ATE555101T1 - Neue benzothiazepin- und benzothiepinverbindungen - Google Patents
Neue benzothiazepin- und benzothiepinverbindungenInfo
- Publication number
- ATE555101T1 ATE555101T1 AT05710810T AT05710810T ATE555101T1 AT E555101 T1 ATE555101 T1 AT E555101T1 AT 05710810 T AT05710810 T AT 05710810T AT 05710810 T AT05710810 T AT 05710810T AT E555101 T1 ATE555101 T1 AT E555101T1
- Authority
- AT
- Austria
- Prior art keywords
- benzothiazepine
- therapeutic agent
- new
- agent
- pharmaceutical useful
- Prior art date
Links
- FHGWEHGZBUBQKL-UHFFFAOYSA-N 1,2-benzothiazepine Chemical compound S1N=CC=CC2=CC=CC=C12 FHGWEHGZBUBQKL-UHFFFAOYSA-N 0.000 title abstract 2
- NIGNBCLEMMGDQP-UHFFFAOYSA-N 1-benzothiepine Chemical class S1C=CC=CC2=CC=CC=C12 NIGNBCLEMMGDQP-UHFFFAOYSA-N 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 230000003449 preventive effect Effects 0.000 abstract 3
- 229940124597 therapeutic agent Drugs 0.000 abstract 3
- 208000004930 Fatty Liver Diseases 0.000 abstract 2
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 abstract 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 abstract 1
- 206010008609 Cholangitis sclerosing Diseases 0.000 abstract 1
- 206010008635 Cholestasis Diseases 0.000 abstract 1
- 206010019708 Hepatic steatosis Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 abstract 1
- -1 benzothiepine compound Chemical class 0.000 abstract 1
- 230000007870 cholestasis Effects 0.000 abstract 1
- 231100000359 cholestasis Toxicity 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 208000010706 fatty liver disease Diseases 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 201000000742 primary sclerosing cholangitis Diseases 0.000 abstract 1
- 208000010157 sclerosing cholangitis Diseases 0.000 abstract 1
- 231100000240 steatosis hepatitis Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004128992 | 2004-02-27 | ||
| PCT/JP2005/003686 WO2005082874A1 (ja) | 2004-02-27 | 2005-02-25 | 新規なベンゾチアゼピン及びベンゾチエピン化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE555101T1 true ATE555101T1 (de) | 2012-05-15 |
Family
ID=34909566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05710810T ATE555101T1 (de) | 2004-02-27 | 2005-02-25 | Neue benzothiazepin- und benzothiepinverbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7973030B2 (de) |
| EP (1) | EP1719768B1 (de) |
| JP (1) | JP4711953B2 (de) |
| KR (1) | KR20070026392A (de) |
| CN (2) | CN1930137B (de) |
| AT (1) | ATE555101T1 (de) |
| AU (1) | AU2005217318B2 (de) |
| CA (1) | CA2557576C (de) |
| WO (1) | WO2005082874A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005502143A (ja) * | 2001-08-29 | 2005-01-20 | 東京エレクトロン株式会社 | 施設モニタ |
| US8124625B2 (en) | 2001-09-14 | 2012-02-28 | Shionogi & Co., Ltd. | Method of enhancing the expression of apolipoprotein AI using olefin derivatives |
| US7312208B2 (en) | 2002-08-28 | 2007-12-25 | Asahi Kasei Pharma Corporation | Quaternary ammonium compounds |
| WO2009152152A1 (en) * | 2008-06-09 | 2009-12-17 | Amarillo Biosciences, Inc. | Treatment of obesity with an interferon |
| WO2010062861A2 (en) * | 2008-11-26 | 2010-06-03 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| ES2687027T3 (es) | 2010-11-04 | 2018-10-23 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermedades hepáticas |
| MX360979B (es) | 2011-09-16 | 2018-11-22 | Galectin Therapeutics Inc | Composiciones de galacto-ramnogalacturonato para el tratamiento de la esteatohepatitis no alcohólica y de la enfermedad del higado graso no alcohólico. |
| US20130108573A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease |
| AU2012328526B2 (en) * | 2011-10-28 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| CA2875979C (en) | 2012-06-06 | 2021-01-26 | Galectin Therapeutics, Inc. | Galacto-rhamnogalacturonate compositions for the treatment of diseases associated with elevated inducible nitric oxide synthase |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| CN106659726A (zh) | 2014-06-25 | 2017-05-10 | Ea制药株式会社 | 固体制剂及其着色防止或着色减少方法 |
| EP3012252A1 (de) | 2014-10-24 | 2016-04-27 | Ferring BV | Kristalline Form von elobixibat |
| WO2017138878A1 (en) | 2016-02-09 | 2017-08-17 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| ES2874669T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
| CN108601739B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 考来烯胺丸剂及其制备方法 |
| CN106588673B (zh) * | 2016-12-20 | 2018-06-26 | 金凯(辽宁)化工有限公司 | 一种2-甲基-5-氨基三氟甲苯的制备方法 |
| US10858351B2 (en) | 2017-04-26 | 2020-12-08 | Alberta Research Chemicals Inc. | Substituted tetrahydropyridine derivatives as IDO-1 inhibitors and uses thereof |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| CN112449637B (zh) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| PL3810581T3 (pl) | 2018-06-20 | 2025-04-28 | Albireo Ab | Modyfikacje kryształu odewiksibatu |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CN118852054A (zh) | 2019-02-06 | 2024-10-29 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 |
| TWI835997B (zh) | 2019-02-06 | 2024-03-21 | 瑞典商艾爾比瑞歐公司 | 苯并噻氮呯化合物及其用作膽酸調節劑之用途 |
| ES2973355T3 (es) | 2019-12-04 | 2024-06-19 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| JP7696898B2 (ja) | 2019-12-04 | 2025-06-23 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| EP4069247B1 (de) | 2019-12-04 | 2025-03-26 | Albireo AB | Benzothiadiazepinverbindungen und ihre verwendung als gallensäuremodulatoren |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| IL293379B2 (en) | 2019-12-04 | 2026-04-01 | Albireo Ab | Benzothia(dia)azepine compounds and their use as bile acid modulators |
| EP4188541B1 (de) | 2020-08-03 | 2024-12-25 | Albireo AB | Benzothia(di)azepin-verbindungen und ihre verwendung als gallensäuremodulatoren |
| CA3196488A1 (en) | 2020-11-12 | 2022-05-19 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| EP4511038A1 (de) | 2022-04-22 | 2025-02-26 | Albireo AB | Subkutane verabreichung eines asbt-hemmers |
| AU2023390975A1 (en) | 2022-12-09 | 2025-06-05 | Albireo Ab | Asbt inhibitors in the treatment of renal diseases |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9203347D0 (en) | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| IL108634A0 (en) * | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| ZA941003B (en) * | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
| ZA956647B (en) * | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| HUP9903047A3 (en) | 1996-03-11 | 2002-12-28 | G D Searle & Co Chicago | Novel benzothiazepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| PL336415A1 (en) | 1997-03-11 | 2000-06-19 | Searle & Co | Combined therapy employing ileic bile acid transport inhibiting benzothiepins as well as a hmg co-enzyme reductase inhibitors |
| DK0864582T3 (da) | 1997-03-14 | 2003-09-29 | Aventis Pharma Gmbh | Hypolidemiske 1,4-benzothiazepin-1,1-dioxider |
| ATE234829T1 (de) | 1997-12-19 | 2003-04-15 | Searle & Co | Verfahren zu herstellung von enantiomerisch- anreicherte tetrahydrobenzothiepin oxyden |
| WO2000038727A1 (en) * | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
| JP2002536440A (ja) * | 1999-02-12 | 2002-10-29 | ジー．ディー．サール エルエルシー | 回腸胆汁酸輸送およびタウロコール酸塩取り込みの阻害剤としての活性を有する新規１，２−ベンゾチアゼピン |
| DE19916108C1 (de) * | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US20020183307A1 (en) * | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
| EG26979A (en) * | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| WO2002053548A1 (fr) | 2000-12-27 | 2002-07-11 | Banyu Pharmaceutical Co.,Ltd. | Derives de la benzothiazepine |
