ATE556596T1 - Regulierte attenuierung von lebendimpfstoffen zur verbesserung der kreuzimmunitätsschutzfunktion - Google Patents
Regulierte attenuierung von lebendimpfstoffen zur verbesserung der kreuzimmunitätsschutzfunktionInfo
- Publication number
- ATE556596T1 ATE556596T1 AT03721711T AT03721711T ATE556596T1 AT E556596 T1 ATE556596 T1 AT E556596T1 AT 03721711 T AT03721711 T AT 03721711T AT 03721711 T AT03721711 T AT 03721711T AT E556596 T1 ATE556596 T1 AT E556596T1
- Authority
- AT
- Austria
- Prior art keywords
- immmunity
- protective function
- live vaccines
- improve cross
- regulated attenuation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37261602P | 2002-04-15 | 2002-04-15 | |
| US37362602P | 2002-04-18 | 2002-04-18 | |
| PCT/US2003/011802 WO2003096812A1 (en) | 2002-04-15 | 2003-04-15 | Regulated attenuation of live vaccines to enhance cross protective immunogenicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE556596T1 true ATE556596T1 (de) | 2012-05-15 |
Family
ID=29553427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03721711T ATE556596T1 (de) | 2002-04-15 | 2003-04-15 | Regulierte attenuierung von lebendimpfstoffen zur verbesserung der kreuzimmunitätsschutzfunktion |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8133493B2 (de) |
| EP (2) | EP1499191B1 (de) |
| AT (1) | ATE556596T1 (de) |
| CA (1) | CA2526895A1 (de) |
| WO (1) | WO2003096812A1 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8337861B2 (en) * | 2003-01-09 | 2012-12-25 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector |
| EP1616029A2 (de) * | 2003-04-18 | 2006-01-18 | Warnex Research Inc. | Oligonukleotide zum nachweis von salmonella-spezies |
| EP2857038B1 (de) | 2006-09-18 | 2019-04-10 | The Board of Trustees of the University of Arkansas | Zusammensetzungen und Verfahren zur Verstärkung von Immunreaktionen |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| US20100317084A1 (en) * | 2007-05-10 | 2010-12-16 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacteria comprising vectors for expression of nucleic acid sequences encoding antigens |
| EP2150616A4 (de) | 2007-05-10 | 2011-07-27 | Univ Arizona | Geregelte antigensynthese und/oder geregelte attenuation zur verbesserung der impfstoff immunogenität und/oder -sicherheit |
| BRPI0812346B1 (pt) * | 2007-06-08 | 2019-01-22 | Australian Poultry Crc Pty Ltd | célula hospedeira, método para a produção de um polipeptídeo isolado, composição, vacinas, método de atenuação da virulência de uma bactéria, método para determinar se um indivíduo foi exposto a um patógeno e uso da célula hospedeira, das vacinas ou da bactéria |
| US20090035815A1 (en) * | 2007-06-29 | 2009-02-05 | Laxmi Srinivas Rao | Synthetic Gene for Enhanced Expression in E. Coli |
| US9040059B2 (en) | 2007-10-05 | 2015-05-26 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting a protective immune response against C. perfringens |
| US9125854B2 (en) * | 2007-10-30 | 2015-09-08 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to flagellated bacterium |
| PT2214701T (pt) | 2007-11-01 | 2016-11-02 | Univ Guelph | Composições e métodos de potenciar respostas imunes a eimeria |
| WO2010045620A1 (en) * | 2008-10-17 | 2010-04-22 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae |
| WO2010094699A1 (en) * | 2009-02-19 | 2010-08-26 | Creatogen Laboratories Gmbh | Attenuated salmonella enteritidis strain |
| US9163219B2 (en) * | 2009-04-14 | 2015-10-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Single expression vector for generation of a virus with a segmented genome |
| US8709444B2 (en) | 2009-05-14 | 2014-04-29 | Northwestern University | Live-attenuated compositions for bacterial infections |
| WO2010135563A1 (en) | 2009-05-22 | 2010-11-25 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium and methods of antigen and nucleic acid delivery |
| US9045742B2 (en) * | 2009-05-29 | 2015-06-02 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant Edwardsiella bacterium |
