ATE556137T1 - Durch einen polyelektrolytkomplex von hyaluronsäure und chitosan verstärkte biomimetische zusammensetzung - Google Patents

Durch einen polyelektrolytkomplex von hyaluronsäure und chitosan verstärkte biomimetische zusammensetzung

Info

Publication number: ATE556137T1
Authority: AT; Austria
Prior art keywords: chitosan; hyaluronic acid; polyelectrolyte complex; composition reinforced; biomimetic composition
Prior art date: 2003-12-01

Application number

AT04812547T

Other languages

English (en)

Inventor

John Brekke

Original Assignee

Tissue Engineering Consultants Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-01

Filing date

2004-12-01

Publication date

2012-05-15

2004-12-01 Application filed by Tissue Engineering Consultants Inc filed Critical Tissue Engineering Consultants Inc

2012-05-15 Application granted granted Critical

2012-05-15 Publication of ATE556137T1 publication Critical patent/ATE556137T1/de

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 4
229920001661 Chitosan Polymers 0.000 title abstract 4
229920002674 hyaluronan Polymers 0.000 title abstract 4
229960003160 hyaluronic acid Drugs 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 4
230000003592 biomimetic effect Effects 0.000 title 1
229920000867 polyelectrolyte Polymers 0.000 title 1
210000004027 cell Anatomy 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000004113 cell culture Methods 0.000 abstract 1
239000006143 cell culture medium Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
210000002536 stromal cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/72—Chitin, chitosan

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Transplantation (AREA)
Organic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Pharmacology & Pharmacy (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Developmental Biology & Embryology (AREA)
Botany (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Composite Materials (AREA)
Materials Engineering (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT04812547T 2003-12-01 2004-12-01 Durch einen polyelektrolytkomplex von hyaluronsäure und chitosan verstärkte biomimetische zusammensetzung ATE556137T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US52596503P	2003-12-01	2003-12-01
US10/999,848 US7524514B2 (en)	2003-12-01	2004-11-30	Biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan
PCT/US2004/040051 WO2005054440A2 (en)	2003-12-01	2004-12-01	A biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan

Publications (1)

Publication Number	Publication Date
ATE556137T1 true ATE556137T1 (de)	2012-05-15

Family

ID=34657208

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04812547T ATE556137T1 (de)	2003-12-01	2004-12-01	Durch einen polyelektrolytkomplex von hyaluronsäure und chitosan verstärkte biomimetische zusammensetzung

Country Status (8)

Country	Link
US (2)	US7524514B2 (de)
EP (1)	EP1702064B1 (de)
AT (1)	ATE556137T1 (de)
AU (1)	AU2004295705A1 (de)
CA (1)	CA2547668A1 (de)
MX (1)	MXPA06006124A (de)
NZ (1)	NZ548177A (de)
WO (1)	WO2005054440A2 (de)

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US7524514B2 (en) *	2003-12-01	2009-04-28	Tissue Engineering Consultants, Inc.	Biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan
GB0329907D0 (en) *	2003-12-23	2004-01-28	Innomed Ltd	Compositions
SE0402272D0 (sv)	2004-09-21	2004-09-21	Amo Groningen Bv	Methods of treating a body site with a viscoelastic preparation
WO2006034383A1 (en) *	2004-09-21	2006-03-30	Advanced Medical Optics, Inc.	Viscoelastic solution or gel formulation, and methods of treating a body site with the same
JP5409009B2 (ja) *	2005-12-01	2014-02-05	エイジェンシーフォーサイエンス，テクノロジーアンドリサーチ	組織工学の足場としての三次元再構成細胞外マトリクス
CN100431624C (zh) *	2005-12-07	2008-11-12	浙江大学	可注射聚乳酸微载体/壳聚糖水凝胶复合支架的制备方法
CN1330386C (zh) *	2005-12-07	2007-08-08	浙江大学	用于组织工程的可注射性壳聚糖水凝胶的制备方法
US8690957B2 (en)	2005-12-21	2014-04-08	Warsaw Orthopedic, Inc.	Bone graft composition, method and implant
CN102695501A (zh)	2009-11-09	2012-09-26	聚光灯技术合伙有限责任公司	碎裂水凝胶
CN106913902A (zh)	2009-11-09	2017-07-04	聚光灯技术合伙有限责任公司	多糖基水凝胶
FR2967580A1 (fr) *	2010-11-18	2012-05-25	Centre Nat Rech Scient	Materiau comprenant un polysaccharide acide et un biopolymere cationique
USH2271H1 (en) *	2010-12-13	2012-07-03	James Thomas Sears	Production and application of an aircraft spreadable, cyanobacterial based biological soil crust inoculant for soil fertilization, soil stablization and atmospheric CO2 drawdown and sequestration
ES2770498T3 (es)	2012-08-28	2020-07-01	Univ Geneve	Hidrogeles híbridos
AU2014324459B2 (en)	2013-09-30	2018-10-11	Bioactive Regenerative Therapeutics, Inc.	Biomimetic hybrid gel compositions and methods of use
FR3029116B1 (fr) *	2014-12-01	2018-03-30	Advanced Chitosan Solutions Biotech	Procede d'obtention d'un gel de cartilage pour la reparation cartilagineuse, comprenant du chitosane et des chondrocytes
CN105903087A (zh) *	2015-12-14	2016-08-31	上海其胜生物制剂有限公司	一种兼具内聚性和弥散性的粘弹剂的制备方法
US11576925B2 (en) *	2016-04-25	2023-02-14	Mizhou Hui	Application of low-molecular-weight hyaluronic acid (LMW-HA) fragments
EP3675922A1 (de) *	2017-10-12	2020-07-08	Solyplus Berlin GmbH	Vernetzung von biopolymeren in halbfestem zustand
TWI732132B (zh) *	2018-09-05	2021-07-01	國立臺灣大學	製造模擬血管新生的細胞球的方法及其應用
US20200095540A1 (en) *	2018-09-25	2020-03-26	Bioactive Regenerative Therapeutics, Inc.	Methods of producing three-dimensional cell culture microenvironments
CN114191608B (zh) *	2021-12-17	2022-07-29	暨南大学附属第一医院（广州华侨医院）	一种温敏凝胶材料组合及其制备方法和应用
CN115105464B (zh) *	2022-08-31	2022-12-02	山东大学齐鲁医院	一种纳米复合水凝胶及其制备方法和应用

