zh) * | 2019-12-04 | 2022-03-11 | 阿里生物新材料（常州）有限公司 | 一种6-（二氟甲基）-2-羟基吡啶-3-磺酰氯的合成方法 |
| CN112876409A (zh) * | 2021-01-20 | 2021-06-01 | 都创(上海)医药科技股份有限公司 | 一种2-(5-溴-6-甲氧基吡啶-2-基)乙腈及其衍生物的合成方法 |
| CN112898200A (zh) * | 2021-01-20 | 2021-06-04 | 都创(上海)医药科技股份有限公司 | 5-溴-6-甲氧基吡啶-2-羧酸酯的合成方法 |
| CN117285510A (zh) * | 2023-09-21 | 2023-12-26 | 西南大学 | 苯并吡啶酮乙烯嘧啶类化合物及其制备方法和医药应用 |
| CN117285509A (zh) * | 2023-09-21 | 2023-12-26 | 西南大学 | 氰乙烯桥联的喹诺酮咪唑类及其类似物的制备方法和医药应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US20040034041A1 (en) | 2000-05-10 | 2004-02-19 | Dashyant Dhanak | Novel anti-infectives |
| US20040097492A1 (en) * | 2002-11-01 | 2004-05-20 | Pratt John K | Anti-infective agents |
| PL376823A1 (pl) * | 2002-11-01 | 2006-01-09 | Abbott Laboratories | Środki przeciwzakaźne |
| CN101044151B (zh) * | 2004-08-23 | 2011-01-19 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒的4＇-叠氮基-核苷 |
| US8546420B2 (en) * | 2006-12-22 | 2013-10-01 | Merck Sharp & Dohme Corp. | 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
| JP5258889B2 (ja) | 2007-08-29 | 2013-08-07 | メルク・シャープ・アンド・ドーム・コーポレーション | ウイルス感染症の治療のための２，３−置換アザインドール誘導体 |
| TW200918536A (en) | 2007-08-29 | 2009-05-01 | Schering Corp | Tetracyclic indole derivatives and methods of use thereof |
| RU2010111550A (ru) | 2007-08-29 | 2011-10-10 | Шеринг Корпорейшн (US) | 2,3-замещенные индольные производные для лечения вирусных инфекций |
| CN104628654A (zh) * | 2007-09-17 | 2015-05-20 | 艾伯维巴哈马有限公司 | 抗感染嘧啶及其用途 |
| CN102746239B (zh) | 2007-09-17 | 2016-02-10 | 艾伯维巴哈马有限公司 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| CN105693626A (zh) | 2007-09-17 | 2016-06-22 | 艾伯维巴哈马有限公司 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| EP2222672B1 (de) | 2007-11-16 | 2013-12-18 | Merck Sharp & Dohme Corp. | 3-aminosulfonylsubstituierte indolderivate und verfahren zu deren anwendung |
| MX2010005356A (es) | 2007-11-16 | 2010-05-27 | Schering Corp | Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. |
| CN105924386A (zh) | 2009-03-25 | 2016-09-07 | Abbvie 公司 | 抗病毒化合物和其用途 |
| RU2552533C2 (ru) | 2009-03-25 | 2015-06-10 | Эббви Инк. | Противовирусные соединения и их применения |
-
2009
- 2009-07-15 WO PCT/EP2009/059039 patent/WO2010010017A1/en not_active Ceased
- 2009-07-15 EP EP09780611A patent/EP2307372B1/de not_active Not-in-force
- 2009-07-15 CA CA2730517A patent/CA2730517A1/en not_active Abandoned
- 2009-07-15 AT AT09780611T patent/ATE555096T1/de active
- 2009-07-15 ES ES09780611T patent/ES2383273T3/es active Active
- 2009-07-15 BR BRPI0916233A patent/BRPI0916233A2/pt not_active IP Right Cessation
- 2009-07-15 PE PE2011000046A patent/PE20110409A1/es not_active Application Discontinuation
- 2009-07-15 MX MX2011000656A patent/MX2011000656A/es not_active Application Discontinuation
- 2009-07-15 CN CN2009801283861A patent/CN102099335A/zh active Pending
- 2009-07-15 KR KR1020117003937A patent/KR20110033291A/ko not_active Ceased
- 2009-07-15 JP JP2011519125A patent/JP2011528686A/ja active Pending
- 2009-07-15 AU AU2009273327A patent/AU2009273327A1/en not_active Abandoned
- 2009-07-20 AR ARP090102751A patent/AR072824A1/es unknown
- 2009-07-22 US US12/460,658 patent/US8273773B2/en not_active Expired - Fee Related
- 2009-07-22 TW TW098124765A patent/TW201008922A/zh unknown
-
2010
- 2010-12-01 IL IL209696A patent/IL209696A0/en unknown
- 2010-12-21 ZA ZA2010/09183A patent/ZA201009183B/en unknown
-
2011
- 2011-01-21 CL CL2011000136A patent/CL2011000136A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0916233A2 (pt) | 2018-03-13 |
| CN102099335A (zh) | 2011-06-15 |
| PE20110409A1 (es) | 2011-06-22 |
| JP2011528686A (ja) | 2011-11-24 |
| ES2383273T3 (es) | 2012-06-19 |
| AU2009273327A1 (en) | 2010-01-28 |
| TW201008922A (en) | 2010-03-01 |
| WO2010010017A1 (en) | 2010-01-28 |
| US20100021423A1 (en) | 2010-01-28 |
| CA2730517A1 (en) | 2010-01-28 |
| AR072824A1 (es) | 2010-09-22 |
| KR20110033291A (ko) | 2011-03-30 |
| US8273773B2 (en) | 2012-09-25 |
| MX2011000656A (es) | 2011-02-23 |
| EP2307372B1 (de) | 2012-04-25 |
| ZA201009183B (en) | 2013-05-29 |
| CL2011000136A1 (es) | 2011-07-08 |
| IL209696A0 (en) | 2011-02-28 |
| EP2307372A1 (de) | 2011-04-13 |
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| BRPI0814426A2 (pt) | Compostos heterocíclicos úteis como inibidores de mk2 | |
| BRPI0918045A2 (pt) | compostos de carboxamida heterocíclicos |