| US9062297B2 (en) | 2010-01-13 | 2015-06-23 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Yersinia pestis vaccine |
| NO2525817T3 (de) | 2010-01-21 | 2018-01-06 | ||
| WO2011091291A1 (en) * | 2010-01-22 | 2011-07-28 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | BACTERIUM COMPRISING A REGULATED rfaH NUCLEIC ACID |
| WO2011150421A2 (en) | 2010-05-28 | 2011-12-01 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium to decrease tumor growth |
| BR112012031211A2 (pt) | 2010-06-09 | 2018-01-30 | Univ Arkansas | métodos e vacina para reduzir a infecção causada pelo campylobacter |
| US9255283B2 (en) | 2010-07-02 | 2016-02-09 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Compositions and methods for bacterial lysis and neutral lipid production |
| BR112014018732A8 (pt) | 2012-02-01 | 2017-07-11 | Univ Arizona | Composições imunogênicas contra campylobacter e usos das mesmas |
| US9303264B2 (en) | 2012-05-18 | 2016-04-05 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Photosynthetic microorganisms expressing thermostable lipase |
| EP2956165B1 (de) | 2013-02-14 | 2019-09-11 | The Board of Trustees of the University of Arkansas | Zusammensetzungen und verfahren zur verstärkung von immunreaktionen gegenüber eimeria oder zur begrenzung von eimeria-infektionen |
| CN105142653B (zh) | 2013-03-15 | 2019-11-15 | 阿肯色大学评议会 | 增强对肠病原体免疫应答的组合物和方法 |
| US9580718B2 (en) | 2013-06-17 | 2017-02-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Attenuated live bacteria with increased acid resistance and methods of use thereof |
| EP3092302A4 (de) * | 2014-01-06 | 2017-06-07 | The United States of America, as Represented by the Secretary of Agriculture | Abgeschwächte salmonella enterica |
| WO2015145250A2 (en) * | 2014-03-27 | 2015-10-01 | Ghosh Sambuddha | Expression of a single chain antibody against salmonella in lactobacillus |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| AR108688A1 (es) | 2016-05-03 | 2018-09-19 | Univ Arkansas | Vector de vacuna de levadura que incluye polipéptidos inmunoestimuladores y antigénicos, métodos para su uso |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP7097438B2 (ja) | 2017-07-11 | 2022-07-07 | アクティム・セラピューティクス・インコーポレイテッド | 遺伝子操作された免疫刺激性細菌菌株およびその使用 |
| JP7340591B2 (ja) | 2018-07-11 | 2023-09-07 | アクティム・セラピューティクス・インコーポレイテッド | 遺伝子操作された免疫刺激性細菌菌株およびその使用 |
| US11242528B2 (en) | 2018-08-28 | 2022-02-08 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
| US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| WO2021222696A1 (en) * | 2020-04-30 | 2021-11-04 | University Of Florida Research Foundation, Incorporated | Live self-destructing bacterial adjuvants to enhance induction of immunity |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US12537071B1 (en) | 2020-07-22 | 2026-01-27 | David Gordon Bermudes | Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins |
| CN112695004A (zh) * | 2020-12-28 | 2021-04-23 | 南通大学 | APEC双基因rpoS和arcA缺失菌株及弱毒疫苗 |
| WO2022271976A1 (en) * | 2021-06-24 | 2022-12-29 | Elanco Us Inc. | Attenuated salmonella, vaccines, and delivery platform |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888170A (en) * | 1981-10-22 | 1989-12-19 | Research Corporation | Vaccines obtained from antigenic gene products of recombinant genes |
| IL86583A0 (en) * | 1987-06-04 | 1988-11-15 | Molecular Eng Ass | Vaccine containing a derivative of a microbe and method for the production thereof |
| US5294441A (en) * | 1987-06-04 | 1994-03-15 | Washington University | Avirulent microbes and uses therefor: salmonella typhi |
| JPH04501351A (ja) | 1987-10-07 | 1992-03-12 | ワシントン ユニバーシティ | 細胞の遺伝的集団において所望の組換え遺伝子を維持する方法 |
| WO1990011687A1 (en) | 1989-03-31 | 1990-10-18 | Washington University | VACCINES CONTAINING AVIRULENT phoP-TYPE MICROORGANISMS |
| GB8912330D0 (en) * | 1989-05-30 | 1989-07-12 | Wellcome Found | Live vaccines |
| AU6737190A (en) * | 1989-11-03 | 1991-05-31 | Washington University | Cross-protective salmonella vaccines |