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2004
- 2004-11-30 US US10/999,848 patent/US7524514B2/en not_active Expired - Lifetime
- 2004-12-01 CA CA002547668A patent/CA2547668A1/en not_active Abandoned
- 2004-12-01 AU AU2004295705A patent/AU2004295705A1/en not_active Abandoned
- 2004-12-01 WO PCT/US2004/040051 patent/WO2005054440A2/en not_active Ceased
- 2004-12-01 AT AT04812547T patent/ATE556137T1/de active
- 2004-12-01 NZ NZ548177A patent/NZ548177A/en unknown
- 2004-12-01 MX MXPA06006124A patent/MXPA06006124A/es not_active Application Discontinuation
- 2004-12-01 EP EP04812547A patent/EP1702064B1/de not_active Expired - Lifetime
2009
- 2009-03-25 US US12/410,537 patent/US8137696B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20050214341A1 (en)	2005-09-29
EP1702064B1 (de)	2012-05-02
WO2005054440A3 (en)	2005-09-29
EP1702064A2 (de)	2006-09-20
MXPA06006124A (es)	2006-08-23
US7524514B2 (en)	2009-04-28
EP1702064A4 (de)	2008-05-07
US20090238874A1 (en)	2009-09-24
US8137696B2 (en)	2012-03-20
CA2547668A1 (en)	2005-06-16
AU2004295705A1 (en)	2005-06-16
WO2005054440A2 (en)	2005-06-16
NZ548177A (en)	2009-06-26

Publication	Publication Date	Title
ATE556137T1 (de)	2012-05-15	Durch einen polyelektrolytkomplex von hyaluronsäure und chitosan verstärkte biomimetische zusammensetzung
Zhai et al.	2019	Dental stem cell and dental tissue regeneration
Bassir et al.	2016	Potential for stem cell‐based periodontal therapy
Ansari et al.	2017	Human periodontal ligament‐and gingiva‐derived mesenchymal stem cells promote nerve regeneration when encapsulated in alginate/hyaluronic acid 3D scaffold
MX2009008559A (es)	2009-08-21	Hepatocitos y condorcitos de celulas madre de la placenta adherentes, y poblaciones de celulas enriquecidas con celulas madre de la placenta cd34+, cd45-.
Lin et al.	2008	Stem cells and periodontal regeneration
Marynka-Kalmani et al.	2010	The lamina propria of adult human oral mucosa harbors a novel stem cell population
MX390753B (es)	2025-03-21	Metodos para reprogramar celulas y usos de los mismos.
WO2009137624A3 (en)	2010-01-07	Hemangio colony forming cells and non-engrafting hemangio cells
MX2012000455A (es)	2012-04-11	Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas.
ATE510005T1 (de)	2011-06-15	Verfahren zur isolierung von zellen aus der nabelschnur
Pozzobon et al.	2014	Stem cells from fetal membranes and amniotic fluid: markers for cell isolation and therapy
NO20060464L (no)	2006-04-20	Use of CXCL6 chemokine in the prevention or repair of cartilage defects
IL187448A0 (en)	2008-02-09	Three-dimensional tissue equivalent using macromass culture
PL1970068T3 (pl)	2018-09-28	Naprawa tkanek z wykorzystaniem komórek multipotencjalnych
WO2010108058A3 (en)	2011-03-17	Small molecule inhibitors of dusp6 and uses therefor
WO2006047743A3 (en)	2006-09-08	Swine multipotent adult progenitor cells
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