| GB0121621D0 (en) * | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| CN100494185C (zh) | 2002-08-28 | 2009-06-03 | 旭化成制药株式会社 | 新型季铵化合物 |
| US7312208B2 (en) * | 2002-08-28 | 2007-12-25 | Asahi Kasei Pharma Corporation | Quaternary ammonium compounds |
-
2005
- 2005-02-25 KR KR1020067017272A patent/KR20070026392A/ko not_active Abandoned
- 2005-02-25 US US10/590,458 patent/US7973030B2/en not_active Expired - Fee Related
- 2005-02-25 AU AU2005217318A patent/AU2005217318B2/en not_active Ceased
- 2005-02-25 EP EP05710810A patent/EP1719768B1/de not_active Expired - Lifetime
- 2005-02-25 CA CA2557576A patent/CA2557576C/en not_active Expired - Fee Related
- 2005-02-25 CN CN200580007914XA patent/CN1930137B/zh not_active Expired - Fee Related
- 2005-02-25 JP JP2006510539A patent/JP4711953B2/ja not_active Expired - Fee Related
- 2005-02-25 WO PCT/JP2005/003686 patent/WO2005082874A1/ja not_active Ceased
- 2005-02-25 CN CN201110176728A patent/CN102293773A/zh active Pending
- 2005-02-25 AT AT05710810T patent/ATE555101T1/de active
-
2011
- 2011-05-16 US US13/108,394 patent/US20120015925A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120015925A1 (en) | 2012-01-19 |
| CN1930137A (zh) | 2007-03-14 |
| CN102293773A (zh) | 2011-12-28 |
| HK1100490A1 (en) | 2007-09-21 |
| CA2557576C (en) | 2010-02-09 |
| CA2557576A1 (en) | 2005-09-09 |
| WO2005082874A1 (ja) | 2005-09-09 |
| EP1719768B1 (de) | 2012-04-25 |
| AU2005217318B2 (en) | 2010-07-01 |
| JP4711953B2 (ja) | 2011-06-29 |
| US20070190041A1 (en) | 2007-08-16 |
| US7973030B2 (en) | 2011-07-05 |
| EP1719768A1 (de) | 2006-11-08 |
| KR20070026392A (ko) | 2007-03-08 |
| EP1719768A4 (de) | 2009-11-04 |
| JPWO2005082874A1 (ja) | 2008-01-17 |
| AU2005217318A1 (en) | 2005-09-09 |
| CN1930137B (zh) | 2011-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE555101T1 (de) | Neue benzothiazepin- und benzothiepinverbindungen | |
| ATE531701T1 (de) | Neue quaternüre ammoniumverbindungen | |
| EP1830228A4 (de) | Zusammensetzung für resist und strahlungsempfindliche zusammensetzung | |
| IL258983B (en) | Novel use of il-1beta compounds | |
| EP2103619A4 (de) | Imidazothiazolderivate | |
| WO2008013925A3 (en) | Fungicidal azocyclic amides | |
| EP2007373A4 (de) | Hemmung der alpha-synuclein-toxizität | |
| MX2008000115A (es) | Derivados de piperidina utiles como antagonistas de histamina h3. | |
| IL183973A0 (en) | Spm 927 for add -on therapy of schizophrenia | |
| NO20052223D0 (no) | Tiazolforbindelser for behandling av neurodegenerative forstyrrelser | |
| ATE538797T1 (de) | Pharmazeutische zusammensetzungen mit neuroaktivem steroid und verwendungen davon | |
| IL189139A0 (en) | Trazodone composition for once a day administration | |
| EP1951731A4 (de) | Azacyclohexanderivate als inhibitoren von stearoyl-coenzym-a-delta-9-desaturase | |
| WO2007087506A3 (en) | Compounds for the treatment of metabolic disorders | |
| PT2428574E (pt) | Oxidorredutases para a redução estereosseletiva de compostos ceto | |
| EP2049158A4 (de) | Osteogenesesteuerung mittels hemmung von osteogenen suppressoren | |
| ATE531717T1 (de) | Neue kristalline form eines pyridazinoä4,5- büindolderivats | |
| WO2004075840A3 (en) | Selective non-steroidal glucocorticoid receptor modulators | |
| EP1978971A4 (de) | Arginin-heteromere für die topische verarbreichung | |
| FR2884079B1 (fr) | Commande d'un transistor mos | |
| WO2009022540A1 (ja) | 化合物及び感放射線性組成物 | |
| FR2896642B1 (fr) | Commande d'un transistor mos | |
| EP1855674A4 (de) | Zusammensetzung zur hemmung von cathepsin k | |
| WO2009084835A3 (en) | Pharmaceutical composition for treatment and prevention of kidney diseases | |
| BRPI0610156A2 (pt) | forma micronizada de um composto, forma purificada i do composto, kit, padrão de referência, e, método de preparaçao de uma composição farmacêutica. |