| CA2143299A1 (en) * | 1992-09-04 | 1994-03-17 | University Of Saskatchewan | Novel bacterial vaccines using vaccine strains of pathogenic bacteria |
| GB9711964D0 (en) | 1997-06-09 | 1997-08-06 | Medical Res Council | Live attenuated vaccines |
| US6024961A (en) | 1997-11-14 | 2000-02-15 | Washington University | Recombinant avirulent immunogenic S typhi having rpos positive phenotype |
| JP2002516068A (ja) * | 1998-03-20 | 2002-06-04 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | Staphylococcusaureus遺伝子およびポリペプチド |
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| US6399074B1 (en) * | 1998-07-24 | 2002-06-04 | Megan Health, Inc. | Live attenuated salmonella vaccines to control avian pathogens |
| US6713073B1 (en) | 1998-07-24 | 2004-03-30 | Megan Health, Inc. | Method of vaccination of newly hatched poultry |
| US6780405B1 (en) * | 2000-04-28 | 2004-08-24 | Avant Immunotherapeutics, Inc. | Regulated antigen delivery system (RADS) |
-
2003
- 2003-04-15 WO PCT/US2003/011802 patent/WO2003096812A1/en not_active Ceased
- 2003-04-15 CA CA002526895A patent/CA2526895A1/en not_active Abandoned
- 2003-04-15 EP EP03721711A patent/EP1499191B1/de not_active Expired - Lifetime
- 2003-04-15 EP EP10181350.9A patent/EP2380440B1/de not_active Expired - Lifetime
- 2003-04-15 US US10/511,616 patent/US8133493B2/en not_active Expired - Lifetime
- 2003-04-15 AT AT03721711T patent/ATE556596T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| US8133493B2 (en) | 2012-03-13 |
| EP1499191A1 (de) | 2005-01-26 |
| EP2380440B1 (de) | 2016-03-09 |
| EP1499191B1 (de) | 2012-05-09 |
| AU2003235457A1 (en) | 2003-12-02 |
| EP1499191A4 (de) | 2006-06-21 |
| US20060233829A1 (en) | 2006-10-19 |
| WO2003096812A1 (en) | 2003-11-27 |
| CA2526895A1 (en) | 2003-11-27 |
| EP2380440A1 (de) | 2011-10-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1499191A4 (de) | Regulierte attenuierung von lebendimpfstoffen zur verbesserung der kreuzimmunitätsschutzfunktion | |
| ATE272410T1 (de) | Adjuvanszusammensetzungen zur erhöhung der immunantwort auf polynukleotid-basierende impfstoffe | |
| ECSP11010975A (es) | Método de uso de una cepa de bacillus subtilis para mejorar la salud de animales | |
| ATE511398T1 (de) | Inaktiviertes poliovirus mischimpfstoff | |
| ATE451119T1 (de) | Untereinheit-impfstoff gegen das respiratorische synzytialvirus | |
| ATE426412T1 (de) | Adjuvante influenza-vakzine | |
| TNSN07387A1 (en) | C.perfringens alpha toxoid vaccine | |
| NO20025590D0 (no) | Fenylglycin-derivater | |
| GB2386072A (en) | Novel vaccine | |
| BR0316346A (pt) | Vacina para vìrus do nilo ocidental | |
| PT650733E (pt) | Vacina in ovo viva atenuada | |
| ATE269104T1 (de) | Salmonella impfstoff, der keinen antikörper gegen flagellin oder gegen flagella induziert | |
| PT1278761E (pt) | Modulacao da estimulacao imunitaria mediada por oligonucleotidos de cpg, por modificacao posicional de nucleosidos | |
| ATE521621T1 (de) | Cpg-einzelstrang-desoxynukleotide zur verwendung als adjuvans | |
| CY1112575T1 (el) | Βελτιωμενα αδρανοποιημενα εμβολια fcv | |
| DE602005012097D1 (de) | Adjuvante zusammensetzung und anwendungsverfahren dafür | |
| MA28268A1 (fr) | Composes et techniques de traitement de la dyslipidemie | |
| DE69824794D1 (de) | Streptococcus equi Impfstoff | |
| ATE359815T1 (de) | Streptococcus-phocae-vakzine | |
| TW200503755A (en) | Avian vaccine composition for the protection of poultry against disease and infection caused by e. coli and salmonella | |
| SG147465A1 (en) | Vaccine | |
| AR009650A1 (es) | Mycoplasma synoviae atenuado vivo, su uso, un cultivo microbiologico que lo comprende, una vacuna bacteriana atenuada viva para la proteccion de las aves de corral contra la infeccion por mycoplasma synoviae y un metodo para preparar dicha vacuna. | |
| HUP9700975A2 (hu) | Élő, legyengített, Pasteurellaceae családba tartozó, RTX-termelő baktériumok | |
| DK1074266T3 (da) | Levende svækkede bakterier til anvendelse i vaccine | |
| AR041090A1 (es) | Uso de toxina labil al calor de esterichia coli como adyuvante en pajaros y aves de corral |